New Hope for the Working Poor: Effects After Eight Years for Families and Children

Implemented in 1994 in Milwaukee, New Hope provided full-time, low-wage workers with several benefits for three years: an earnings supplement, low-cost health insurance, and subsidized child care. A random assignment study shows positive effects for both adults and children, some of which persisted five years after the program ended

Addition of Fat to Diets of Lactating Sows. I. Effects on Sow and Pig Performance

Sow energy intake during lactation is an important factor to consider when trying to maximize sow and pig performance. It has been shown that inadequate energy intake during lactation results in decreased litter weaning weight. Poor energy intake during lactation is also thought to result in a reduction in postweaning reproductive performance by extending the period from weaning to rebreeding. This reduction in postweaning performance is typically preceded by the excessive loss of weight and backfat during lactation. One method that has been used to increase sow energy intake, and thus alleviate the problems described above is to add dietary fat. The addition of high concentrations of fat (e.g., 7.5 to 15% of the diet) has been shown to result in increased sow energy intake during lactation, and if consumed for approximately one week before farrowing, increased survival rates for pigs with light birthweights. This article reports the effects of high fat diets on sow lactation performance, litter performance, and sow feed and energy intake. A subsequent article will discuss the effects of added dietary fat on energy intake, meal patterns, and blood hormones and metabolites. A specific objective of this research was to determine the effects of dietary fat on milk production and composition

The Effects of Tallow Addition to the Diets of Lactating Sows on Hormone and Metabolite Concentrations

The metabolic responses of sows fed a corn-soybean meal or a corn-soybean meal-10% tallow diet were measured. The addition of tallow to lactating sows diets had no effect on feed or energy intake. In addition, there were no effects on the concentrations of glucose, non-esterified fatty acids (NEFA), insulin, or glucagon. No differences in either the time spent consuming feed or the number of meals consumed were observed. Finally, no linear association between eating time and area under the curve for insulin was observed for sows consuming either diet. These results show the addition of tallow to lactation diets does not affect the concentrations of glucose, NEFA, insulin or glucagon in the fed state

Community-associated Methicillin-resistant Staphylococcus aureus Isolates and Healthcare-Associated Infections1

MRSA isolates phenotypically similar to community-associated strains have become the predominant isolates associated with healthcare-associated MRSA in our hospital

Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: A phase 1 dose-escalation study

BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody-liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer.MethodsPatients were enrolled in four cohorts: MM-302 monotherapy (8, 16, 30, 40, and 50 mg/m2 every 4 weeks [q4w]); MM-302 (30 or 40 mg/m2 q4w) plus trastuzumab (4 mg/kg q2w); MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) q3w; MM-302 (30 mg/m2) plus trastuzumab (6 mg/kg) and cyclophosphamide (450 mg/m2) q3w.ResultsSixty-nine patients were treated. The most common adverse events (AEs) were fatigue and nausea. Grade 3/4 AEs of special interest included neutropenia, fatigue, mucosal inflammation, anemia, thrombocytopenia, febrile neutropenia, and palmar-plantar erythrodysesthesia. The MTD was not reached. With MM-302 ≥ 30 mg/m2, overall response rate (ORR) was 13% and median progression-free survival (mPFS) 7.4 months (95% CI: 3·5-10·9) in all arms. In 25 anthracycline-naïve patients, ORR was 28·0% and mPFS 10·9 months (95% CI: 1·8-15·3). Imaging with 64Cu-labeled MM-302 visualized tumor-drug penetrance in tumors throughout the body, including the brain.ConclusionMM-302 monotherapy, in combination with trastuzumab, or trastuzumab plus cyclophosphamide, was well tolerated and showed promising efficacy. The selected phase 2 MM-302 dose was 30 mg/m2 plus 6 mg/kg trastuzumab q3w

The transition to parenthood in obstetrics: Enhancing prenatal care for 2-generation impact

Obstetrics, the specialty overseeing infant and parent health before birth, could be expanded to address the interrelated areas of parents\u27 prenatal impact on children\u27s brain development and their own psychosocial needs during a time of immense change and neuroplasticity. Obstetrics is primed for the shift that is happening in pediatrics, which is moving from its traditional focus on physical health to a coordinated, whole-child, 2- or multigeneration approach. Pediatric care now includes developmental screening, parenting education, parent coaching, access to developmental specialists, brain-building caregiving skills, linkages to community resources, and tiered interventions with psychologists. Drawing on decades of developmental origins of health and disease research highlighting the prenatal beginnings of future health and new studies on the transition to parenthood describing adult development from pregnancy to early postpartum, we have proposed that, similar to pediatrics, the integration of education and intervention strategies into the prenatal care ecosystem should be tested for its potential to improve child cognitive and social-emotional development and parental mental health. Pediatric care programs can serve as models of change for the systematic development, testing and, incorporation of new content into prenatal care as universal, first-tier treatment and evidenced-based, triaged interventions according to the level of need. To promote optimal beginnings for the whole family, we have proposed an augmented prenatal care ecosystem that aligns with, and could build on, current major efforts to enhance perinatal care individualization through consideration of medical, social, and structural determinants of health

Near-Infrared Spectroscopy of Low Mass X-ray Binaries : Accretion Disk Contamination and Compact Object Mass Determination in V404 Cyg and Cen X-4

We present near-infrared (NIR) broadband (0.80--2.42 $\mu$m) spectroscopy of two low mass X-ray binaries: V404 Cyg and Cen X-4. One important parameter required in the determination of the mass of the compact objects in these systems is the binary inclination. We can determine the inclination by modeling the ellipsoidal modulations of the Roche-lobe filling donor star, but the contamination of the donor star light from other components of the binary, particularly the accretion disk, must be taken into account. To this end, we determined the donor star contribution to the infrared flux by comparing the spectra of V404 Cyg and Cen X-4 to those of various field K-stars of known spectral type. For V404 Cyg, we determined that the donor star has a spectral type of K3 III. We determined the fractional donor contribution to the NIR flux in the H- and K-bands as $0.98 \pm .05$ and $0.97 \pm .09$, respectively. We remodeled the H-band light curve from \citet{sanwal1996} after correcting for the donor star contribution to obtain a new value for the binary inclination. From this, we determined the mass of the black hole in V404 Cyg to be $M_{BH}= 9.0^{+.2}_{-.6}M_{\odot}$. We performed the same spectral analysis for Cen X-4 and found the spectral type of the donor star to be in the range K5 -- M1V. The donor star contribution in Cen X-4 is $0.94\pm.14$ in the H-band while in the K-band, the accretion disk can contribute up to 10% of the infrared flux. We remodeled the H-band light curve from \citet{shahbaz1993}, again correcting for the fractional contribution of the donor star to obtain the inclination. From this, we determined the mass of the neutron star as $M_{NS}= 1.5^{+.1}_{-.4}M_{\odot}$. However, the masses obtained for both systems should be viewed with some caution since contemporaneous light curve and spectral data are required to obtain definitive masses

Capturing Complete Spatial Context in Satellite Observations of Greenhouse Gases

Scientific consensus from a 2015 pre-Decadal Survey workshop highlighted the essential need for a wide-swath (mapping) low earth orbit (LEO) instrument delivering carbon dioxide (CO_2), methane (CH_4), and carbon monoxide (CO) measurements with global coverage. OCO-2 pioneered space-based CO_2 remote sensing, but lacks the CH_4, CO and mapping capabilities required for an improved understanding of the global carbon cycle. The Carbon Balance Observatory (CARBO) advances key technologies to enable high-performance, cost-effective solutions for a space-based carbon-climate observing system. CARBO is a compact, modular, 15-30° field of view spectrometer that delivers high-precision CO_2, CH_4, CO and solar induced chlorophyll fluorescence (SIF) data with weekly global coverage from LEO. CARBO employs innovative immersion grating technologies to achieve diffraction-limited performance with OCO-like spatial (2x2 km^2) and spectral (λ/Δλ ≈ 20,000) resolution in a package that is >50% smaller, lighter and more cost-effective. CARBO delivers a 25- to 50-fold increase in spatial coverage compared to OCO-2 with no loss of detection sensitivity. Individual CARBO modules weigh < 20 kg, opening diverse new space-based platform opportunities

How penalizing substance use in pregnancy affects treatment and research: A qualitative examination of researchers\u27 perspectives

INTRODUCTION: Laws regulating substance use in pregnancy are changing and may have unintended consequences on scientific efforts to address the opioid epidemic. Yet, how these laws affect care and research is poorly understood. METHODS: We conducted semi-structured qualitative interviews using purposive and snowball sampling of researchers who have engaged pregnant people experiencing substance use. We explored views on laws governing substance use in pregnancy and legal reform possibilities. Interviews were double coded. Data were examined using thematic analysis. RESULTS: We interviewed 22 researchers (response rate: 71 per cent) and identified four themes: (i) harms of punitive laws, (ii) negative legal impacts on research, (iii) proposals for legal reform, and (iv) activism over time. DISCUSSION: Researchers view laws penalizing substance use during pregnancy as failing to treat addiction as a disease and harming pregnant people and families. Respondents routinely made scientific compromises to protect participants. While some have successfully advocated for legal reform, ongoing advocacy is needed. CONCLUSION: Adverse impacts from criminalizing substance use during pregnancy extend to research on this common and stigmatized problem. Rather than penalizing substance use in pregnancy, laws should approach addiction as a medical issue and support scientific efforts to improve outcomes for affected families