1,126 research outputs found
Executive Blogging: Indian Corporate Heads in the Blogosphere
This study analyzes the content, usability, interactivity and connectivity of Indian executive blogs. Results indicate that among the Indian CEOs and top executives who blog, most are associated with the Information Technology and Internet sectors. A content analysis of the blogs shows that popular blogging topics include industry outlook, technology trends and tips, current affairs and insights on the economy. Executives working with privately-held companies blog more about their personal lives and topics such as entrepreneurship, marketing and advertising, and entertainment than those with public companies. The blog posts of these executives are often in the nature of individual opinions. The executives also provide actionable tips on various topics and products on their blog. While the blogs score high in the interactivity category and do reasonably well in the usability category, most suffer from poor connectivity in terms of providing links to other blogs and websites in the blogroll. Indian executive bloggers need to break out of their isolation and get better exposure by improving connectivity.
Site-Specific Colloidal Crystal Nucleation by Template-enhanced Particle Transport
The monomer surface mobility is the single most important parameter that
decides the nucleation density and morphology of islands during thin film
growth. During template-assisted surface growth in particular, low surface
mobilities can prevent monomers from reaching target sites and this results in
a partial to complete loss of nucleation control. While in atomic systems a
broad range of surface mobilities can be readily accessed, for colloids, owing
to their large size, this window is substantially narrow and therefore imposes
severe restrictions in extending template-assisted growth techniques to steer
their self-assembly. Here, we circumvented this fundamental limitation by
designing templates with spatially varying feature sizes, in this case moire
patterns, which in the presence of short-range depletion attraction presented
surface energy gradients for the diffusing colloids. The templates serve a dual
purpose, first, directing the particles to target sites by enhancing their
surface mean free paths and second, dictating the size and symmetry of the
growing crystallites. Using optical microscopy, we directly followed the
nucleation and growth kinetics of colloidal islands on these surfaces at the
single-particle level. We demonstrate nucleation control, with high fidelity,
in a regime that has remained unaccessed in theoretical, numerical and
experimental studies on atoms and molecules as well. Our findings pave the way
for fabricating non-trivial surface architectures composed of complex colloids
and nanoparticles.Comment: 12 pages, 3 figure
Impact of cost of substitution and joint replenishment on inventory decisions for joint substitutable and complementary items under asymmetrical substitution
[EN] In this paper, impact of cost of substitution and joint replenishment on inventory decisions for joint substitutable and complementary items under asymmetrical substitution has been studied. The phenomenon of substitution is considered in a stock-out situation and when items become out of stock due to demand then unfulfilled demand is asymmetrically substituted by another item. We formulate the inventory model mathematically and derived optimal ordering quantities, optimal total costs and extreme value of substitution rate for all possible cases. Moreover, pseudo-convexity of the total inventory cost function is obtained and the solution procedure is provided. Numerical example and sensitivity analysis have been presented to validate the effectiveness of the inventory model and substantial improvement in total optimal inventory cost with substitution with respect to optimal total inventory cost without substitution is seen.Mishra, RK.; Mishra, VK. (2020). Impact of cost of substitution and joint replenishment on inventory decisions for joint substitutable and complementary items under asymmetrical substitution. WPOM-Working Papers on Operations Management. 11(2):1-26. https://doi.org/10.4995/wpom.v11i2.13730OJS12611
Variance Estimation Using Quality Characteristic
This paper deals with estimation of unknown population variance of study variable (y) using auxiliary qualitative characteristic. The properties of the proposed class of estimators is studied and is supported through two real data sets
A RAPID VALIDATED UNI-DIMENSIONAL DOUBLE DEVELOPMENT HPTLC-DENSITOMETRY METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE, GLICLAZIDE AND PIOGLITAZONE HYDROCHLORIDE
Objective: To develop and validate a uni-dimensional double development high-performance thin layer chromatography (UDDD-HPTLC) for estimation of anti-diabetic medicine compromising of metformin (MET) gliclazide (GLZ) and pioglitazone hydrochloride (PIO).
Methods: The chromatographic separation of these drugs was carried out on precoated TLC plates silica gel 60F254by two mobile phases consisting of Ammonium Sulphate: Methanol: Acetonitrile: Water (4:3:2:1) for MET and PIO and Toluene: Ethyl Acetate: Formic Acid (6:4:0.5) for GLZ respectively for ideal separation and good resolution. The densitometric detection and quantification were carried out at 237 nm for MET and 200 nm for GLZ and PIO. The validation parameters were strictly followed as per the ICH guidelines.
Results: The linearity range was obtained at 3000-8000ng/spot, 360-960 ng/spot, 90-240 ng/spot for MET, GLZ and PIO with r2value>0.999. The other parameters such as precision, reproducibility, robustness were efficiently obtained within the limits. The proposed method was successfully applied for simultaneous determination of MET, GLZ and PIO in the commercial formulation.
Conclusion: In simultaneous estimation, the different polarity of drugs makes it more cumbersome to develop and validate any chromatographic method. In the present study, a uni-dimensional double development high-performance thin layer chromatography (UDDD-HPTLC) for estimation of these drugs have been developed and validated to resolve the estimation problem. It is an effortless and speedy method which was developed and validated using ICH guidelines. The developed and validated method using ICH guidelines is effortless and speedy technique
Design and Validation of Blast Non-propagation Wall for Multi-Compartmented Explosive Storage Structure of Capacity 5T NEC per Compartment
Conventional magazines for hazard division 1.1 are constructed using bricks and reinforced cement concrete (RCC) for which storage inside quantity distance (SIQD) is 2.4 W1/3 m, where W is Net Explosive Content in kg. New composite called laced reinforced concrete (LRC) has been developed recently, for which SIQD has been reduced up to 0.5 W1/3 m. Due to substantial reduction in separation distances, the requirement of land area has been reduced significantly. Although SIQD has been reduced drastically due to development of new composite, the other quantity distances like process inside quantity distance (PIQD) and outside quantity distance (OQD) decreased marginally. To reduce these quantity distances, the solution is multi-compartmented structures based on Unit Risk Principle. The application of unit risk principle enables the separation of explosives into compartments in such a manner that initiation of explosives in one compartment does not result in initiation of the explosives in adjacent compartments. This is achieved by special design of explosive storage buildings incorporating blast non-propagation walls between adjacent compartments storing explosives. Quantity distances are reduced for such magazines, as maximum credible limit corresponds to the quantity of explosive in one compartment. Present paper describes design and full scale testing of blast non-propagation wall between two compartments of a multi-compartmented explosive storage structure with storage capacity of 5 T Net Explosive Content (NEC) of HD 1.1 per compartment. The blast non-propagation wall comprising of sand filling and air gap between LRC walls has been designed for desired attenuation of blast parameters as well as for arresting high velocity fragments/debris. The design has been validated by fully instrumented design validation field trial. The conduct of the trial as well as the results are discussed in this paper
CLINICAL STUDY OF BABOOL (ACACIA ARABICA WILLD.) AND KUKUNDAR (BLUMEA LACERA D.C.) ON ASRIGDARA
Rakta is known to be a vital substance of body. As the disease is characterized by excess flow of blood out of the body, Raktastambhana Chikitisa is beneficial. Treatment prescribed for Raktatisara, Raktapitta, Raktarsha, Guhyaroga and Garbhasrava is also useful. Considering this aspect, Raktastambhaka, Raktsodhana, Raktapittaghna effects are desired in treatment. Haemostatic drugs should be used by giving due consideration to the association of Doshas diagnosed on the basis of colour and smell of the blood. Aims and Objectives: To evaluate the efficacy of Babool and Kukundar and comparative clinical study of Babool and Kukundar on Asrigdara. Materials and Methods: For the present study, patients fulfilling the clinical criteria for diagnosis of Asrigdara will be selected irrespective of their age, sex, religion, etc, in random from O.P.D. section of M. M. M. Govt. Ayurveda College hospital, Udaipur (Raj.). Case history of all the patients was taken in the specially prepared proforma. Conclusion: Babool due to its astringent taste and Kunkundar due to its bitter taste, both drugs pacify excessive Pitta humour which is main cause of Asrigdara. Their chemical constituents possess haemostatic and anti-inflammatory properties thus considering these facts, these drugs have been selected for present study
MEDA- AN IMPORTANT MEMBER OF ASTAVARGA IS SUFFERING FROM IDENTIFICATION AND STANDARDIZATION
Meda is one of the most important plants included in Astavarga. This plant is used in variety of Ayurvedic formulations such as Cyavanprasa. Dried underground parts (rhizomes) of this plant are used for medicinal purpose. This plant is claimed to possess rejuvenating, health promoting, immune system strengthening, anti-oxidant and cell regenerating properties. Also claimed to promote body fat, healing fractures, control fever, abdominal thirst, diabetic condition, seminal weakness, and as a cure for Vata, Pitta and Rakta dosa. The demand of this herb is increasing day by day but due to scarcity of this plant in wild, unaware about authentic botanical source, non-existing cultivation practices there is widespread problem of adulteration or substitution with other plants. The poor quality of raw material affect the quality of end product formed. So by taking into account the above situation this systematic review/ metadata analysis has conducted to find out adulteration in Meda
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