9,638 research outputs found

    Regularized pointwise map recovery from functional correspondence

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    The concept of using functional maps for representing dense correspondences between deformable shapes has proven to be extremely effective in many applications. However, despite the impact of this framework, the problem of recovering the point-to-point correspondence from a given functional map has received surprisingly little interest. In this paper, we analyse the aforementioned problem and propose a novel method for reconstructing pointwise correspondences from a given functional map. The proposed algorithm phrases the matching problem as a regularized alignment problem of the spectral embeddings of the two shapes. Opposed to established methods, our approach does not require the input shapes to be nearly-isometric, and easily extends to recovering the point-to-point correspondence in part-to-whole shape matching problems. Our numerical experiments demonstrate that the proposed approach leads to a significant improvement in accuracy in several challenging cases

    Microelectrode arrays and the use of PEG-functionalized diblock copolymer coatings

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    PEG-modified diblock copolymer surfaces have been examined for their compatibility with microelectrode array based analytical methods. The use of PEG-modified polymer surfaces on the arrays was initially problematic because the redox couples used in the experiments were adsorbed by the polymer. This led the current measured by cyclic voltammetry for the redox couple to be unstable and increase with time. However, two key findings allow the experiments to be successful. First, after multiple cyclic voltammograms the current associated with the redox couple does stabilize so that a good baseline current can be established. Second, the rate at which the current stabilizes is consistent every time a particular coated array is used. Hence, multiple analytical experiments can be conducted on an array coated with a PEG-modified diblock copolymer and the data obtained is comparable as long as the data for each experiment is collected at a consistent time point

    Financial regulation in the post-crisis environment

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    The Chicago Fed’s 46th annual Conference on Bank Structure and Competition, which took place May 5–7, 2010, focused on the future of the financial services industry in light of the recent financial crisis and forthcoming industry reforms.Financial crises ; Bank supervision

    A preferred vision for administering elementary and secondary schools : a reflective essay

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    There was a time the school principal\u27s job was clear and relatively simple - not easy, but simple. Everyone understood the role of the principal. That is no longer the case. In today\u27s society, the public education system in America is one that is fraught with dissension, politics and numerous other variables. Leaders and managers in the public sector are under far greater scrutiny than those in the public sector and the school principal is one position that is frequently caught in a maelstrom. This essay will explore the literature to identify the numerous characteristics, knowledge and skills that are linked to an effective principal

    Social Media Usage and Romantic Development: Testing Attachment Anxiety and Avoidance as Moderators

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    Social media use is linked with the development and maintenance of romantic relationships, exhibiting both positive and negative effects on relationship quality depending on the social media behavior. However, many of these studies focus on a singular social media platform rather than multiple social media platforms. Also, studies on Facebook have linked anxious attachment to more surveillance and Facebook-induced jealousy (Marshall, Benjanyan, Di Castro, & Lee, 2013). Thus, the impact of social media behaviors for relationship quality may depend on attachment behaviors. Therefore, the goal of the current study is to examine how attachment avoidance and attachment anxiety predict relationship quality for established and developing relationships. Data comes from 183 college students (86.9% female, 87.4% heterosexual) who completed an online survey for ten consecutive days regarding their social media use and quality of their relationship with a romantic partner or crush. Results of linear regression analyses illustrated that avoidance was negatively associated with relationship quality for established relationships, whereas minutes spent private messaging a crush was positively associated with relationship satisfaction. Additionally, anxiety moderated the relationship between commenting and posting photos of partners for relationship satisfaction for established relationships. Avoidance moderated the relationship between commenting and relationship satisfaction for established relationships. No interactions were found between attachment behaviors and social media behaviors for quality of relationships between single participants and crushes. Attachment anxiety and avoidance may explain how social media promotes and hinders the quality of established relationships. Implications regarding attachment security and social media use will be discussed

    TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching.

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    The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein remodelers NSF and p97, while its overall hexameric architecture and likely structural mechanism bear close similarities to the bacterial protein unfoldase ClpX. We find that TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint protein MAD2 from a signaling-active 'closed' conformer to an inactive 'open' conformer. We propose that TRIP13 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational conversion and disassembly of mitotic checkpoint complexes. A parallel HORMA protein disassembly activity likely underlies TRIP13's critical regulatory functions in meiotic chromosome structure and recombination
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