The fossil vertebrates from Somosaguas (Pozuelo, Madrid, Spain)

[ES] Dos yacimientos de vertebrados, situados en el Campus de Somosaguas de la Universidad Complutense (Pozuelo de Alarcón, Madrid), han proporcionado unos 600 restos identificables en estados de conservación muy variados, pertenecientes a unas veinte especies de tamaños muy diversos, desde mastodontes a musarañas. Su estudio permite fechar su edad en unos 14 m.a. y reconstruir un periodo árido en la cuenca de Madrid, ocupada durante el Mioceno medio por bosques y sabanas subtropicales con fuertes avenidas y sin ríos permanentes. En estos yacimientos se puede realizar una enseñanza práctica de la Paleontología de Vertebrados, para formación de estudiantes universitarios en el estudio y la gestión del Patrimonio Paleontológico.[EN] Two vertebrate fossil sites, situated in the Universidad Complutense Campus of Somosaguas, (Pozuelo de Alarcón, Madrid, Spain) have yielded about 600 identifiable rests in different preservation states, belonging to about twenty species of highly diverse sizes, from mastodons to shrews. Their study allows dating at about 14 m.y., and reconstructing an arid climate epoch in the Madrid basin during middle Miocene times, occupied by subtropical woodlands and savannahs with strong floods and without permanent rivers. These fossil sites allow practical teaching of Vertebrate Palaeontology, and preparing university students in the Palaeontological Heritage study and management.Hemos recibido financiación y personal respaldo del Rectorado de la Universidad Complutense de Madrid, de los Decanatos de la Facultad de Ciencias Políticas y Sociología y de la Facultad de Ciencias Geológicas, y del Departamento de Paleontología de esta Facultad. El Departamento de Paleobiología del Museo Nacional de Ciencias Naturales (CSIC) realiza su investigación en el marco del Convenio de Colaboración con la Comunidad de Madrid a través de la Dirección General de Patrimonio Histórico Artístico de la Consejería de Educación.Peer reviewe

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

Hepatocellular carcinoma (HCC) is a heterogeneous tumor that develops via activation of multiple pathways and molecular alterations. It has been a challenge to identify molecular classes of HCC and design treatment strategies for each specific subtype. MicroRNAs (miRNAs) are involved in HCC pathogenesis and their expression profiles have been used to classify cancers. We analyzed miRNA expression in human HCC samples to identify molecular subclasses and oncogenic miRNAs

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Contributions from Spatial Models to Non-Life Insurance Pricing: An Empirical Application to Water Damage Risk.

This paper explores the application of spatial models to non-life insurance data focused on the multi-risk home insurance branch. In the pricing modelling and rating process, spatial information should be considered by actuaries and insurance managers because frequencies and claim sizes may vary by region and the premium should be different considering this rating variable. In addition, it is relevant to examine the spatial dependence due to the fact that the frequency of claims in neighbouring regions is often expected to be more closely related than those in regions far from each other. In this paper, a comparison between spatial models, such as spatial autoregressive models (SAR), the spatial error model (SEM), and the spatial Durbin model (SDM), and a non-spatial model has been developed. The data used for this analysis are for a home insurance portfolio located in Spain, from which we have selected peril of water coverage.post-print904 K

Retroperitoneal perivascular epithelioid cell tumor in a 47-years old woman

Perivascular epithelioid cell tumors (PEComa) are rare neoplasms defined as mesenchymal tumors with distinctive histology and immunohistochemistry. They tend to occur in middle-aged patients and mostly in women. The tumours cells show an association with the walls of blood vessels. Most PEComas are benign although a proportion of these tumours behave aggressively. Case report of 47-years-old woman with retroperitoneal mass and laparoscopic resection that pathological anatomy showed retroperitoneal tumour compatible with PEComas. We describe the main characteristics of PEComas as well as their therapeutic approach. Resumen: Los tumores de células epitelioides perivasculares (PEComa) son neoplasias raras definidas como tumores mesenquimales con histología e inmunohistoquímica distintivas. Suelen aparecer en pacientes de mediana edad y principalmente en mujeres. Las células tumorales muestran una asociación con las paredes de los vasos sanguíneos. La mayoría de los PEComas son benignos, aunque una proporción de estos tumores se comporta de forma agresiva. Se presenta el caso de una mujer de 47 años con una masa retroperitoneal y resección laparoscópica cuya anatomía patológica mostró un tumor retroperitoneal compatible con PEComa. Describimos las principales características de los PEComas así como su abordaje terapéutico