The Arab uprisings and the return of repression

The Arab uprisings of 2011 led to a reassessment of comparative politics research on authoritarianism in the Middle East and North Africa. The Arab region made its way from area studies into mainstream comparative politics, and research foci have shifted towards civil-military relations and repression. Ten years later, we observe higher levels of repression across the region, reflecting a diversity of repressive trends. Advocating comprehensive research on this variation, we review recent literature that tackles various dimensions of repression in Arab autocracies. In addition to disaggregating forms and targets of repression, we call for its justifications, agents and transnational dimensions to be considered next to the implications of digital technologies of coercion. We also reflect on how repression affects the possibility of doing research and how we can investigate the proposed dimensions of repression

How authoritarian rulers seek to legitimize repression: framing mass killings in Egypt and Uzbekistan

How do authoritarian rulers legitimate repressive actions against their own citizens? Although most research depicts repression and legitimation as opposed strategies of political rule, justified coercion against some groups may generate legitimacy in the eyes of other parts of the population. Building upon this suggested link between legitimation and repression, this article studies the justifications of mass killings. To this end, framing theory is combined with recent research on the domestic and international dimensions of authoritarian rule. We contend that frames are directed towards specific audiences at home and abroad. Moreover, given the common threats at the global level and the diffusion of repressive tactics, we assume that learning processes influence discursive justifications of repression in authoritarian regimes. We provide an analysis of government rhetoric by comparing the protest crackdowns of Rabi'a 'Adawiya Square in Egypt and Fergana Valley in Uzbekistan, taking into account the audiences and the sources of the frames that justify repression. In both cases, we find the terrorism frame to emerge as dominant

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling

Retinoic acid (RA) induces proliferation arrest, differentiation, and apoptosis, and defects in retinoic acid receptor (RAR) signaling have been implicated in cancer. The human tumor antigen PRAME is overexpressed in a variety of cancers, but its function has remained unclear. We identify here PRAME as a dominant repressor of RAR signaling. PRAME binds to RAR in the presence of RA, preventing ligand-induced receptor activation and target gene transcription through recruitment of Polycomb proteins. PRAME is present at RAR target promoters and inhibits RA-induced differentiation, growth arrest, and apoptosis. Conversely, knockdown of PRAME expression by RNA interference in RA-resistant human melanoma restores RAR signaling and reinstates sensitivity to the antiproliferative effects of RA in vitro and in vivo. Our data suggest that overexpression of PRAME frequently observed in human cancers confers growth or survival advantages by antagonizing RAR signaling