16 research outputs found
Successful Pre- and Posttransplant Sofosbuvir-Based Anti-Hepatitis C Virus Treatment in Persons Living With Human Immunodeficiency Virus Infection
This retrospective study reports the data of sofosbuvir-based anti-hepatitis C virus treatment in 24 candidates and 24 recipients of liver transplantation coinfected with human immunodeficiency virus. Sustained virologic response was cumulatively 85% (90% and 100% in those treated with optimal schedules pre- and posttransplant, respectively).This retrospective study reports the data of sofosbuvir-based anti-hepatitis C virus treatment in 24 candidates and 24 recipients of liver transplantation coinfected with human immunodeficiency virus. Sustained virologic response was cumulatively 85% (90% and 100% in those treated with optimal schedules pre- and posttransplant, respectively)
Microchemical and microscopic characterization of the pictorial quality of egg-tempera polyptych, late 14th century, Florence, Italy
Analysis of the current world biofuel production under a waterâfoodâenergy nexus perspective
This paper assesses the sustainability of bioenergy production under a nexus perspective through a new efficiency type index. The index describes 1st generation biofuel production under the perspective of the implied consumption of natural resources. We consider the sustainability of energy production as a sequence of steps, each characterised by its efficiency, and propose an index which returns an overall efficiency value describing the adequacy or inadequacy of the considered processes under a nexus perspective. The direct application of the nexus index entails an indication of the possible improvements needed to move production towards most sustainable processes or places. Moreover, it allows evaluating the efficiency of the main crops currently used in biofuel production with respect to the waterâfoodâenergy nexus. The results depict countries presently capable of performing sustainable production of 1st generation biofuel from particular crops. Furthermore, the analysis of the single components of the nexus index allows understanding the effects of possible improvements (e.g. soil and water management, new generation biofuels) on the overall production efficiency under a nexus perspectiv
A Comparison between Abacavir and Efavirenz as the Third Drug Used in Combination with a Background Therapy Regimen of 2 Nucleoside ReverseâTranscriptase Inhibitors in Patients with Initially Suppressed Viral Loads
Discordant Liver Fibrosis Predictors in Virologically Suppressed People Living with HIV without Hepatitis Virus Infection
Severe liver fibrosis (LF) is associated with poor long-term liver-related outcomes in people living with HIV (PLWH). The study aimed to explore the prevalence and predictors of LF and the concordance between different non-invasive methods for the estimation of LF in HIV-infected individuals without hepatitis virus infection. We enrolled PLWH with HIV-1-RNA <50 copies/mL for >12 months, excluding individuals with viral hepatitis. LF was assessed by transient elastography (TE) (significant >6.65 kPa), fibrosis-4 (FIB-4) (significant >2.67), and AST-to-platelet ratio index (APRI) (significant >1.5). We included 234 individuals (67% males, median age 49 years, median time from HIV diagnosis 11 years, 38% treated with integrase strand transfer inhibitors). In terms of the TE, 13% had ≥F2 stage; FIB-4 score was >1.5 in 7%; and APRI > 0.5 in 4%. Higher body mass index, diabetes mellitus, detectable baseline HIV-1 RNA and longer atazanavir exposure were associated with higher liver stiffness as per TE. Predictors of higher APRI score were CDC C stage and longer exposure to tenofovir alafenamide, while HBcAb positivity and longer exposure to tenofovir alafenamide were associated to higher FIB-4 scores. Qualitative agreement was poor between FIB-4/TE and between APRI/TE by non-parametric Spearman correlation and kappa statistic. In our study, in the group of PLWH without viral hepatitis, different non-invasive methods were discordant in predicting liver fibrosis
James Baldwin and American Identity
James Baldwinâs nonfiction workâprimarily The Fire Next Timeâ seeks to define the concept of the American identity by exploring the influence of racial relations within the United States on both black and white Americansâ perceptions of the American identity. My research involves the use of academic journals and literary criticism regarding Baldwinâs nonfiction work, as well as a thorough study of The Fire Next Time. In my project on The Fire Next Time, I articulate Baldwinâs argument that the creation and development of the American identity is determined by oneâs race and perpetuated by American society