THE ANTIBIOTICS RESISTANCE AND THE PRESCRIPTIONS’ PATTERN FOR URINARY TRACT INFECTIONS AT KING FAHAD SPECIALIST HOSPITAL

Objectives: Urinary tract infection (UTI) is one of the diseases with a highest prevalence in the world. This study evaluated the antibiotics resistant and the prescription pattern for UTI with the aim to participate as an effective monitoring study that enhances rational antibiotics’ prescription. Methods: We conducted a retrospective cross-sectional study at King Fahad Specialist Hospital from May 2018 to January 2019. We included a total of 306 patients with UTI. 204 patients diagnosed clinically and empirically treated (Group A), 102 patients underwent urine for culture and sensitivity tests (Group B). Results: UTI showed higher occurrence in female in both Groups A (61%) and B (65%). The mean age was higher in Group B (55.8 years) than Group A (39.44 years). The most commonly prescribed antibiotics for UTI were Trimethoprim + Sulfamethoxazole (TMP+SMX) (56%) and ciprofloxacin (15%). Escherichia coli was the most commonly isolated organism (36.3%) followed by Klebsiella pneumonia (30%). Although 41.17% of organisms were sensitive to TMP+SMX, 38.2% were resistant to it. The organisms were sensitive to amikacin in 80.4% and to gentamicin in 61.8% whereas, 61.8% were resistant to ampicillin. Luckily, no resistance was reported neither for nitrofurantoin nor for vancomycin. Conclusion: The study showed significant resistance to the commonly prescribed TMP+SMX and ciprofloxacin compared to absolute sensitivity to the less prescribed nitrofurantoin. This necessitates special consideration for local susceptibility in empirical therapy

Effect of progressive prone plank exercise program on diastasis of rectus abdominis muscle in postpartum women: A randomized controlled trial

Diastasis of Rectus Abdominis (DRA) muscle is a concerning health issue that commonly affects female within pregnancy and postpartum time, persistent lower back pain and pelvic instability are common consequences to DRA. Thus, this study was conducted to examine the effect of progressive prone plank exercises on narrowing the inter-Rectus distance (IRD) in postpartum women diagnosed with (DRA). A prospective, randomized, single-blind, controlled trial was conducted at the Faculty of Physical Therapy Clinic of Beni-Suef University. Fifty postpartum women presented with (DRA) of at least 2 finger widths assigned into 2 equal groups (A&B). A Toshiba Xario100, 8–12 MHz ultrasonography was used to accurately measure IRD before and after 8 weeks of the exercise program. Group (A), received progressive prone plank exercise program and advice relevant to DRA as well as wore abdominal binder, while group (B) continued their ordinary lifestyle after receiving advice and wearing abdominal binder as group (A).The study results revealed a statistical significant decrease within each group and between groups in IRD (p < .05) above and below the umbilicus both at rest and during Rectus Abdominis (RA) contraction, with a significantly narrower IRD in favoured of participants of group (A) (p < .05). To sum it up, progressive prone plank exercise program is very effective in decreasing IRD in postpartum women presented with DRA

Successful Conservative Management of Scrotal Edema Resulting from Uncomplicated Peritoneal Fluid Leak

Introduction: Peritoneal fluid leaks are frequent in continuous ambulatory peritoneal dialysis (CAPD) patients and may manifest as subcutaneous or genital edema or as apparent ultrafiltration (UF) failure. Genital swelling in CAPD patients is often due to dialysate leak through a small clinically-undetectable inguinal hernia, and may require herniorrhaphy. If imaging studies exclude an associated hernia or patent processus vaginalis, a conservative approach may be adopted. Case report: An 80 year-old bed-ridden male developed gross bilateral scrotal swelling (without cough impulse) and apparent UF failure shortly after initiation of CAPD. Computed tomography peritoneography (CTP) showed bilateral scrotal fluid collections without a hernia or patent processus vaginalis. An attempt to maintain the patient on CAPD by reducing the dialysate volume, scrotal elevation and adopting a supine position was not successful; CAPD was substituted with temporary hemodialysis (HD) for four weeks. Scrotal swelling reversed after one week of CAPD cessation and did not recur when supine PD with intermittent dry periods was reinstituted a few weeks later. Satisfactory UF could also be easily attained. This was compatible with caudal fluid migration through peritoneal defects being the underlying cause. The patient had been successfully maintained on CAPD for the last 18 months. Conclusion: Fluid dissection through soft tissues can result in gross genital edema and apparent ultrafiltration failure in CAPD patients. Supine PD, scrotal elevation with intermittent dry periods may be a practical alternative management in the absence of automated dialysis facilities. The severity of dialysate leak does not preclude a satisfactory response to this conservative management. Keywords: peritoneal dialysis, dialysate leak, genital edema, ultrafiltration failur

Thymoquinone Lowers Blood Glucose and Reduces Oxidative Stress in a Rat Model of Diabetes

The aim of the present study was to assess the short-term effects of Thymoquinone (TQ) on oxidative stress, glycaemic control, and renal functions in diabetic rats. DM was induced in groups II and III with a single dose of streptozotocin (STZ), while group I received no medication (control). The rats in groups I and II were then given distilled water, while the rats in group III were given TQ at a dose of 50 mg/kg body weight/day for 4 weeks. Lipid peroxidase, nitric oxide (NO), total antioxidant capacity (TAC), glycated haemoglobin (HbA1c), lipid profiles, and renal function were assessed. Moreover, the renal tissues were used for histopathological examination. STZ increased the levels of HbA1c, lipid peroxidase, NO, and creatinine in STZ-induced diabetic rats in comparison to control rats. TAC was lower in STZ-induced diabetic rats than in the control group. Furthermore, rats treated with TQ exhibited significantly lower levels of HbA1c, lipid peroxidase, and NO than did untreated diabetic rats. TAC was higher in diabetic rats treated with TQ than in untreated diabetic rats. The histopathological results showed that treatment with TQ greatly attenuated the effect of STZ-induced diabetic nephropathy. TQ effectively adjusts glycaemic control and reduces oxidative stress in STZ-induced diabetic rats without significant damaging effects on the renal function

تقييم تاثير ضخ مياه الصرف الصحي المعالجة الناتجة عن محطة خانيونس على جودة الشاطئ لاغراض الاستجمام

In this thesis, the derivation of first and second Painlev´e hierarchies and their Hamiltonian structures are studied. The first Painlev´e hierarchy is derived from the Kadomtsev-Petviashvili hierarchy and the linear problem of that first Painlev´e hierarchy is used to derive the Hamiltonian structure of that first Painlev´e hierarchy. In addition, The Modified Korteweg-de Vries hierarchy is derived from the Kortewegde Vries hierarchy and the Modified Korteweg-de Vries hierarchy is used to derive a ,second Painlev´e hierarchy. The linear problem for the second Painlev´e hierarchy are found and the canonical coordinates for it are built. Moreover, the linear problem is used to drive the Hamiltonian structure of that second Painlev´e hierarchy

Utilization of mobile phone sensors for complex human activity recognition

Activity recognition is a significant part of pervasive computing as it can be employed in a wide range of fields which include eldercare and healthcare. While previous efforts have proven to be successful in identifying simple human activities, the means for identifying complex human activities remains an on-going effort. It has been established that more often than not, in an actual circumstance, human activities are conducted in an intricate mode. The objectives of this study are (a) to examine the utilization of solely the sensors of a mobile phone to distinguish complex human activities and (b) to enhance the complex activities recognition capacity of mobile phones through the application of multiple or other forms of sensors. This endeavour reassesses earlier studies on mobile phone utilization for complex activity recognition with the emphasis on schemes directed at smart home applications. An overall configuration for a human activity recognition (HAR) scheme, as well as an analysis of the latest investigations related to the use of mobile phones for complex activity recognition is also included in this paper. We conclude with a discussion on the results obtained and the forwarding of our proposals

System and Information Qualities in Mobile Fitness Apps and Their Effects on User Behavior and Performance

Grounded in goal setting theory and other IS models, this study introduces a robust model, that examines the determinants of MFA goal setting and goal tracking use, and their impact on user behavior and achievement. The empirical results show that system quality and information quality are two key determinants of MFA goal setting and goal tracking use, which significantly influence a user’s goal achievement and behavioral change in terms of physical activities

The influence of vancomycin on renal functions, the predictors and associated factors for nephrotoxicity.

BackgroundVancomycin has been widely used in the last six decades to treat methicillin-resistant S. aureus (MRSA) and other resistant gram-positive infections. The risk of vancomycin toxicity increases with the utilization of higher doses while treating the resistant form of bacterial infections. Nephrotoxicity is one of the major complications reported to be a hinderance in the prognosis of vancomycin therapy.ObjectivesThis hospital-based study aimed to highlight the influence of vancomycin on renal function with special emphasis on identifying the predictors and augmenting factors for nephrotoxicity.MethodologyA cross-sectional, unicentric, hospital-based study was conducted at King Fahad Specialist Hospital (KFSH) in Qassim region in Saudi Arabia (KSA). It included 319 hospitalized patients who received vancomycin at intermittent doses (15 to 30 mg/kg IV per day) based on the diseased state. Data regarding vancomycin dose, frequency, duration and data of renal function tests and type of admission were analysed to evaluate their influence on the renal function using parameters such as blood urea, serum creatinine levels and creatinine clearance. One-way ANOVA and Spearman correlation test were used in the analysis of data.ResultsBoth male and female patients treated with vancomycin had significantly (pConclusionData suggested that vancomycin treatment reduced the renal function in patients and indicated its association with several predictors and confounding factors. The findings of the study might assist in identifying the patients under risk from the vancomycin-induced nephrotoxicity and in designing the preventive strategies to reduce such complications

Correlation summary between the variables and renal functions after treatment with vancomycin.

Correlation summary between the variables and renal functions after treatment with vancomycin.</p

Effect of vancomycin on the renal functions according to dose, frequency and duration of treatment.

Effect of vancomycin on the renal functions according to dose, frequency and duration of treatment.</p