Effect of 670 Nm Laser Beam on the Action Potentials of Sural Nerve in Healthy Individuals

Introduction: Low Level Laser (LLL) is being used in physiotherapy for pain relief in various pathologies and particularly on peripheral nerve entrapments. In the present study, the effect of LLL on the electrophysiological parameters of sural in humans was investigated. The results might be used as a basis for further clinical research in abnormal conditions. Methods and Materials: Thirty-eight normal men voluntarily participated in the current study and 670 nm LLL beam was applied to the left sural nerve at 5 points for 10 sessions. The electrophysiological parameters such as onset latency, peak latency, negative peak amplitude, peak to peak amplitude, and duration were measured before and after the application of LLL (0.5, 1.5 & 2.5 J/cm² energy density). Results: Overall, 670 nm laser beam increased the latency and reduced the nerve conduction velocity (NCV). In addition, LLL beam decreased the amplitude of action potentials. Among the various values of energy densities, application of 2.5 J/cm² had the most effective results (P < 0.001). Conclusion: These results might suggest that 670 nm laser beam could affect the latency and reduce the NCV in sural nerve of human. Probably, LLL affects the bioelectric and bioenergetic properties of the neural biomembrane. These findings might have clinical signlificance in non-surgical treatment of entrapment syndromes, such as carpal, tarsal syndromes and trigeminal entrapment in human. Further investigations are needed to elucidate the effects of LLL beam on the human peripheral nerves in pathological conditions.Keywords: Low-level laser, Sural nerve, Electrophysiology, Pai

Effects of a Designed Discharge Plan on Anxiety and Length of Hospital Stay in Patients Undergoing Heart Valve Replacement

Background & Objective: Anxiety is the most common issue in the candidates of surgical heart valve replacement. The length of hospital stay in these patients is economically and organizationally important as a predictor of their recovery from acute physical conditions. The present study aimed to assess the effects of a designed discharge plan on anxiety and length of hospital stay in patients undergoing heart valve replacement. Materials and Methods: This clinical trial was conducted on 65 candidates of heart valve replacement in Chamran Hospital in Isfahan, Iran, who were randomly divided into the intervention and control groups. In the intervention group, the designed discharge plan was implemented and continued one month after discharge via phone follow-up. Length of hospital stay and anxiety were analyzed before the intervention and one and three months after discharge in both groups in SPSS. Results: ANOVA indicated that the mean anxiety in the study groups was significantly different at different times (P0.05). Conclusion: The designed discharge plan reduced anxiety in the patients, while its effect on the length of hospital stay requires further investigation. Therefore, it is recommended that the discharge program be used as an effective approach to maintaining care in patients undergoing heart valve replacement. Keywords: Discharge Plan, Anxiety, Hospitalization, Heart Valve Replacemen

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021. Methods: The GBD 2021 risk factor analysis used data from 54 561 total distinct sources to produce epidemiological estimates for 88 risk factors and their associated health outcomes for a total of 631 risk–outcome pairs. Pairs were included on the basis of data-driven determination of a risk–outcome association. Age-sex-location-year-specific estimates were generated at global, regional, and national levels. Our approach followed the comparative risk assessment framework predicated on a causal web of hierarchically organised, potentially combinative, modifiable risks. Relative risks (RRs) of a given outcome occurring as a function of risk factor exposure were estimated separately for each risk–outcome pair, and summary exposure values (SEVs), representing risk-weighted exposure prevalence, and theoretical minimum risk exposure levels (TMRELs) were estimated for each risk factor. These estimates were used to calculate the population attributable fraction (PAF; ie, the proportional change in health risk that would occur if exposure to a risk factor were reduced to the TMREL). The product of PAFs and disease burden associated with a given outcome, measured in disability-adjusted life-years (DALYs), yielded measures of attributable burden (ie, the proportion of total disease burden attributable to a particular risk factor or combination of risk factors). Adjustments for mediation were applied to account for relationships involving risk factors that act indirectly on outcomes via intermediate risks. Attributable burden estimates were stratified by Socio-demographic Index (SDI) quintile and presented as counts, age-standardised rates, and rankings. To complement estimates of RR and attributable burden, newly developed burden of proof risk function (BPRF) methods were applied to yield supplementary, conservative interpretations of risk–outcome associations based on the consistency of underlying evidence, accounting for unexplained heterogeneity between input data from different studies. Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. Findings: Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7–9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4–9·2]), smoking (5·7% [4·7–6·8]), low birthweight and short gestation (5·6% [4·8–6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8–6·0]). For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9–21·7] for high BMI and 7·9% [3·3–12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6–1·9) for high BMI and 1·3% (1·1–1·5) for high FPG. By contrast, the global risk-attributable burden and exposure to many other risk factors declined, notably for risks such as child growth failure and unsafe water source, with age-standardised attributable DALYs decreasing by 71·5% (64·4–78·8) for child growth failure and 66·3% (60·2–72·0) for unsafe water source. We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). Interpretation: Substantial progress has been made in reducing the global disease burden attributable to a range of risk factors, particularly those related to maternal and child health, WaSH, and household air pollution. Maintaining efforts to minimise the impact of these risk factors, especially in low SDI locations, is necessary to sustain progress. Successes in moderating the smoking-related burden by reducing risk exposure highlight the need to advance policies that reduce exposure to other leading risk factors such as ambient particulate matter air pollution and high SBP. Troubling increases in high FPG, high BMI, and other risk factors related to obesity and metabolic syndrome indicate an urgent need to identify and implement interventions

Joining of silicon nitride-to-silicon nitride and to molybdenum for high-temperature applications

The evolution of advanced ceramic materials over the past two decades has not been matched by improvements in ceramic joining science and technology, particularly for high temperature applications. Of the techniques being evaluated for joining ceramics, brazing has been found to be the simplest and most promising method of fabricating both ceramic/ceramic and ceramic/metal joints. A key factor in ceramic brazing is wetting of the ceramic by the filler metal.This study deals with the application of brazing for the fabrication of $rm Si sb3N sb4/Si sb3N sb4$ and $rm Si sb3N sb4/Mo$ joints using Ni-Cr-Si brazing alloys based on AWS BNi-5 (Ni-18Cr-19Si atom%). Thermodynamic calculations were performed to predict wetting at $rm Si sb3N sb4$/Ni-Cr-Si alloys interfaces. By using some simplifying assumptions and suitable scaling of the reaction, the model predicted that Ni-Cr-Si alloys with Ni/Cr = 3.5 and X$sb{ rm Si}$ $<$ 0.25 would react chemically with and wet $rm Si sb3N sb4$. Good agreement was found between the theoretical calculations and experimental results.Brazing experiments were carried out to study the joinability of $rm Si sb3N sb4$ with various Ni-Cr-Si filler metals which had already shown good wetting characteristics on $rm Si sb3N sb4$. The $rm Si sb3N sb4/Si sb3N sb4$ joints formed with a 10 atom% Si brazing alloy exhibited the highest strength ($approx$120 MPa) which was mainly due to the presence of a CrN reaction layer at the ceramic/filler metal interface. The high temperature four-point bend strengths of $rm Si sb3N sb4/Si sb3N sb4$ joints were markedly higher than the room temperature values. A high strength of about 220 MPa was achieved when the joints were tested at 900$sp circ$C.From the results of the $rm Si sb3N sb4/Mo$ joining experiments it was found that the joint quality and microstructure were strongly influenced by the composition of the filler metal and such brazing variables as time and temperature. Of all the $rm Si sb3N sb4$/Mo joints, those made with the S10 brazing alloy at 1300$sp circ$C for 1 min. exhibited the highest strength of 55 MPa.Finally, in all the cases, the shear strength of all the joints was found to be lower than their four-point bend values

On multiplicative (strong) linear preservers of majorizations

‎In this paper, we study some kinds of majorizations on $textbf{M}_{n}$ and their linear or strong linear preservers. Also, we find the structure of linear or strong linear preservers which are multiplicative, i.e.  linear or strong linear preservers like $Phi$ with the property $Phi (AB)=Phi (A)Phi (B)$ for every $A,Bin textbf{M}_{n}$

Comparison of Antifungal Activity of 2% Chlorhexidine, Calcium Hydroxide, and Nanosilver gels against Candida Albicans.

Residual microorganisms in the root canal system (RCS) after endodontic therapy such as Candida albicans are a major cause of endodontic failure. Calcium hydroxide (CH) and chlorhexidine (CHX) have suitable antimicrobial activity against bacteria and can be used as intracanal medicaments. Nanosilver has also shown antimicrobial activity against microorganisms. This study aimed to compare the antifungal effect of calcium hydroxide, 2% chlorhexidine and nanosilver gels on Candida albicans.Eighty-one single-rooted teeth were selected. After root canal preparation, the teeth were contaminated. After culture, the teeth were randomly divided into 4 groups. In experimental groups, 24 teeth were selected and completely filled with CH, 2% CHX and nanosilver gels in each group. Nine teeth were selected in the control group and filled with saline solution. After 1, 3, and 7 days, samples were obtained by #30 sterile paper points, and #2 and #4 Gates Glidden drills and cultured on solid Sabouraud agar.The results demonstrated that CH and 2% CHX had equal antifungal effects on samples taken by paper point and #2 Gates Glidden drill at all time points. Both CH and 2% CHX were more effective than nanosilver at all time periods. There was no statistically significant difference between medicaments in samples taken by #4 Gates Glidden drill.CH and 2% CHX gels have significantly higher antifungal activity than nanosilver gel. Also, CH and 2% CHX gels are equally effective against Candida albicans

Latin-majorization and its linear preservers

In this paper we study the concept of Latin-majorizati-\on. Geometrically this concept is different from other kinds of majorization in some aspects. Since the set of all $x$s Latin-majorized by a fixed $y$ is not convex, but, consists of union of finitely many convex sets. Next, we hint to linear preservers of Latin-majorization on $mathbb{R}^{n}$ and ${M_{n,m}}$

Application of Various Methods of Lumbar Kinesio Taping on Pain and Disability in Patients with Chronic Low Back Pain: Narrative Review

Context: Kinesio taping (KT) is recently used as a therapeutic tool for the treatment of chronic low back pain (CLBP). However, the effectiveness of different types of lumbar KT is still unclear when not combing with other therapeutic methods. This review aimed to summarize the results of studies investigating the effect of various methods of lumbar KT alone on pain and functional disability in patients with CLBP. Evidence Acquisition: A search was performed on the electronic databases PubMed, ProQuest, Science Direct, Thomson, OVID, Google Scholar, Scopus, MEDLINE, and PEDro, from 1990 to January 31, 2020, using the following keywords: Kinesiology Taping, Kinesio Taping, chronic low back pain. In total, seven studies met the inclusion criteria using three different methods of KT and corresponded to the aim of this review. Results: The methods consisted of I shape, Y shape, and star shape of KT. The studies suggested that all three KT methods can reduce pain and disability in CLBP patients. Based on the included studies, it seems that KT might reduce pain and disability. Conclusions: Three methods of lumbar KT, including I shape, Y shape, and star shape, may reduce pain and disability in patients with CLBP, possibly by improving pain, circulation, muscle tone, and proprioception. However, owing to limited studies, they cannot be compared, and the best method is unclear, which should be investigated by future high-quality studies