Medicinal Plants in Wound Healing

Wound healing process is known as interdependent cellular and biochemical stages which are in trying to improve the wound. Wound healing can be defined as stages which is done by body and delayed in wound healing increases chance of microbial infection. Improved wound healing process can be performed by shortening the time needed for healing or lowering the inappropriate happens. The drugs were locally or systemically administrated in order to help wound healing. Antibiotics, antiseptics, desloughing agents, extracts, etc. have been used in order to wound healing. Some synthetic drugs are faced with limitations because of their side effects. Plants or combinations derived from plants are needed to investigate identify and formulate for treatment and management of wound healing. There is increasing interest to use the medicinal plants in wound healing because of lower side effects and management of wounds over the years. Studies have shown that medicinal plants improve wound healing in diabetic, infected and opened wounds. The different mechanisms have been reported to improve the wound healing by medicinal plants. In this chapter, some medicinal plants and the reported mechanisms will be discussed

Evaluation of the wound healing activity of Cinnamomum zeylanicum extract on experimentally induced wounds in rats

The present study was undertaken to determine the effect of Cinnamomum zeylanicum on experimentally induced excision wounds in rats. Thirty-two rats were divided into four groups of eight rats each. Group A received a placebo containing 0.75% cinnamon, Group B received a placebo containing 1.5% cinnamon, Group C as a control group did not receive any treatment, and finally, Group D received blank placebo; Groups C and D were considered as one group (standard). The results were taken on days 3, 7, 14 and 21 and a histological evaluation was carried out on the samples. The result shows that cinnamon extract had a significant (p<0.05, **p<0.01) effect on wound healing; it accelerated the healing process of the wounds. Significant enclosure rates were seen after 7 days of study. The present study proved that C. zeylanicum was effective in treating experimentally induced wounds and hasten healing, showing a dose-dependent treatment trend. It especially increased epithelialization in treatment groups compared to other groups.Key words: Cinnamomum zeylanicum, induced excision, epithelialization, wound healing

VITRO ANTIOXIDANT PROPERTIES AND WOUND HEALING ACTIVITY OF HYDROETHANOLIC TURMERIC RHIZOME EXTRACT (ZINGIBERACEAE)

Objective: In the present study, we evaluated the ethno pharmacological effect of the different doses of Turmeric rhizome hydroethanolic extract ointment (TRO), using in vitro antioxidant activity and in vivo excision, incision and dead space wound models in Wistar rats. Methods: The antioxidant activity and acute toxicity studies were performed. In excision wound model, period of epithelization time and wound area were monitored on days 2, 4, 6, 8, 10, 12, 14, 16, 18 and 20 using graph paper. Additionally, histological evaluation was carried out on days 3, 7, 14 and 21. Incision wound modle and dead space, were perfomed for breaking strength value and hydroxyproline content. Results: The results of wound contraction and skin breaking strength a significant increased showed in wound contraction and breaking strength value rate, in all treatment groups with TRO, especially in high dose of TRO. Thus, results of histopathological evaluation showed that TRO accelerate wound healing process specifically in re-epithelization period, angiogenesis and collagen disposition in all treatment groups. Conclusion: Data revealed that ointment formulation prepared with hydroethanolic extract of Turmeric rhizome had remarkable wound healing activities

Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

The present study was designed to evaluate the in vivo effect of Allium sativum (garlic) hydroalcoholic extract on wound healing in rats. For this purpose, 72 mature Wistar rats were divided into four groups (n=18/each) to receive no treatment, placebo, Cicalfate(r), or 2% Allium sativum (AS) extract, administered topically to the wound area, for 21 days. Following the experimental period, tissue samples were dissected out and underwent to histopathological analyses. Fibroblasts, fibrocytes, mast cells, intra-cytoplasmic carbohydrate ratio, neovascularization, collagen deposition, and re-epithelialization were analyzed in all groups. Animals in the treated groups showed significant enhancement in fibroblast, fibrocyte, and mast-cell distribution. Significantly higher neovascularization was observed on day 3 after wound induction in AS-treated animals versus those in the placebo, Cicalfate, and untreated groups (

Topical application of <i>Salvia officinalis </i> hydroethanolic leaf extract improves wound healing process

98-106Salvia officinalis L. (common sage) is a popular herb in the mint family, Lamiaceae. To our knowledge, literature regarding the wound healing properties hydroethanolic extract of Salvia officinalis is scarce. Here, we tried to evaluate the in vitro antioxidant properties and in vivo wound healing activity of the hydroethanolic extract of S. officinalis. About 105 healthy Wistar rats were inflicted with wound by excision and incisionand were randomly divided into five experimental groups: Group I, as control; Group II, received placebo; groups III-V treated with 1, 3 and 5% S. officinalis hydroethanolic leaf extract, respectively. Thehydroethanolic leaf extract of Salvia officinalis showed the highest total flavonoid and phenolic content and antioxidant capacity. Topical application of S. officinalis extract, especially higher dose,significantly (P S. officinalis significantly (P S. officinalis,especially S. officinalis 5%,were significantly promoting wound healing effect and can be considered as an appropriate compound for clinical application in wound care

Facile fabrication of carboxymethylcellulose/ZnO/g-C3N4 containing nutmeg extract with photocatalytic performance for infected wound healing

Abstract New topical antibacterial agents are required to inhibit and development of bacteria and also promoting the wound healing process. This study was evaluating the healing effect of Myristica fragrans extract coated with carboxymethyl cellulose, zinc oxide and graphite carbon nitride (CMC/ZnO/g-C3N4/MyR) by photocatalytic process on the healing process of full-thickness infectious excision wounds in mice. Nanosheets were prepared and physicochemical properties were evaluated. Safety, in vitro release, antibacterial activities under in vitro and in vivo condition, wound contraction, histopathological properties and the protein expressions of tumor necrosis factor-α (TNF-α), collagen 1A (COL1A) and CD31 were also evaluated. Physicochemical properties confirmed their successful synthesis. Nanosheets exhibited antibacterial activity under in vitro and in vivo conditions. The formulations containing CMC/ZnO/g-C3N4/MyR, significantly (P < 0.05) competed with standard ointment of mupirocin for accelerating the wound healing process due to their effects on bacterial count and the expression of TNF-α and also accelerating the proliferative phase. This structure can be used as a safe structure in combination with other agents for accelerating the wound healing process following future clinical studies

Hydroethanolic Allium sativum extract accelerates excision wound healing: evidence for roles of mast-cell infiltration and intracytoplasmic carbohydrate ratio

ABSTRACT The present study was designed to evaluate the in vivo effect of Allium sativum (garlic) hydroalcoholic extract on wound healing in rats. For this purpose, 72 mature Wistar rats were divided into four groups (n=18/each) to receive no treatment, placebo, Cicalfate(r), or 2% Allium sativum (AS) extract, administered topically to the wound area, for 21 days. Following the experimental period, tissue samples were dissected out and underwent to histopathological analyses. Fibroblasts, fibrocytes, mast cells, intra-cytoplasmic carbohydrate ratio, neovascularization, collagen deposition, and re-epithelialization were analyzed in all groups. Animals in the treated groups showed significant enhancement in fibroblast, fibrocyte, and mast-cell distribution. Significantly higher neovascularization was observed on day 3 after wound induction in AS-treated animals versus those in the placebo, Cicalfate, and untreated groups (P<0.05). A dose-dependent, significantly higher intra-cytoplasmic carbohydrate storage was observed in treated animals. Our data show that AS promotes wound healing due to its preliminary impact on mast-cell distribution, which enhanced collagen synthesis and upregulated angiogenesis, and shortened the healing process by enhancing the intra-cytoplasmic carbohydrate ratio