Sediment transport on the inner shelf off Khao Lak (Andaman Sea, Thailand) during the 2004 Indian Ocean tsunami and former storm events: evidence from foraminiferal transfer functions

We have investigated the benthic foraminiferal fauna from sediment event layers associated with the 2004 Indian Ocean tsunami and former storms that have been retrieved in short sediment cores from offshore environments of the Andaman Sea, off Khao Lak, western Thailand. Species composition and test preservation of the benthic foraminiferal faunas exhibit pronounced changes across the studied sections and provide information on the depositional history of the tsunami layer, particularly on the source water depth of the displaced foraminiferal tests. In order to obtain accurate bathymetric information on sediment provenance, we have mapped the distribution of modern faunas in non-tsunamigenic surface sediments and created a calibration data set for the development of a transfer function. Our quantitative reconstructions revealed that the resuspension of sediment particles by the tsunami wave was restricted to a maximum water depth of approximately 20 m. Similar values were obtained for former storm events, thus impeding an easy distinction of different high-energy events

Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: The MARCIE Trial

<p>Abstract</p> <p>Background</p> <p>Treatment standard for patients with atypical or anaplastic meningioma is neurosurgical resection. With this approach, local control ranges between 50% and 70%, depending on resection status. A series or smaller studies has shown that postoperative radiotherapy in this patient population can increase progression-free survival, which translates into increased overall survival. However, meningiomas are known to be radioresistant tumors, and radiation doses of 60 Gy or higher have been shown to be necessary for tumor control.</p> <p>Carbon ions offer physical and biological characteristics. Due to their inverted dose profile and the high local dose deposition within the Bragg peak precise dose application and sparing of normal tissue is possible. Moreover, in comparison to photons, carbon ions offer an increased relative biological effectiveness (RBE), which can be calculated between 2 and 5 depending on the cell line as well as the endpoint analyzed.</p> <p>First data obtained within the Phase I/II trial performed at GSI in Darmstadt on carbon ion radiotherapy for patients with high-risk meningiomas has shown safety, and treatment results are promising.</p> <p>Methods/design</p> <p>The Phase II-MARCIE-Study will evaluate a carbon ion boost applied to the macroscopic tumor in conjunction with photon radiotherapy in patients with atypical menigiomas after incomplete resection or biopsy.</p> <p>Primary endpoint is progression-free survival, secondary endpoints are overall survival, safety and toxicity.</p> <p>Discussion</p> <p>Based on published data on the treatment of atypical meningiomas with carbon ions at GSI, the present study will evaluate this treatment concept in a larger patient population and will compare outcome to current standard photon treatment.</p> <p>Trial registration</p> <p>NCT01166321</p

Radiation techniques for acromegaly

Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatment, especially high rates of hypopituitarism. Stereotactic radiotherapy has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. Radiation can be delivered in a single fraction by stereotactic radiosurgery (SRS) or as fractionated stereotactic radiotherapy (FSRT) in which smaller doses are delivered over 5-6 weeks in 25-30 treatments. A review of the recent literature suggests that pituitary irradiation is an effective treatment for acromegaly. Stereotactic techniques for GH-secreting pituitary tumors are discussed with the aim to define the efficacy and potential adverse effects of each of these techniques

Applicability of transfer functions for relative sea-level reconstructions in the southern North Sea coastal region based on salt-marsh foraminifera

We studied the foraminiferal distribution in two naturally grown salt marshes from the southern North Sea with respect to the tidal frame, salinity, grain size and pH. The salt marshes are situated on the landward sides of the islands of Sylt (Rantum, Germany) and Fanø (Sønderho, Denmark). In both study areas, foraminifera have a vertical distribution with respect to water level, but also show inter-site variability, which can be related to environmental differences (e.g., in salinity and pH) and different flooding dynamics of the coastal salt marsh (Rantum) and the tidal-creek salt marsh (Sønderho). We developed different transfer functions, based on the widely applied standardized water level index (SWLI) approach and on three flooding parameters (duration of submergence (DoS), mean submergence time (MST), and flooding frequency (FF)), in order to assess their predictive ability for relative sea-level estimates for the southern North Sea coastal region. The water-level data used for these approaches are determined based on local water-level conditions, corrected for tidal distortions using water-level measurements for the Sønderho salt marsh and the Rantum tide gauge. The SWLI approach shows a precision (root mean squared error of prediction (RMSEP) of 0.23m), which is around 15 of the tidal range. All three flooding approaches show comparable results at around mean tide level to mean high water, while at higher elevations, foraminiferal distribution becomes non-linearly correlated to flooding parameters resulting in lower precision of >1.0m. Our results suggest that the SWLI approach performs well and that the flooding approaches offer a suitable addition for assessing relative sea-level estimates in the North Sea region. We enhanced the knowledge on changing precision for tide level reconstructions along the elevational gradient in a storm dominated tidal area where elevation and flooding parameters are non-linear correlated

Health, migration and the 2030 agenda for sustainable development

The Marine Isotope Stage (MIS) 11 (424–374 ka) was characterized by a protracted deglaciation and an unusually long climatic optimum. It remains unclear to what degree the climate development during this interglacial reflects the unusually weak orbital forcing or greenhouse gas trends. Previously, arguments about the duration and timing of the MIS11 climatic optimum and about the pace of the deglacial warming were based on a small number of key records, which appear to show regional differences. In order to obtain a global signal of climate evolution during MIS11, we compiled a database of 78 sea surface temperature (SST) records from 57 sites spanning MIS11, aligned these individually on the basis of benthic (N = 28) or planktonic (N = 31) stable oxygen isotope curves to a common time frame and subjected 48 of them to an empirical orthogonal function (EOF) analysis. The analysis revealed a high commonality among all records, with the principal SST trend explaining almost 49% of the variability. This trend indicates that on the global scale, the surface ocean underwent rapid deglacial warming during Termination V, in pace with carbon dioxide rise, followed by a broad SST optimum centered at ~410 kyr. The second EOF, which explained ~18% of the variability, revealed the existence of a different SST trend, characterized by a delayed onset of the temperature optimum during MIS11 at ~398 kyr, followed by a prolonged warm period lasting beyond 380 kyr. This trend is most consistently manifested in the mid-latitude North Atlantic and Mediterranean Sea and is here attributed to the strength of the Atlantic meridional overturning circulation. A sensitivity analysis indicates that these results are robust to record selection and to age-model uncertainties of up to 3–6 kyr, but more sensitive to SST seasonal attribution and SST uncertainties >1 °C. In order to validate the CCSM3 (Community Climate System Model, version 3) predictive potential, the annual and seasonal SST anomalies recorded in a total of 74 proxy records were compared with runs for three time slices representing orbital configuration extremes during the peak interglacial of MIS11. The modeled SST anomalies are characterized by a significantly lower variance compared to the reconstructions. Nevertheless, significant correlations between proxy and model data are found in comparisons on the seasonal basis, indicating that the model captures part of the long-term variability induced by astronomical forcing, which appears to have left a detectable signature in SST trends