7 research outputs found
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
- Akbar Maha Ghulam
- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka â â
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safaâ
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
- Alameen Maram
- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
- Alariby Fatima
- Alatefi Dawood
- Alathameen Nassar
- Albakosh Bashir Abobaker
- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
- Albashaireh Alaa
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- Albayadi Eslam
- Alboon Mosab
- Alboridy Muneera
- Alboueishi Asraa Ali
- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
- Ali Maab
- Ali Manal
- Ali Muhammad
- Ali Radwa
- Ali Rawan Alsheikh
- Ali Rzan Ali Hamedelneel
- Ali Shehroz
- Aliosin Oleg
- Aljamal Mohammad
- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
- Allam Shereen
- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
- Alnajjar Majjd
- Alnatsheh Wesam
- Alnour Ammar
- Alomar Rabiaa
- Alomari Yazan
- Alqaarh Aya
- Alragig Zahra
- Alrifae Ghaliya Mohamed H
- Alrosan Risan
- Alsagoff Sharifah Nor Amirah Syed Abdul Latiff
- Alsaid Hamza
- Alsaify Esmat
- Alsaih Sawsan
- Alsari Najah
- Alshareea Entisar
- Alshawadfy Abdelrhman
- Alshawesh Aisha
- Alsheik Ahmad
- Alsori Mohamed
- Alsoudani Ali
- Altabbaa Hashem
- Altahir Mohamed
- Altair Mawadda
- Altaweel Ahmad
- Altughar Bushra
- Alvarez Matias
- Alvarez-Lozada Luis Adrian
- Alvarez-Lozada Luis Adrian
- Alwahaib Anas
- Alwash Mohammed
- Alzarga Ali
- Alzarouq Ebtisam
- Alzarroug Amal
- Alzghoul Bader
- Alzyoud Osama
- Amarasekara Mishka
- Amary Marwa
- Ametov Amet
- Amin Mostafa K
- Aminu Bashiru
- Aminu Muhammad Baffah
- Ammar Ahmed Siddique
- Amro Dana
- Ananthapadmanabhan Shravankrishna
- Anderson Paul
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- Atadag Yildiz Buyukdereli
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- Atia Ahmed
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- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- âAladna âAbdallah
- âAljoumaa âAbdullah
- âNawfal âHamdi
- âNiazi âAmmar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial
- Author
- Aasia Kayani
- Abalaka Aye
- Abdalla Mohammed
- Abdulfetah Abdulkadir
- Abdulfetah Abdulkadir
- Abdulfetah Abdulkadir
- Abdulrasaq Sambo
- Abida Sajid
- Abiodun Aboyeji
- Abiodun Adeniran
- Abraham Onwe
- Abu Kholdun
- Adebayo Adewale
- Adebola Owodunni
- Adeniyi Fasanu
- Adesina Akintan
- Adesina Akintan
- Adetunji Adeniji
- Adeyemi Okunowo
- Ado Geidam
- Adolphe Somé
- Adrian Grant
- Aferdita Kruja
- Affiss Adelodun
- Afshan Batool
- Ahmad Kazumari
- Aisha Iftikhar
- Ajay Agrawal
- Akhtar Sherin
- Akintunde Ayinde
- Akpojaro Ikpen
- Alex Nyakundi Bosire
- Alexander Kawimbe
- Alfred Osoti
- Alia Bano
- Alice Ashu
- Alice Ntem
- Alison Bates
- Alysha Allibone
- Amadou Ly
- Amadou Ndouoya
- Amaitari Bariweni
- Ambreen Ikram
- Amos Otara
- Amtullah Zarreen
- Andrea Jogo
- Andrew Sharpe
- André Simo
- Angeline Njoache
- Aniefiok Umoiyoho
- Anita Ali
- Anna Danford
- Anthony Kwame Dah
- Anthony Massinde
- Antony Wanjala
- Arafat Ifemeje
- Armida Tola
- Asia Nazir
- Asma Baloch
- Audu Idrisa
- Augustine Adeniyi
- Austin Ojo
- Awadia Ali
- Ayesha Mobeen
- Ayiko Jackson
- Babalola Adeyemi
- Babalola Adeyemi
- Babasola Okusanya
- Babatunde Adebudo
- Babatunde Awolaja
- Badibanga Musau
- Bamidele Adeleye
- Bartthy Okorochukwu
- Basharat Ahmad
- Bellington Vwalika
- Bellington Vwalika
- Bellington Vwalika
- Bernadette Nakawooya Lwasa
- Berno Mwambe
- Besnik Brahimaj
- Beverley Hunt
- Bhola Ram Shrestha
- Blessed Adeyemi
- Bonface Musila
- Brian Liyayi
- Brigadier Naila
- Bukola Fawole
- Bukola Fawole
- Bukola Fawole
- Carine Ronsmans
- Carine Ronsmans
- Carroli
- Carys Smith
- Catherine Gilliam
- Cesar Sanchez
- Chapman
- Charles Kacha
- Chris Aimakhu
- Christine Biryabarema
- Christine Namulwasira
- Christine Nanyongo
- Chrstine Biryabarema
- Clare Tower
- Collette Barrow
- Dachollom Audu
- Daniel Gilbert
- Daniel Onwusulu
- Danielle Beaumont
- Danielle Beaumont
- Danielle Prowse
- David Isah
- Dawn Edmundson
- Desire Tshombe
- Dewan
- Diana Elbourne
- Dominic Drametu
- Dorothy Keka
- Ducloy-Bouthors
- Duria Rayis
- Egbaname Aigere
- Elhassan Safa
- Elizabeth Buligho
- Elizabeth Ndagire
- Elizabeth Nionzima
- Emily Nzeribe
- Emmanuel Byaruhanga
- Emmanuel Gbejegbe
- Emmanuel Inyang-Etoh
- Emmanuel Okpako
- Eni Balogun
- Enyinnaya Chikwendu Nduka
- Eta Ngole Mbong
- Etienne Asonganyi
- Etienne Asonganyi
- Eugene Oteng-Ntim
- Evelyn Muthoka
- Ezekiel Ladan
- Eziamaka Pauline Ezenkwele
- Ezukwa Omoronyia
- Faiza Aleem
- Faiza Nassir
- Fareesa Waqar
- Farjana Basher
- Faryal Sardar
- Farzana Burki
- Fatimah Habeebu-Adeyemi
- Fehmida Shaheen
- Felix Okogbo
- Ferdousi Chowdhury
- Ferdousi Islam
- Fikre Geremew
- Folasade Oyelade
- Fouzia Gul
- Francis Alu
- Francis Banya
- Gabriel Essetchi Faye
- George Bugg
- George Mtove
- Georges Nko'ayissi
- Getachew Ayana
- Ghazala Taj
- Gilda Piaggio
- Gillian Houghton
- Gladys Dibia
- Glen Mola
- Grace Adekola-Oni
- Grace Akinbinu
- Grace Meregurwa
- Gulfareen Arain
- Gyanendra Karki
- Habiba Sharaf Ali
- Hadia Mustafa
- Hadiza Galadanci
- Hadiza Idris
- Hailemariam Segni
- Hajaratu Sulayman
- Hajira Masood
- Hakim Miah
- Hala Abdullahi
- Haleema Hashmi
- Haleema Shakur
- Haleema Shakur
- Haleema Shakur
- Hassen Hussien
- Henry Mwangi
- Henry Opare-Addo
- Herman Kalyana
- Hillary Mabeya
- Hina Rajani
- Horace Fletcher
- Huida Almardi
- Huida Eltaib
- Huma Quddusi
- Hussein Iman
- Hussein Khamis
- Hussein Kidanto
- Hussein Kidanto
- Hussein Kidanto
- Iain Chalmers
- Ian Roberts
- Ian Roberts
- Ian Roberts
- Ian Roberts
- Ibrahim Habib
- Ifeoma Offiah
- Ikemefuna Nwosu
- Ilir Tasha
- Isabirye Rebecca
- Isaiah Hansingo
- Jacob Awoleke
- Jane Mumba
- Jean Robert Lubamba
- Jeanne Fouedjio
- Jeharat Gul
- Jim Thornton
- Joanne Wilkins
- John Ogudu
- Joselyn Ayikoru
- Joseph Agulebe
- Joseph Ikechebelu
- Joseph Ngonzi
- Josiah Mutihir
- Kamil Shoretire
- Kaosar Afsana
- Kastriot Dallaku
- Kastriot Dallaku
- Kato Faida
- Kayode Olayinka
- Kayode Oluwatosin
- Kehinde Ologunde
- Kenfack Bruno
- Ker
- Ker
- Khadija Mayumba
- Khalid Elfadl
- Khidir Awadalla
- Kim Hinshaw
- Kiran Jabeen
- Kiran Javaid
- Kruithof
- Kubasu Wekesa
- Kusasira Anitah
- Kwadwo Nyarko-Jectey
- Lamaran Dattijo
- Lauren Frimley
- Lawrence Omo-Aghoja
- Lema Felix
- Leon Kaza
- Leonard Madame
- Leslie Samuels
- Liliana Vallecilla
- Lin Barneston
- Lisa Cook
- Lubna Bashir
- Lubna Dar
- Lubna Kahloon
- Lucky Oyeye
- Magdy El Rahman
- Magreth Zacharia
- Mahdi Bushra
- Mahwish Jamil
- Maimoona Hafeez
- Maimoona Munawar
- Maliha Zafar
- Malts Wai
- Manahil Jaffer
- Margret Nankya
- Maria Fernanda Escobar
- Maria Ramos
- Mariam Tariq
- Mark Ogbiti
- Martin Saadio
- Mateus Sahani
- Mateus Sahani
- Mathew Ng'ambi
- Matilda Ngarina
- Mesack Tchana
- Metin GĂŒlmezoglu
- Metin GĂŒlmezoglu
- Misbah Harim
- Mohamed Ahmed
- Mohamed El-Sheikh
- Mohamed El-Sheikh
- Mohammed Gana
- Mohammed Musa
- Mohan Regmi
- Mohan Regmi
- Mohd Chohan
- Moses Alao
- Moussa Bambara
- Murwan Ibrahim
- Musarrat Jabeen
- Musimbi Soita
- Muzdalifat Abeid
- Mwansa Ketty Lubeya
- Mwansa Lubeya
- Myles
- Nabia Tariq
- Nabila Salman
- Nadia Sadiq
- Naila Israr
- Naila Israr
- Nakirigya Nuulu
- Nankat Joseph
- Naseem Saba
- Naseema Usman
- Nasira Tasnim
- Nayiga Annet
- Nazlima Nargis
- Nazneen Begum
- Neelam Surhio
- Nick Grace
- Nicolas Meda
- Nigel Quashi
- Nighat Shaheen
- Nike Bello
- Nikita Dhakal
- Nilofar Mustafa
- Nishat Akram
- Nji Eric
- Nkeiruka Ameh
- Nkonwa Innocent
- Nneka Madueke
- Noah Olaomo
- Noojiri Bopili
- Noonari Mukhtiar
- Nurudeen Onaolapo
- Nzanzu Kikuhe Jason
- Odel Gwan
- Odidika Umeora
- Okpe James
- Ola Nene Okike
- Ola Okike
- Olabisi Loto
- Oladapo
- Oladapo Olayemi
- Oladapo Olayemi
- Olaide Salau
- Olalekan Awonuga
- Olatunde Onafowokan
- Olubunmi Ladipo
- Olufemi Abidoye
- Olufemi Akinsanya
- Olufemi Odekunle
- Olugbenga Akintunde
- Olujide Okunade
- Olusade Adetayo
- Olusegun Ajenifuja
- Oluseyi Adelekan
- Oluwabusola Monehin
- Oluwarotimi Akinola
- Oluwaseun Adeyemi
- Omer Babiker
- Omololu Adegbola
- Onyebuchi Udegbunam
- Osagie Osayande
- Owigho Opreh
- Palmer Henry
- Pascal Foumane
- Patrick Komagum
- Paul Ayuk
- Paul Kua
- Pauline Assomo
- Peninah Waigi
- Peter Achara
- Phanny Simisi
- Phil Edwards
- Philemon Nsem
- Pierre Marie Tebeu
- Pisake Lumbiganon
- Pramila Pradhan
- Prieto-Merino
- Punita Yadav
- Pushpa Sachdev
- Qurratul Ain
- Rabia Batool
- Rabindra Bhatt
- Raheela Asmat
- Rashida Sultana
- Razia Khero
- Regina Akello
- Riffat Shaheen
- Riham Desougi
- Rita Atim
- Rizwana Chaudhri
- Rizwana Chaudhri
- Rizwana Chaudhri
- Rizwana Chaudhri
- Roamba Pabakba
- Rob Jackson
- Robert Tchounzou
- Robert Tchounzou
- Roberts
- Roderick Larsen-Reindorf
- Roger Paluku-Hamuli
- Rokeya Begum
- Ronsmans
- Rophina Msengeti
- Rose Bwotya
- Rose Wangui
- Roseline Iheagwam
- Roshan Qazi
- Rubina Hussain
- Rubina Sohail
- Rukhsana Karim
- Ruth Bulime
- Rwakyendela Onesmo
- Saba Javed
- Sabaratnam Arulkumaran
- Sadaf Mufti
- Sadaqat Jabeen
- Sadia Khan
- Saeed Abdelrahman Abdelgabar
- Saeeda Majeed
- Safia Khalil
- Saima Iqbal
- Saimir Cenameri
- Saira Dars
- Sajila Karim
- Salma Khudaidad
- Samana Aleem
- Samar Amin
- Samina Dojki
- Samina Iqbal
- Samina Kausar
- Samina Manzoor
- Samirra Ahmed
- Sanobar Ashfaq
- Sara Saeed
- Sarah Babirye
- Saturday Etuk
- Saturday Etuk
- Sawamura
- Say
- Sayeba Akhter
- Sayeba Akhter
- Sebastian Kitengile Ganyaka
- Serge Mulyumba
- Sergey Kostrov
- Shabana Rizvi
- Shabween Masood
- Shah
- Shahela Jesmin
- Shahenzad Sohail
- Shahid Rao
- Shakur
- Shakur
- Shama Chaudhry
- Shamayela Hanif
- Shamsa Humayun
- Shamsunnisa Sadia
- Sharmeen Arshad
- Shazia Batool
- Shazia Rasul
- Shazia Sultana
- Shehla Manzoor
- Shehla Noor
- Shehla Noor
- Shrodha Paul
- Shyam Gupta
- Simeon Bazuaye
- Sofia Manzoor
- Sola Abubakar
- Somia Abdelrahiem
- Sophia Udonwa
- Sumaya Huque
- Summera Aslam
- Sununu Yusuf
- Swati Singh
- Syeda Mazhar
- Syeda Rabia Bukhari
- Taemi Kawahara
- Taha Umbeli
- Tahir Kyani
- Tahira Batool
- Tasneem Ashraf
- Tayyiba Wasim
- Temitope Onile
- Theresa Azonima Irinyenikan
- Tom Godec
- Tony Brady
- Tort
- Tracey Pepple
- Ubong Akpan
- Uduak Udofia
- Umar Ibrahim
- Umbreen Akram
- Useneno Okon
- Uzma Shaheen
- Venantius Mutsu
- Veronicah Ongwae
- Victor Wanjohi
- Vincent Oyiengo
- Wafaa Basta
- Willard Mtambo
- William Golit
- William Haleke
- Willies Silwimba
- Willis Missumba
- Wisal Nabag
- Wu
- Yinka Amode
- Ymele Fouelifack
- Yusuf Baffah Adamu
- Zahida Qureshi
- Zahida Qureshi
- Zahida Qureshi
- Zarko Alfirevic
- Zarko Alfirevic
- Zarko Alfirevic
- Zeinab Zubier
- Ziche Makukula
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2017
- Field of study
Background
Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage.
Methods
In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15â000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15â000 to 20â000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283.
Findings
Between March, 2010, and April, 2016, 20â060 women were enrolled and randomly assigned to receive tranexamic acid (n=10â051) or placebo (n=10â009), of whom 10â036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10â036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65â1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52â0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88â1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group.
Interpretation
Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset.
Funding
London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation
Prospective, multicentre study of screening, investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland
- Author
- Agarwal Aastha
- Ahmad Reddin
- Allison Callum
- Anderson Ian
- Anzak Anam
- Arora Sloni
- Asanitthong Praoparn
- Bahl Sarthak
- Baker Jordan
- Baker Olivia
- Bandyopadhyay Soham
- Baweja Kirun
- Baweja Kirun
- Belli Antonio
- Bettoli Giovanna
- Bin Jalal Arif Hanafi
- Birt Katie
- Boukas Alex
- Brennan Paul M
- Carr Harry
- Chambers Thomas J G
- Chan Huan Wee
- Chan Vinson Wai-Shun
- Cheong Jeremy
- Chia Wen Li
- Chiu Jodi
- Cope Jack
- Croyle Jaclyn
- Cummins Tom
- Dasgupta Debayan
- Daswani Harsha
- Denham Katherine
- Dheden Ngawang
- Dumitrascu Flavia
- Foster Kate
- Frantzias Joseph
- Freer-Smith Charlotte
- Galloway Luke
- George Alan M
- Giannakaki Venetia
- Glancz Laurence Johann
- Goitiandia Sofia Weiss
- Gough Melissa
- Gressmann Kassandra
- Grufferty David
- Grundy Tom
- Haley Mark
- Haley Mark
- Hall Emily
- Hall Samuel
- Hardcastle Niamh
- Harris Lauren
- Hashim Sinan Laith Osama
- Hawkins Sophie
- Hollingworth Milo
- Holmes David
- Honeyman Susan Isabel
- Hughes James T
- Hutton Dana
- Ingale Harshal
- John Anushka
- Johnson Jonathan Armitage
- Jung Josephine
- Kakwani Mehak
- Kalra Neeraj
- Kam Sen Yin Melina
- Kaskun Oleksandra
- Kehoe Kristy
- Khan Mehdi
- Khan Taufiq
- Kotikalapudi Siddharth
- Kouli Omar
- Kumaria Ashwin
- Kundu Simran
- Kundu Simran S
- Kyriacou Harry
- Lamb Catherine
- Lammy Simon
- Latinwo Rotimi Babajide
- Lea Alexander
- Lee Keng Siang
- Loan James
- Loan James J M
- Lyons Adam
- Maqsood Raeesah
- Marwaha Pavan Kaur
- Matloob Samir
- McCandless Conor
- McLean Lily
- McSorley Nathan
- Meghrawi Khadija
- Mehta Bhumi
- Mehta Shaily
- Merican Diyanah
- Merola Joseph
- Millward Christopher P
- Minnock Eoin
- Mohamed Aisha Abubakar
- Mohammed Sophia
- Mohammed Wail
- Mohan Midhun
- Mona Taslima
- Mukerji Nitin
- Nabahin Maram
- Nair Sanjay Govind
- Namono Sarah Ferbrache
- O'Brien David
- On behalf of the Sodium after Subarachnoid Haemorrhage (SaSH) audit collaborators
- Osunronbi Temidayo
- Othman Lara
- Pai Hari
- Paranathala Menaka
- Patel Parthik
- Phuah Yu Zhi
- Piper Rory
- Poolovadoo Yanish
- Poon Michael T C
- Radcliffe Heather
- Rajashekar Devika
- Rajesh Joel
- Ramali Mohamed Rashad
- Rees Nicholas
- Reyhani Hadis
- Robbin Kiran
- Robin Nicole
- Roman Elena
- Rooprai Navleen
- Russell Jordan
- Sall Jagbir Kaur
- Sanghvi Hazel
- Scott Caroline
- Sells Lauren
- Senior Harry
- Shehab Mai
- Sheikh Mustafa El
- Siah Qi Zhuang
- Siddique Amar Naqash
- Siva Saranya
- Sofela Agbolahan
- Sohrabi Catrin
- Southey Charles
- Sravanam Sanskrithi
- Stokes Stuart
- Tang H Y Josephine
- Tang Josephine
- Taqvi Ahsan Ali
- Teo Mario
- Thomas Dominic
- Thompson Alysha
- Tijare Chinmay
- Toma Arina
- Tominey Steven
- Tominey Steven
- Tze Shan Tiffany Ye
- Vivian Pak Hei Yi
- Vyas Neel
- Vyas Ruchika
- Walters Rachel
- Wiggins Anthony N
- Woodfield Julie
- Yakoub Kamal
- Yang Ooi Setthasorn Zhi
- Zaidi Syed
- Zorman Mark Jernej
- Publication venue
- 'BMJ'
- Publication date
- 23/09/2022
- Field of study
Background: Hyponatraemia often occurs after subarachnoid haemorrhage (SAH). However, its clinical significance and optimal management are uncertain. We audited the screening, investigation and management of hyponatraemia after SAH. Methods: We prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or Ireland. We reviewed medical records daily from admission to discharge, 21 days or death and extracted all measurements of serum sodium to identify hyponatraemia (<135 mmol/L). Main outcomes were death/dependency at discharge or 21 days and admission duration >10 days. Associations of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission duration. We assessed hyponatraemia-free survival using multivariable Cox regression. Results: 175/407 (43%) patients admitted to 24 neurosurgical units developed hyponatraemia. 5976 serum sodium measurements were made. Serum osmolality, urine osmolality and urine sodium were measured in 30/166 (18%) hyponatraemic patients with complete data. The most frequently target daily fluid intake was >3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes. 26% (n/N=42/164) patients with hyponatraemia received sodium supplementation. 133 (35%) patients were dead or dependent within the study period and 240 (68%) patients had hospital admission for over 10 days. In the multivariable analyses, hyponatraemia was associated with less dependency (adjusted OR (aOR)=0.35 (95% CI 0.17 to 0.69)) but longer admissions (aOR=3.2 (1.8 to 5.7)). World Federation of Neurosurgical Societies grade IâIII, modified Fisher 2â4 and posterior circulation aneurysms were associated with greater hazards of hyponatraemia. Conclusions: In this comprehensive multicentre prospective-adjusted analysis of patients with SAH, hyponatraemia was investigated inconsistently and, for most patients, was not associated with changes in management or clinical outcome. This work establishes a basis for the development of evidence-based SAH-specific guidance for targeted screening, investigation and management of high-risk patients to minimise the impact of hyponatraemia on admission duration and to improve consistency of patient care
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- A. Mohammed Kalakwa
- A. Nemer Ayoub
- Abantanga Francis A.
- Abatli Safa' Jamal
- Abbas Wisam
- Abbo Olivier
- Abdelbaqi Reem
- Abdelhady Dina Sobhy
- Abdelhafez Mohammad Omar Mohammad
- Abdelhamid Sultan S.
- Abdelmaksoud Sherif
- Abdelmoumen Roua
- Abdelmutalib Fakereldeen
- Abdul-Mumin Alhassan
- Abduljawad Fatima Mousa
- Abdullah Fizan
- Abdullah Mohd Yusof bin
- Abdulraheem Nurudeen
- Abdulrahman Alaa
- Abdulsalam Moruf Adekunle
- Abdunomonovich Dekhkonboev Avazjon
- Aboelela Ahmed
- Abouheba Mohamed
- Abrahamsson Kate
- Abrunhosa Matias Marcia
- Abu-Nejmah Fawzi
- Abuajaila Abdulsalam
- Abuattaya Adham Ashraf
- Abubakar Auwal M
- Abueideh Ahmad
- Abuhayyeh Husam Aldean
- Abuhlega Ma'aly A.
- Abukhalaf Sadi
- Abumunshar Ali Abdelhay
- Acuna Gaston
- Adams Stephen
- Adamu Sani
- Adanan Mohd Fitri Shukri bin Mohamed
- Adawi Ihda
- Adawi Samer
- Adawy Ahmad
- Ade-Ajayi Niyi
- Adegboyega Rilwan
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adhiwidjaja Cathline Freya
- Adofo-Ansong Nana
- Agboola Titiloye Hannah
- Agelebe Efeturi
- Aguilar Aguilar Faye
- Aguilar Gargurevich Prince Pamela
- Aguirre-Lopez Pastor
- Agulham Miguel Angelo
- Ahmad Hira
- Ahmad Zahidah Adlynee Haji
- Ahmed Hazem
- Ahmed Mahmoud Abdelfattah
- Ajai Olalekan Temitope
- Ajao Emmanuel Akinlabi
- Ajiboye Olalekan S.
- Ajrami Yara
- Ajwa Ahmad Elian Abu
- Akan M. Eren
- Akhbari Melika
- Akhter Nadeem
- Akova Fatih
- Al-Attar Hala M.
- Al-Halbouni Layana
- Al-Mamun Abdullah
- Al-Mayoof Ali Farooq
- Al-Momani Hashem M.
- Al-Mouakeh Ahmad
- Al-Rayyes Maisara
- Al-saleem Hasan Subhi Hasan Abu
- Al-Salhi Ashraf Ayman
- Al-Shwaikh Samar H.
- Al-Slaibi Ibrahim
- Al-Taher Raed Nael
- Al-Taher Raed Nael
- Al-Tammam Hiba
- Alakaloko Felix
- Alamrain Abdulwhhab Ayman Abu
- Alanguia Chipana Cathy Lee
- Alattas Khalid
- Alberto Carlos
- Albozidi Aya
- AlcĂĄntara Elvyn
- ALDIRAWI MOHAMMED A. M.
- Alebbini Mohanad Mutasem
- Alfoghi Mabroka
- Algabri Hayder Nadhim Obaid
- Alglaib Mohammed Meftah
- Alhamid Ahmad
- Alhamid Aos
- Alhassan Priscilla
- Ali Hassan
- Ali Karim Osamy
- Ali Liza
- Ali Mansour
- Alijla Sharif
- Alijla Sharif S.
- Aliwisat Ahmad Hasan
- Aljaboo Hajir
- Aljadidi Wesal Omar F. Saied
- Aljarad Ziad
- Alkareem Raghad mohammad abdu
- Almada Suad Ahmed
- Almadhoun Walaa
- Almasri Murad
- Almeida Aguiar Arthur
- Almeida Giovana
- Almengar Inas
- Almohamady Hisham
- Almosaibli Mohammad
- Almusleh Tasneem Fathi Hasan
- Alnaeri Ali
- Alnahhal Khaled
- Alonso VerĂłnica
- Alosta Hasan Mustafa
- Alqarajeh Firas
- Alqor Mohammad Omar Ibrahim
- Alsaadi Nijmeh Nasser
- Alsaggaf Ameen
- Alsaied Amer
- Alser Mohammed
- Alser Osaid H.
- Alshaikhkhalil Haya Abdulnasser Ali
- Alshehri Abdullah
- Altaweel Ahmed
- Altın Merve
- Altokhais Tariq
- Altomi Mohamed
- Alturki Fahad
- Alvarado Zelada Jackelyne
- Alves Dutra da Silva Ărika
- Alwadia Soha Marwan Salem
- Alwaggaa Nouriyah Ali
- Alzamari Ainaa Ata Mohammad
- Alzate Gallego Edgar
- Alzeer Asmahan Mohammad Suliman
- Alzerei Sulaiman T.
- Alzraikat Sayel H.
- Alzubair Afnan
- Alzughayyar Tareq Z.
- Amad Mohamed
- Amado Fernando
- Amaechi Chukwubinyelum
- Amah Christopher Chim
- Amarin Justin Z.
- Amarin Marzouq
- Ambriz-GonzĂĄlez Gabriela
- Ameh Emmanuel
- Amjad Muhammad Bin
- Amoabin Afua Amoabin
- Anatole Nzanzu
- Anatole Nzanzu Kipata
- Anaya Dominguez Marlene
- Anaya Firas
- Andrade Jerhy
- Andreussi Lorna
- Anicama Elias Rocio
- Annajjar Mohammad hasan
- Anntinea Jessmine
- Antunes Amanda
- Antunez-Mora Alexandra
- Anyomih Theophilus Teddy Kojo
- Anzelewicz Stefan
- Apaza Leon Jose Luis
- Appeadu-Mensah William
- Arabiat Esraa
- Arafa Mohamed Ahmed
- Arafat Hasan
- AragĂŁo Liliana
- Arancibia Gutiérrez Elsa
- Aranda SĂĄnchez Cristian Irela
- Arar Ahmad Samih
- Arauco Jenny
- Arbab Hana
- Arboleda Jenny
- Aremo Anuoluwapo
- ArnadĂłttir Helena
- Arnaud Alexis P
- Arnold Marion
- Arnoletto Lucia Beatriz
- Arrmali Saddam
- Arrmalli Lina Ali
- Arshad Muhammad
- Arthur Felicity
- Arul Suren
- Ashour Dina Ayman
- Ashour Yara shareef
- Aslan Yakup
- Aspirot Ann
- Assi Ahmadfateh
- Assi Muath Abdelrahem Fuad
- Astudillo Miguel
- Atatri Yazid yousef mahmoud
- Atta Ahmed
- Attia Alaa Mobarak
- Avile Romina
- Avolio Luigi
- Awad Hadeel
- Aydin Emrah
- Aykut Merve
- Ayque Rosas Fernando
- Aziz Dayang Anita Abdul
- Ba'baa' Basheer
- Badr Helmy
- Baertschiger Reto
- Bagbio Dominic
- Bah Abdoulie
- Bai Qiang
- Bai Yu Zuo
- Baistrocchi Valentina
- Bakar Ainal Huda Abu
- Baker Wisam
- Ballouhey Quentin
- Balousha Abrar ghassan
- Bamanga Ahmed
- Baniowda Muath A. M.
- Bao Xiaozhou
- Barauskas Vidmantas
- Barbosa Patricia Reis
- Baseggio Natalia
- Bashir Fatma
- Bashir Muhammad Kashif
- Bassan Gonçalves Paulo César
- Bataineh Ziad A.
- Batal Mohammad Mohannad
- Bazozi Hana Milad
- Beasley Spencer
- Becker Karin
- Belmino Gadelha AluĂsio Augusto
- Benaskeur Yousra-Imane
- Beres Alana
- BerkovĂĄ KlĂĄra
- Bernaus Marianela
- Berrocal Anaya Waldo
- Berzanskis Mindaugas
- Beshtawi Doha mustafa saleh
- BeĆir Ahmet
- Bianchin Ezequiel
- Bibas Fatma
- Biber Elna
- Bischoff Cristiano
- Bismarck Sylvester von
- Blain Otilia Eva
- Blanc Thomas
- Blazquez-Gomez Eva
- Bobadilla Morales Lucina
- Bode Christopher
- Bonnard Arnaud
- Boonthai Ampaipan
- Borbonet Daniel
- Bouhadiba Nordeen
- Bowder Alex
- Bracho Blanchet Eduardo
- Bradshaw Kate
- Bragagnini Paolo
- Brahmamdam Pavan
- Bravo Mauro Nicolas
- Bright Benedict Paul
- Brito Quevedo Luz Mery
- Broch Aline
- Brolin Santis Isolan Paola Maria
- Brunero Marco
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- Shokri Hajer Ali
- Shonubi Amo
- Shoubaki Ali
- Shu Qiang
- Shyaka Gashugi Ian
- Siddiqui Sabina M
- Sidler Daniel
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- Suzen Alev
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- Tabari Ahmad Khaleghnejad
- Tabiri Stephen
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- Tahyneh Abdulraheem Adnan Abdulraheem
- Takrouney Mohammed Hamada
- Talat Nabila
- Tallaa Mohamed Anwer El
- Tamada HorĂĄcio
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- Tang Weibing
- Tanimola Adebayo Gbenga
- Tanming Patchareeporn
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- Tarmohamed Murad
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- TĂŒrkyılmaz Canan
- TĂŒrkyılmaz Zafer
- Ubhi Harmony
- Ugwu Jideofor O
- Ugwunne Chuka A
- Ulasi Ikechukwu
- Ullrich Sarah
- Vacek Jonathan
- Vaitkiene Agota
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- Vanis Nedim
- Vaquila Justo
- Varela Maria Florencia
- Vasquez Matos Juan Pedro
- Vatta Fabrizio
- Vega Centen Stephany
- Velaña Junior
- Vellusamy V Muthualhagi M
- Venant Ntakarutimana
- Venkatraman Soundappan Sannappa
- Verdeata Roxana
- Verduga Ivan
- Verduga Leonardo
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- Vianney Butoyi Jean Marie
- Vida Lucian
- Vidal Cristian R. Zalles
- Vierboom Liam
- Villalba Villalba Araceli
- Villegas Silva RaĂșl
- Vinskaite Asta
- Vos Corné de
- Vosoughi Armin
- Wafa Tamer
- Walker Gregor
- Wang Jinhu
- Wang Peng
- Waseem Basma
- Weeratunga Naveen
- Weiszewsk Alicja
- Wen Gang
- Werneck Raposo Juliana
- Wester Tomas
- Wijekoon Naveen
- Wilke Alexandra
- Williams Isabelle
- Williams Omolara
- Williams Regan
- Win Win Sabai Phyu
- Wishah Bisan D. M.
- Wishah Nidal
- Wissanji Hussein
- Wolak Przemyslaw
- Wolny Agnieszka
- Wong Janice
- Wong Marilyn
- Wright Naomi Jane
- Wu Guowei
- Wyrzykowski Dariusz
- Xiaodong Guo
- Xie Hua
- Yacoub Mina A.
- Yaghi Bashar
- Yaghi Dua Hasan
- Yalcinkaya Ali
- Yang Hee-Beom
- Yanis Ahmad H.
- Yanowsky Reyes Guillermo
- Yao Yang
- Yapo Benjamin
- Yarza FernĂĄndez Jessica
- Yeniay Aslı ĂztĂŒrk
- Yola Mariya Mukhtar
- Yong Feng
- Youn Joong Kee
- Yousuf Hina
- Yu Mengnan
- Yu Raisa
- Yuen Quah Soong
- Yuldashev Rustam Z.
- Yunus Aayenah
- Za'nouneh Faris J. Abu
- Zaghlol Louay Y.
- Zahari Dato' Dr Zakaria bin
- Zain Mostafa
- Zaman Azrina SK
- Zanellato Josiane Bernartt
- Zarwawi Ahmad Zulhisyam bin
- Zea-Salazar Luis Enrique
- Zeinelabdeen Ali
- Zhao Xiaoxia
- Zhu Jianming
- Zhu Libin
- Zidan Mazen
- Zivanovic Dragoljub
- Zottis Barcelos Fabricio
- Zreeg Dafer abdulhakim . S.
- Zurikat Rajai O.
- Zvizdic Nada
- Zvizdic Zlatan
- Ăekiç Bahanur
- Ăelik MĂŒge
- Ăzçelik Zerrin
- Ćeref Kıvanç
- Ć afus AntonĂn
- Ć kvaĆil Jan
- Ć tichhauer Radek
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprungâs disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprungâs disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36â39) and median bodyweight at presentation was 2·8 kg (2·3â3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
pâ€0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88â4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59â2·79], p<0·0001), sepsis at presentation (1·20
[1·04â1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4â5 vs ASA 1â2, 1·82 [1·40â2·35], p<0·0001; ASA 3 vs ASA 1â2, 1·58, [1·30â1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02â1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41â2·71], p=0·0001; parenteral nutrition 1·35, [1·05â1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47â0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50â0·86], p=0·0024) or percutaneous central line (0·69 [0·48â1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- A Nizarudeen
- Aalem Hajer Abd Alhamed
- Ababneh Hazim
- Abbas Ahmed
- Abbas Aram
- Abbas Hussain
- Abbasi Arezou
- Abbassi Fariba
- Abbasy Jibran
- Abbood Ali H
- Abboud Kirellos
- Abdallah Ahmed
- Abdalsalam Sabriya Juma Ali
- Abdelaal Abdelrahman
- Abdelalemm Mohamed
- Abdelhafez Mohammed Hisham Zayan
- Abdelhalim Karim
- Abdeljalil Mahmoud
- Abdelkarem Mohamed
- Abdelmageed Abdelfatah
- Abdelmageed Abdelfatah
- Abdelmaksoud Mohamed
- Abdelmawgoud Sherif
- Abdelmawla Mohamed
- Abdelmawla Mohamed Osama Mohammed Kamel
- Abdelmoneim Noha
- Abdelnoor Ahmad
- Abdelrahman Fatma
- Abdelrazek Hussein A
- Abdelrhman Reham
- Abdelzaher Abdurrahman
- Abdelzaher Abdurrahman Taha
- Abdou Khaled
- Abdoun Meriem
- Abdualqader Mahmmoud
- Abdualqader Mahmmoud Yehia Mohammed
- Abdulhaq Aram
- Abduljawad Heba
- Abdullaev Abakar
- Abdullah Nik Azim Nik
- Abdulmonem Aya
- Abdulwahed Eman
- Abebrese John
- Abiyere Henry
- Abobakr Abobakr Mahfoz
- Aboelfath Shiamaa
- Abosamak Nour Eldin
- Abu-Elfatth Ahmed Mohammed
- Abu-Ghazal Sara
- Abu-Ghazal Sara Yassir
- Abuali Ahmed S A M E
- Abuelazm Mohamed
- Abuelnaga Yasmeen
- Abuelnaga Yasmeen
- Abughazal Sara Yasser
- Abuleil Amro
- Abusannuga Malek
- Abuzaina Khalil
- Adam Islam
- Aday Ulaş
- Adeyeye Ademola
- Adeyeye Nigeria Ademola
- Adham Mustapha
- Adhikari Krishna Mohan
- Affary Anter Al
- Afzal Ameer
- Afzal Iqraa
- Aghdassi Ali
- Ahmed Emad Ali
- Ahmed Mohamed Bahaa Eldin
- Ahmed Randa
- Ahmeed Sultan
- Ajayi Peter
- Akahoshi Keiichi
- Akbar Ali
- Akhtar Naseem
- Al-Abdi Radfan
- Al-Abed Omar
- Al-Ameri Saba
- Al-Ameri Saba Ahmed Ahmed Saleh
- Al-Asadi Mohammed Abdulkhaleq Mohammed Mohsen
- Al-Dowsh Nagra Are
- Al-Eryani Fatima
- Al-Faiq Siham
- Al-Haj Ahmad
- Al-Hyari Abdelkareem
- Al-Isawi Ali
- Al-juaifari Maytham Aqeel
- Al-Khawlani Qaeid
- Al-Kubati Waheeb
- Al-Maadani Basma
- Al-Mallah Rozana
- Al-Markiz Eman
- Al-Mekhlafi Ayat
- Al-Melhani Watheeq
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Ogaili Mustafa
- Al-Qasrawi Shahd
- Al-Saban Rafat
- Al-saban Rafat Ameen Mohammed
- Al-Sader Maytham Al-Juaifari
- Al-Samawi Abdulaziz
- Al-Samawi Hytham
- Al-Sarireh Bilal
- Al-Shami Khayry
- Al-shami Manar
- Al-sharabi Ebrahim Ahmed Esmail
- Al-Shehari Mohammed
- Al-Tekreeti Sarah
- Alahmed Farouq
- Alahmed Hoor
- Alaimo Laura
- Alali Mahmoud Bilal
- Alannaz Omar
- Alansary Marwa Nasrelden
- Alatise Olusegun
- Alattas Zainab
- Alawna Reem
- Alazab Emad
- Albaba Safa'
- Albakry Rudaina
- Albar Aisha
- Albaraesi Mohammed N
- Albarouni Sofian
- Albishti Ahmed
- Alboridy Muneera
- Aldoescu Sorin
- AlDowsh Nagran Aref
- Aldressi Wafa
- Aldumaini Hamdan
- Alegria Cesar Rodriguez
- Alfano Marie Sophie
- Alfatah Maryam Abd
- Alfonso Cenon
- Alfurais Sarah
- Alghazo Heyam
- Alhaboob Nassir
- Alharthi Mohammed
- Alhashemi Mais
- Alhmaidi Riad
- Alhouri Ahmad
- Alhouri Ahmad Nabil
- Ali Ahmed Youssef Mohamed
- Ali Dina
- Ali Ramzi Abdullah Yahya
- Ali Ramzi Ali Abdullah Yahya
- Ali Suhil Ben
- Alissawi Subhi
- Alissawi Subhi Zahi
- Aliwy Marwan Al
- Aljaber Ahmad
- Aljamal Sarah
- Aljiffry Murad
- Alkhadem Maeen Ali
- Alkhaleel Wael
- Alkhateb Hossain
- Allah Mohamed Abd
- Allam Ahmed
- Allam Mohamed
- Allam Shrouq
- Allisiardi Fabrizio
- Alloush Ali
- Almarashi Hassan
- Almarkiz Eman
- Almasri Tabarak Abedlnaser
- Almassaudi Ali
- Almekhlafi Tofik
- Almiani Sari
- Almjersah Abdulrahman
- Alnammourah Walaa Mohammed
- Alnammourah Walaa Mohammed
- Alnimr Ahmed
- Aloulou Marwa
- Alowjali Fatoom
- Alsabah Mohamed
- Alsabbagh Feras
- AlSaffaf Mohamed
- Alsanany Ghadeer Mohammed
- Alsayadi Ramzi
- Alshaghel Mohammed
- Alsharabi Ebrahim
- Alshareea Entisar
- Alsharif Doaa
- Alsharif Doaa Sabry
- Alsharif Doaa Sabry
- Alsharif Doaa Sabry
- Alshatshat Abdulhadi
- Alsori Mohamed
- Alsoudani Ali
- Altatari Abdulrahman
- Altatari Ahmad Mohammad
- Alwafy Khaled
- Alwan Hussein Mohammed
- Alyasin Ismaeil
- Alzabadiah Asmaa Hasan Mohammad
- Alzghoul Mohammad W
- Alzoubi Mohammed
- Amarin Zouhair
- Amic Fedor
- Amina Houmada
- Ammar Khaled
- Amrani Laila
- Amro Sarah
- Amro Sarah
- Anas Omar
- Anas Omar
- Anastasi Alessandro
- Anatolievna Li Natalya
- Andersson Bodil
- Andersson Roland
- Andrade Juan Camilo Barreto
- Andreou Andreas
- Andreuccetti Jacopo
- Andriola Valeria
- Andujar Rafael LoÌpez
- Ang Dr Dante
- Angelico Roberta
- Anghinoni Marciano
- Aniukstyte Laura
- Anthoni Christoph
- Antic Andrija
- Antonucci Adelmo
- Anyla Morgan
- Apel Roy
- Apers Thomas
- Apostolos Kambaroudis
- Apostolou Christos
- Apostolou Christos
- Appeltans Bart
- Appeltans Bart
- Appukuttan Murali
- Arabiyat Hamza
- Arabiyat Hamza Ayman Abdelhalem
- Arbutina Dragana
- Arbutina Dragana
- Ardhanari Ramesh
- Ardito Francesco
- ArguÌello Pedro
- Arıkan Turkmen
- Arıkan TuÌrkmen Bahadır
- Arkadopoulos Nikolaos
- Armentano Serena
- Arnau Ana Belen Martin
- Aroori Somaiah
- Artigues Enrique
- Asano Toshimichi
- Asghar Mohammad
- Atanasov Boiko
- Atici Ali Emre
- Atici Semra Demirli
- Atstupens Kristaps
- Attalla Almoatazbellah
- Augustinus Simone
- Ausania Fabio
- Avgerinos Konstantinos
- Awad Ahmed K
- Awad Selmy
- Awad Selmy
- Awadi Sajeda
- Awan Altaf Awan
- Aya Boudouh
- Aydin Husnu
- AydogÌan Serdar
- Ayoub Seba
- Azab Mohammed A
- Azaman Nur Sabrina Binti Babe
- Azizeh Oula
- Azizian Azadeh
- Azman Azlanudin
- Azri Yahya Al
- Azzam Ahmed
- aÌlvarez Pablo Muriel
- Babor Richard
- Babu E
- Bacalbaşa Nicolae
- Badovinac David
- Badr Helmy
- Badr Karim
- Badran Youssef
- Bagmet Nikolay
- Bahaa Mohamed
- Bahroun Sumayyah
- Bahroun Sumayyah Ghayth
- Bahroun Sumayyah Ghayth
- Baiocchi Gian Luca
- Bairamidis Eugenios
- Bajjah Hadeel
- Bajjah Hadeel Mohmmed
- Bajjah Hadeel Muhammed Ahmed Hussein
- Balalis Dimitrios
- Balci Deniz
- Baldi Caterina
- Balduzzi Alberto
- Ballarin Roberto
- Baltagiannis Evangelos
- Balzan Silvio
- Bansal Varun
- Banting Samuel
- Banting Simon
- Barakat Ahmed
- Barakat Ahmed Tarek Mohamed
- Baraket Oussama
- Baraket Oussama
- Baranov Andrey Igorevich
- Barauskas Giedrius
- Barberis Andrea
- Barbier Louise
- Barbu Sorin Traian
- Barbu Sorin Traian
- Bareig Elham
- Bari Hassaan
- Barros Aldo Vieira
- Barroso Ryan Ruel
- Bartella Isabel
- Bartlett Adam
- Bartos Adrian
- Bashir Manahil
- Basile Prof Francesco
- Bassi Claudio
- Bassi Domenico
- Bassiony Mahmoud
- Batova Anastasia
- Bayhan HuÌseyin
- Bayhan Zulfu
- Bayomi Abdulrahman
- Bedzhanyan Arkady
- Belaid Wafae Ait
- Belal Mohamed
- Belev Nikolay
- Belev Nikolay
- Belkhadir Zakaria
- Belli Andrea
- Belloni Elena
- Beltran-Miranda Pablo
- Belyaev Alexander
- Belyaev Orlin
- Benamwor Aihab
- Bencini Lapo
- Benedetto Fabrizio Di
- Benkabbou Amine
- Benkabbou Amine
- Bentabak Kamel
- Bentabak Kamel
- Benuzzi Laura
- Beradze Nikolaos
- Berrevoet Frederik
- Berry Roger
- Besselink Marc
- Besselink Marc G
- Beugniez Cesar
- Bezmarevic Mihailo
- Bhalerao Suryabhan
- Bhandari Ramesh Singh
- Bhatti Imran
- Bhogal Ricky
- Bieze Matthanja
- Bilyak Andriy
- Bindra Vanshay
- Binnawara Muhannud
- Bjornsson Bergthor
- Bleem Hikma Abdullh
- Boalot Ahmed
- Bodea Raluca
- Boff Marcio
- Bogdanovic Aleksandar
- Bogdanovic Marko
- Boggi Ugo
- Bolli Martin
- Bong Jin
- Bonomo Michele
- BonÌar Nuria Losa
- Boone Brian
- Borakati Aditya
- Borghi Felice
- Bork Ulrich
- Boterbergh Kim
- Bouali Imene
- Bouaoud Souad
- Bouaziz Hanen
- Boudjenan-Serradj Nabil
- boumzebra yassmine
- Boumzebra Yassmine
- Bounaim Ahmed
- Bourazani Maria
- Boutti Ahmed Sami
- Bouzid Chafik
- Bowne Wilbur
- Bozhkov Vasil Markov
- Bracke Bart
- Braicu Vlad
- Bramis Konstantinos
- BranÌes Alejandro
- BranÌes Alejandro
- Bratlie Svein Olav
- Brebu Dan
- Bredikhin Mikhail
- Brennfleck Frank W
- Brezean Iulian
- Brizzolari Marco
- Brizzolari Marco
- Brolese Alberto
- Brown Kai
- Brown Lisa
- Brum Sarah L
- Brunner Maximilian
- Brunner Stefan
- Brustia Raffaele
- Buarque Igor Lima
- Bubalo Tomislav
- Buckel Erwin
- Bulian Dirk
- Bull Nicholas
- Burda Lukas
- Burgan Dania
- Burnett David
- Burridge Isobel
- Bursics Attila
- Buscemi Salvatore
- Busch Olivier
- Busquets Juli
- Busset Michele Droz dit
- Butori Eugenia
- Butt Usman
- Butt Usman Ismat
- Butte Jean
- Butturini Giovanni
- Buwaitel Mohammad Musallam
- Byshetty Rajendar
- Caccamo Lucio
- Cai Lei
- Calabrese Francesco
- Calabretto Francesca
- Calik Bulent
- Callery Mark
- Campagnaro Tommaso
- Caneparo Andrea
- Canonico Giuseppe
- Canteras Carlos Augusto
- Cantos Dra MiÌriam
- Capitanich Pablo
- Capoglu Recayi
- Capurso Gabriele
- Caputo Damiano
- Carganico Giacomo
- Carlo Isidoro Di
- Carr-Boyd Peter
- Carvalho Nubyhelia
- Casadei Riccardo
- Castro Maria
- Castro Tiago
- Casupang Amornetta
- Catrina Eduard
- Celotti Andrea
- CerdenÌo Ruby
- Cereda Marco
- Ceresa Carlo
- Chaaban Majd
- Chaaban Mohammad Karam
- Chaaban Mohammad Karam
- Chabot John
- Chakravartty Saurav
- Chand Jithin Thulsi
- Chang David
- Chardalias Leonidas
- Chardarov Nikita
- Chasiotis Dimitrios
- Chattopadhyay Somnath
- Chaturvedi Arun
- Chatzialis Iosif
- Chatzis Iosif
- Chatzizacharias Nikolaos
- Chaudhry Ahmad Areeb
- Chaudhury Prosanto
- Chen Stanley
- Chen Yiming
- Cherif Rim
- Chernopolsky Plamen Milchev
- Cheung Tan To
- Cheverdiuk Dmytro
- Chibane Aissam
- Chierici Andrea
- Chihaka Onesai
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- Chik Ian
- Chikkala Bhargava
- Chiow Adrian
- Chisthi Meer M
- Chong Lynn
- Chooklin Serge
- Choudhary Satyaprakash Ray
- Chowdhury Mohammad
- Christodoulidis Grigorios
- Christodoulou Spyridon
- Christophides Thalis
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- Christou Chrysanthos
- Chu Michael Jen Jie
- Chuklin Serhii
- Ciarleglio Francesco
- Ciesielski Wojciech
- Cillo Umberto
- Ciola Michele
- Cirelli Riccardo
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- Clancy Thomas
- Clavien Pierre-Alain
- Coayla Guillermo
- Cobianchi Lorenzo
- Coelho Gustavo
- Coelho Gustavo
- Coimbra Felipe
- Coimbra Felipe JoseÌ FernaÌndez
- Colak Elif
- Colledan Michele
- CompanÌ Antonio
- Conci Simone
- Conlon Kevin
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- Coppa Jorgelina
- Coppola Alessandro
- Cossa Alessandra
- Cotsoglou Christian
- Crespi Michele
- CrinoÌ Stefano Francesco
- Cristaudi Alessandra
- Cristaudi Alessandra
- Croagh Daniel
- Cross Andrea
- Cruz Miguel Charco
- Cuadrado Angel
- Cucchetti Alessandro
- Cuk Vladica
- Cunningham Steven
- Cuticone Giuseppe
- Cyrochristos Dimitrios
- çelik Muhammet
- çetiindagÌ oÌzhan
- Çiftci Ahmet Burak
- çoker Ahmet
- D'Acapito Fabrizio
- D'Souza Daniel
- D'Ugo Stefano
- da Silva Diego Vaz
- Dabbous Hany
- Dahhan Hiba Talal
- Dailidenas Sarunas
- Dallavalle Raffaele
- Daraghmeh Motaz Ayman Mahmoud
- Dario Lorenzin
- Das Kshaunish
- Dasari Bobby VM
- Dassanayake B K
- David Avril
- Davide JoseÌ
- Davidson Brian
- Davydkin Vasili
- Dawood Ahmad Jamal
- De Cian Franco
- De Francesco Maura
- de Graaf Nine
- de Heredia Juan Beltran
- de la Hoz Rogriguez aÌngela
- de la RuÌa Jorge F RoldaÌn
- de la Serna Sofia
- de LeoÌn Alberto Miyar
- De Marchi Francesco
- de Meijer VE
- De Mello Eduardo
- De Rosa Raffaele
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- Konstantinidis Konstantinos M
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- Oldani Graziano
- Oldhafer Karl J
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- Uzunoglu Faik G
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- Van den Bossche Bert
- van Eijck Casper HJ
- van Laarhoven Stijn
- Vanagas Tomas
- Varshney Vaibhav
- Vasavada Bhavin
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- Vass David
- Vassiliu Pantelis
- Vazquez Pedro Gil
- Velagala Jayapala Reddy
- Velagala Jayapala Reddy
- VelaÌzquez Patricia SaÌnchez
- Velenciuc Natalia
- Veneroni Luigi
- Venkatesh N R
- Vennarecci Giovanni
- Vera Valle
- Vereczkei Andras
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- Vilhav Caroline
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- Waechter FaÌbio Luiz
- Waffa Zuraiha
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- Wahib El Mahdi
- Wake Rudyard
- Wang Huaizhi
- Wang Jiping
- Waqar Usama
- Waqar Usama
- Wardeh Salah
- Wardeszkiewicz Aleksander
- Wassmer Charles-Henri
- Weber Markus
- Wei Alice
- Wei Kongyuan
- Wei Kongyuan
- Weitz JuÌrgen
- Wellner Ulrich
- Welsch Thilo
- Welsh Fraser
- Wen Daniel
- Wennerblom Johanna Hansson
- Wenning Anna Silvia
- Wicherts Dennis
- Wierzchowski MichaĆ
- Wikar Tomasz
- Williamsson Caroline
- Windsor John
- Winslow Emily
- Wlazlak Michal
- Wolfgang Christopher
- Wu Chien Hui
- Wu Chien Hui
- WuÌllenweber Hans-Peter
- WyrosÌlak-Najs Justyna
- Yadav Kaushal
- Yadev Induprabha
- Yadev Induprabha
- Yaghan Rami
- Yamamoto Tomohisa
- Yang Po-Chih
- Yassin Laya Moayyad Ahmed
- Yassin Raya
- Yegen Cumhur
- Yeo Charles
- Yesilyurt Degercan
- Yip Vincent
- Yoong Boon
- Yoong Boon Koon
- Younes Eman
- Younes Eman
- Young Alistair
- Yousef Amal
- Youssef Amal
- Yu Ming-Chin
- Zacharakis Emmanouil
- Zacharoulis Dimitrios
- Zachiotis Marinos
- Zagainov Vladimir
- Zaharie Florin
- Zahed Mohamed
- Zahed Mohamed Samir Mohamed
- Zakaria Andee Dzulkarnaen
- Zamri Fatimah Mardhiyyah Binti
- Zanatta Michela
- Zanello Matteo
- Zanini Nicola
- Zanus Giacomo
- Zanus Giacomo
- Zaruba Pavel
- Zawia Ali
- Zayed Ahmed
- Zdujic Predrag
- Zedelj Jurica
- Zeh Herbert J
- Zentar Aziz
- Zerbi Alessandro
- Zidan Taha
- Zidan Taha
- Zironda Andrea
- Zitawi Abdullah
- Zivanovic Marko
- Zogopoulos George
- Zonta Sandro
- Zonta Sandro
- Zorrilla Carlos Florez
- Zozaya Gabriel
- Zreqat Qusai
- Zuhdi Zamri
- Zuhdy Mohammad
- Zygomalas Apollon
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
- Author
- Aamir Junaid
- Abaalkhail Muath
- Ababneh Adnan
- Ababneh Hazim
- Ababneh Laila
- Ababneh Roba
- Abad-Motos Ane
- Abaker Mussab
- Abary Ryan
- Abass Adam
- Abate Emmanuele
- Abayomi Olukayode
- Abazeed Alaa
- Abbad Bader
- Abbadessa Francesco
- Abbadi Osaid
- Abbakar Malaz
- Abbas Ahmed
- Abbas Alzhraa
- Abbas Asad
- Abbas Aya
- Abbas Jihad
- Abbas Manzar
- Abbas Mohammad
- Abbas Omer
- Abbasov Aykhan
- Abbo Olivier
- Abbott Daniel
- Abbott Tom
- Abboud Omar
- Abd Waleed
- Abd-Elkariem Ahmed
- Abd-Elsalam Sherief
- Abdalah Ahmad
- Abdalhadi Alya
- Abdalla Ahmed
- Abdalla Eman
- Abdalla Samir
- Abdalla Shimaa
- Abdalla Siddig
- Abdallah Emne
- Abdallah Ghaida
- Abdallah Lubna
- Abdallah Munir
- Abdallah Murad Al
- Abdallah Rasha
- Abdalnour Hani
- Abdeen Bashar
- Abdeewi Saedah
- Abdeh Louai
- Abdel-Aleem Mahmoud
- Abdel-Elsalam Wafaa
- Abdel-Fattah Areej
- Abdel-Fattah Nour
- Abdel-Hafez Ibrahim
- Abdelaal Abdelrahman
- Abdelaty Ahmed Adel
- Abdelazeem Khaled
- Abdelaziz Areej
- Abdelaziz Mohammed
- Abdelbagi Mohamad
- Abdelbaset Abouelnour
- Abdeldayem Hesham
- Abdelfattah Mahmoud
- Abdelgadir Alwaleed
- Abdelgalel Khaled
- Abdelghafar Moslem
- Abdelhafez Mohammed
- Abdeljalil Abdelkarim
- Abdelkabir Mohammed
- Abdelkareem Mohamed
- Abdelkarem Mohamed
- Abdelkarim Mostafa
- Abdelkhalek Mohamed
- Abdellah Fatima
- Abdelmajeed Ahmed
- Abdelmalik Abubaker
- Abdelmawla Ahmed
- Abdelrahman Abdelrahman
- Abdelrahman Haneen
- Abdelraouf Ali
- Abdelsamed Ahmed
- Abdelwahab Omar
- Abderrazaq Hafni
- Abdissa Desalegn
- Abdo Adnan Sayid
- Abdou Hossam
- Abdou Mostafa
- Abdoun Meriem
- Abdow Mohammad
- Abdrabou Ahmed
- Abdualqader Mahmmoud
- Abdul-Jabar Hani
- Abdul-Mumin Alhassan
- Abdulaal Safaa
- Abdulateef Omar
- Abdulfattah Ammar Yasser
- Abdulkareem Amal
- Abdull Mohammed
- Abdullaev Abakar
- Abdullah Abdullah
- Abdullah Bahiyah
- Abdullah Duha Milad
- Abdullah Muhammad Tariq
- Abdullah Nabila
- Abdullah Saleha
- Abdullah Shahbaz
- Abdullaha Lamess
- Abdullahi Alhassan
- Abdullahi Habiba
- Abdullahi Lawal
- Abdullahi Mohammed Kabir
- Abdullahi Sani
- Abdullahi Yasir Younis
- Abdulmalek Abdulmalek
- Abdulmalik Abdulmuez
- Abdulmohsen Ahmed
- Abdulqawi Nabil
- Abdulrahem Abdullah
- Abdulrahman Mamuda
- Abdulrahman Mohamed
- Abdulrahman Taha
- Abdulsalam Albaraa
- Abdulsalam Fareed
- Abdulsalam Khalifa
- Abdulsalam Moruf
- Abdulwahab Taiceer
- Abdulwahed Eman
- Abdunabi Murad
- Abdur-Rahman Lukman
- Abdurab Ebrahim
- Abdurehman Oumer
- Abdurrazzaaq Abdussemee
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abe Anthonia
- Abe Nobutsugu
- Abe Tatsuro
- Abebe Engida
- Abebe Kirubel
- Abebe Metasebia
- Abebe Nebyou
- Abebrese John Tabiri
- Abed Arsan Abu
- Abed Francisco
- Abed Haneen
- Abed Laith Abu
- Abedalqader Lina
- Abedin Yasmin
- Abel Joel Reuben
- Abel Livingston
- Abel Mary Kathryn
- Abelevich Alexander
- Abella Andrei Cesar
- Abichou Wijden
- Abid Rubaba
- Abiodun Adekunle
- Abiola Olajide
- Abiola Paul
- Abiyere Henry
- Aboalsamh Ghaleb
- Aboazamazem Hajir
- Abodeeb Aya
- Aboelkhel Roger
- Abojeila Farah
- Abosamak Nour Eldin
- Abosnaina Yahya
- Abostate Ahmed
- Abou-Abbass Hussein
- Abou-Khalil Jad
- Abouassi Layth
- Abouassi Majd
- Aboubakr Samar
- Aboubeirah Mohammed
- Abouelazayem Mohamed
- Abouelnagah Galal
- Abouelnagah Yossof
- Aboutaleb Shereen
- Aboutrab Ayham
- Abouzid Amr
- Abozied Hesham
- Abraham Bejoy
- Abrahams Jenevive
- Abramowicz Shelly
- Abrate Alberto
- Abreha Tassew
- Abrha Teklebirhan
- Abu-Arish Hamdoon
- Abu-Eisheh Basil
- Abu-Ishkerih Nizar
- Abu-Ismail Luai
- Abu-Libdeh Tareq
- Abu-Mehsen Marah
- Abu-Zaid Ahmed
- Abualteen Faisal
- Abuawad Carla
- Abubakar Abdullah
- Abubakar Ahmed
- Abubakar Mohammed Kabir
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- Andriantsoa Herimampionona E
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- Deniz Elif Akova
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- Dhoun Sajedah Al
- Dosouky Mohammed Al
- Draz Najib Abu
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- El-Ghani Wael
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- GarcĂa Fernando Acebes
- GarcĂa Miguel Adeba
- Ghafri Wadha Al
- Ghafry Alaa Al
- Glasbey James
- Gohary Rawda Al
- GonzĂĄlez Francisco Andrade
- Gujjuri Rohan
- Gurumeta Alfredo
- Habes Hessa Al
- Hameed Jumana Abdul
- Hameed Najat Abdul
- Haq Zainab Ahmad
- Harthi Abdulaziz Al
- Hasan Ziad Aboharp
- Hilal Mohammed Abu
- Hosni Mohammed Al
- Humaid Lama Al
- Imaz Ainhoa Andres
- Ingabire Jc Allen
- Jamahir Mohammed Al
- Jarad Ziad Al
- Jarmozi Buthina Al
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- Jayyab Mustafa Abu
- Juarranz Miguel Alonso
- Junior Joel
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- Kalbani Moza Al
- Kamarajah Sivesh
- Kharusi Lamya Al
- Kharusi Safiya Al
- Khassawneh Ahmad Al
- Koculen
- KöylĂŒ Zehra Alan
- Lahham Salim Al
- Lara IvĂĄn AndĂșjar
- Lara MarĂa Adrien
- Li Elizabeth
- Lucas Miriam Abellan
- Maadany Faraj Al
- Mahdawi Leyla Al
- Mahdy Hossam Al
- Makari Reem Al
- Manji Adil Al-Karim
- Maqtari Siham Al
- Mariño Mauricio AgĂŒero
- Martinez Yicel Alvarez
- Maryam A
- Matas Fernando Alcaide
- Mendoza Veronica Alonso
- Mensah Kwasi Agyen
- Mintah Dominic Annor
- Moagal Rehab Al
- Moawad Karim Abdelraouf
- Mohamed Mohamed Ali
- Mohsen Mustafa Abo
- Momani Tareg Al
- Muhfouz Dima Abu
- Muhtadi Fadhl Al
- Mulke Rahaf Al
- Murgueitio Natalia Cortes
- Mutani Mohammed Al
- Nafesa Aminah Al
- Nahian Syed Al
- Najjar Majed Al
- Najjar Tasneem Al
- Nami Awaji Al
- Nassar Saleh Al
- Nepogodiev Dmitri
- Neto Alfeu Accorsi
- Noval Patricia Corriols
- Nwijy Khaled Ai
- Obead Hamza Abu
- Oliver Renato Aguera
- Omair Shehanah Al
- Otaibi Faisal Al
- Picciochi Maria
- Pinto JoĂŁo Almeida
- Polo Miriam Abdulkarim
- Qadhi Hani Al
- Qudhaya Rashed Al
- Qureshi Talha Ahmed
- Rahim Norazila
- Rahman Noorneza Abdul
- Rahman Norhafiza
- Raisi Amani Al
- Rashed Asmaa Al
- Rego Juliana Almeida
- Riaz Shujat Ahmed
- Riobello Eva Andreu
- Riyami Nihal Al
- Riyami Salim Al
- Ros Conrado Andrés
- RosellĂł Irene Vives
- Rubio Eva Corral
- Rueda Ignacio AlcalĂĄ
- Saad Sarah Ahmed
- Sabti Hilal Al
- Saez Iago Alvarez
- Saied Ghiath Al
- Salam Omar Abdul
- Salama Ibrahim Abdelkader
- Sanany Ghadeer Al
- Santos Daniel Costa
- Sayed Mohamed Al
- Sebastian Isabel Alonso
- Shaalah Ahmed Abdullah
- Shaibi Maha Al
- Shaikh Shafqat Ali
- Shanab Ahmed Abo
- Sharie Ahmed Al
- Shukri Asmaa Al
- Simoes Joana
- Smadi Omar Al
- Soares Rui Costa
- Soucheiron Maria Coronas
- Subaie Saud Al
- Suyyagh Kais Al
- Tarieh Ammar Abu
- Torres Eva Alvarez
- Victoria Czarlo Dela
- Villamayor VerĂłnica Alen
- Vinayagam Raman
- Vincenti Cara
- Vincenzi Matteo
- Vinz Franziska
- Violante Tommaso
- Violas Philippe
- Violette Mukanyange
- Viotti Fabio
- Virdi Amrita
- Virgilio Edoardo
- Virgincar Ashwini
- Virta Ville P
- Viscido German
- Vishnoi Jeewan Ram
- Vishwakarma Sunil Kumar
- Vishwani Vartika
- Vissapragada Ravi
- Viste Claire
- Viswanath Yks
- Vitowanu Julius
- Viveiros Octavio
- Viveros-Carreño David
- Vives Inmaculada
- Vives-Barquiel Marian
- Vivian-Taylor Josephine
- Vix Michel
- Vlad Ioan Catalin
- Vlad Schitcu
- Vladimir Novgorodskii
- Vleminckx Nils
- Vo Uyen Giao
- Vogel Jon
- Vogel Keianna
- Vogel Rachel
- Vogelsang Holger
- Vogler Thomas
- Vogt Kelly
- Vohra Ravinder
- Vokshi Ismail
- Volkova Olga
- Volpe Gustavo Jardim
- Volpin Enrico
- Volpin Francesco
- von Ehrlich-TreuenstÀtt Viktor H
- von Renesse Janusz
- von Rundstedt Friedrich-Carl
- Voonna Murali Krishna
- Voppuru Saiesh Reddy
- Vora Sameer
- Voros Peter
- Vosoughi Fardis
- Vossler Kristen
- Vounckx Manon
- Vourganti Srinivas
- Vovola Fernanda
- Vozian Marin
- Vrakopoulou Gavriella Zoi
- Vömel Jacob
- Wadei Hajr Al
- Yahya Zakaria Al
- Zahran Mohammed
- Zahrani Attiya Al
- Zahrani Turki Ai
- Zaid Muna
- Zein Zeina Al
- Ălvarez Sofia
- ĂlgĂ„ Andreas
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.
Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty.
Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year.
Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population
International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module
- Author
- A. Ahmad Zaatari
- A. Ahmed
- A. Alves De Oliveira
- A. Anirban Karmakar
- A. Anwar Al Souheil
- A. ArgĂŒello-Ruiz
- A. Azim
- A. Bat-Erdene
- A. Bhakta
- A. Borgi
- A. Bouziri
- A. Cerero-Gudino
- A. Chawla
- A. Dagys
- A. Dilek
- A. Dwivedy
- A. Engin
- A. Flores-Alvarado
- A. Florin-Rogobete
- A. Gashi
- A. Gunduz
- A. Kaya
- A. Kubler
- A. Lagares-GuzmĂĄn
- A. Lesnakova
- A. MartĂnez
- A. Molkov
- A. Mubarak
- A. Oncul
- A. Ozgultekin
- A. Palaoro
- A. Patil
- A. Poojary
- A. Ramazanoglu
- A. Romani
- A. Romario-Mendes
- A. Sasidharan
- A. Simic
- A. Solano-Chinchilla
- A. Thakur
- A. Willke
- A. Zamores-Pedroza
- A.A. Zeggwagh
- A.C. Bianchi
- A.M. Elansary
- A.M. Mathew
- A.M. Mohamed
- A.M. Montanini
- A.M. RĂos
- A.N. Manked
- A.N. Yalcin
- A.P. GonzĂĄlez
- A.R. Vargas-GarcĂa
- A.S.K. Rillorta
- A.V. Dharan
- Aamer Ikram
- Abd El Moniem Moustafa
- Abdulrahim Al Khamis
- Abeer A. Omar
- Abeera Ahmed
- Adnan Soliman Alsaadi
- Ahmad Mahmoud Ali
- Ahmed Abdoh Al-Jarie
- Ahmed Hasanin
- Ainul Auzani Othman
- Aisha Hassan Mutwalli
- Alejandra Sepulveda-Chavez
- Ali Pekcan Demiroz
- Aliza Mohamad Yusof
- Amani Ali El-Kholy
- Ameena Isa Alsayegh
- Ana Marcela Quesada-Mora
- Ana P. Dy
- Anahita Sanaei
- Anamma Philip
- Andrew Trotter
- Anil Kumar Bilolikar
- Anis Siham Zainal Abidin
- Anjeela Koirala
- Anna Lyn N. Tajanlangit
- Antoine Abdel Messih
- Anucha Apisarnthanarak
- Anuja Kulkarni
- Anumol Thomas
- Anuradha Agarwal
- Anuradha Sriram
- Arnab Dasgupta
- Arnefelina S. Tamayo
- Arul Rose Suganya
- Arwa Ramadan
- Ashraf Elhoufi
- Ashraf Kelany
- Ashwin Kumar Mani
- Asmita Sakle
- Asuman Inan
- Athena Manao
- Aun Raza
- Azra Parveen
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- Banambar Ray
- Basak Ceyda Meco
- Basanta Kumar Pati
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- Batsuren Choijamts
- Battsetseg Tuvdennyam
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- Farid Zand
- Fatema Hasan Yaseen
- Fatima Abdullah Al Qasmah
- Fazil Abubakar
- Felcy Chacko
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- Gortap Sitohang
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- Hakan Leblebicioglu
- Hala Ahmed
- Hala Hamza
- Hala Mounir Agha
- Hala Roshdi
- Halima Yahia Al-Alkami
- Hana Hanafi
- Hasan Agin
- Hasimah Zainol
- Hassan Eisa Ammari
- Hatem Mohd Al Hani
- Hatice Cabadak
- Hector Miguel Telechea
- Hindra Irawan Satari
- Hulya Sungurtekin
- Humberto Guanche-Garcell
- Humeyra Zengin
- Hussain Alrahma
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- I. Devrim
- I. Erdem
- I. Ozgunes
- I. Perez
- I. Zeid
- I.A. Valderrama-Marquez
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- J.V. Divatia
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- Jeffrey Asidera Mendoza
- Jehangir Sorabjee
- Jincy Eappen
- Jomol Philipose
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- Justin Mathew
- Jyotishka Pal
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- K. Liu
- K.F. Aibar-Yaranga
- K.H. Chuluunchimeg
- Kamal Bashar Abu Bakar
- Karthikeya Varma
- Kashmira Limaye Joshi
- Katarina Furova
- Katerina Jankovska
- Katja Popovska
- Kavita Sandhu
- Khalid Mohammed Ghalilah
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- L. Josph
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- L. Meneses-Ovallos
- L. Montes-Bravo
- L. Nikolic
- L. Pushparaj
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- L.G. Salvio
- L.I. Castillo-Bravo
- L.M. Canas-Giraldo
- L.M. Santivanez-Monge
- L.N. Pazmino
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- L.Y.M. Rincon
- Lakshmi Ranganathan
- Lateefa Fardan Hani
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- M. Caridi
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- M. Chakravarthy
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- M.C. Culebro-Burguet
- M.C. Oyola
- M.C. RodrĂguez
- M.C. Sg-Buenaflor
- M.E. Gomez
- M.E. Guzman Siritt
- M.E. Sanchez-Castuera
- M.F. Garcia
- M.F. Geyik
- M.F. Trajano
- M.G. Manuel
- M.G. Miranda-Novales
- M.I. Rojas-Bonilla
- M.J. Mayorga-Espichan
- M.L. Maciel-Canuto Amaral
- M.L. Spadaro
- M.L.G. Rosario-Tueros
- M.M. Bovera
- M.M.A. Haleim
- M.N. Sivakumar
- M.O. Gamar-Elanbya
- M.S. Olivieri
- M.T. Mendoza
- M.T. Tenorio
- M.V. Changano-Rodriguez
- Madhav Lavate
- Madhavi Latha
- Madhupriya Suryawanshi
- Maithili Kavathekar
- Manal Mansour Al-Gethamy
- Manoj Kumar Agarwal
- Mansoor Masjedi
- Maria Carmen S.G. Buenaflor
- Maria Khan
- Marjory Madco
- Marzida Mansor
- Masoud Alebouyeh
- May Abdel Fattah
- May Osman Gamar Elanbya
- Mayur Patel
- Mazuin Kamarul Zaman
- Mehul Shah
- Mervat Aldalaton
- Mervat Elanany
- Michael M. Petrov
- Milena Petrovska
- Modhi Alkhamaly
- Mohamad Fadhil Hadi Jamaluddin
- Mohammad Masfar
- Mohammed Ahmed Ali Karrar
- Mohd Shahnaz Hasan
- Mohit Kharbanda
- Mona Foda Salama
- Mrinmoy Bej
- Mrunalini Potdar
- Munayfa Musallam Al Azmi
- Myrna Lim Quisai
- Myrna Misador Torres
- N. Al Zharani
- N. Al-Abdullah
- N. Alquinga
- N. Baftiu
- N. Barahona-GuzmĂĄn
- N. Ben-Jaballah
- N. Elaldi
- N. Gad
- N. Gita
- N. Jaggi
- N. Kuyucu
- N. Madani
- N. Navarrete
- N. Orozco
- N. Oztoprak
- N. Ramakrishnan
- N. Saini
- N. Sen
- N. Unal
- N. Yasar
- N.E. Salazar-Ramirez
- N.K. Pawar
- N.K. Zahreddine
- N.P. Rao
- Nadeem Paul
- Nader Ahmed Tawfic
- Naglaa Mahmoud Abdo
- Naheed Elahi
- Najla Ben Jaballah
- Namphon Supa
- Naranpurev Mendsaikhan
- Nargis Daud
- Nashwa Elsayed
- Nawal Salah Abdulkhalik
- Nehad Abdulshakour Bugis
- Neilia Cardinal Ariola
- Nepomuceno Mejia
- Nesreen Alghosn
- Ngo uy Chau
- Nguyen Gia Binh
- Nguyen Phuc Tien
- Nguyen Quoc Anh
- Nguyen Viet Hung
- Nidal Tashkandi
- Nikhil Modi
- Nirav Pandya
- Nisith Mohanty
- null Kehkashan
- null Sijo
- null Tsuyanga
- null Velupandi
- Nurettin Erben
- Nuri Bayram
- O. Chavarria-Ugalde
- O. Coskun
- O. Mancera-Paez
- O.G. Ramires
- O.P. Javellana
- O.S. Espinosa
- Oguz Dursun
- Oguz Karabay
- Otgon Baatar
- Ovidiu Horea Bedreag
- Ozden Ozgur Horoz
- Ozge Turhan
- Ozlem Sarac Sandal
- P. Botta
- P. Mathur
- P. Saul
- P. Suvderdene
- P.A. De Vera
- P.A. Rios-Arana
- P.D. Juarez
- Phan Thi Hang
- Pooja Thakkar
- Pornpheth Prasan
- Pradnya Joshi
- Prafulla Kumar Sahoo
- Pravin Kumar Nair
- Priyadarshini Senthil Kumar
- Priyanka Patil
- Purnima Mukherjee
- Purvi Shah
- R. Abouqal
- R. Ahmadieh
- R. Amaral De Moraes
- R. Cabrera-Montesino
- R. De Leon-Escobedo
- R. Fouda
- R. Kelkar
- R. Kevalas
- R. Li
- R. Ortega
- R. Penuliar
- R. Popescu
- R. Rocha-Vasconcelos Carneiro
- R. Ruiz-Rendon
- R. Salas-Flores
- R. Sukanya
- R.H. PĂ©rez
- R.R. Maglente
- R.S. Campos-Uchoa
- R.V. Lozada
- Radhika Krishnan
- Raed Hassan Al Shehri
- Raha Abdul Rahman
- Rajalakshmi Arjun
- Rajesh Chawla
- Ram Gopalakrishnan
- Ramesh Venkataraman
- Rasha Hamed El-Sherif
- Rasha Nour Aldeen Jaha
- Rashmi Giri
- Ravikumar Krupanandan
- Rayo Morfin Otero
- Recep Tekin
- Reham H.A. Yousef
- Reny Thomas
- Reshma Tejam
- Retno Kadarsih
- Rhea Lynn Cresencia
- Rhendra Hardy Mohamad Zaini
- Richa Misra
- Ritesh Debroy
- Rosliza Zhazali
- Rungratchanee Pimathai
- S. Al Qahtani
- S. Baigalmaa
- S. Basu
- S. Bekeit
- S. Biswas
- S. Esparza-Ahumada
- S. Gerah
- S. Gualtero
- S. Hlinkova
- S. Petersen-Morfin
- S. Raut
- S. Sahu
- S. Saranya
- S. Shah
- S. Shetty
- S. Singh
- S. Singh
- S. Valderrama
- S. Vega-Gonzalez
- S.A. Aguirre-Diaz
- S.C. Do Nascimento
- S.D. Grecu
- S.J. Ramos
- S.K. Patnaik
- S.K. Todi
- S.L. Romero-Torres
- S.M. George
- S.M. Pulido-Leon
- S.N. Myatra
- S.S. Dalal
- Saban Esen
- Safa A Aziz AlKhawaja
- Sajith Narayanan
- Saleh Fakher Sowar
- Samana Sainju
- Sameh Twfik
- Sana Yusuf
- Sanghamitra Mishra
- Sanjith Saseedharan
- Sankar Sengupta
- Sarah Hassan Al Faraj
- Sasheela Sri La Sri Ponnampala
- Saswati Sinha
- Seelas Blessymole
- Seema Rohra
- Selvi Yener Erdogan
- Senthilkumar Rajagopal
- Serhat Unal
- Sevim Karacorlu
- Shanta Mukherjee
- Sharmila Sengupta
- Sheeba John
- Shefali Bhattacharya
- Sherin El-Sherbiny
- Sinchan Bhattacharyya
- Siti Jhulmina B. Alih
- Snezana Tufekcievska Guroska
- Soad Khamis
- Solita Briones
- Somayeh Jahani Sherafat
- Sonali Vadi
- Soo Lin Chuah
- Souha Sami Kanj
- Subhash Prasad Acharya
- Subodh Kumar
- Sudha Kansal
- Sudhjan Misra
- Sudipta Bhattacharyya
- Suha Sen
- Suha Sen
- Suhas Nirkhiwale
- Suja Thomas
- Sujit Kar Purkayastha
- Sujoy Mukherjee
- Summiya Nizamuddin
- Sunil Sharma
- Suresh Kumar
- Suthinee Wanitanukool
- Suwara Somabutr
- Suzan Sacar
- Syed Zahid Bukhari
- T. De Jesus Pinheiro-Bandeira
- T. Kardas
- T. Khajidmaa
- T. Kondratas
- T. Liu
- T. Mahfouz
- T. Mapp
- T. Moreira-Matos
- T. Singhal
- T. Sohanlal
- T.M. Lima-De Barros Araujo
- Tahira Anwar Magray
- Tanja Anguseva
- Tarek Dendane
- Tariq Saad Abdulhadi Alotaibi
- Thara Francis
- Thejasvini Anand
- Tran Thi My Hanh
- Tran Thi Thuy Hang
- Truong Anh Thu
- Tsolmon Begzjav
- Uma Gopal
- Umesh Gupta
- Usha Nair
- V. Bayani
- V. Bermudez
- V. Chediack
- V. De Iturrado
- V. Delgado
- V. Dumitrascu
- V. Gaona-Flores
- V. Kothari
- V. RamĂrez
- V. Tanzi
- V. Venkateshwar
- V.A. Marquez-Mondalgo
- V.A. Monroy-Colin
- V.A. Velinova
- V.J. Dicheva
- V.L. Machado-Silva
- V.M. Moreno-Mejia
- Vaidotas Gurskis
- Valsa Thomas
- Vesna Mioljevic
- Vineya Rai
- Vini Kantroo
- Vladislav Belskiy
- Vo Thi Hong Thoa
- Volkan Yarar
- VĂctor Daniel Rosenthal
- W. Chilon
- W. Raigoza-Martinez
- W. Villamil-Gomez
- W.M. Santos Monteiro
- Wael Abdulrahman Abdulatif
- Waleed Mohd Hussain
- Walter Enrique Prudencio Leon
- Wan Fadzlina Wan Mohd Shukeri
- Wan Nazaruddin Wan Hassan
- Wan Nurbayah Wan Yusoff
- Wan Rahiza Wan Mat
- Wieslawa Duszynska
- Wynndale Mae Demotica
- X. Guo
- X. Yang
- Y. Arreza-Galapia
- Y. Ruiz
- Y. Yang
- Y.A. Pardo-Lopez
- Y.M. Abdelhamid
- Y.S. Elkholy
- Yassir Khidir Mohamed
- Yatin Mehta
- Yeliz Oruc
- Yusuf Sahip
- Z. Ariyasuren
- Z. Cruz-Rivera
- Z. Duran-Gil De Anez
- Z. Hammoud
- Z. Kanafani
- Zan Mitrev
- Zaneta Bogoevska Miteva
- Zeinab Salah
- Zeynep Kaya
- Publication venue
- Elsevier Inc
- Publication date
- 01/12/2016
- Field of study
âąWe report INICC device-associated module data of 50 countries from 2010-2015.âąWe collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.âąDA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.âąDevice utilization ratio in the INICC ICUs was similar to CDC-NHSN's.
Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific.
Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days.
Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs.
Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically