The Ecology of New World Rodent Borne Hemorrhagic Fevers

Few, if any, human settlements are free of peridomestic rodent populations. The threat of rodent borne zoonotic diseases has been widely recognized since the bubonic plague outbreaks of the Middle Ages. In the last decades, outbreaks of human disease caused by the rodent borne hemorrhagic fever viruses, the arenaviruses (family Arenaviridae), and the hantaviruses (family Bunyaviridae, genus Hantavirus) have again generated interest in the general public and scientific community regarding the biology of these types of diseases. Recent studies have identified more than 30 new members of these two groups of viruses. Most are associated with rodents in the family Muridae and many are known to be pathogenic. Ongoing studies are investigating aspects of the ecology and systematics of these viruses and their reservoirs. Ecological studies are currently examining modes of transmission between members of the host species, and environmental factors associated with increased frequency of infection. Systematic research is identifying patterns of co-evolution between the viruses and their hosts. The overall goal of these research efforts is develop predictive models that will identify times and places of increased risk and therefore provide an opportunity for risk reduction in these areas. The information resulting from these efforts will benefit individuals who live or work in close proximity to known wild rodent reservoirs and are at risk of contracting rodent borne diseases

Brief Note Bat Species Diversity Patterns in East Central Indiana

Author Institution: Aullwood Audubon Center; Department of Zoology, Miami University; Department of Biology, Earlham Colleg

Using PLSI-U to Detect Insider Threats by Datamining Email

Despite a technology bias that focuses on external electronic threats, insiders pose the greatest threat to an organisation. This paper discusses an approach to assist investigators in identifying potential insider threats. We discern employees\u27 interests from e-mail using an extended version of PLSI. These interests are transformed into implicit and explicit social network graphs, which are used to locate potential insiders by identifying individuals who feel alienated from the organisation or have a hidden interest in a sensitive topic. By applying this technique to the Enron e-mail corpus, a small number of employees appear as potential insider threats

Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors

The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are seemingly disparate roles of GSK3 stems from the complex regulation of many cellular functions by GSK3. This review focuses on the regulation of GSK3, its role in survival, apoptosis and DNA damage, and finally its potential therapeutic impact in brain cancer. A thorough understanding of this versatile protein is critical for improving the outcome of various diseases, especially cancer

Sequence Pattern Mining with Variables

Sequence pattern mining (SPM) seeks to find multiple items that commonly occur together in a specific order. One common assumption is that all of the relevant differences between items are captured through creating distinct items, e.g., if color matters then the same item in two different colors would have two items created, one for each color. In some domains, that is unrealistic. This paper makes two contributions. The first extends SPM algorithms to allow item differentiation through attribute variables for domains with large numbers of items, e.g, by having one item with a variable with a color attribute rather than distinct items for each color. It demonstrates this by incorporating variables into Discontinuous Varied Order Sequence Mining (DVSM). The second contribution is the creation of Sequence Mining of Temporal Clusters (SMTC), a new SPM that addresses the interleaving issue common to SPM algorithms. Most SPM algorithms address interleaving by using a distance measure to separate co-occurring sequences. SMTC addresses interleaving by clustering all subsets of temporally close items and deferring the sequencing of mined patterns until the entire dataset if examined. Evaluation of the SPM algorithms on a digital forensics media analysis task results in a 96% reduction in terms to review, 100% detection of true positives and no false positives

Potential mammalian filovirus reservoirs

Centers for Disease Control and Prevention http://www.cdc.gov/ncidod/EID/vol10no12/04-0346.htmEbola and Marburg viruses are maintained in unknown reservoir species; spillover into human populations results in occasional human cases or epidemics. We attempted to narrow the list of possibilities regarding the identity of those reservoir species. We made a series of explicit assumptions about the reservoir: it is a mammal; it supports persistent, largely asymptomatic filovirus infections; its range subsumes that of its associated filovirus; it has coevolved with the virus; it is of small body size; and it is not a species that is commensal with humans. Under these assumptions, we developed priority lists of mammal clades that coincide distributionally with filovirus outbreak distributions and compared these lists with those mammal taxa that have been tested for filovirus infection in previous epidemiologic studies. Studying the remainder of these taxa may be a fruitful avenue for pursuing the identity of natural reservoirs of filoviruses

Infusing Critical Thinking into Communication Courses

The importance of critical thinking is generally recognized by educators and during the past 20 years numerous initiatives have been taken to improve critical thinking. Although research demonstrates courses in communication study can have a positive impact on critical thinking skills, we argue that instruction in critical thinking can be more explicitly covered in basic communication courses. This article details our efforts to infuse critical thinking into an entrylevel communication course and outlines a guide to help communication teachers integrate critical thinking into their courses

Generationing development

The articles in this special issue present a persuasive case for accounts of development to recognise the integral and fundamental roles played by age and generation. While the past two decades have witnessed a burgeoning of literature demonstrating that children and youth are impacted by development, and that they can and do participate in development, the literature has tended to portray young people as a special group whose perspectives should not be forgotten. By contrast, the articles collected here make the case that age and generation, as relational constructs, cannot be ignored. Appropriating the term ‘generationing’, the editors argue that a variety of types of age relations profoundly structure the ways in which societies are transformed through development – both immanent processes of neoliberal modernisation and the interventions of development agencies that both respond and contribute to these. Drawing on the seven empirical articles, I attempt to draw some of the ideas together into a narrative that further argues the case for ‘generationing’ but also identifies gaps, questions and implications for further research

A hemispheric study of weather types

http://hdl.handle.net/10945/14243http://www.archive.org/details/hemisphericstudy00hollU.S. Navy (U.S.N.) author.U.S. Marine Corps (U.S.M.C.) author