817 research outputs found
The inverse Laplace transform as the ultimate tool for transverse mass spectra
New high statistics data from the second generation of ultrarelativistic
heavy-ion experiments open up new possibilities in terms of data analysis. To
fully utilize the potential we propose to analyze the -spectra of
hadrons using the inverse Laplace transform. The problems with its inherent
ill-definedness can be overcome and several applications in other fields like
biology, chemistry or optics have already shown its feasability. Moreover, the
method also promises to deliver upper bounds on the total information content
of the spectra, which is of big importance for all other means of analysis.
Here we compute several Laplace inversions from different thermal scenarios,
both analytically and numerically, to test the efficiency of the method.
Especially the case of a two component structure, related to a possible first
order phase transition to a quark gluon plasma, is closer investigated and it
is shown that at least a signal to noise ratio of is necessary to
resolve two individual components.Comment: 13 pages (PostScript, including figures), BNL-NTHES
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Importance of Supernovae at z<0.1 for Probing Dark Energy
Supernova experiments to characterize dark energy require a well designed low redshift program; we consider this for both ongoing/near term (e.g. Supernova Legacy Survey) and comprehensive future (e.g., SNAP) experiments. The derived criteria are: a supernova sample centered near z=0.05 comprising 150-500 (in the former case) and 300-900 (in the latter case) well measured supernovae. Low redshift Type Ia supernovae play two important roles for cosmological use of the supernova distance-redshift relation: as an anchor for the Hubble diagram and as an indicator of possible systematics. An innate degeneracy in cosmological distances implies that 300 nearby supernovae nearly saturate their cosmological leverage for the first use, and their optimum central redshift is z=0.05. This conclusion is strengthened upon including velocity flow and magnitude offset systematics. Limiting cosmological parameter bias due to supernova population drift (evolution) systematics plausibly increases the requirement for the second use to less than about 900 supernovae
Abaloparatide: an anabolic treatment to reduce fracture risk in postmenopausal women with osteoporosis
Objective
Fractures due to osteoporosis represent a serious burden on patients and healthcare systems. The objective of this review is to provide an overview of the anabolic agent abaloparatide (ABL) for the treatment of postmenopausal women with osteoporosis at high risk for fracture.
Methods
A literature review was conducted using PubMed to identify articles focused on ABL published prior to February 10, 2020, using the search term âabaloparatideâ.
Results
ABL, a synthetic analog of human parathyroid hormone-related protein, increased bone mineral density (BMD), improved bone microarchitecture, and increased bone strength in preclinical and clinical studies. The pivotal phase 3 trial ACTIVE and its extension (ACTIVExtend) demonstrated the efficacy of initial treatment with ABL for 18âmonths followed by sequential treatment with alendronate (ALN) for an additional 24âmonths to reduce the risk of vertebral, nonvertebral, clinical, and major osteoporotic fractures and to increase BMD in postmenopausal women with osteoporosis. Discontinuations from ACTIVE were slightly more common in ABL-treated patients due to dizziness, palpitations, nausea, and headache. Post hoc analyses of ACTIVE and ACTIVExtend support the efficacy and safety of ABL in relevant subpopulations including postmenopausal women with various baseline risk factors, women â„80âyears, women with type 2 diabetes mellitus, and women with renal impairment.
Conclusions
ABL is an effective and well-tolerated treatment for women with postmenopausal osteoporosis at high risk for fracture. Its therapeutic effects are sustained with subsequent ALN therapy
A quark model analysis of the charge symmetry breaking in nuclear force
In order to investigate the charge symmetry breaking (CSB) in the short range
part of the nuclear force, we calculate the difference of the masses of the
neutron and the proton, , the difference of the scattering
lengths of the p-p and n-n scatterings, , and the difference of the
analyzing power of the proton and the neutron in the n-p scattering, , by a quark model. In the present model the sources of CSB are the
mass difference of the up and down quarks and the electromagnetic interaction.
We investigate how much each of them contributes to , and . It is found that the contribution of CSB of the
short range part in the nuclear force is large enough to explain the observed
, while is rather underestimated.Comment: 26 pages,6 figure
Evidence for the formation of magnetic moments in the cuprate superconductor HgCuBaCaCuO below seen by NQR
We report pure zero field nuclear magnetic resonance (NQR) measurements on
the optimally doped three layer high--compounds HgBaCaCuO and
HgBaCaCuO(F) with 134 K. Above two Cu NQR line pairs are
observed in the spectra corresponding to the two inequivalent Cu lattice sites.
Below the Cu NQR spectra show additional lines leading to the extreme
broadened Cu NQR spectra at 4.2 K well known for the HgBaCaCuO compounds. The
spin-lattice relaxation curves follow a triple exponential function with
coefficients depend onto the saturation time (number of saturation pulses),
whereas the spin-spin relaxation curve is described by a single exponential
function. From the spin-lattice relaxation we deduced a complete removal of the
Kramers degeneracy of the Cu quadrupole indicating that the additional lines
are due to a Zeemann splitting of the Cu lines due to the spontaneous
formation of magnetic moments within the CuO layers. Below 140 K, the spectra
are well fitted by a number of 6 Cu line pairs. From the number of
the Cu lines, the position of the lines relative to each other and the complete
removal of the Kramers degeneracy we deduced an orientation of the magnetic
moments parallel to the symmetry axis of the electric field gradient tensor
with magnitudes of the order of 1000 G. We also discuss the possible
microscopic origin of the observed internal magnetic fields.Comment: 11 pages, 12 figure
Multicanonical Multigrid Monte Carlo
To further improve the performance of Monte Carlo simulations of first-order
phase transitions we propose to combine the multicanonical approach with
multigrid techniques. We report tests of this proposition for the
-dimensional field theory in two different situations. First, we
study quantum tunneling for in the continuum limit, and second, we
investigate first-order phase transitions for in the infinite volume
limit. Compared with standard multicanonical simulations we obtain improvement
factors of several resp. of about one order of magnitude.Comment: 12 pages LaTex, 1 PS figure appended. FU-Berlin preprint FUB-HEP 9/9
Observation of Precipitation Evolution in Fe-Ni-Mn-Ti-Al Maraging Steel by Atom Probe Tomography
We describe the full decomposition sequence in an Fe-Ni-Mn-Ti-Al maraging steel during isothermal annealing at 550 °C. Following significant pre-precipitation clustering reactions within the supersaturated martensitic solid solution, (Ni,Fe)3Ti and (Ni,Fe)3(Al,Mn) precipitates eventually form after isothermal aging for ~60 seconds. The morphology of the (Ni,Fe)3Ti particles changes gradually during aging from predominantly plate-like to rod-like, and, importantly, Mn and Al were observed to segregate to these precipitate/matrix interfaces. The (Ni,Fe)3(Al,Mn) precipitates occurred at two main locations: uniformly within the matrix and at the periphery of the (Ni,Fe)3Ti particles. We relate this latter mode of precipitation to the Mn-Al segregation
Homogeneous nucleation of quark-gluon plasma, finite size effects and long-lived metastable objects
The general formalism of homogeneous nucleation theory is applied to study
the hadronization pattern of the ultra-relativistic quark-gluon plasma (QGP)
undergoing a first order phase transition. A coalescence model is proposed to
describe the evolution dynamics of hadronic clusters produced in the nucleation
process. The size distribution of the nucleated clusters is important for the
description of the plasma conversion. The model is most sensitive to the
initial conditions of the QGP thermalization, time evolution of the energy
density, and the interfacial energy of the plasma-hadronic matter interface.
The rapidly expanding QGP is first supercooled by about . Then it reheats again up to the critical temperature T_c. Finally it
breaks up into hadronic clusters and small droplets of plasma. This fast
dynamics occurs within the first . The finite size effects and
fluctuations near the critical temperature are studied. It is shown that a drop
of longitudinally expanding QGP of the transverse radius below 4.5 fm can
display a long-lived metastability. However, both in the rapid and in the
delayed hadronization scenario, the bulk pion yield is emitted by sources as
large as 3-4.5 fm. This may be detected experimentally both by a HBT
interferometry signal and by the analysis of the rapidity distributions of
particles in narrow p_T-intervals at small p_T on an event-by-event basis.Comment: 29 pages, incl. 12 figures and 1 table; to be published in Phys. Rev.
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