The network substrate of confabulatory tendencies in Alzheimer's disease

Confabulatory phenomena are rare in the early stage of Alzheimer's disease (AD), are often provoked and are triggered by questions or in response to neuropsychological testing. In this retrospective study functional connectivity alterations were investigated for the first time in a group of patients with early AD who had shown evidence of verbal and non-verbal confabulatory tendencies. Resting-state functional magnetic resonance imaging (fMRI) scans of 18 confabulating patients were compared with those of 18 non confabulators. The finding showed that confabulators had decreased connectivity between a seed region in the right inferolateral frontal cortex and right mediotemporal and insular regions, and increased connectivity with frontal areas and a homologous region on the left. The seed control region in the left inferolateral frontal cortex showed increased connectivity with midline frontal and anterior cingulate regions, while a decrease was found in temporal areas. Confabulatory tendencies appear in early AD as a result of disconnection between crucial computational hubs in frontal and mediotemporal regions. This disconnection is coupled with the presence of up-regulation of frontal activity, and especially of midline and anterior cingulate regions, which might disrupt efficient output monitoring in confabulators

Ecodesign of Low-Voltage Systems and Exposure to ELF Magnetic Fields

The Ecodesign of modern residential and commercial low-voltage systems implements energy and equipment cost savings, optimizing the size of the distribution system without compromising their functionality or causing environmental contamination, including electromagnetic pollution. Protection of persons against shock hazards should result increased, and the electrical interferences among power systems reduced. To achieve the aforementioned improvements, a possible Ecodesign calls for an earthing system utilizing single-phase separation transformers installed in the unit, grounded at the mid-point of their secondary side. The introduction of a source of magnetic fields into the premises at the power frequency of 60/50 Hz (i.e. extremely low frequency, ELF) might expose persons to their potential adverse health effects, as well as, sensitive electronic equipment to disturbances. This paper seeks to clarify this matter by evaluating the ELF magnetic fields as produced by the user's own transformer and by other units eventually present in the vicinity

Characterisation of the Ionian-Lucanian coastal plain aquifer

This paper deals with a Southern Italy area, 40 km by 10 km wide, located where four river valleys anastomose themselves in the coastal plain. The geological and hydrogeological features of the study area and the chemical-physical groundwater characterisation have been inferred from the data analysis of 1130 boreholes. Some aquifers, connected among them, constituted by soils of different geological origin -marine terraces deposits, river valley alluvial deposits and alluvial and coastal deposits - have been considered. The coastal plain aquifer is the most interesting for practical utilisation. Groundwater flow is mainly unconfined in the marine terraces and in the river valleys while it becomes mostly confined in the coastal plain aquifer. An upper clayey layer overlies the sandy coastal aquifer characterised by a mean hydraulic conductivity value equal to 2.3 10-4 m/s. The bottom is a silty-clayey bed which lies under the sea level. Being the direct natural recharge extremely low, the recharge of this coastal aquifer is mainly guaranteed by the discharge from upward aquifers and from the river leakage. The new acquired knowledge permits to delineate scenarios useful for an optimization of the groundwater resources tapping and for pursuing the safeguard of them

A General Methodology for Short-circuit Calculations in Hybrid AC/DC Microgrids

In this paper, the issues related to short-circuit calculations in hybrid AC/DC microgrids are discussed. The reference standard for short-current calculations in DC systems is the IEC 61660, which provides a mathematical formulation of the problem. The standard only includes radial DC grids and does not consider a more complex system, such as meshed DC systems or a hybrid AC/DC microgrid. This paper proposes a generalized approach that can be used independently of the characteristics of the hybrid system. The proposed approach is applied to four test microgrids with different distributed sources and number of nodes and the results are compared with those obtained simulating the same grids with Neplan 360®

Characterisation of Ionian-Lucanian coastal aquifer and seawater intrusion hazard

e paper deals with the seawater intrusion hazard along the Ionian coastal plain (Southern Italy), between the mouths of Sinni and Bradano Rivers. Subjected to intense agricultural activities, the good-quality of the tapped groundwater is seriously important for the economic growth of this coastal area. The stratigraphical and hydrogeological set-up of the area as the geochemical features of the groundwater arise from the data analysis of 1130 boreholes, widespread over the whole area and from 1.3 up to 423 meters deep. The contribution of seawater intrusion to salinization processes of the studied groundwater system is characterised. As pointed out by chemical-physical data, this phenomenon involves the studied coastal plain for a width of 1-1.5 km on average and it is less evident moving inwards where the altitude of the clayey bottom of the aquifer becomes progressively higher than the sea level. A preliminary seawater hazard map has been carried out through piezometric and aquifer geometrical data

Non-Pharmacological Treatments in Lewy Body Disease: A Systematic Review

Introduction: Lewy body disease (LBD) is the second most common neurodegenerative disorder in patients older than 65 years. LBD is characterized by heterogeneous symptoms like fluctuation in attention, visual hallucinations, Parkinsonism, and REM sleep behaviour disorders. Considering the relevant social impact of the disease, identifying effective non-pharmacological treatments is becoming a priority. The aim of this systematic review was to provide an up-to-date literature review of the most effective non-pharmacological treatments in patients with LBD, focussing on evidence-based interventions. Methods: Following PRISMA criteria, we carried out a systematic search through three databases (PubMed, Cochrane Libraries, and PEDro) including physical therapy (PT), cognitive rehabilitation (CR), light therapy (LT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), deep brain stimulation (DBS). All studies were qualitatively assessed using standardized tools (CARE and EPHPP). Results: We obtained a total of 1,220 studies of which 23 original articles met eligibility criteria for inclusion. The total number of LBD patients included was 231; mean age was 69.98, predominantly men (68%). Some PT studies highlighted improvements in motor deficits. CR produced significant improvements in mood, cognition, and patient's quality of life and satisfaction. LT outlined a partial trend of improvements in mood and sleep quality. DBS, ECT, and TMS showed some partial improvements mainly on neuropsychiatric symptoms, whereas tDCS provided partial improvements in attention. Conclusion: This review highlights the efficacy of some evidence-based rehabilitation studies in LBD; however, further randomized controlled trials with larger samples are needed to provide definitive recommendations

Cyclooxygenase-2-Derived Prostacyclin Protective Role on Endotoxin-Induced Mouse Cardiomyocyte Mortality

Cardiovascular dysfunction characterizes septic shock, inducing multiple organ failure and a high mortality rate. In the heart, it has been shown an up-regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions with subsequent overproduction of nitric oxide (NO) and eicosanoids. This study is focused on the links between these products of inflammation and cell loss of mouse cardiomyocytes during treatment by the Salmonella typhimurium lipopolysaccharide (LPS) in presence or in absence of NOS or COX inhibitors. LPS induced RelA/NF-κB p65 activation, iNOS and COX-2 up-regulations, resulting in NO and prostacyclin releases. These effects were reversed by the NO-synthase inhibitor and increased by the specific COX-2 inhibitor. Immunostainings with FITC-conjugated anti-Annexin-V and propidium iodide and caspase 3/7 activity assay showed that cardiomyocyte necrosis was inhibited by L-NA during LPS treatment challenge, while apoptosis was induced in presence of both LPS and NS-398. No effect on LPS cellular injury was observed using the specific cyclooxygenase-1 (COX-1) inhibitor, SC-560. These findings strongly support the hypothesis of a link between iNOS-dependent NO overproduction and LPS-induced cell loss with a selective protective role allotted to COX-2 and deriving prostacyclins

New Insights into the Evolution and Gene Structure of the Mitochondrial Carrier Family Unveiled by Analyzing the Frequent and Conserved Intron Positions

Mitochondrial carriers (MCs) belong to a eukaryotic protein family of transporters that in higher organisms is called the solute carrier family 25 (SLC25). All MCs have characteristic triplicated sequence repeats forming a 3-fold symmetrical structure of a six-transmembrane α-helix bundle with a centrally located substrate-binding site. Biochemical characterization has shown that MCs altogether transport a wide variety of substrates but can be divided into subfamilies, each transporting a few specific substrates. We have investigated the intron positions in the human MC genes and their orthologs of highly diversified organisms. The results demonstrate that several intron positions are present in numerous MC sequences at the same specific points, of which some are 3-fold symmetry related. Many of these frequent intron positions are also conserved in subfamilies or in groups of subfamilies transporting similar substrates. The analyses of the frequent and conserved intron positions in MCs suggest phylogenetic relationships not only between close but also distant homologs as well as a possible involvement of the intron positions in the evolution of the substrate specificity diversification of the MC family members

White Matter Hyperintensity Load Modulates Brain Morphometry and Brain Connectivity in Healthy Adults: A Neuroplastic Mechanism?

© 2017 The Authors. White matter hyperintensities (WMHs) are acquired lesions that accumulate and disrupt neuron-to-neuron connectivity. We tested the associations between WMH load and (1) regional grey matter volumes and (2) functional connectivity of resting-state networks, in a sample of 51 healthy adults. Specifically, we focused on the positive associations (more damage, more volume/connectivity) to investigate a potential route of adaptive plasticity. WMHs were quantified with an automated procedure. Voxel-based morphometry was carried out to model grey matter. An independent component analysis was run to extract the anterior and posterior default-mode network, the salience network, the left and right frontoparietal networks, and the visual network. Each model was corrected for age, global levels of atrophy, and indices of brain and cognitive reserve. Positive associations were found with morphometry and functional connectivity of the anterior default-mode network and salience network. Within the anterior default-mode network, an association was found in the left mediotemporal-limbic complex. Within the salience network, an association was found in the right parietal cortex. The findings support the suggestion that, even in the absence of overt disease, the brain actuates a compensatory (neuroplastic) response to the accumulation of WMH, leading to increases in regional grey matter and modified functional connectivity.European Union Seventh Framework Programme (FP7/2007–2013) Grant Agreement no. 601055, VPH-DARE@IT

Survey of DC-DC Non-Isolated Topologies for Unidirectional Power Flow in Fuel Cell Vehicles

The automobile companies are focusing on recent technologies such as growing Hydrogen (H2) and Fuel Cell (FC) Vehicular Power Train (VPT) to improve the Tank-To-Wheel (TTW) efficiency. Benefits, the lower cost, `Eco\u27 friendly, zero-emission and high-power capacity, etc. In the power train of fuel cell vehicles, the DC-DC power converters play a vital role to boost the fuel cell stack voltage. Hence, satisfy the demand of the motor and transmission in the vehicles. Several DC-DC converter topologies have proposed for various vehicular applications like fuel cell, battery, and renewable energy fed hybrid vehicles etc. Most cases, the DC-DC power converters are viable and cost-effective solutions for FC-VPT with reduced size and increased efficiency. This article describes the state-of-the-art in unidirectional non-isolated DC-DC Multistage Power Converter (MPC) topologies for FC-VPT application. The paper presented the comprehensive review, comparison of different topologies and stated the suitability for different vehicular applications. This article also discusses the DC-DC MPC applications more specific to the power train of a small vehicle to large vehicles (bus, trucks etc.). Further, the advantages and disadvantages pointed out with the prominent features for converters. Finally, the classification of the DC-DC converters, its challenges, and applications for FC technology is presented in the review article as state-of-the-art in research