Equivalency of the quality of sublethal lesions after photons and high-linear energy transfer ion beams

The quality of the sublethal damage (SLD) after irradiation with high–linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Accelerator in the Chiba facility. The cells were kept at room temperature and then exposed to a secondary test dose of X-rays. Based on the repair kinetics study, the surviving fraction of cells quickly increased with the repair time, and reached a plateau in 2–3 h, even when cells had received priming monoenergetic high-LET beams or spread-out Bragg peak beams as well as X-ray irradiation. The shapes of the cell survival curves from the secondary test X-rays, after repair of the damage caused by the high-LET irradiation, were similar to those obtained from cells exposed to primary X-rays only. Complete SLD repairs were observed, even when the LET of the primary ion beams was very high. These results suggest that the SLD caused by high-LET irradiation was repaired well, and likewise, the damage caused by the X-rays. In cells where the ion beam had made a direct hit in the core region in an ion track, lethal damage to the domain was produced, resulting in cell death. On the other hand, in domains that had received a glancing hit in the low-LET penumbra region, the SLD produced was completely repaired

Webを母集団とした超大規模コーパスの開発 : 収集と組織化

国立国語研究所 コーパス開発センター国立国語研究所 コーパス開発センター プロジェクト研究員国立国語研究所 コーパス開発センター プロジェクト研究員国立国語研究所 コーパス開発センター 非常勤研究員国立国語研究所 言語資源研究系Center for Corpus Development, NINJALPostdoctoral Research Fellow, Center for Corpus Development, NINJALPostdoctoral Research Fellow, Center for Corpus Development, NINJALAdjunct Researcher, Center for Corpus Development, NINJALDepartment of Corpus Studies, NINJAL国立国語研究所コーパス開発センターでは2011年より超大規模コーパスプロジェクトとして,Webを母集団とした100億語規模のコーパスの構築を進めている。構築にあたっては,工程を収集・組織化・利活用・保存の四つに分割して実装を進めている。本論文ではそのうち最初の2工程について報告する。収集に関しては,2012年第4四半期より3か月ごとに1億URLのクロールを繰り返し実施している。また組織化に関しては,2013年第3四半期までの約1年間に収集されたWebページの文抽出・形態素解析・係り受け解析を実施した。これらの作業に生じた問題とその解決法を示した後,2013年末において構築されたコーパスデータの基礎統計量を示し,本コーパスを用いてどのような理論的・応用的研究が可能になると考えられるかを論じる。In 2011, the National Institute for Japanese Language and Linguistics launched a corpus compilation project with the aim of constructing a ten-billion-word Web corpus. The project was split into the following four sub-projects: page collection, linguistic annotation, release, and preservation. During the page collection stage, crawling began during the fourth quarter of 2012. We crawled 100 million URLs every three months as fixed-point observations. During the linguistic annotation, normalization (HTML tag removal and character encoding conversion), Japanese morphological analysis (word segmentation and part-of-speech tagging), and Japanese dependency analysis were performed on the data that were crawled in the timespan of one year, specifically from the fourth quarter of 2012 to the third quarter of 2013. In this paper, we present the basic statistics of the crawled data and discuss possible theoretical and practical implications of the language resources. Additionally, we address issues encountered during the page collection and linguistic annotation stages, and offer tentative solutions

Photosensitivity and gene abnormality in circadian rhythm sleep disorders

科学研究費補助金研究成果報告書研究種目: 基盤研究(C)研究期間: 2004～2005課題番号: 16614005研究代表者: 大川 匡子（滋賀医科大学・医学部・教授）研究分担者: 金井 裕彦（滋賀医科大学・医学部・助手）研究分担者: 尾関 祐二（滋賀医科大学・医学部・助手）研究分担者: 小西 瑞穂（滋賀医科大学・医学部・教務職員）研究分担者: 定松 美幸（滋賀医科大学・医学部・講師