Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Government control and factors determining foreign news coverate : a comparative study of the Indian, Korean and Japanese presMi

ix, 183 leaves : diagrs. ; 29 cm

Citizens, Knowledge, and the Information Environment

In a democracy, knowledge is power. Research explaining the determinants of knowledge focuses on unchanging demographic and socioeconomic characteristics. This study combines data on the public’s knowledge of nearly 50 political issues with media coverage of those topics. In a two-part analysis, we demonstrate how education, the strongest and most consistent predictor of political knowledge, has a more nuanced connection to learning than is commonly recognized. Sometimes education is positively related to knowledge. In other instances its effect is negligible. A substantial part of the variation in the education-knowledge relationship is due to the amount of information available in the mass media. This study is among the first to distinguish the short-term, aggregate-level influences on political knowledge from the largely static individual-level predictors and to empirically demonstrate the importance of the information environment