Paleopathological Approach to the Study of a Christian Relic: The Case of the Blessed Maria Lorenza Longo

The Blessed Maria Lorenza Longo, founder of the hospital of Santa Maria del Popolo degli Incurabili and the Order of the Capuchin Poor Clares in Naples, Italy, died on 21 October 1539 and was recently beatified on 9 October 2021. The relic, a fully skeletonized cranium, underwent visual and radiological inspection. The biological profile supports the at¬tribution of female sex of the relic, whereas the age at death is estimated to be younger than that reported by historians. A paleopathological survey was conducted to evaluate the historical reports of poisoning or rheumatoid arthritis affecting Maria Longo. Given the limited skeletal data, it was not possible to confirm the presence of these claims. No obvious in¬dicators of dietary deficiencies were observed, and the tertiary syphilis hypothesized by textual sources was excluded. Postmortem alterations of the relic were clearly visible on the superior aspect of the cranium and testified to the worship of the relic

MK-4101 - a potent inhibitor of the hedgehog pathway - is highly active against medulloblastoma and basal cell carcinoma

Aberrant activation of the Hedgehog (Hh) signaling pathway is implicated in the pathogenesis of many cancers, including medulloblastoma and basal cell carcinoma (BCC). In this study, using neonatally irradiated Ptch1+/- mice as a model of Hh-dependent tumors, we investigated the in vivo effects of MK-4101, a novel SMO antagonist, for treatment of medulloblastoma and BCC. Results clearly demonstrated a robust antitumor activity of MK-4101, achieved through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. Of note, beside antitumor activity on transplanted tumors, MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. By identifying the changes induced by MK-4101 in gene expression profiles in tumors, we also elucidated the mechanism of action of this novel, orally administrable compound. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors. Members of the IGF and Wnt signaling pathways, were among the most highly deregulated genes by MK-4101, suggesting that the interplay among Hh, IGF and Wnt is crucial in Hh-dependent tumorigenesis. Altogether, the results of this preclinical study support a therapeutic opportunity for MK-4101 in the treatment of Hh-driven cancers, also providing useful information for combination therapy with drugs targeting pathways cooperating with Hh oncogenic activity

A silicon imaging calorimeter prototype for antimatter search in space: experimental results

Abstract This report presents the results obtained with a prototype silicon-tungsten (Si-W) electromagnetic calorimeter, conceived as a fine-grained imaging device to carry out studies of the antimatter component in primary cosmic radiation. The calorimeter prototype contains 20 x , y sampling layers interleaved with 19 showering material planes. One sensitive layer is obtained with two silicon strip detectors (Si-D) (60 × 60) mm 2 , each divided into 16 strips, 3.6 mm wide; the two detectors are assembled back to back with perpendicular strips. This allows the transverse distributions of the shower in both coordinates at each sampling (0.5 X 0 ) to be pictured. The basic characteristics of the design and the experimental results obtained on a test beam at the CERN proton synchrotron (PS) for electrons and pions are reported. The main results presented are the response of the calorimeter to the electron at various energies (1–7 GeV), and the transverse shower profiles at different calorimeter depths as well as the patterns of the electromagnetic shower and those of the interacting and non-interacting pions. The capability of the calorimeter in measuring the direction of the incoming electromagnetic particle from the pattern of the shower has been evaluated at different energies. These results are encouraging in view of the possible use of this detector to search for high-energy γ sources in space

Silicon calorimeter for cosmic antimatter search

Abstract The silicon sampling calorimeter presented is conceived as a fine grained imaging device to carry out studies of the anti-matter component in the primary cosmic radiation; it will be used in balloon payload program starting in 1993. The first sampling layer (48×48 cm2) of this silicon calorimeter has been completed and successfully tested. We report the first results form studies performed at the CERN PS t7 beam. The complete calorimeter contains 20 xy sampling layers (strip pitch 3.6 mm) interleaved with 19 showering material planes (tungsten 0.5 X0). This allows to picture the transverse distributions of the shower in both coordinates at each sampling. The outstanding imaging capabilities reflects in high particle identification power. Preliminary results from beam tests performed with antiprotons at 3.5 GeV on a tower prototype of the calorimeter are reported

La restauración del Retrato Trivulzio de Antonello da Messina

El artículo presenta la intervención llevada a cabo en 2006 sobre el Retrato de hombre de Antonello da Messina, que pertenece a las colecciones del Museo Cívico de Arte Antiguo del Palacio Madame. The article presents the intervention carried out in 2006 about the Portrait of a man of Antonello da Messina, which belongs to the collections of the Civic Museum of Ancient Art of the Madame Palace.El artículo presenta la intervención llevada a cabo en 2006 sobre el Retrato de hombre de Antonello da Messina, que pertenece a las colecciones del Museo Cívico de Arte Antiguo del Palacio Madame.&nbsp

Smart Augmented Fields for Emergency Operations

The impressive development of wearable computing and augmented reality technologies which is occurring in recent years allows to devise ICT systems that can bring a disruptive innovation in how emergency medical operations take place. In this paper we describe first explorations in that direction, represented by a distributed collaborative system called SAFE (Smart Augmented Field for Emergency) for teams of rescuers and operators involved in a rescue mission. SAFE is based on the integration of wearable computing and augmented reality technologies with intelligent agents and multi-agent systems

Programming Mirror Worlds: An Agent-Oriented Programming Perspective

The impressive development of technologies is reducing the gulf between the physical and the digital matter, reality and virtuality. Mirror worlds (MW) are agent-based systems that live on this edge. They are meant to be a conceptual blueprint for designing future smart environment systems, providing an innovative conceptual framework for investigating inter-disciplinary aspects – from cognition to interaction, cooperation, governance – concerning human-agent mixed-reality and augmented systems. In this paper we focus on the problem of how to concretely design and program mirror worlds, in particular adopting high-level programming abstractions that are provided by state-of-the-art agent-oriented programming models and technologies

Multi-agent Systems Meet Aggregate Programming: Towards a Notion of Aggregate Plan

Recent works foster the idea of engineering distributed situated systems by taking an aggregate stance: design and development are better conducted by abstracting away from individuals\u2019 details, directly programming overall system behaviour instead. Concerns like interaction protocols, self-organisation, adaptation, and large-scaleness, are automatically hidden under the hood of the platform supporting aggregate programming. This paper aims at bridging the apparently significant gap between this idea and agent autonomy, paving the way towards an aggregate computing approach for multi-agent systems. Specifically, we introduce and analyse the idea of \u201caggregate plan\u201d: a collective plan to be played by a dynamic team of cooperating agents

Modelling aspects of a CNG injection system to predict its behavior under steady state conditions and throughout driving cycle simulations

Alternative fuels such as compressed natural gas (CNG) have lately gained an increasing interest due to the even more stringent emission regulations and environmental policies. Considerable R&D activity has been carried out in order to enhance the mixture formation and to improve the after treatment efficiency. The achievement of these goals cannot disregard the importance of the injection system and of its component (common rail, injectors and pressure reducing valve) on the air-to-fuel mixing. The amount of injected fuel should in fact be properly targeted by the ECU basing on the estimation of the induced air and accounting for the embedded closed-loop strategies. Still, these latter are normally derived from engine-base routines and totally ignore the injection system dynamics. The present paper aims at developing a thorough model of the injection system with specific attention to the one component which significantly contributes to fully defining its dynamic response, i.e. the pressure reducing valve. The pressure reducer is made up of various elements that retain diverse weights on the valve behavior and should consequently be differently addressed to. The research has been focused on defining the set of parameters to be precisely reproduced in the 0D-1D simulation so as to match the injection system experimental behavior. A refined model of the pressure reducer has hence been proposed and the model has been calibrated, tested and run under various operating conditions so as to assess for the set-up validity. Comparisons have been carried out on steady state points as well as through out a vehicle driving cycle and the model capability to properly reproduce the real system characteristic has been investigated into. The proposed valve model has proved to consistently replicate the injection system response for different speed and load conditions. A few methodological indications concerning modeling aspects of a pressure regulator can be drawn from the present study. Finally, the model has been run in a predictive mode so as to inquiry into the response of the system to fast transient operations, both in terms of speed and load. The model outputs have highlighted mismatches between the ECU target mass and the actually injected one and have hinted at the need for dedicated and refined control strategies capable of preventing anomalies in the mixture formation and hence in the engine functioning