1,234 research outputs found
Inland and The Frenchman's garden
University of Technology, Sydney. Faculty of Humanities and Social Sciences.My submission for the degree of Master of Arts in Writing from the University of Technology, Sydney, presents and discusses two radiophonic works made for broadcast on The Listening Room, ABC Classic FM. These are ‘Inland, and The Frenchman’s Garden’, both of which explore a listening approach to the Australian landscape.
There are three components to the submission.
The first consists of compact disc recordings of the works. They were written, composed, produced and partially performed by myself and include location recordings I made around the inland regions of Australia, alongside performances by actors and musicians.
‘Inland’ tells stories of mythic figures moving through a vast, Australian space, suspended in a landscape which is continually shifting and metamorphosing.
‘The Frenchman’s Garden’ is a radio documentary of an eccentric French botanist named Albert De Lestang, who planted a botanic garden in the Gulf Country of far north-western Queensland, in the first half of the 20th Century.
The second component of the submission is a written version of each work. Neither is intended to accompany the listening to the radiophonic version. This version of ‘The Frenchman’s Garden’ is a record of a radio production. But the text of ‘Inland’ is intended to be read as a fictional work and a piece of writing in its own right. Thus I have indicated character and documentary names in ‘The Frenchman’s Garden’, but not in ‘Inland’. Instead variations in tempo and tone are shown through indentations and italics. References to sounds the reader will hear are indicated on the left hand page in both scripts.
The third component of the submission is an essay, ‘Composing Radio, Writing Sound’, which examines the development of an artistic approach through ‘Inland’ and ‘The Frenchman's Garden’, in the context of radiophonic practices as they are found in the Audio Arts Department of ABC Radio. The programs were produced in this department, and its working style was a considerable influence upon the productions.
I look at some guiding principles- the radiophonic diary and mimesis and the body – and consider these through the work of four other works made for this department. I also examine the approaches of composers to radio and the 'writing with sound' tradition, and I discuss place and space as they are manifested in the work of contemporary Australian radio makers. In so doing I find a place for my own work within the Australian radiophonic milieu
A Damping of the de Haas-van Alphen Oscillations in the superconducting state
Deploying a recently developed semiclassical theory of quasiparticles in the
superconducting state we study the de Haas-van Alphen effect. We find that the
oscillations have the same frequency as in the normal state but their amplitude
is reduced. We find an analytic formulae for this damping which is due to
tunnelling between semiclassical quasiparticle orbits comprising both
particle-like and hole-like segments. The quantitative predictions of the
theory are consistent with the available data.Comment: 7 pages, 5 figure
Dilepton Production in Nucleon-Nucleon Reactions With and Without Hadronic Inelasticities
We calculate elementary proton-proton and neutron-proton bremsstrahlung and
their contribution to the invariant mass distribution. At 4.9 GeV, the
proton-proton contribution is larger than neutron-proton, but it is small
compared to recent data. We then make a first calculation of bremsstrahlung in
nucleon-nucleon reactions with multi-hadron final states. Again at 4.9 GeV, the
many-body bremsstrahlung is larger than simple nucleon-nucleon bremsstrahlung
by more than an order of magnitude in the low-mass region. When the
bremsstrahlung contributions are summed with Dalitz decay of the ,
radiative decay of the and from two-pion annihilation, the result
matches recent high statistics proton-proton data from the Dilepton
Spectrometer collaboration.Comment: 1+17 pages plus 11 PostScript figures uuencoded and appended,
McGill/93-9, TPI-MINN-93/18-
Inclusive Dielectron Cross Sections in p+p and p+d Interactions at Beam Energies from 1.04 to 4.88 GeV
Measurements of dielectron production in p+p and p+d collisions with beam
kinetic energies from 1.04 to 4.88 GeV are presented. The differential cross
section is presented as a function of invariant pair mass, transverse momentum,
and rapidity. The shapes of the mass spectra and their evolution with beam
energy provide information about the relative importance of the various
dielectron production mechanisms in this energy regime. The p+d to p+p ratio of
the dielectron yield is also presented as a function of invariant pair mass,
transverse momentum, and rapidity. The shapes of the transverse momentum and
rapidity spectra from the p+d and p+p systems are found to be similar to one
another for each of the beam energies studied. The beam energy dependence of
the integrated cross sections is also presented.Comment: 15 pages and 16 figure
Discovery and characterization of ORM-11372, a novel inhibitor of the sodium-calcium exchanger with positive inotropic activity
BACKGROUND AND PURPOSE: The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 inhibitor. EXPERIMENTAL APPROACH: A flavan series-based pharmacophore model was constructed. Virtual screening helped us identify a novel scaffold for NCX inhibition. A distinctively different NCX 1.1 inhibitor, ORM-11372, was discovered after lead optimization. Its potency against human and rat NCX 1.1 and selectivity against other ion channels was assessed. The cardiovascular effects of ORM-11372 were studied in normal and infarcted rats and rabbits. Human cardiac safety was studied ex vivo using human ventricular trabeculae. KEY RESULTS: ORM-11372 inhibited human NCX 1.1 reverse and forward currents; IC(50) values were 5 and 6 nM respectively. ORM-11372 inhibited human cardiac sodium 1.5 (I(Na) ) and hERG K(V) 11.1 currents (I(hERG) ) in a concentration-dependent manner; IC(50) values were 23.2 and 10.0 μM. ORM-11372 caused no changes in action potential duration; short-term variability and triangulation were observed for concentrations of up to 10 μM. ORM-11372 induced positive inotropic effects of 18 ± 6% and 35 ± 8% in anaesthetized rats with myocardial infarctions and in healthy rabbits respectively; no other haemodynamic effects were observed, except improved relaxation at the lowest dose. CONCLUSION AND IMPLICATIONS: ORM-11372, a unique, novel, and potent inhibitor of human and rat NCX 1.1, is a positive inotropic compound. NCX inhibition can induce clinically relevant improvements in left ventricular contractions without affecting relaxation, heart rate, or BP, without pro-arrhythmic risk.Peer reviewe
Pars plana vitrectomy for the repair of primary, inferior rhegmatogenous retinal detachment associated to inferior breaks. A comparison of a 25-gauge versus a 20-gauge system
The impact of vitamin D status on changes in bone mineral density during treatment with bisphosphonates and after discontinuation following long-term use in post-menopausal osteoporosis
BACKGROUND: It is still unclear whether addition of calcium/vitamin D supplements leads to an incremental benefit in patients taking bisphosphonates and whether achievement of serum level of 25 (OH) vitamin D of at least 70 nmol/L has an impact on the skeletal response to bisphosphonates. Moreover the maintenance of BMD after bisphosphonates withdrawal with the continuation of calcium/vitamin D supplements only, remains uncertain. The aims were to assess the impact of vitamin D status on changes in bone mineral density (BMD) in firstly patients with post-menopausal osteoporosis on bisphosphonates and secondly following discontinuation of bisphosphonates after long-term use. METHODS: Two patient groups were recruited. The first study population comprised of 112 women treated with a bisphosphonate. The second study population consisted of 35 women who had been on bisphosphonates for > 5 years in whom the treatment agent was discontinued. Baseline BMD, changes in BMD following treatment, duration of treatment, serum 25 (OH) vitamin D, parathyroid hormone (PTH), urine C-terminal telopeptides of type 1 collagen (CTX) were obtained on the study participants. RESULTS: In the first study group, subjects with serum vitamin D concentrations (> 70 nmol/L) had a significantly lower serum PTH level (mean [SEM] 41 [2] ng/L). PTH concentrations of 41 ng/L or less was associated with a significantly higher increase in BMD at the hip following treatment with bisphosphonates compared to patients with PTH > 41 ng/L (2.5% [0.9] v/s -0.2% [0.9], P = 0.04). In the second study group, discontinuation of bisphosphonate for 15 months after long-term treatment did not result in significant bone loss at the lumbar spine and total hip, although a trend towards gradual decline in BMD at the femoral neck was observed. CONCLUSION: the data suggest that optimal serum 25 (OH) vitamin D concentration may lead to further reduction in bone loss at the hip in patients on bisphosphonates. A prospective controlled trial is needed to evaluate whether the response to bisphosphonates is influenced by vitamin D status. BMD is preserved at the lumbar spine and total hip following discontinuation of bisphosphonate for a short period following long-term treatment, although a gradual loss occurs at the femoral neck
Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study
Quark helicity distributions in the nucleon for up, down, and strange quarks from semi--inclusive deep--inelastic scattering
Polarized deep--inelastic scattering data on longitudinally polarized
hydrogen and deuterium targets have been used to determine double spin
asymmetries of cross sections. Inclusive and semi--inclusive asymmetries for
the production of positive and negative pions from hydrogen were obtained in a
re--analysis of previously published data. Inclusive and semi--inclusive
asymmetries for the production of negative and positive pions and kaons were
measured on a polarized deuterium target. The separate helicity densities for
the up and down quarks and the anti--up, anti--down, and strange sea quarks
were computed from these asymmetries in a ``leading order'' QCD analysis. The
polarization of the up--quark is positive and that of the down--quark is
negative. All extracted sea quark polarizations are consistent with zero, and
the light quark sea helicity densities are flavor symmetric within the
experimental uncertainties. First and second moments of the extracted quark
helicity densities in the measured range are consistent with fits of inclusive
data
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