Curcumin: a modulator of inflammatory signaling pathways in the immune system

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1

Correction to: Curcumin: a modulator of inflammatory signaling pathways in the immune system (Inflammopharmacology, (2019), 27, 5, (885-900), 10.1007/s10787-019-00607-3)

Unfortunately, the 4th author name was incorrectly published in the original article. The complete correct name is given below. Mohammad Javad Mousav

New classifications of nonlinear Schrödinger model with group velocity dispersion via new extended method

This work investigates the nonlinear Schrödinger equation (NLSE) with group velocity dispersion and second order spatiotemporal dispersion coefficients. The governing model is reduced into the classical nonlinear ordinary differential equation. Extended direct algebraic method (EDAM) is implemented to construct many novel mixed dark, and complex optical solutions. As a result, some important analytical solutions such as travelling mixed dark, and complex travelling wave solutions for the model are extracted.</p

Experimental investigation of co-flow jet’s airfoil flow control by hot wire anemometer

An experimental flow control technique is given in this paper to study the jet effect on the coflow jet’s airfoil with injection and suction and compared with the jet-off condition. The airfoil is CFJ0025-065-196, and the Reynolds number based on the airfoil’s chord length is 105. To measure the turbulence components of flow, a hot wire anemometry apparatus in a wind tunnel has been used. In this paper, the effect of the average velocity and boundary layer thickness on the coflow jet’s airfoil is analyzed. The test is done for two different coflow velocities and for different angles of attack. It is also shown that, by increasing the velocity difference between the jet and the main flow, separation is delayed, and this delay can be preserved by raising coflow velocity at higher angles of attack. So, this flow control method has a good efficiency, and it is possible to reach higher numbers of lift and lower numbers of drag coefficients.https://aip.scitation.org/journal/rsi2020-12-11am2020Mechanical and Aeronautical Engineerin

Superior vena cava obstruction after heart transplantation

Superior vena cava obstruction can be a serious complication after heart transplantation. A 58-year-old man with ischemic cardiomyopathy underwent orthotopic bicaval heart transplantation. On the 12th postoperative day, one hour after removing the central venous line, he developed sudden onset of facial edema, cyanosis, and tachycardia. Emergency transesophageal echocardiography revealed superior vena caval thrombosis at the site of anastomosis. Considering the risks of surgical reexploration, the superior vena cava was recanalized by stent deployment. All of the patient's symptoms were relieved a few hours after stent placement. © 2014 SAGE Publications

A low-power high-speed hybrid multi-threshold full adder design in CNFET technology

In this paper, a low-power high-speed hybrid full adder cell is proposed, which is implemented based on two-input multi-threshold (Formula presented.) XNOR circuit and transmission gate multiplexers. In order to implement this circuit, carbon nanotube field-effect transistors are utilized. For evaluating the proposed design, comprehensive simulations are performed with regard to the most important aspects of digital circuits: power, delay and power�delay product. The results are presented and confirm the superiority of the proposed cell with the previously reported one in different voltage levels, load conditions, temperatures and robustness in large structures and against process variations. © 2018 Springer Science+Business Media, LLC, part of Springer Natur

Superior vena cava obstruction after heart transplantation

Superior vena cava obstruction can be a serious complication after heart transplantation. A 58-year-old man with ischemic cardiomyopathy underwent orthotopic bicaval heart transplantation. On the 12th postoperative day, one hour after removing the central venous line, he developed sudden onset of facial edema, cyanosis, and tachycardia. Emergency transesophageal echocardiography revealed superior vena caval thrombosis at the site of anastomosis. Considering the risks of surgical reexploration, the superior vena cava was recanalized by stent deployment. All of the patient's symptoms were relieved a few hours after stent placement. © 2014 SAGE Publications

The protective effect of prenatally administered vitamin E on behavioral alterations in an animal model of autism induced by valproic acid

Vitamin E is a fat-soluble vitamin that has a powerful antioxidant activity. Previous studies reported reduced plasma levels of vitamin E in autism-spectrum patients and also as the result of treatment with valproic acid (VPA). The present study was conducted to investigate the effect of prenatally vitamin E on autism-like behavior in prenatally VPA-exposed rats. Animals were divided into four groups. Sham (saline-treated 1ml/kg), Vit E (were injected 500mg/kg vitamin E), VPA (400mg/kg valproic acid dissolved in saline), and Vit E + VPA received vitamin E (500mg/kg) plus VPA (400mg/kg). VPA was injected intraperitoneally on the 8th, 9th, and 10th days of pregnancy and Vitamin E one hour before VPA administration. Prenatal administration of vitamin E resulted in a significant reduction of the repetitive/stereotypic-like activities, anxiety-like behaviors, and sociability impairments in rats prenatally exposed to VPA. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group