Ovarian carcinoma associated with pregnancy: A clinicopathologic analysis of 23 cases and review of the literature

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to analyze and describe cases of ovarian cancer in pregnant women treated at our center and to review the literature concerned, and to discuss the rationale for therapy.</p> <p>Methods</p> <p>Twenty-Three patients of ovarian malignancies during pregnancy were treated at Vali- Asr Hospital between 1991 and 2002. Data on treatment and follow-up were evaluated.</p> <p>Results</p> <p>The incidence of ovarian carcinoma associated with pregnancy in our series was 0.083/1000 deliveries. Eleven (47.8%) were found with ovarian malignant germ cell tumors, five (21.7%) with low malignant potential tumors, four (17.4%) with invasive epithelial tumors, and three (13%) with sex cord stromal tumors. Seventeen (73.9%) of the patients were diagnosed in stage I and had complete remission. Five of the six in advanced stage died. The mean follow-up was 36.3 months. The prognosis was significantly related with stage and histological type (<it>P </it>< 0.05). Sixteen healthy live babies were recorded in this group, and two premature newborn died of respiratory distress syndrome. Chemotherapy was administered to 44% of the patients, in two cases during pregnancy. Overall survival at 5 years was 61%. In most of case conservative surgical treatment could be performed with adequate staging and debulking.</p> <p>Conclusion</p> <p>Early finding of ascitis by ultrasound and persistent large ovarian mass during pregnancy may be related to malignancy and advanced stage. Pregnant women in advanced stage of ovarian cancer seem to have poor prognosis.</p

Optimalni neizraziti reglutor tipa 2 za sustave za grijanje, ventilaciju i klimatizaciju

In this paper a novel Optimal Type-2 Fuzzy Proportional-Integral-Derivative Controller (OT2FPIDC) is designed for controlling the air supply pressure of Heating, Ventilation and Air-Conditioning (HVAC) system. The parameters of input and output membership functions, and PID controller coefficients are optimized simultaneously by random inertia weight Particle Swarm Optimization (RNW-PSO). Simulation results show the superiority of the proposed controller than similar non-optimal fuzzy controller.U radu je predložena nova upravljačka shema optimalnog neizrazitog PID regulatora tipa 2 za upravljanje sustavima za grijajne, ventilaciju i klimatizaciju. Predložena je shema zasnovana na neizrazitom regulatoru (FLC) učestalo korištenom za upravljajne nelinearnim procesima. Kako bi se premostio problem neizrazitih regulatora, neodstatak metode dizajnirajna, parametri ulazno-izlaznih funkcija pripadanja, kao i parametri PID regulatora se optimiraju metodom roja čestica sa slučajnim parametrima inercije (RNW-PSO). Simulacijski rezultati pokazuju izvedivost predloženog pristupa

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Development of an integrated system for distribution planning in supply chain

Distribution planning, which includes Vehicle Routing and Scheduling Problem (VRSP), has become an important element in Supply Chain impacting its service level and efficiency. Computer Aided Routing and Scheduling (CARS) has been developed and implemented, which can handle complicated distribution models using advanced heuristic optimization algorithms. A classification scheme is introduced to classify various types of routing and scheduling problems in a structured manner, based on the main objects of VRSP. The integrated system described in this paper can manage the dynamic aspects of the Supply Chain in practice. The modelling and solution approach in the CARS optimization engine, its user interface, sample performance measurements, and planning and operational features of the system are described in detail

Complications of radical hysterectomy and pelvic lymphadenectomy in 120 early stage cervical cancers

We evaluated the clinical experience of 120 women with early stage cervical cancer who underwent radical hysterectomy combined with pelvic lymphadenectomy (class III Rutledge) in our gynecologic oncology clinic. Of these, 74 patient. (61.66%) were in stage I and 46 patients (38.34%) were in stage II a. Intraoperation complications comprised of great vessel injuries encountered in 4 (3.3%) patients. Postoperative complications included 12 (10%) bladder dysfunction, 2 (1.66%) lymphocyte formation, 10 (8.3%) urinary infection, 8 (7%) wound infection, 10 (8.3%) pelvic infections and 5 (4.16%) acute ileus. However, no death occurred due to intraoperative or postoperative complications. Pelvic lymph metastases were observed in 22 patients. Para-aortic lymph node metastases were diagnosed in 6 (2.5%) patients all of whom fell in stage II

ffect of Sowing Date on Yield and Yield Components of Three Grain SorghumCultivars

Abstract\ud In order to study the effect of sowing date on yield and yield components of sorghum cultivars, a field experiment was conducted at experimental field of agriculture factuly, Tarbiat Modares University which is located in 17 km Tehran-Karaj freeway. In this research effect of two factors, sowing date and cultivars of sorghum bicolor, was studied in split-plot based on randomized complete block design with 4 replications. Main plots were sowing date with three levels (8th June, 28th June and 18th July) and sub plots were cultivars with three levels (Payam, Sepideh and Kimia). Investigated traits include biological yield and its component, panicle weight, grain yield, percent and yield of protein, harvest index and grain yield component. Result showed that total biomass and vegetative biomass were not affected by any of factors. panicle dry weight and harvest index was significantly affected by cultivars (p≤0.01) although in grain yield was significant in 95 percent level. Weight of 1000 seeds was also affected by sowing date and cultivar (p≤0.05) and was affected by sowing date × cultivar interaction (p≤0.01). In spite of non significant effect of sowing date on grain yield, the highest grain yield was obtained by Sepideh in 28th June. In the result for higher grain yield in this region and other places with similar conditions, sowing Sepideh cultivar in mid June is recommended.\ud \ud Keywords: Grain sorghum, Sowing date, Leaf and stem biomass, Grain yield, Yield component

Effect of irrigation and nutrient on physical properties of safflower seeds

The effect of irrigation and nutrient treatments on physical properties of safflower seeds was investigated. Physical properties of safflower seeds were determined at a moisture content of 7% w.b. The parameters determined at different treatments were: size, geometric mean diameter, sphericity, surface area, mass, volume, bulk and true densities, porosity, and static and dynamic coefficient of friction. The results showed a better effect of the use of organic fertilizers in comparison with chemical ones. The results showed that nutrient and irrigation treatments had a significant effect on most of the physical properties of safflower seeds at p<0.01

Comparison of Logistic Regression and Discriminate Analysis in Recognition of the Factors Affecting on the Distribution of Quercus Libanii of Armardeh Forests at Baneh, Kurdistan Province

The study site, Armardeh forest, is located in Baneh, Kurdistan Province. The study area covers approximately 17000 ha. In this study, logistic regression and discriminant analysis methods were used and their performances were compared. Two random sampling grids were overlaid on the presence and absence area of Quercus libani type as dependent variables. Physiographic factors including slope, aspect, elevation and distance from drains were extracted for each sampling site and considered as independent variables. The results showed that the area under the ROC curve (0.746) for logistic regression method is higher than the discriminant analysis with 0.502. Furthermore, the overall accuracy of the classification of the logistic regression was higher than discriminate analysis. The results of this study can be used in management and restoration of these forests