Unparticle Physics and A_{FB}^b on the Z pole

An attempt has been made to address the 3\sigma anomaly of the forward-backward asymmetry of b quark in LEP data via an unparticle sector. For most part of the parameter space except certain particular regions, the anomaly could not be explained away plausibly, when constraints from other LEP observables are taken into account.Comment: Version to appear in Phys. Lett. B. 13 pages, 5 figure

Computational Analysis of the Spatiotemporal Coordination of Polarized PI3K and Rac1 Activities in Micro-Patterned Live Cells

Polarized molecular activities play important roles in guiding the cell toward persistent and directional migration. In this study, the polarized distributions of the activities of phosphatidylinositol 3-kinase (PI3K) and the Rac1 small GTPase were monitored using chimeric fluorescent proteins (FPs) in cells constrained on micro-patterned strips, with one end connecting to a neighboring cell (junction end) and the other end free of cell-cell contact (free end). The recorded spatiotemporal dynamics of the fluorescent intensity from different cells was scaled into a uniform coordinate system and applied to compute the molecular activity landscapes in space and time. The results revealed different polarization patterns of PI3K and Rac1 activity induced by the growth factor stimulation. The maximal intensity of different FPs, and the edge position and velocity at the free end were further quantified to analyze their correlation and decipher the underlying signaling sequence. The results suggest that the initiation of the edge extension occurred before the activation of PI3K, which led to a stable extension of the free end followed by the Rac1 activation. Therefore, the results support a concerted coordination of sequential signaling events and edge dynamics, underscoring the important roles played by PI3K activity at the free end in regulating the stable lamellipodia extension and cell migration. Meanwhile, the quantification methods and accompanying software developed can provide a convenient and powerful computational analysis platform for the study of spatiotemporal molecular distribution and hierarchy in live cells based on fluorescence images

Identification of Differentially Expressed miRNAs in Porcine Adipose Tissues and Evaluation of Their Effects on Feed Efficiency

Feed efficiency (FE) is a very important trait affecting the economic benefits of pig breeding enterprises. Adipose tissue can modulate a variety of processes such as feed intake, energy metabolism and systemic physiological processes. However, the mechanism by which microRNAs (miRNAs) in adipose tissues regulate FE remains largely unknown. Therefore, this study aimed to screen potential miRNAs related to FE through miRNA sequencing. The miRNA profiles in porcine adipose tissues were obtained and 14 miRNAs were identified differentially expressed in adipose tissues of pigs with extreme differences in FE, of which 9 were down-regulated and 5 were up-regulated. GO and KEGG analyses indicated that these miRNAs were significantly related to lipid metabolism and these miRNAs modulated FE by regulating lipid metabolism. Subsequently, quantitative reverse transcription–polymerase chain reaction (qRT-PCR) of five randomly selected DEMs was used to verify the reliability of miRNA-seq data. Furthermore, 39 differentially expressed target genes of these DEMs were obtained, and DEMs–target mRNA interaction networks were constructed. In addition, the most significantly down-regulated miRNAs, ssc-miR-122-5p and ssc-miR-192, might be the key miRNAs for FE. Our results reveal the mechanism by which adipose miRNAs regulate feed efficiency in pigs. This study provides a theoretical basis for the further study of swine feed efficiency improvement

Integration of Landsat time-series vegetation indices improves consistency of change detection

Vegetation indices (VIs) were used to detect when and where vegetation changes occurred. However, different VIs have different or even diametrically opposite results, which obstructed the in-depth understanding of vegetation change. Therefore, this study examined the spatial and temporal consistency of five VIs (EVI; NBR; NDMI; NDVI; and NIRv) in detecting abrupt and gradual vegetation changes, and provided an ensemble algorithm which integrated the change detection results of the five indices to reduce the uncertainty of change detection using a single index. The spatial consistency of the five indices in abrupt change detection accounted for 50.6% of the study area, but the temporal consistency was low (21.6%). Wetness indices (NBR, NDMI) were more sensitive to negative abrupt changes, greenness indices (EVI, NDVI, NIRv) were more sensitive to positive abrupt changes; and both types of indices were similar in detecting gradual and total changes. The overall accuracy of the ensemble method was 81.60% and higher than that of any single index in abrupt change detection. This study provides a comprehensive evaluation of the spatial and temporal inconsistencies of change detection in model-fitting errors and various types of vegetation changes. The proposed ensemble method can support robust change-detection

Raziskava modela in dinamičnih lastnosti novega proporcionalnega hidravličnega ventila, ki ga poganja zvočniška tuljava

As the key control component of the water hydraulic systems, water hydraulic proportional valve has an important influence on the control performance of the systems. Due to the poor viscous and lubricity of water, the valve spool resistance is not only large, but also nonlinear. In this study, a novel fast-response water hydraulic proportional valve is presented. The actuator of the valve adopts voice coil motor (VCM), which has the advantages of fast response, high control precision and small volume. In order to realize the fast control of the valve, a lever amplifier is designed to obtain enough actuation force. A detailed and precise nonlinear mathematical model of the valve considering both the valve structural parameters and VCM electromagnetic characteristics is developed. A comprehensive performance simulation analysis has been carried out, which can be mainly divided into electromagnetic simulation, characteristics analysis of lever magnifier and dynamic performance simulation of the valve. The simulation results show that the adjusting time is about 28ms and the maximum overshoot is about 5%. The step response rise time is about 15ms. The test rig of the valve and VCM have been built, respectively. The test results of the prototype show that the optimal stroke range of VCM is 4mm ~15mm. The maximum overshoot of the valve is all around 10%, the adjusting time is about 30 ms in the opening process, and 35 ms in the closing process. The test results prove that the valve has good static and dynamic control performance

Can Industrial Restructuring Improve Urban Air Quality?—A Quasi-Experiment in Beijing during the COVID-19 Pandemic

The conflict between economic growth and environmental pollution has become a considerable bottleneck to future development throughout the world. The industrial structure may become the possible key factor in resolving the contradiction. Using the daily data of air quality from January to April in 2019 and 2020, we used the DID model to identify the effects of industrial structure on air quality by taking the COVID-19 pandemic as a quasi-experiment. The results show that, first, the impact of profit of the secondary industry on air quality is ten times higher than that of the tertiary industry. Therefore, the secondary industry is the main factor causing air pollution. Second, the effect of the reduction in the secondary industry on the improvement of air quality is better than that of the tertiary industry in Beijing. Therefore, the implementation of Beijing’s non-capital function relief policy is timely and reasonable, and the adjustment of the industrial structure is effective in the improvement of air quality. Third, PM2.5, NO2, and CO are affected by the secondary and tertiary industries, where PM2.5 is affected most seriously by the second industry. Therefore, the transformation from the secondary industry to the tertiary industry can not only solve the problem of unemployment but also relieve the haze. Fourth, the result of O3 is in opposition to other pollutants. The probable reason is that the decrease of PM2.5 would lead to an increase in the O3 concentration. Therefore, it is difficult to reduce O3 concentrationby production limitation and it is urgent to formulate scientific methods to deal with O3 pollution. Fifth, the air quality in the surrounding areas can also influence Beijing. As Hebei is a key area to undertake Beijing’s industry, the deterioration of its air quality would also bring pressure to Beijing’s atmospheric environment. Therefore, in the process of industrial adjustment, the selection of appropriate regions for undertaking industries is very essential, which is worth our further discussion

Can Industrial Restructuring Improve Urban Air Quality?—A Quasi-Experiment in Beijing during the COVID-19 Pandemic

The conflict between economic growth and environmental pollution has become a considerable bottleneck to future development throughout the world. The industrial structure may become the possible key factor in resolving the contradiction. Using the daily data of air quality from January to April in 2019 and 2020, we used the DID model to identify the effects of industrial structure on air quality by taking the COVID-19 pandemic as a quasi-experiment. The results show that, first, the impact of profit of the secondary industry on air quality is ten times higher than that of the tertiary industry. Therefore, the secondary industry is the main factor causing air pollution. Second, the effect of the reduction in the secondary industry on the improvement of air quality is better than that of the tertiary industry in Beijing. Therefore, the implementation of Beijing’s non-capital function relief policy is timely and reasonable, and the adjustment of the industrial structure is effective in the improvement of air quality. Third, PM2.5, NO2, and CO are affected by the secondary and tertiary industries, where PM2.5 is affected most seriously by the second industry. Therefore, the transformation from the secondary industry to the tertiary industry can not only solve the problem of unemployment but also relieve the haze. Fourth, the result of O3 is in opposition to other pollutants. The probable reason is that the decrease of PM2.5 would lead to an increase in the O3 concentration. Therefore, it is difficult to reduce O3 concentrationby production limitation and it is urgent to formulate scientific methods to deal with O3 pollution. Fifth, the air quality in the surrounding areas can also influence Beijing. As Hebei is a key area to undertake Beijing’s industry, the deterioration of its air quality would also bring pressure to Beijing’s atmospheric environment. Therefore, in the process of industrial adjustment, the selection of appropriate regions for undertaking industries is very essential, which is worth our further discussion

Candidate Gene Identification of Feed Efficiency and Coat Color Traits in a C57BL/6J × Kunming F2 Mice Population Using Genome-Wide Association Study

Feed efficiency (FE) is a very important trait in livestock industry. Identification of the candidate genes could be of benefit for the improvement of FE trait. Mouse is used as the model for many studies in mammals. In this study, the candidate genes related to FE and coat color were identified using C57BL/6J (C57) × Kunming (KM) F2 mouse population. GWAS results showed that 61 and 2 SNPs were genome-wise suggestive significantly associated with feed conversion ratio (FCR) and feed intake (FI) traits, respectively. Moreover, the Erbin, Msrb2, Ptf1a, and Fgf10 were considered as the candidate genes of FE. The Lpl was considered as the candidate gene of FI. Further, the coat color trait was studied. KM mice are white and C57 ones are black. The GWAS results showed that the most significant SNP was located at chromosome 7, and the closely linked gene was Tyr. Therefore, our study offered useful target genes related to FE in mice; these genes may play similar roles in FE of livestock. Also, we identified the major gene of coat color in mice, which would be useful for better understanding of natural mutation of the coat color in mice