Experimental Studies of Markets with Buyers Ignorant of Quality Before Purchase: When do "Lemons" Drive out High Quality Products? A Report to the Federal Trade Commission

Experiments indicated that if sellers could not develop reputations for poor quality, then the market would consist entirely of poor quality products. The need to attract re-purchase is not sufficient incentive to have the seller build a reputation for supplying good quality, while the imposition of a requirement for truthful advertising or labelling is sufficient

Processing The Interspecies Quorum-Sensing Signal Autoinducer-2 (AI-2) Characterization Of Phospho-(S)-4,5-Dihydroxy-2,3-Pentanedione Isomerization By LsrG Protein

The molecule (S)-4,5-dihydroxy-2,3-pentanedione (DPD) is produced by many different species of bacteria and is the precursor of the signal molecule autoinducer-2 (AI-2). AI-2 mediates interspecies communication and facilitates regulation of bacterial behaviors such as biofilm formation and virulence. A variety of bacterial species have the ability to sequester and process the AI-2 present in their environment, thereby interfering with the cell-cell communication of other bacteria. This process involves the AI-2-regulated lsr operon, comprised of the Lsr transport system that facilitates uptake of the signal, a kinase that phosphorylates the signal to phospho-DPD (P-DPD), and enzymes (like LsrG) that are responsible for processing the phosphorylated signal. Because P-DPD is the intracellular inducer of the lsr operon, enzymes involved in P-DPD processing impact the levels of Lsr expression. Here we show that LsrG catalyzes isomerization of P-DPD into 3,4,4-trihydroxy-2-pentanone-5-phosphate. We present the crystal structure of LsrG, identify potential catalytic residues, and determine which of these residues affects P-DPD processing in vivo and in vitro. We also show that an lsrG deletion mutant accumulates at least 10 times more P-DPD than wild type cells. Consistent with this result, we find that the lsrG mutant has increased expression of the lsr operon and an altered profile of AI-2 accumulation and removal. Understanding of the biochemical mechanisms employed by bacteria to quench signaling of other species can be of great utility in the development of therapies to control bacterial behavior

An overview of jets and outflows in stellar mass black holes

In this book chapter, we will briefly review the current empirical understanding of the relation between accretion state and and outflows in accreting stellar mass black holes. The focus will be on the empirical connections between X-ray states and relativistic (`radio') jets, although we are now also able to draw accretion disc winds into the picture in a systematic way. We will furthermore consider the latest attempts to measure/order jet power, and to compare it to other (potentially) measurable quantities, most importantly black hole spin.Comment: Accepted for publication in Space Science Reviews. Also to appear in the Space Sciences Series of ISSI - The Physics of Accretion on to Black Holes (Springer Publisher

Advances in the Understanding of the Genetic Determinants of Congenital Heart Disease and Their Impact on Clinical Outcomes

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143784/1/jah33022.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/143784/2/jah33022_am.pd

On the Role of the Accretion Disk in Black Hole Disk-Jet Connections

Models of jet production in black hole systems suggest that the properties of the accretion disk - such as its mass accretion rate, inner radius, and emergent magnetic field - should drive and modulate the production of relativistic jets. Stellar-mass black holes in the "low/hard" state are an excellent laboratory in which to study disk-jet connections, but few coordinated observations are made using spectrometers that can incisively probe the inner disk. We report on a series of 20 Suzaku observations of Cygnus X-1 made in the jet-producing low/hard state. Contemporaneous radio monitoring was done using the Arcminute MicroKelvin Array radio telescope. Two important and simple results are obtained: (1) the jet (as traced by radio flux) does not appear to be modulated by changes in the inner radius of the accretion disk; and (2) the jet is sensitive to disk properties, including its flux, temperature, and ionization. Some more complex results may reveal aspects of a coupled disk-corona-jet system. A positive correlation between the reflected X-ray flux and radio flux may represent specific support for a plasma ejection model of the corona, wherein the base of a jet produces hard X-ray emission. Within the framework of the plasma ejection model, the spectra suggest a jet base with v/c ~ 0.3, or the escape velocity for a vertical height of z ~ 20 GM/c^2 above the black hole. The detailed results of X-ray disk continuum and reflection modeling also suggest a height of z ~ 20 GM/c^2 for hard X-ray production above a black hole, with a spin in the range 0.6 < a < 0.99. This height agrees with X-ray time lags recently found in Cygnus X-1. The overall picture that emerges from this study is broadly consistent with some jet-focused models for black hole spectral energy distributions in which a relativistic plasma is accelerated at z = 10-100 GM/c^2.Comment: Accepted for publication in Ap