From Material Collection to Ideological Presentation: A Paradigm Shift in Museum Practice

Under the impetus of the New Museum Movement, the definition of museum has been updated. Museums are no longer merely places of “collection, storage and exhibition”, but also have functions of “research, education and pleasure”. Although “comprehensive and scarce” collection is important, it is no longer the only standard for museum exhibition. At the same time, new ideas have emerged that emphasize “human” subjectivity, multiple expressions, and situational narratives. As a result, the paradigm shift from material collection to ideological presentation has become a specific direction for museum practice in China today

Investigation and Analysis of Present Situation and Educational Countermeasures and Cultural Needs of Farmers

The samples, from 21 provinces, municipalities directly under the central government, 107 villages, 30 towns, are altogether 3,577. The survey found, the cultural demand of farmers is generally healthy and positive. What they need most are cultural knowledge of computer technology, disease prevention knowledge, legal knowledge to deal with disputes, migrant workers rights of women and children protection law, recreational activities are singing and dancing, favorite sports activities the first three are the small ball (table tennis badminton), major sports (basketball and volleyball football) and the short or long runs. And there are some differences in age, gender, and cultural degree of life state between these demands. Investigation and analysis reflect that, some activities already undertaken can’t meet the need, and some farmers on the surface needn’t culture, but actually reflect the lag of cultural spiritual pursuit. By contrast with sports, entertainment is more short of physical activity. Farmers’ favorite access to cultural knowledge is face-to-face teaching. However, the “information price ratio” of “three rural areas “ activities are lower than others. According to the problems, we put forward some strategic suggestions on software and hardware

Mechanical characterization of therapeutic cells and physical property-based sorting in microfluidic systems

Bone marrow-derived mesenchymal and hematopoietic stem cells (MSCs and HSCs) have rapidly become the leading cells for consideration to aid tissue regeneration following injury. However, potential HSCs and MSCs migration to the injured tissue after infusion is impeded by cell trap within the upstream vessels, where physical and mechanical properties of cells play an important role. Microfluidic system has a potential to sort cells/particles based on their mechanical properties. It is hypothesized that such sorting system could be utilized to separate smaller and more deformable SCs from a cell population, infusion of which might be able to enhance the recruitment of the cells. The mechanical properties of murine HSCs were determined using micromanipulation and atomic force microscopy (AFM). Microfluidic devices were fabricated to separate sub-set of HSCs, followed by the infusion of the isolated cells into ischemia-reperfusion injured animals. HSCs as a whole became weaker and more deformable after pre-treatment with SDF-la and H 2 02, but HSC surface stiffened after the same pre-treating, accompanied by the expansion and polymerization ofF-actin interacting with the plasma membrane. A spiral microfluidic system with channel width 300m and height 40m was found to effectively isolate smaller and more deformable HSCs from a cell population, resulting in a significant increase of free flowing cells in vivo. This study comprehensively characterized cell mechanics at different levels using micromanipulation and AFM, determining mechanical markers of therapeutic cells. Most importantly, a simple cell sorting system was successfully developed to isolate target cells without introducing any chemical modification, and the possible underlying mechanism was discussed, which can be valuable to cellular therapy

Mechanical characterization of therapeutic cells and physical property-based sorting in microfluidic systems

Bone marrow-derived mesenchymal and hematopoietic stem cells (MSCs and HSCs) have rapidly become the leading cells for consideration to aid tissue regeneration following injury. However, potential HSCs and MSCs migration to the injured tissue after infusion is impeded by cell trap within the upstream vessels, where physical and mechanical properties of cells play an important role. Microfluidic system has a potential to sort cells/particles based on their mechanical properties. It is hypothesized that such sorting system could be utilized to separate smaller and more deformable SCs from a cell population, infusion of which might be able to enhance the recruitment of the cells. The mechanical properties of murine HSCs were determined using micromanipulation and atomic force microscopy (AFM). Microfluidic devices were fabricated to separate sub-set of HSCs, followed by the infusion of the isolated cells into ischemia-reperfusion injured animals. HSCs as a whole became weaker and more deformable after pre-treatment with SDF-la and H 2 02, but HSC surface stiffened after the same pre-treating, accompanied by the expansion and polymerization ofF-actin interacting with the plasma membrane. A spiral microfluidic system with channel width 300m and height 40m was found to effectively isolate smaller and more deformable HSCs from a cell population, resulting in a significant increase of free flowing cells in vivo. This study comprehensively characterized cell mechanics at different levels using micromanipulation and AFM, determining mechanical markers of therapeutic cells. Most importantly, a simple cell sorting system was successfully developed to isolate target cells without introducing any chemical modification, and the possible underlying mechanism was discussed, which can be valuable to cellular therapy

In-wheel motor vibration control for distributed-driven electric vehicles:A review

Efficient, safe, and comfortable electric vehicles (EVs) are essential for the creation of a sustainable transport system. Distributed-driven EVs, which often use in-wheel motors (IWMs), have many benefits with respect to size (compactness), controllability, and efficiency. However, the vibration of IWMs is a particularly important factor for both passengers and drivers, and it is therefore crucial for a successful commercialization of distributed-driven EVs. This paper provides a comprehensive literature review and state-of-the-art vibration-source-analysis and -mitigation methods in IWMs. First, selection criteria are given for IWMs, and a multidimensional comparison for several motor types is provided. The IWM vibration sources are then divided into internally-, and externally-induced vibration sources and discussed in detail. Next, vibration reduction methods, which include motor-structure optimization, motor controller, and additional control-components, are reviewed. Emerging research trends and an outlook for future improvement aims are summarized at the end of the paper. This paper can provide useful information for researchers, who are interested in the application and vibration mitigation of IWMs or similar topics

Sini San inhibits breast cancer cell migration and angiogenesis via the HIF 1 /VEGF pathway

Purpose: To investigate the effects of Sini San (SNS) on breast cancer (BC), and the mechanism of action.Methods: MDA-MB-231 and SK-BR-3 cells were used as breast cancer cell models. Cell viability, migration, and invasion were determined by CCK-8, Transwell and wound healing assays, respectively. SNS mechanism of action and its anti-cancer effect were investigated by network pharmacological analysis, and further verified by Immunoblot.Results: Sini San inhibited the proliferation of the breast cancer (BC) cells., and also suppressed the migration as well as the invasion of BC cells, and also restrained the angiogenesis of BC cells. In performing the network pharmacological analysis of Sini Powder in the treatment of BC, 337 drugdisease targets were obtained. PPI network was established through String, and GO and KEGG enrichment analysis was performed on the target sites. KEGG analysis showed that genes were enriched in HIF-1 and VEGF pathways.Conclusion: Sini San suppressed cell migration as well as angiogenesis via the HIF-1 /VEGF pathway&nbsp