The effect of regulatory fit on value.

This study investigates whether the effects of "feeling right\u27 due to regulatory fit vanish depending on the existence or not of a fit between regulatory focus and advertising conditions (object valance).The values of desirable and undesirable rewards are aJso assessed. Undergraduate student (n=81)participated in the study and the data for 60 participants were analyzed. The results of an analysis ofvariance (ANOVA) indicate a two-way interaction between regulatory focus and advertising conditions，such that participants with a promotion focus within a two-sided advertising condition and participants with a prevention focus within a one-sided advertising condition offered high preferences for desirable rewards. On the other hand，the results did not reveal a significant two-way interaction between regulatory focus and strategy，or a three-way interaction among all factors. Finally，the study discusses the significance of investigating the conditions under which "feeling right" influences value

Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

BACKGROUND AND PURPOSE: Microglia are resident immunocompetent and phagocytic cells of central nervous system (CNS), which produce various cytokines and growth factors in response to injury and thereby regulate disease pathology. The purpose of this study is to investigate the effects of microglial transplantation on focal cerebral ischemia model in rat. METHODS: Transient middle cerebral artery occlusion (MCAO) in rats was induced by the intraluminal filament technique. HMO6 cells, human microglial cell line, were transplanted intravenously at 48 hours after MCAO. Functional tests were performed and the infarct volume was measured at 7 and 14 days after MCAO. Migration and cell survival of transplanted microglial cells and host glial reaction in the brain were studied by immunohistochemistry. Gene expression of neurotrophic factors, cytokines and chemokines in transplanted cells and host rat glial cells was determined by laser capture microdissection (LCM) and quantitative real time-PCR. RESULTS: HMO6 human microglial cells transplantation group demonstrated significant functional recovery compared with control group. At 7 and 14 days after MCAO, infarct volume was significantly reduced in the HMO group. In the HMO6 group, number of apoptotic cells was time-dependently reduced in the infarct core and penumbra. In addition, number of host rat microglia/macrophages and reactive astrocytes was significantly decreased at 7 and 14 days after MCAO in the penumbra. Gene expression of various neurotrophic factors (GDNF, BDNF, VEGF and BMP7) and anti-inflammatory cytokines (IL4 and IL5) was up-regulated in transplanted HMO6 cells of brain tissue compared with those in culture. The expression of GDNF and VEGF in astrocytes in penumbra was significantly up-regulated in the HMO6 group. CONCLUSIONS: Our results indicate that transplantation of HMO6 human microglial cells reduces ischemic deficits and apoptotic events in stroke animals. The results were mediated by modulation of gliosis and neuroinflammation, and neuroprotection provided by neurotrophic factors of endogenous and transplanted cells-origin

Beam and SKS spectrometers at the K1.8 beam line

High-resolution spectrometers for both incident beams and scattered particles have been constructed at the K1.8 beam line of the Hadron Experimental Facility at J-PARC. A point-to-point optics is realized between the entrance and exit of QQDQQ magnets for the beam spectrometer. Fine-pitch wire chamber trackers and hodoscope counters are installed in the beam spectrometer to accept a high rate beam up to 107 Hz. The superconducting kaon spectrometer for scattered particles was transferred from KEK with modifications to the cryogenic system and detectors. A missing-mass resolution of 1.9 ± 0.1 MeV/c2 (FWHM) was achieved for the ∑ peaks of (π±, K+) reactions on a proton target in the first physics run of E19 in 2010

Cavity Formation in a SiC/SiC Composite under Simultaneous Irradiation of Hydrogen, Helium and Silicon Ions

Cavity formation was investigated in a SiC/SiC composite under multi-ion beam irradiation up to 10 dpa at 1073 K, 1273 K and 1573 K by transmission electron microscopy. The cavity formation behavior of each component of the composite was dependent on the component's grain structure, the helium and/or hydrogen implantation mode, and irradiation temperature. It was found that helium rather than hydrogen is likely to enhance cavity formation or cavity swelling. The contributions of helium and hydrogen to cavity formation in the composite components are discussed in detail