A dual approach to the linear analysis of elastic structure

Imperial Users onl

A critical appraisal of the design, construction and influence of the Unité d'Habitation, Marseilles, France

The Unité d'Habitation is a seventeen-storey apartment block built between 1947 and 1952 in Marseilles, France. Today the construction of such a building, in almost any part of the world, would hardly be newsworthy; however the construction of the Unité d'Habitation not only attracted global interest at the time, but it can also be seen as one of the most influential buildings of the twentieth century. This was for a number of reasons. The architect was Charles-Edouard Jeanneret-Gris who, better known as Le Corbusier for most of his adult life, was probably the most influential architect of the twentieth century. The building, in many ways, initiated the hegemony of Modern Movement architecture throughout the world. But, perhaps most importantly, it was seen by much of the architectural profession as a prototype for how people should be housed in the future – with consequential major social, environmental and urban impacts. This paper examines the background of the design and describes the construction in detail. It also comments critically on the building's suitability as a model for mass housing, revealing the extent of its various functional failings that have not, as far as the author is aware, previously been exposed

Exploring Data in Virtual Reality: Comparisons with 2D Data Visualizations

© 2018 Copyright is held by the owner/author(s). Virtual Reality (VR) has often been discussed as a promising medium for immersive data visualization and exploration. However, few studies have evaluated users’ open-ended exploration of multi-dimensional datasets using VR and compared the results with that of traditional (2D) visualizations. Using a workload- and insight-based evaluation methodology, we conducted a user study to perform such a comparison. We find that there is no overall task-workload dierence between traditional visualizations and visualizations in VR, but there are dierences in the accuracy and depth of insights that users gain. Our results also suggest that users feel more satisfied and successful when using VR data exploration tools, thus demonstrating the potential of VR as an engaging medium for visual data analytics

Graphic Interlude

This graphic interlude features a selection of pictures which can illustrate the topic of this issue: “Are you Game?”.Cet interlude iconographique comporte une sélection d’images illustrant à leur manière le thème de ce numéro: « Êtes-vous prêt(e) à jouer ? »

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.

Funder: Allergan Incorporated (now AbbVie)INTRODUCTION: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer's disease (AD) on background donepezil 10 mg/day. METHODS: A randomized, double-blind, placebo-controlled 4-week safety study of HTL0018318 with up-titration and maintenance phases, observing exploratory effects on electrophysiological biomarkers and cognition. RESULTS: Treatment-emergent adverse events (TEAEs) were mild and less frequently reported during maintenance versus titration. Headache was most commonly reported (7-21%); 0 to 13% reported cholinergic TEAEs (abdominal pain, diarrhea, fatigue, nausea) and two patients discontinued due to TEAEs. At 1 to 2 hours post-dose, HTL0018318-related mean maximum elevations in systolic and diastolic blood pressure of 5 to 10 mmHg above placebo were observed during up-titration but not maintenance. Postive effects of HTL0018318 were found on specific attention and memory endpoints. DISCUSSION: HTL0018318 was well tolerated in mild-to-moderate AD patients and showed positive effects on attention and episodic memory on top of therapeutic doses of donepezil

The Anatomy of Memory Politics: A Formalist Analysis of Tate Britain’s ‘Artist and Empire’ and the Struggle over Britain’s Imperial Past

In this paper, I propose a new approach for understanding the meaning of memory politics, which draws upon the archetypal literary criticism of Northrop Frye. I suggest that the four archetypes elaborated by Frye—comedy, romance, tragedy, and satire—can be used as a heuristic device for interpreting the contested historical narratives that are associated with the politics of memory. I illustrate this approach through a case-study of Artists and Empire: Facing Britain’s Imperial Past, an exhibition held at Tate Britain in 2016, amidst increasing contestation over the meaning of the British Empire. In sum, I find that the exhibit narrated Britain’s imperial past as a comedy, in which a key theme was the progressive cultural mixing of the British and the people they colonized. To conclude, I discuss the implications of such a narrative for constructing an inclusive, postcolonial British identity. As an alternative, I draw on Aristotle to suggest that a tragic narrative would have been more propitious