65 research outputs found
Will the recently approved LARES mission be able to measure the Lense-Thirring effect at 1%?
After the approval by the Italian Space Agency of the LARES satellite, which
should be launched at the end of 2009 with a VEGA rocket and whose claimed goal
is a about 1% measurement of the general relativistic gravitomagnetic
Lense-Thirring effect in the gravitational field of the spinning Earth, it is
of the utmost importance to reliably assess the total realistic accuracy that
can be reached by such a mission. The observable is a linear combination of the
nodes of the existing LAGEOS and LAGEOS II satellites and of LARES able to
cancel out the impact of the first two even zonal harmonic coefficients of the
multipolar expansion of the classical part of the terrestrial gravitational
potential representing a major source of systematic error. While LAGEOS and
LAGEOS II fly at altitudes of about 6000 km, LARES will be placed at an
altitude of 1450 km. Thus, it will be sensitive to much more even zonals than
LAGEOS and LAGEOS II. Their corrupting impact \delta\mu has been evaluated by
using the standard Kaula's approach up to degree L=70 along with the sigmas of
the covariance matrices of eight different global gravity solutions
(EIGEN-GRACE02S, EIGEN-CG03C, GGM02S, GGM03S, JEM01-RL03B, ITG-Grace02s,
ITG-Grace03, EGM2008) obtained by five institutions (GFZ, CSR, JPL, IGG, NGA)
with different techniques from long data sets of the dedicated GRACE mission.
It turns out \delta\mu about 100-1000% of the Lense-Thirring effect. An
improvement of 2-3 orders of magnitude in the determination of the high degree
even zonals would be required to constrain the bias to about 1-10%.Comment: Latex, 15 pages, 1 table, no figures. Final version matching the
published one in General Relativity and Gravitation (GRG
Phenomenology of the Lense-Thirring effect in the Solar System
Recent years have seen increasing efforts to directly measure some aspects of
the general relativistic gravitomagnetic interaction in several astronomical
scenarios in the solar system. After briefly overviewing the concept of
gravitomagnetism from a theoretical point of view, we review the performed or
proposed attempts to detect the Lense-Thirring effect affecting the orbital
motions of natural and artificial bodies in the gravitational fields of the
Sun, Earth, Mars and Jupiter. In particular, we will focus on the evaluation of
the impact of several sources of systematic uncertainties of dynamical origin
to realistically elucidate the present and future perspectives in directly
measuring such an elusive relativistic effect.Comment: LaTex, 51 pages, 14 figures, 22 tables. Invited review, to appear in
Astrophysics and Space Science (ApSS). Some uncited references in the text
now correctly quoted. One reference added. A footnote adde
An Assessment of the Systematic Uncertainty in Present and Future Tests of the Lense-Thirring Effect with Satellite Laser Ranging
We deal with the attempts to measure the Lense-Thirring effect with the
Satellite Laser Ranging (SLR) technique applied to the existing LAGEOS and
LAGEOS II terrestrial satellites and to the recently approved LARES
spacecraft.The first issue addressed here is: are the so far published
evaluations of the systematic uncertainty induced by the bad knowledge of the
even zonal harmonic coefficients J_L of the multipolar expansion of the Earth's
geopotential reliable and realistic?
Our answer is negative. Indeed, if the differences Delta J_L among the even
zonals estimated in different Earth's gravity field global solutions from the
dedicated GRACE mission are assumed for the uncertainties delta J_L instead of
using their covariance sigmas sigma_JL, it turns out that the systematic
uncertainty \delta\mu in the Lense-Thirring test with the nodes Omega of LAGEOS
and LAGEOS II may be up to 3 to 4 times larger than in the evaluations so far
published () based on the use of the sigmas of one model at a time
separately. The second issue consists of the possibility of using a different
approach in extracting the relativistic signature of interest from the
LAGEOS-type data. The third issue is the possibility of reaching a realistic
total accuracy of 1% with LAGEOS, LAGEOS II and LARES, which should be launched
in November 2009 with a VEGA rocket. While LAGEOS and LAGEOS II fly at
altitudes of about 6000 km, LARES will be likely placed at an altitude of 1450
km. Thus, it will be sensitive to much more even zonals than LAGEOS and LAGEOS
II. Their corrupting impact has been evaluated with the standard Kaula's
approach up to degree L=60 by using Delta J_L and sigma_JL; it turns out that
it may be as large as some tens percent.Comment: LaTex, 19 pages, 1 figure, 12 tables. Invited and refereed
contribution to The ISSI Workshop, 6-10 October 2008, on The Nature of
Gravity Confronting Theory and Experiment in Space To appear in Space Science
Review
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P<5 × 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease
Cosmic Dynamics in Gravity
In this paper we consider FRW cosmology in gravity. It is shown
that in particular cases the bouncing behavior may appears in the model whereas
the equation of state (EoS) parameter may crosses the phantom divider. For the
dynamical universe, quantitatively we also find parameters in the model which
satisfies two independent tests:the model independent Cosmological Redshift
Drift (CRD) test and the type Ia supernova luminosity distances.Comment: 15 pages, 12 figure
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation
Improving Genetic Prediction by Leveraging Genetic Correlations Among Human Diseases and Traits
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published genome-wide association study (GWAS) summary statistics across many different traits. We apply this framework to predict risk of schizophrenia and bipolar disorder in the Psychiatric Genomics consortium data, finding substantial heterogeneity in prediction accuracy increases across cohorts. For six additional phenotypes in the UK Biobank data, we find increases in prediction accuracy ranging from 0.7 for height to 47 for type 2 diabetes, when using a multi-trait predictor that combines published summary statistics from multiple traits, as compared to a predictor based only on one trait. © 2018 The Author(s)
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