Novel Calibration systems for the dynamic and steady-state testing of digital instrument transformers

Within the frame of the European project 'Future Grid II-Metrology for the next-generation digital substation instrumentation', several partners developed traceable calibration systems which allow the calibration of conventional or non-conventional instrument transformers (IT) even with a sampled value (digital) output according to IEC 61869-9. Different setups are prepared to allow the calibration with complex test waveforms to emulate steady state, dynamic or temporary events during the assessment of the ITs. The laboratory calibration setups for either current transformers or voltage transformers are briefly described. Several results obtained for different kind of voltage or current transformers are presented

Paracetamol serum concentrations in preterm infants treated with paracetamol intravenously: a case series

<p>Abstract</p> <p>Introduction</p> <p>Until now, studies on paracetamol given intravenously have mainly been performed with the pro-drug propacetamol or with paracetamol in preterm babies above 32 weeks of gestation. Studies in these babies indicate that intravenous paracetamol is tolerated well, however studies on the efficacy of intravenous paracetamol are lacking. There are no pharmacokinetic data on the administration of multiple doses of paracetamol in preterm babies with a gestational age below 32 weeks.</p> <p>Case presentation</p> <p>We present a case series of nine Caucasian preterm babies, six boys and three girls, with a mean gestational age of 28.6 weeks (range 25.9 to 31.6 weeks). Case one, a girl with a gestational age of 25 weeks and six days, presented with necrotizing enterocolitis. In the second case, a female baby with a gestational age of 26 weeks and two days presented with hematoma. In case three, a female baby with a gestation of 26 weeks and one day developed intraventricular hemorrhage. In case four, a male baby with a gestational age of 31 weeks and four days presented with pain after vacuum delivery. Case five, a female baby born after a gestation of 29 weeks and six days presented with hematoma. In case six, a male baby with a gestation of 30 weeks and six days presented with hematoma. In case seven, a male baby, born with a gestational age of 30 weeks and six days, presented with caput succedaneum and hematoma. In case eight, a male baby, born after a gestation of 28 weeks and four days, developed abdominal distention. Case nine, a female baby, born with a gestational age of 27 weeks and three days presented with hematoma. These babies were treated with intravenous paracetamol 15 mg/kg every six hours. Serum concentrations and aspartate transaminase were determined after prolonged administration. Pain scores were assessed using the Premature Infant Pain Profile.</p> <p>Conclusion</p> <p>Paracetamol serum concentrations ranged from 8 to 64 mg/L after eight to 12 doses of intravenous paracetamol. Adequate analgesia was obtained in seven babies. During paracetamol therapy the median serum level of aspartate transaminase was 20 U/L (range 12 to 186 U/L). This case series indicates that prolonged intravenous administration of paracetamol in preterm babies with a gestational age of less than 32 weeks is tolerated well in the first days after birth. However, in the absence of proper pharmacokinetic data in this age group we cannot advocate the use of paracetamol intravenously.</p

Test equipment and its effect on the calibration of instrument transformers

State-approved test centres in Germany supplying accuracy tests for instrument transformers must, in the future, provide measurement uncertainty budgets for their quality management systems. In this work, the cause of ratio error and phase displacement of instrument transformers are therefore discussed. The traceability to the national standards of PTB, the attainable uncertainty, and the permitted error limits of test equipment for testing instrument transformers are presented. Finally, an example of an uncertainty budget for a current transformer of the class 0,2 S is given

Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission

A dynamic interplay between intrinsic regional molecular cues and extrinsic factors from the thalamus shape multiple features of early cortical development. It remains uncertain and controversial, however, whether the initial formation of cortical columns depends on neuronal activity, and there is little evidence that cortical lamination or neuronal differentiation is influenced by extrinsic activity. We examined the role of thalamic-derived factors in cortical development by selectively eliminating glutamatergic synaptic transmission from thalamocortical neurons in mice and found that eliminating thalamocortical neurotransmission prevented the formation of "barrel" columns in somatosensory cortex. Interestingly, based on cytoarchitectonic criteria and genetic markers, blocking thalamocortical neurotransmission also perturbed the development of superficial cortical lamina and the morphologic development of neurons. These experiments demonstrate that barrels and aspects of the layer-dependent pattern of cortical cytoarchitecture, gene expression, and neuronal differentiation depend on thalamocortical neurotransmission, extending the apparent influence of extrinsic, presumably activity-dependent factors, on cortical developmen

Measurement Methods and Procedures for Assessing Accuracy of Instrument Transformers for Power Quality Measurements

Instrument transformers (ITs) are vital components of power quality (PQ) measurement systems in electrical transmission and distribution grids. Whereas measurement methods and accuracy are well defined for PQ measurement instruments, accurate knowledge about IT performance in presence of grid disturbances is missing. Main research themes of a project recently funded within the EMPIR program are described in the paper. The project focuses on the set-up of a metrological framework to enable the traceable measurement of PQ parameters when ITs are included in the measurement chains. Attention is focused on the development of reference measurement systems and the definition of IT test procedures, as well as on the quantification of the performance of ITs under realistic disturbance conditions. Moreover, an extensive characterization of voltage and current ITs will provide the basis for the identification of different sets of limits for the IT accuracy performance in PQ application and the definition of PQ accuracy classes