LIVING ON THE EDGE: RETHINKING PUEBLO PERIOD: (AD 700 – AD 1225) INDIGENOUS SETTLEMENT PATTERNS WITHIN GRAND CANYON NATIONAL PARK, NORTHERN ARIZONA

This dissertation challenges traditional interpretations that indigenous groups who settled the Grand Canyon during the Pueblo Period (AD 700 -1225) relied heavily on maize to meet their subsistence needs. Instead they are viewed as dynamic ecosystem engineers who employed fire and natural plant succession to engage in a wild plant subsistence strategy that was supplemented to varying degrees by maize. By examining the relationship between archaeological sites and the natural environment throughout the Canyon, new settlement pattern models were developed. These models attempt to account for the spatial distribution of Virgin people, as represented by Virgin Gray Ware ceramics, Kayenta as represented by Tusayan Gray Ware ceramics, and the Cohonina as represented by San Francisco Mountain Gray Ware ceramics, through an examination of the relationships of sites to various aspects of the natural environment (biotic communities, soils, physical geography, and hydrology). Inferences constructed from the results of geographic information system analyses of the Park’s legacy site data, indicate that Virgin groups were the first to arrive at the Canyon, around AD 700 and leaving around AD 1200. They practiced a split subsistence strategy, which included seasonal movements between maize agricultural areas in the western Inner Canyon and wild resource production areas in the pinyon-juniper forests on the western North Rim plateaus. The Kayenta occupied the North Rim, South Rim and Inner Canyon, throughout the entire Pueblo Period. Their subsistence system relied heavily on wild resource production on both rims supplemented by low-level maize agriculture practiced seasonally on the wide deltas in the eastern Inner Canyon. The Cohonina were the last to arrive and the first to leave, as they occupied the Canyon for about 300 years from AD 800–1100. They were the most prolific maize farmers, practicing it in the Inner Canyon near the mouth of Havasu Creek, but still seasonally exploiting wild resource on the western South Rim. Based on my interpretations, use of the Canyon from AD 700-1225, is viewed as a dynamic interplay between indigenous groups and their environment. As they settled into the Canyon and managed the diverse ecology to meet their subsistence needs

Predictive Archaeological Modeling using GIS-Based Fuzzy Set Estimation: A Case Study in Woodford County, Kentucky

Analytic predictive archaeological models can have great utility for state Departments of Transportation, but it is difficult to model the likelihood of prehistoric settlement using geographical proxy predictor variables because of the complexity of how settlement choices were actually made, and the complex interaction between these variables using GIS. In many cases classic statistical modeling approaches require too much data to be useful. This research reports on a preliminary predictive model that combines Spatial Analyst and fuzzy logic modeling to capture expert archaeological knowledge and convert this into predictive surface. A test area was defined in Woodford County, KY and five influencing factors were defined and calculated using ArcMap. Locations were sampled and probabilities estimated using both small and large group structured processes from a range of archeologists that fed an iterative fuzzy logic induction process. An output probability function was generated to create a predictive decision support layer

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α

Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B and TNF) coding for these two cytokines. Prior to induction, TNF exhibited pre-bound TATA Binding Protein (TBP) and paused RNA Polymerase II (Pol II), hallmarks of poised immediate-early (IE) genes. In contrast, unstimulated IL1B displayed very low levels of both TBP and paused Pol II, requiring the lineage-specific Spi-1/PU.1 (Spi1) transcription factor as an anchor for induction-dependent interaction with two TLR-activated transcription factors, C/EBPβ and NF-κB. Activation and DNA binding of these two pre-expressed factors resulted in de novo recruitment of TBP and Pol II to IL1B in concert with a permissive state for elongation mediated by the recruitment of elongation factor P-TEFb. This Spi1-dependent mechanism for IL1B transcription, which is unique for a rapidly-induced/poised IE gene, was more dependent upon P-TEFb than was the case for the TNF gene. Furthermore, the dependence on phosphoinositide 3-kinase for P-TEFb recruitment to IL1B paralleled a greater sensitivity to the metabolic state of the cell and a lower sensitivity to the phenomenon of endotoxin tolerance than was evident for TNF. Such differences in induction mechanisms argue against the prevailing paradigm that all IE genes possess paused Pol II and may further delineate the specific roles played by each of these rapidly expressed immune modulators. © 2013 Adamik et al

Cosmic Rates of Black Hole Mergers and Pair-Instability Supernovae from Chemically Homogeneous Binary Evolution

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2020 The Author(s). Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.During the first three observing runs of the Advanced gravitational-wave detector network, the LIGO/Virgo collaboration detected several black hole binary (BHBH) mergers. As the population of detected BHBH mergers grows, it will become possible to constrain different channels for their formation. Here we consider the chemically homogeneous evolution (CHE) channel in close binaries, by performing population synthesis simulations that combine realistic binary models with detailed cosmological calculations of the chemical and star-formation history of the Universe. This allows us to constrain population properties, as well as cosmological and aLIGO detection rates of BHBH mergers formed through this pathway. We predict a BHBH merger rate at redshift zero of $5.8 \hspace{1mm} \textrm{Gpc}^{-3} \textrm{yr}^{-1}$ through the CHE channel, to be compared with aLIGO's measured rate of ${53.2}_{-28.2}^{+55.8} \hspace{1mm} \text{Gpc}^{-3}\text{yr}^{-1}$, and find that eventual merger systems have BH masses in the range $17 - 43 \hspace{1mm} \textrm{M}_{\odot}$ below the pair-instability supernova (PISN) gap, and $>124 \hspace{1mm} \textrm{M}_{\odot}$ above the PISN gap. We further investigate the effects of momentum kicks during black hole formation, calculate cosmological and magnitude limited PISN rates and investigate the effects of high-redshift deviations in the star formation rate. We find that momentum kicks tend to increase delay times of BHBH systems, and our magnitude limited PISN rate estimates indicate that current deep surveys should be able to detect such events. Lastly, we find that our cosmological merger rate estimates change by at most $\sim 8\%$ for mild deviations of the star formation rate in the early Universe, and by up to $\sim 40\%$ for extreme deviations.Peer reviewe

Cranial movement disorders: clinical features, pathophysiology, differential diagnosis and treatment

Cranial movement disorders are a common neurological problem. These disorders can be limited to the cranial muscles alone or manifest as part of a more generalized movement disorder. Cranial movement disorders can originate from the highest (motor cortex) to the lowest (cranial nerve and muscle) levels of the motor system. Owing to the lack of diagnostic tests and biomarkers for these disorders, their differential diagnosis can be difficult even for the experienced neurologist. Advances have, however, been made in the identification and treatment of these conditions, and most can be managed effectively with appropriate knowledge of the diagnostic signs and effective treatments. Here, we review the clinical features, pathophysiologies and therapies of the main movement disorders that affect the face, jaw, tongue and palate.Giovanni Fabbrini, Giovanni Defazio, Carlo Colosimo, Philip D. Thompson and Alfredo Berardell