Oxidation of o-chloro and o-hydroxy benzyl alcohols catalyzed by copper (II) tetraphenylporphyrin nanoparticles synthesized by mixed solvent method

Tetraphenylporphyrin (TPP) and copper tetraphenylporphyrin (CuTPP) were synthesized and characterized by IR, UV-Vis, 1HNMR and 13CNMR. The CuTPP nanoparticles were synthesized by sonication and mixed solvent methods. These nanoparticles were characterized by AFM and SEM images and UV-Vis spectra. The catalytic activity of nanoparticles was investigated by oxidation of o-choloro and o-hydroxy benzyl alcohols in presence of molecular oxygen and isobutyraldehyde. The yields of oxidation of o-hydroxy benzyl alcohol by the two catalysts, CuTPP NPs and CuTPP, are 96.5% and ~ 2%, respectively. It is very obvious that the oxidation at the presence of CuTPP NPs catalyst is very high but selectivity for both reactants is 100%.

A Review on biomedical application of polysaccharide-based hydrogels with a focus on drug delivery systems

Over the last years of research on drug delivery systems (DDSs), natural polymer-based 18 hydrogels have shown many scientific advances due to their intrinsic properties and a wide variety 19 of potential applications. While drug efficacy and cytotoxicity play a key role, adopting a proper 20 DDS is crucial to preserve the drug along the route of administration and possess desired therapeu-21 tic effect at the targeted site. Thus, drug delivery technology can be used to overcome the difficulties 22 of maintaining drugs at a physiologically related serum concentration for prolonged periods. Due 23 to their outstanding biocompatibility, polysaccharides have been thoroughly researched as a bio-24 logical material for DDS advancement. To formulate a modified DDS, polysaccharides can cross-25 link with different molecules, resulting in hydrogels. According to our recent findings, targeted 26 drug delivery at a certain spot occurs due to external stimulation like temperature, pH, glucose, or 27 light. As an adjustable biomedical device, the hydrogel has tremendous potential for nanotech ap-28 plications in the involved health area like pharmaceutical and biomedical engineering. An overview 29 of hydrogel characteristics and functionalities is provided in this review. We focus on discussing 30 the various kinds of hydrogel-based on their potential for effectively delivering drugs that are made 31 of polysaccharides

Folate-Targeted Curcumin-Loaded Niosomes for Site-Specific Delivery in Breast Cancer Treatment: In Silico and In Vitro Study

As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were higher compared to free drug and Nio-Cur. With PEG-FA-decorated Nio-Cur, levels of Bcl2 were lower than the free drug and Nio-Cur. When MCF7 and 4T1 cell uptake tests of PEG-FA@Nio-Cur and Nio-Cur were investigated, the results showed that the PEG-FA-modified niosomes exhibited the most preponderant endocytosis. In vitro experiments demonstrate that PEG-FA@Nio-Cur is a promising strategy for the delivery of Cur in breast cancer therapy. Breast cancer cells absorbed the prepared nanoformulations and exhibited sustained drug release characteristics

One-pot synthesis of quinazolinone heterocyclic compounds using functionalized SBA-15 with natural material ellagic acid as a novel nanocatalyst

Abstract The nanoporous compound SBA-15 was functionalized using (3-aminopropyl)trimethoxysilane (APTES). Then the obtained product was modified with ellagic acid (ELA), a bioactive polyphenolic compound. The structure of the prepared nanoporous composition SBA-15@ELA was extensively characterized and confirmed by various techniques, such as Fourier-transform infrared (FT-IR) spectroscopy, Energy dispersive X-ray (EDX) elemental analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM) and N2 adsorption–desorption isotherms (BET). The novel, recoverable, heterogenous SBA-15@ELA nanoporous compound was used to investigate its catalytic effect in the synthesis of 4-oxo-quinazoline derivatives (19 examples) with high yields (78–96%), as an important class of nitrogen-containing heterocyclic compounds. The use of an inexpensive mesoporous catalyst with a high surface area, along with easy recovery by simple filtration are among the advantages of this catalysis research work. The catalyst has been used in at least 6 consecutive runs without a significant loss of its activity

Chemo-Selective Protection of Aldehydes Functional Group Catalyzed by MOFs

A metal-organic framework Zn2(BDC)2(DABCO) was employed as a reusable heterogeneous acidic catalyst in the acylation reaction of various benzaldehydes with acetic anhydride under microwave irradiation. The outstanding features of this efficient solvent-free method are short reaction time, ease of product separation, greatest yields, and the ability to reuse the catalyst several times

Chemo-Selective Protection of Aldehydes Functional Group Catalyzed by MOFs

A metal-organic framework Zn2(BDC)2(DABCO) was employed as a reusable heterogeneous acidic catalyst in the acylation reaction of various benzaldehydes with acetic anhydride under microwave irradiation. The outstanding features of this efficient solvent-free method are short reaction time, ease of product separation, greatest yields, and the ability to reuse the catalyst several times

Development of new magnetic nanocomposite designed by reduced graphene oxide aerogel and HKUST-1, and its catalytic application in the synthesis of polyhydroquinoline and 1,8-dioxo-decahydroacridine derivatives

Abstract In this study, new magnetic reduced graphene oxide aerogel/HKUST-1 nanocomposite was designed and synthesized given the transformation of graphene oxide sheets to three-dimensional reduced graphene oxide aerogel, the in-situ magnetization of aerogel substrate, and the in-situ formation of HKUST-1 particles. Apart from characterizing the chemistry and structure of the designed magnetic nanocomposite (FT-IR, EDX, ICP, FE-SEM, DLS, XRD, VSM, and TG analyses), its catalytic performance was evaluated in the one-pot synthesis of biologically active 1,8-dioxo-decahydroacridine and polyhydroquinoline derivatives. The combination of magnetized reduced graphene oxide aerogel and HKUST-1 in the form of a new heterogeneous magnetic nanocatalyst was accompanied by a high synergetic catalytic effect in the symmetric and unsymmetrical Hantzsch condensation reactions. Compared to previous research studies, the pharmaceutical 1,8-dioxo-decahydroacridine and polyhydroquinoline derivatives can be synthesized using a partial amount of this nanocatalyst with a high percentage of yields in a short reaction time

Fire Performance of Intumescent Flame Retardant/Nanosilica/Thermoplastic Polyurethane Composite: A Study on Synergism

Hypothesis: The aim of this research is to improve the fire behavior of thermoplastic polyurethane (TPU) using an intumescent flame retardant system (IFR) and nanosilica as a synergistic agent Methods: A three-component IFR system consisting of ammonium polyphosphate (APP), melamine polyphosphate (MPP), and pentaerythritol (PER) was added to TPU by melt mixing. The flammability of the TPU-IFR was evaluated by UL94 vertical burning test and the efficiency of the IFR was investigated by cone calorimeter test (CCT). A nanosilica as a synergist with low loading was added to the TPU-IFR composite, and fire properties were investigated. Thermal stability and char morphology were investigated by thermal analysis and scanning electron microscopy, respectively.Findings: The results show that the IFR system is effective with a significant decrease of 62.6% in peak heat release rate (PHRR) and 58.3% in peak smoke production (pSPR). By incorporation of 0.5% (by wt) nanosilica into TPU-IFR, there are decreases in PHRR and pSPR by 75.0% and 79.2%, respectively, compared to the original TPU, while the dripping is removed. This has confirmed the effective synergism of nanosilica in enhancing the flame retardancy of TPU-IFR. Further, the amount of residual char has reached 31.2% and 58.9% for TPU-IFR and TPU-IFR-nanosilica, respectively, compared to 6.2% in a neat TPU. Both TPU composites have reached V0 grade in UL-94 test. FESEM shows an integrated compact char in IFR-TPU-nanosilica, while there are small holes in the char structure of IFR-TPU. Thermal analysis (TGA) has shown enhanced thermal stability in the two TPU composites by formation of a carbon layer as a thermal barrier during burning. This work introduces an efficient intumescent flame retardant system for improving the fire behavior of TPU which can significantly enhance the fire safety of TPU by a low loading of nanosilica as a synergist

Novel magnetic propylsulfonic acid-anchored isocyanurate-based periodic mesoporous organosilica (Iron oxide@PMO-ICS-PrSO3H) as a highly efficient and reusable nanoreactor for the sustainable synthesis of imidazopyrimidine derivatives

Abstract In this study, preparation and characterization of a new magnetic propylsulfonic acid-anchored isocyanurate bridging periodic mesoporous organosilica (Iron oxide@PMO-ICS-PrSO3H) is described. The iron oxide@PMO-ICS-PrSO3H nanomaterials were characterized by Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy and field emission scanning electron microscopy as well as thermogravimetric analysis, N2 adsorption–desorption isotherms and vibrating sample magnetometer techniques. Indeed, the new obtained materials are the first example of the magnetic thermally stable isocyanurate-based mesoporous organosilica solid acid. Furthermore, the catalytic activity of the Iron oxide@PMO-ICS-PrSO3H nanomaterials, as a novel and highly efficient recoverable nanoreactor, was investigated for the sustainable heteroannulation synthesis of imidazopyrimidine derivatives through the Traube–Schwarz multicomponent reaction of 2-aminobenzoimidazole, C‒H acids and diverse aromatic aldehydes. The advantages of this green protocol are low catalyst loading, high to quantitative yields, short reaction times and the catalyst recyclability for at least four consecutive runs