479 research outputs found

    The Gelfand-Naimark-Segal construction for unitary representatins of Z2n\mathbb Z_2^n-graded Lie supergroups

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    We establish a Gelfand-Naimark-Segal construction which yields a correspondence between cyclic unitary representations and positive definite superfunctions of a general class of Z2n\mathbb Z_2^n-graded Lie supergroups

    A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption

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    Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. Methods. A novel in vitro in vivo correlation, IVIVC, model denoted as double reciprocal area method was presented and applied to 19 drugs from 55 nano formulations with total 336 data, gathered from literature. Results. The proposed model correlated the in vitro with in vivo parameters with overall error of 12.4 ± 3.9%. Also the trained version of the model predicted the test formulations with overall error of 15.8 ± 3.7% indicating the suitability of the approach. A theoretical justification was provided for the model considering the unified classical release laws. Conclusion. The model does not necessitate bolus intravenous drug data and seems to be suitable for IVIVC of drugs with release rate-limited absorption

    SETTLE DISPUTE METHODS IN DOMESTIC AND INTERNATIONAL MARITIME TRANSPORTATION

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    Abstract. The rapid economic growth of Iran in the middle of the last century on the one hand and the large number of maritime trade exchanges between Iran and other countries on the other hand led to the Iranian legislator ratified the regulations on maritime transport, therefore, the Iranian Marine Law was approved in 1964. Although today, due to rapid industrial progress, most of the domestic and international transportation is carried out through air and land; the movement of passengers by sea, especially in short trips or sea voyages, is still a major contributor to domestic and international transport. Now, one of the questions that arises is that in the event of a dispute how it is resolved, which we will discuss in this study (both at the domestic and international levels).Keywords: Contract, transport, carrier, convention, arbitration

    Kinetic analysis of drug release from nanoparticles

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    PURPOSE. Comparative drug release kinetics from nanoparticles was carried out using conventional and our novel models with the aim of finding a general model applicable to multi mechanistic release. Theoretical justification for the two best general models was also provided for the first time. METHODS. Ten conventional models and three models developed in our laboratory were applied to release data of 32 drugs from 106 nanoparticle formulations collected from literature. The accuracy of the models was assessed employing mean percent error (E) of each data set, overall mean percent error (OE) and number of Es less than 10 percent. RESULTS. Among the models the novel reciprocal powered time (RPT), Weibull (W) and log-probability (LP) ones produced OE values of 6.47, 6.39 and 6.77, respectively. The OEs of other models were higher than 10%. Also the number of errors less than 10% for the models was 84.9, 80.2 and 78.3 percents of total number of data sets. CONCLUSIONS. Considering the accuracy criteria the reciprocal powered time model could be suggested as a general model for analysis of multi mechanistic drug release from nanoparticles. Also W and LP models were the closest to the suggested model RPT

    Relationship between EFL Teachers' Emotional Intelligence, Reflective teaching, Autonomy and their Students' L2 Learning

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    This study set out to provide empirical evidence on the relationship between EFL teachers' emotional intelligence, reflectivity, and autonomy, and their students' L2 performance. The participants of this study included 88 EFL teachers who taught English at different private English teaching institutes and their students (N = 1266). First, the teachers completed three validated questionnaires: Emotional Quotient Inventory (Bar-On, 1997), Teacher Reflectivity Questionnaire (Akbari, Behzadpour & Dadvand, 2010), and Teacher Work-Autonomy Scale (Friedman, 1999). Then, their learners’ scores on their final English proficiency exams were collected as indication of their L2 performance. The results of the study revealed that there was significant positive relationship between teachers' reflectivity, emotional intelligence and autonomy, on the one hand, and their students' L2 performance, on the other. The results of multiple regression analysis showed that from among the variables of this study, reflectivity was the stronger predictor of the learners' L2 performance. In addition, the findings indicated that EFL teachers' educational degree and gender significantly affect their levels of emotional intelligence and reflectivity. The findings of this study offer evidence to substantiate teachers’ emotional intelligence, reflectivity, and autonomy as important variables in L2 teaching and confirm their instructional nature

    A review of studies in the field of knowledge and safe behaviors of workers in Iran

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    Background and objective: One of the ways to prevent and control occupational accidents and educate people informing them of the risks and how to work safely. The aim of this study was to study the effectiveness of educational interventions to promote safe behavior and knowledge workers is studied. Methods: A systematic search of PubMed SID database and to obtain titles and abstracts containing data related to worker safety behaviors by examining the full text of 22 articles were selected and the results of which were analyzed Results: The group of workers includes training class. The impact of educational interventions: improving the safety of workers and the development of a safety culture in the workplace can be named. Most of the training programs designed for group discussion and the principles of adult learning. Conclusion: summary and analysis of the literature showed the need to promote safe behavior of workers. Since this behavior is very important, intervention is capable of knowledge, attitude, and perceived behavioral control about unsafe behavior change and improve the performance of their safety Paper Type: review Article
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