Dimethyl 2-(amino­methyl­ene)malonate

In the title compound, C6H9NO4, which is an example of a push–pull alkene, N—H⋯O inter­actions stabilize the crystal structure

Reachability analysis for timed automata using max-plus algebra

International audienceWe show that max-plus polyhedra are usable as a data structure in reachability analysis of timed automata. Drawing inspiration from the extensive work that has been done on difference bound matrices, as well as previous work on max-plus polyhedra in other areas, we develop the algorithms needed to perform forward and backward reachability analysis using max-plus polyhedra. To show that the approach works in practice and theory alike, we have created a proof-of-concept implementation on top of the model checker opaal

Documenting and harnessing the biological potential of molecules in Distributed Drug Discovery (D3) virtual catalogs

Virtual molecular catalogs have limited utility if member compounds are (i) difficult to synthesize or (ii) unlikely to have biological activity. The Distributed Drug Discovery (D3) program addresses the synthesis challenge by providing scientists with a free virtual D3 catalog of 73,024 easy-to-synthesize N-acyl unnatural α-amino acids, their methyl esters, and primary amides. The remaining challenge is to document and exploit the bioactivity potential of these compounds. In the current work, a search process is described that retrospectively identifies all virtual D3 compounds classified as bioactive hits in PubChem-cataloged experimental assays. The results provide insight into the broad range of drug-target classes amenable to inhibition and/or agonism by D3-accessible molecules. To encourage computer-aided drug discovery centered on these compounds, a publicly available virtual database of D3 molecules prepared for use with popular computer docking programs is also presented

Successful Integration of Distributed Drug Discovery (D3) Components: Computational, Synthetic, and Biological Evaluation of Phenylalanine Derivatives as Potential Biofilm Inhibitors

poster abstractDistributed Drug Discovery (D3) is a multidisciplinary approach to identifying molecules that exhibit activity in the treatment of neglected diseases such as malaria, leishmaniasis, and tuberculosis as well as recalcitrant cystic fibrosis (CF) airway infections. D3 seeks to accomplish this task by combining computational chemistry, synthetic chemistry, and biological screening all within an educational framework. Recent reports suggest that D-amino acids are effective in the disassembly and inhibition of bacterial biofilms, which are important for a number of bacterial infections, including those in the CF lung. Utilizing chemical drawing software, we constructed (enumerated) target phenylalanine derivatives from commercially available benzyl halides by substitution at the α position of an amino acid scaffold. A subset of these enumerated molecules was computationally selected for synthesis based on chemical properties. These compounds were synthesized using simple, solid-phase techniques in an undergraduate organic chemistry laboratory class. The resulting racemic unnatural amino acid derivatives were then screened for activity in a biofilm assay. The results show biofilm inhibition with synthesized phenylalanine derivatives. Analysis of the results reveals a trend between lipophilicity and the degree of biofilm inhibition. These new molecules may lead to an avenue for therapy for those CF individuals suffering with bacterial lung infection. As a part of the undergraduate curriculum, this work provides the first example of D3-linked undergraduate student computational analysis, synthesis, and biological evaluation

Labour Risk Assessment for the Ltd Company, Siemens s.r.o., elektromotory Frenštát pod Radhoštěm

Import 04/07/2011Bakalářská práce se zabývá hodnocením pracovních rizik ve firmě Siemens, s.r.o., odštěpný závod Elektromotory Frenštát pod Radhoštěm. Pojednává o povinnostech zaměstnavatele vyplývajících z legislativy v oblasti bezpečnosti práce a analyzuje pracovní rizika a pracovní úrazovost tohoto závodu. Úvod práce je věnován charakteristice podniku a legislativě v oblasti bezpečnosti práce, následují statistické analýzy pracovních úrazů, rozbor jejich zdrojů a příčin. Nakonec zjistíme, ve kterých útvarech se vyskytují úrazy nejčastěji a ve vyhodnocení se u nich zaměřím na konkrétní rizika ovlivňující výkon práce u jednotlivých pracovních činností a poukážu na základní bezpečnostní opatření. Cílem této práce je zhodnocení pracovních rizik a zjištění jejich vlivu na pracovní úrazovost v závodě.The bachelor thesis makes assessment of occupational hazards in the electromotor factory Frenštát pod Radhoštěm, the branch of Siemens Ltd Company. Deals with work safety legislative duties of employer and analyses occupational hazards and work injuries in the factory. The introduction includes characteristics of the factory and is focused on work safety legislative. In other parts are statistical analyses of work injuries and their sources in details. In the final part we will find out which sector of production process has the most work injuries with their concrete hazards and impact on production. Obviously will make some propose of basic safety devices. The main goal of the thesis is assessment of occupational hazards and finding out their influence on work injuries in the factory.Prezenční545 - Institut ekonomiky a systémů řízenívýborn

IR síťové zařízení pro spojení PC

Import 20/09/2006Prezenční456 - Katedra informatik

Konfigurovatelný přijímač IR signálu dálkových ovladačů

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Fakulta elektrotechniky a informatiky. Katedra (456) informatik

Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism

Activated enol ethers derived from esters or the dinitrile of malonic acid, or from pentane-2,4-dione were treated with hydrazine hydrate. The structures of the obtained products – pyrazoles 5 – were studied with a focus on tautomerism and supramolecular structure. A reverse addition of the reagents led to the isolation of two novel products, namely bis-enehydrazines 6 with an unsymmetrical arrangement of the formally equivalent subunits