Facilitating student engagement: Social responsibility and freshmen learning communities

Human rights education is advanced as a method for promoting social responsibility, with an emphasis on promoting ideals of “global citizenship” among undergraduate students. At the same time, the practice of learning communities is widespread on college campuses for retaining freshmen and promoting student success. However, there is limited research on the effectiveness of combining these approaches. In response to this literature gap, this article first provides an overview of key concepts—social responsibility, human rights education, and learning communities—and outlines how these terms are currently understood within higher education. Second, the methods and initial findings of a longitudinal study within Webster University’s Social Engagement Learning Community focus on gauging and assessing human rights knowledge and social engagement. Initial findings suggest that most freshmen respondents lack basic human rights knowledge and an activist orientation, yet their empathy and perspective-taking abilities provide foundations for building awareness of human rights issues and social responsibility. Lastly, recommendations are outlined for addressing learning goals related to identity awareness, helping students step outside of their “comfort zones,” and promoting awareness and solutions

Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis

The endothelium plays a critical role in the host response to infection and has been a focus of investigation in sepsis. While it is appreciated that intravascular thrombus formation, severe inflammation, and loss of endothelial integrity impair tissue oxygenation during sepsis, the precise molecular mechanisms that lead to endothelial injury remain poorly understood. We demonstrate here that endothelial ADAM10 was essential for the pathogenesis of Staphylococcus aureus sepsis, contributing to α-toxin-mediated (Hla-mediated) microvascular thrombus formation and lethality. As ADAM10 is essential for endothelial development and homeostasis, we examined whether other major human sepsis pathogens also rely on ADAM10-dependent pathways in pathogenesis. Mice harboring an endothelium-specific knockout of ADAM10 were protected against lethal Pseudomonas aeruginosa and Streptococcus pneumoniae sepsis, yet remained fully susceptible to group B streptococci and Candida albicans sepsis. These studies illustrate a previously unknown role for ADAM10 in sepsis-associated endothelial injury and suggest that understanding pathogen-specific divergent host pathways in sepsis may enable more precise targeting of disease

The Data Stream: Assessing the Flow of Real Time Marine Science Data from Research Vessel to the Classroom

Today’s technology-based society makes information more accessible than ever, in turn creating a growing demand for a workforce that has the skills necessary to utilize data. Contributing to this influx of data is Oregon State University (OSU), who was selected to guide the design and construction process of three Regional Class Research Vessels (RCRVs). These vessels will be capable of producing enormous amounts of crucial, real-time oceanographic data. As part of the RCRV Education and Outreach team effort, this two-phase project seeks to support data literacy by streamlining the Data Stream, or the flow of data from researcher to educator to student. Phase one of the project utilized a literature review; 32 interviews with marine researchers, educators, and professional development providers; 8 years of professional development surveys; a data-portal review with classroom; and data-portal surveys with classroom teachers to identify key challenges faced when utilizing research data in outreach and learning activities. These methods result in informed recommendations that can aid in facilitating the transfer of data between researcher and teachers/students. Phase two of this project assessed how data-focused experiential learning impacted student data literacy, attitudes toward science, and beliefs about science. Two high school biology classes participated in hands-on, data-focused learning activities, whereas two other classes participated in passive learning activities. The lessons utilized authentic oceanographic data that were collected off the Oregon Coast by researchers. Over the course of three days, students were introduced to the concepts of oceanography and collection of marine science data, how to understand and critically evaluate sets of data, and were encouraged to reflect on and discuss why understanding ocean data is an important skill in today's world. Surprisingly, the passive learning group (PLG) showed significant changes in all three variables (data literacy, attitudes toward science, beliefs about science), whereas the experiential learning group (ELG) did not have any significant change. This, however, does not negate a connection between positive impacts and data-focused experiential learning, but instead highlights additional challenges that need to be addressed when attempting to foster data literacy in students.

Conditioned Reinforcement can be Mediated by Either Outcome-Specific or General Affective Representations

Conditioned reinforcers are Pavlovian cues that support the acquisition and maintenance of new instrumental responses. Responding on the basis of conditioned rather than primary reinforcers is a pervasive part of modern life, yet we have a remarkably limited understanding of what underlying associative information is triggered by these cues to guide responding. Specifically, it is not certain whether conditioned reinforcers are effective because they evoke representations of specific outcomes or because they trigger general affective states that are independent of any specific outcome. This question has important implications for how different brain circuits might be involved in conditioned reinforcement. Here, we use specialized Pavlovian training procedures, reinforcer devaluation and transreinforcer blocking, to create cues that were biased to preferentially evoke either devaluation-insensitive, general affect representations or, devaluation-sensitive, outcome-specific representations. Subsequently, these cues, along with normally conditioned control cues, were presented contingent on lever pressing. We found that intact rats learned to lever press for either the outcome or the affect cues to the same extent as for a normally conditioned cue. These results demonstrate that conditioned reinforcers can guide responding through either type of associative information. Interestingly, conditioned reinforcement was abolished in rats with basolateral amygdala lesions. Consistent with the extant literature, this result suggests a general role for basolateral amygdala in conditioned reinforcement. The implications of these data, combined with recent reports from our laboratory of a more specialized role of orbitofrontal cortex in conditioned reinforcement, will be discussed

Impact of an Adaptive Worksite Diabetes Prevention Trial on Health Action Process Approach Outcomes regarding Dietary Intake and Physical Activity

Weight loss, through a reduction in energy intake and increase in energy expenditure, can reduce diabetes risk in people with prediabetes. However, lifestyle change can be challenging even with positive intentions. The Health Action Process Approach (HAPA) theoretical framework bridges the intention-behavior gap by targeting planning behaviors and strengthening efficacious beliefs for behavioral change. In the current trial, an adaptive design was employed to examine differences in HAPA measures (i.e., planning and self-efficacy) regarding the target behaviors of dietary intake and physical activity (PA). Adults ≥ 21 years old with overweight or obesity and prediabetes (n = 185) received the standard Group Lifestyle Balance (GLB) intervention during the first month of treatment. Weight loss responders (lost \u3e 2.5% of weight) at week five remained in GLB during weeks 5-16; slow responders (lost ≤ 2.5%) were stratified to the adaptive GLB Plus (GLB+) intervention during weeks 5-16. GLB+ augmented self-regulatory skills and practices consistent with HAPA. We conducted mixed model analyses with a group-by-time interaction for fixed effects at four months. GLB experienced greater improvement in behavioral intention for both diet and PA, planning behaviors (action and coping planning) for diet, and self-efficacy beliefs (action and maintenance self-efficacy) for PA compared to GLB+ (all ps \u3c .0125). However, GLB+ also experienced statistically significant improvement in planning and self-efficacy and in energy intake and food group servings (all ps \u3c .01). Whereas an adaptive intervention can be advantageous in improving HAPA measures and food choices, greater focus on increasing PA is needed. Additional research may help to determine effective PA strategies

Early frontotemporal dementia targets neurons unique to apes and humans

Objective: Frontotemporal dementia (FTD) is a neurodegenerative disease that erodes uniquely human aspects of social behavior and emotion. The illness features a characteristic pattern of early injury to anterior cingulate and frontoinsular cortex. These regions, though often considered ancient in phylogeny, are the exclusive homes to the von Economo neuron (VEN), a large bipolar projection neuron found only in great apes and humans. Despite progress toward understanding the genetic and molecular bases of FTD, no class of selectively vulnerable neurons has been identified. Methods: Using unbiased stereology, we quantified anterior cingulate VENs and neighboring Layer 5 neurons in FTD (n = 7), Alzheimer's disease (n = 5), and age‐matched nonneurological control subjects (n = 7). Neuronal morphology and immunohistochemical staining patterns provided further information about VEN susceptibility. Results: FTD was associated with early, severe, and selective VEN losses, including a 74% reduction in VENs per section compared with control subjects. VEN dropout was not attributable to general neuronal loss and was seen across FTD pathological subtypes. Surviving VENs were often dysmorphic, with pathological tau protein accumulation in Pick's disease. In contrast, patients with Alzheimer's disease showed normal VEN counts and morphology despite extensive local neurofibrillary pathology. Interpretation: VEN loss links FTD to its signature regional pattern. The findings suggest a new framework for understanding how evolution may have rendered the human brain vulnerable to specific forms of degenerative illness

Preoperative PROMIS Scores Predict Postoperative PROMIS Score Improvement for Patients Undergoing Hand Surgery

Background: Patient-Reported Outcomes Measurement Information System (PROMIS) can be used alongside preoperative patient characteristics to set postsurgery expectations. This study aimed to analyze whether preoperative scores can predict significant postoperative PROMIS score improvement. Methods: Patients undergoing hand and wrist surgery with initial and greater than 6-month follow-up PROMIS scores were assigned to derivation or validation cohorts, separating trauma and nontrauma conditions. Receiver operating characteristic curves were calculated for the derivation cohort to determine whether preoperative PROMIS scores could predict postoperative PROMIS score improvement utilizing minimal clinically important difference principles. Results: In the nontrauma sample, patients with baseline Physical Function (PF) scores below 31.0 and Pain Interference (PI) and Depression scores above 68.2 and 62.2, respectively, improved their postoperative PROMIS scores with 95%, 96%, and 94% specificity. Patients with baseline PF scores above 52.1 and PI and Depression scores below 49.5 and 39.5, respectively, did not substantially improve their postoperative PROMIS scores with 94%, 93%, and 96% sensitivity. In the trauma sample, patients with baseline PF scores below 34.8 and PI and Depression scores above 69.2 and 62.2, respectively, each improved their postoperative PROMIS scores with 95% specificity. Patients with baseline PF scores above 52.1 and PI and Depression scores below 46.6 and 44.0, respectively, did not substantially improve their postoperative scores with 95%, 94%, and 95% sensitivity. Conclusions: Preoperative PROMIS PF, PI, and Depression scores can predict postoperative PROMIS score improvement for a select group of patients, which may help in setting expectations. Future work can help determine the level of true clinical improvement these findings represent

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

Antisense oligonucleotides (ASOs) have demonstrated variation of efficacy in patient populations. This has prompted our investigation into the contribution of genetic architecture to ASO pharmacokinetics (PK) and pharmacodynamics (PD). Genome wide association (GWA) and transcriptomic analysis in a hybrid mouse diversity panel (HMDP) were used to identify and validate novel genes involved in the uptake and efficacy of a single dose of a Malat1 constrained ethyl (cEt) modified ASO. The GWA of the HMDP identified two significant associations on chromosomes 4 and 10 with hepatic Malat1 ASO concentrations. Stabilin 2 (Stab2) and vesicle associated membrane protein 3 (Vamp3) were identified by ciseQTL analysis. HMDP strains with lower Stab2 expression and Stab2 KO mice displayed significantly lower PK than strains with higher Stab2 expression and the wild type (WT) animals respectively, confirming the role of Stab2 in regulating hepatic Malat1 ASO uptake. GWA examining ASO efficacy uncovered three loci associated with Malat1 potency: Small Subunit Processome Component (Utp11l) on chromosome 4, Rho associated coiled-coil containing protein kinase 2 (Rock2) and Aci-reductone dioxygenase (Adi1) on chromosome 12. Our results demonstrate the utility of mouse GWAS using the HMDP in detecting genes capable of impacting the uptake of ASOs, and identifies genes critical for the activity of ASOs in vivo

Brain network adaptability across task states.

Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in network science to analyze patterns of functional interactions between brain regions. We use dynamic network representations to probe the landscape of brain reconfigurations that accompany task performance both within and between four cognitive states: a task-free resting state, an attention-demanding state, and two memory-demanding states. Using the formalism of hypergraphs, we identify the presence of groups of functional interactions that fluctuate coherently in strength over time both within (task-specific) and across (task-general) brain states. In contrast to prior emphases on the complexity of many dyadic (region-to-region) relationships, these results demonstrate that brain adaptability can be described by common processes that drive the dynamic integration of cognitive systems. Moreover, our results establish the hypergraph as an effective measure for understanding functional brain dynamics, which may also prove useful in examining cross-task, cross-age, and cross-cohort functional change