1,504 research outputs found
Charmonium mass splittings at the physical point
We present results from an ongoing study of mass splittings of the lowest
lying states in the charmonium system. We use clover valence charm quarks in
the Fermilab interpretation, an improved staggered (asqtad) action for sea
quarks, and the one-loop, tadpole-improved gauge action for gluons. This study
includes five lattice spacings, 0.15, 0.12, 0.09, 0.06, and 0.045 fm, with two
sets of degenerate up- and down-quark masses for most spacings. We use an
enlarged set of interpolation operators and a variational analysis that permits
study of various low-lying excited states. The masses of the sea quarks and
charm valence quark are adjusted to their physical values. This large set of
gauge configurations allows us to extrapolate results to the continuum physical
point and test the methodology.Comment: 7 pp, 6 figs, Lattice 201
Java Web Start based software for automated quantitative nuclear analysis of prostate cancer and benign prostate hyperplasia
BACKGROUND: Androgen acts via androgen receptor (AR) and accurate measurement of the levels of AR protein expression is critical for prostate research. The expression of AR in paired specimens of benign prostate and prostate cancer from 20 African and 20 Caucasian Americans was compared to demonstrate an application of this system. METHODS: A set of 200 immunopositive and 200 immunonegative nuclei were collected from the images using a macro developed in Image Pro Plus. Linear Discriminant and Logistic Regression analyses were performed on the data to generate classification coefficients. Classification coefficients render the automated image analysis software independent of the type of immunostaining or image acquisition system used. The image analysis software performs local segmentation and uses nuclear shape and size to detect prostatic epithelial nuclei. AR expression is described by (a) percentage of immunopositive nuclei; (b) percentage of immunopositive nuclear area; and (c) intensity of AR expression among immunopositive nuclei or areas. RESULTS: The percent positive nuclei and percent nuclear area were similar by race in both benign prostate hyperplasia and prostate cancer. In prostate cancer epithelial nuclei, African Americans exhibited 38% higher levels of AR immunostaining than Caucasian Americans (two sided Student's t-tests; P < 0.05). Intensity of AR immunostaining was similar between races in benign prostate. CONCLUSION: The differences measured in the intensity of AR expression in prostate cancer were consistent with previous studies. Classification coefficients are required due to non-standardized immunostaining and image collection methods across medical institutions and research laboratories and helps customize the software for the specimen under study. The availability of a free, automated system creates new opportunities for testing, evaluation and use of this image analysis system by many research groups who study nuclear protein expression
The Mass-Radius Relationship for Very Low Mass Stars: Four New Discoveries from the HATSouth Survey
We report the discovery of four transiting F-M binary systems with companions
between 0.1-0.2 Msun in mass by the HATSouth survey. These systems have been
characterised via a global analysis of the HATSouth discovery data, combined
with high-resolution radial velocities and accurate transit photometry
observations. We determined the masses and radii of the component stars using a
combination of two methods: isochrone fitting of spectroscopic primary star
parameters, and equating spectroscopic primary star rotation velocity with
spin-orbit synchronisation. These new very low mass companions are HATS550-016B
(0.110 -0.006/+0.005 Msun, 0.147 -0.004/+0.003 Rsun), HATS551-019B (0.17
-0.01/+0.01 Msun, 0.18 -0.01/+0.01 Rsun), HATS551-021B (0.132 -0.005/+0.014
Msun, 0.154 -0.008/+0.006 Rsun), HATS553-001B (0.20 -0.02/+0.01 Msun, 0.22
-0.01/+0.01 Rsun). We examine our sample in the context of the radius anomaly
for fully-convective low mass stars. Combining our sample with the 13 other
well-studied very low mass stars, we find a tentative 5% systematic deviation
between the measured radii and theoretical isochrone models.Comment: 17 pages, 8 figures, accepted for publication in MNRA
HATS-5b: A Transiting hot-Saturn from the HATSouth Survey
We report the discovery of HATS-5b, a transiting hot-Saturn orbiting a G type
star, by the HAT-South survey. HATS-5b has a mass of Mp=0.24 Mj, radius of
Rp=0.91 Rj, and transits its host star with a period of P=4.7634d. The radius
of HATS-5b is consistent with both theoretical and empirical models. The host
star has a V band magnitude of 12.6, mass of 0.94 Msun, and radius of 0.87
Rsun. The relatively high scale height of HATS-5b, and the bright,
photometrically quiet host star, make this planet a favourable target for
future transmission spectroscopy follow-up observations. We reexamine the
correlations in radius, equilibrium temperature, and metallicity of the
close-in gas-giants, and find hot Jupiter-mass planets to exhibit the strongest
dependence between radius and equilibrium temperature. We find no significant
dependence in radius and metallicity for the close-in gas-giant population.Comment: 10 pages, submitted to A
Increased Expression of Androgen Receptor Coregulator MAGE-11 in Prostate Cancer by DNA Hypomethylation and Cyclic AMP
Melanoma antigen gene protein-A11 (MAGE-11) of the MAGE family of cancer-germline antigens increases androgen receptor (AR) transcriptional activity through its interaction with the AR NH2-terminal FXXLF motif. The present study investigated the regulatory mechanisms that control MAGE-11 expression during androgen deprivation therapy and prostate cancer progression. Studies include the CWR22 xenograft model of human prostate cancer, clinical specimens of benign and malignant prostate, and prostate cancer cell lines. MAGE-11 mRNA levels increased 100 to 1500 fold during androgen deprivation therapy and prostate cancer progression, with highest levels in the castration-recurrent CWR22 xenograft and clinical specimens of castration-recurrent prostate cancer. Pyrosequencing of genomic DNA from prostate cancer specimens and cell lines indicated the increase in MAGE-11 resulted from DNA hypomethylation of a CpG island in the 5´ promoter of the MAGE-11 gene. Sodium bisulfite sequencing of genomic DNA from benign and malignant prostate tumors and prostate cancer cell lines revealed DNA hypomethylation at individual CpG sites at the transcription start site were most critical for MAGE-11 expression. Cyclic AMP also increased MAGE-11 expression and AR transcriptional activity in prostate cancer cell lines. However, cyclic AMP did not alter DNA methylation of the promoter and its effects were inhibited by extensive DNA methylation in the MAGE-11 promoter region. Increased expression of the AR coregulator MAGE-11 through promoter DNA hypomethylation and cyclic AMP provides a novel mechanism for increased AR signaling in castration-recurrent prostate cancer
Central quadrant procurement of radical prostatectomy specimens
Obtaining high quality fresh or frozen prostate tissue in gram amounts promotes the research of prostate cancer. Due to the inability to effectively recognize prostate cancer upon the cut section of a fresh prostate many pathology departments perform whole organ processing precluding the procurement of prostate tissue. Some sites randomly procure tissue, while others perform specialized procedures that can be difficult to duplicate. Neither of these types of procurement consistently results in gram quantities of tissue procured from each prostate with a high percentage of samples yielding tissue corresponding to cancer. In this study, we present a simplified model of prostate tissue procurement that has no impact on Gleason grade, tumor stage or margin status, requires minimal specialized processing, and obtains gram amounts of fresh tissue from each radical prostatectomy specimen with a high percentage yielding cancer tissue
A modified two-process Knox test for investigating the relationship between law enforcement opioid seizures and overdoses
Recent research has shown an association between monthly law enforcement drug seizure events and accidental drug overdose deaths using cross-sectional data in a single state, whereby increased seizures correlated with more deaths. In this study, we conduct statistical analysis of street-level data on law enforcement drug seizures, along with street-level data on fatal and non-fatal overdose events, to determine possible micro-level causal associations between opioid-related drug seizures and overdoses. For this purpose, we introduce a novel, modified two-process Knox test that controls for self-excitation to measure clustering of overdoses nearby in space and time following law enforcement seizures. We observe a small, but statistically significant (p < 0.001), effect of 17.7 excess non-fatal overdoses per 1000 law enforcement seizures within three weeks and 250 m of a seizure. We discuss the potential causal mechanism for this association along with policy implications
The ESPRI project: astrometric exoplanet search with PRIMA I. Instrument description and performance of first light observations
The ESPRI project relies on the astrometric capabilities offered by the PRIMA
facility of the Very Large Telescope Interferometer for the discovery and study
of planetary systems. Our survey consists of obtaining high-precision
astrometry for a large sample of stars over several years and to detect their
barycentric motions due to orbiting planets. We present the operation
principle, the instrument's implementation, and the results of a first series
of test observations. A comprehensive overview of the instrument infrastructure
is given and the observation strategy for dual-field relative astrometry is
presented. The differential delay lines, a key component of the PRIMA facility
which was delivered by the ESPRI consortium, are described and their
performance within the facility is discussed. Observations of bright visual
binaries are used to test the observation procedures and to establish the
instrument's astrometric precision and accuracy. The data reduction strategy
for astrometry and the necessary corrections to the raw data are presented.
Adaptive optics observations with NACO are used as an independent verification
of PRIMA astrometric observations. The PRIMA facility was used to carry out
tests of astrometric observations. The astrometric performance in terms of
precision is limited by the atmospheric turbulence at a level close to the
theoretical expectations and a precision of 30 micro-arcseconds was achieved.
In contrast, the astrometric accuracy is insufficient for the goals of the
ESPRI project and is currently limited by systematic errors that originate in
the part of the interferometer beamtrain which is not monitored by the internal
metrology system. Our observations led to the definition of corrective actions
required to make the facility ready for carrying out the ESPRI search for
extrasolar planets.Comment: 32 pages, 39 figures, Accepted for publication in Astronomy and
Astrophysic
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