Reconstruction of boundary controls in parabolic systems

In the paper, an inverse dynamic problem is considered. It consists in reconstructing a priori unknown boundary controls in dynamical systems described by boundary value problems for partial differential equations of parabolic type. The source information for solving the inverse problem is the results of approximate measurements of the states of the observed system's motion. The problem is solved in the static case; i. e., to solve it, we use all the measurement data accumulated during some specified observation interval. The problem under consideration is ill-posed. To solve it, we propose the Tikhonov method with a stabilizer containing the sum of the mean-square norm and total time variation of the control. The use of such nondifferentiable stabilizer allows us to obtain more precise results than the approximation of the desired control in the Lebesgue spaces. In particular, this method provides the pointwise and piecewise uniform convergences of regularized approximations and makes possible the numerical reconstruction of the subtle structure of the desired control. In the paper, the subgradient projection method for obtaining a minimizing sequence for the Tikhonov functional is described and substantiated. Also, we demonstrate the two-stage finitedimensional approximation of the problem and present the results of numerical simulation. © 2013 Pleiades Publishing, Ltd

Assessment of the recreational potential of the forest territory of the Sverdlovsk region

The purpose of this study is to present our vision of assessing the recreational potential of the territory (RPT) for its effective management. We suggest using this territory assessment method, which consists of two main stages: assessment of the recreational component of the natural environment and assessment of the necessary amount of investment to use the recreational biodiversity of the territories.The article analyzes the approaches and presents the results of a comprehensive assessment of the recreational potential of the forest lands of the Sverdlovsk region. Created a map ranking the Sverdlovsk region according to the results of research with application for developing a comprehensive assessment of RPT on the methods, developed on the basis of the theory of "games with nature": the method of structured comparison of RPT on the Hurwitz criterion, aspiring to the maximum and to identify the factors dominating the impact from the application of the Wald criterion. Based on the conducted research on the analysis of the influence of forests on the formation of recreational characteristics, the authors obtained weighted average generalized coefficients of recreational attractiveness of forests of different types in the forest management areas of the Sverdlovsk region and identified 10 forest-cadastre areas in the Sverdlovsk region. This paper also presents a developed and tested method for a comprehensive assessment of the recreational potential of forest lands in the territory of the Sverdlovsk region in order to attract investment. Preliminary investment volumes for the development of the Sverdlovsk region's RPT (based on the cost of forest biodiversity) are presented. We consider the proposed territory ranking to be a necessary indicator for effective management of the subject's territories. © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Common

TOPICAL ISSUES OF ESTIMATION OF COST OF THE CAPITAL OF THE ENTERPRISE AND ITS BASIC ELEMENTS

Article is devoted to a complex research of perspective growth of market capitalization of innovatively active enterprise by formation and implementation of his competitive development strategy. As the main criterion for evaluation of market value of the capital of the enterprise authors offer to use its average cost. Following the results of the conducted research the conclusion is drawn that when forming competitive strategy of innovatively active enterprise it is extremely important to provide an optimum ratio of dynamics of development of separate components of the capital

TOPICAL ISSUES OF ESTIMATION OF COST OF THE CAPITAL OF THE ENTERPRISE AND ITS BASIC ELEMENTS

Article is devoted to a complex research of perspective growth of market capitalization of innovatively active enterprise by formation and implementation of his competitive development strategy. As the main criterion for evaluation of market value of the capital of the enterprise authors offer to use its average cost. Following the results of the conducted research the conclusion is drawn that when forming competitive strategy of innovatively active enterprise it is extremely important to provide an optimum ratio of dynamics of development of separate components of the capital

Justification of the program therapy of acute hepatitis C

Treatment of acute hepatitis C remains one of the main problems of modern hepatology. There are many variants of treatment, but there is no common opinion about scheme and time of onset of the therapy. From the other hand, early treatment can prevent chronisation in more than 70% of cases. Specific therapy was used 135 patients with acute hepatitis C aged from 16 to 52 years (26,5+0,7 years). Our analysis has shown, that its better to start specific therapy on the second month of the disease with -interferon monotherapy by induction scheme

Metaphorization of space in a scientific text

The metaphorical sections of the Russian sub-systems and typical models of the semantic derivation in the scientific text are analysed. The scientific metaphor is viewed as an epistemic phenomenon. The cognitive approach lets comprehend the semantic of the space as a language embodiment of the world model which exists in the Russian speakers’ consciousness and expressed by a system of metaphorical nominations. The two concepts of space are introduced on the basis of which the semantic classes “space-container” and “space-construction” are singled out. These classes include several groups which are characterised by the difference of the space relations in the initial meaning and the created metaphorical images. The author analyses the lexical units which are regularly employed for the metaphorical formation of terms. The space meaning of these lexical units becomes the motivation ground for the nomination of the non-space sphere phenomena. The role of the metaphorical transfer axiological components is shown. This role is determined by the reinterpretation of the objects’ spatial characteristics.В статье анализируются метафорические участки русских терминосистем и типовые модели семантической деривации в научном тексте. Научная метафора рассматривается как гносеологический феномен. Когнитивный подход позволяет осмыслить семантику пространства как языковое воплощение модели мира, существующую в сознании носителей русского языка и выраженную системой метафорических номинаций. Представлены две концепции пространства, на основе которых выделены семантические классы «пространство-вместилище» и «пространство-конструкт», включающие ряд групп, характеризующихся различиями пространственных отношений в исходном значении и создаваемых метафорических образах. Проанализированы регулярно задействованные в процессах метафорического терминообразования лексические единицы, пространственное значение которых становится мотивационной основой для номинации явлений непространственной сферы. Показана роль аксиологических компонентов метафорического переноса, обусловленного переосмыслением пространственных характеристик объектов

The Semantic Subject in Russian Impersonal Sentences

The article is relevant because of the semantic ambiguity in the interpretation of impersonal sentences in Russian, and the diverse approaches to categorizing the subject. The object of the analysis is the semanticsubject of an utterance as a property of the predicate.В статье рассматривается семантическая специфика русских безличных предложений

In situ characterization of main reaction products in alkali-activated slag materials by Confocal Raman Microscopy

The re-use of different aluminosilicates, such as blast furnace slag, in the preparation of alternative binders (alkali-activated materials) to Portland cement materials is well document and evaluated by conventional techniques. The use of XRD, FTIR and TG techniques allows obtaining information about the hydration products formed under the conditions of alkaline activation. The formation of the main reaction product (C-A-S-H gel), due to its low crystallinity, is not easily stablished by XRD or FTIR, and it is also quite complex to obtain quantitative information. Confocal Raman Microscopy (CRM) technique reveals information of each of the present phases during the slag activation and in particular. Moreover, CRM provide the evolution of C-A-S-H gel confirming that the growth of the C-A-S-H gel in activate alkaline-systems is different from that an Ordinary Portland Cement system. C-A-S-H gel grows randomly in the regions rich in calcium and silicon. The use of CRM opens a new possibility for the in situ study of complex systems such as the activation of alkali-activated or geopolymers in the search for alternative materials to Portland cement.This work was supported by the Spanish Ministry of Economy and Competitiveness through the Project MAT-2017-86450-C4-1-R and Spanish National Research Council Project NANOMIND 201560E068. Dr. M. Torres-Carrasco is also indebted to MINECO for a postdoctoral fellowship "Juan de la Cierva-Formación" (ref: FJCI-2016-28488). In addition, O. Mikhailova enjoyed a pre-doctoral fellowship with specific junior project FAST-J-18-5568 from the Brno University of Technology (Czech Republic) for internship in Spain

COMPARISON OF COLORIMETRIC AND CHEMILUMINESCENT ELISA TESTS FOR DETECTION OF IgG ANTIBODIES TO HUMAN EPO IN THE SERA OF EXPERIMENTAL ANIMALS

Production of antibodies to erythropoietin-stimulating drugs is an important problem of therapy with recombinant human erythropoietin (EPO). It leads to changes in the pharmacokinetic profile and decreased therapeutic efficiency. Upon long-term treatment with EPO preparations, neutralizing antibodies can result in rare cases, thus leading to complete pure red cell aplasia. Hence, detection of antibodies to EPO is an important stage in the assessment of the drug immunogenicity in preclinical and clinical studies, as well as during the treatment with EPO. We have compared colorimetric and chemiluminescent ELISA tests for detection of IgG antibodies to human EPO with 3,3’,5,5’-tetramethylbenzidine – hydrogen peroxide and luminol -hydrogen peroxide detection systems, respectively. Аntibodies to human EPO were determined in blood serum samples of experimental animals, i.e., rabbits and guinea pigs following their immunization withdifferent doses of pegylated human recombinant EPO-beta subcutaneously or intravenously. The affinitypurified rabbit polyclonal antibodies to human EPO were used as a reference material. The effects of hydrogen peroxide and luminol concentrations upon sensitivity of a chemiluminescent method were also studied. We have shown a 1.5-2-fold increase in sensitivity when using 4-iodophenol for amplification of chemiluminescence. A comparison of the chemiluminescence intensity with time has demonstrated a better stability for the substrate mixture prepared on borate buffer. A decrease in chemiluminescence signal with time was proportional to the decrease in background signal, thus rendering stability of the signal/background ratio for 3 to 30 minutes. Due to optimizing the substrate mixture composition and conditions of chemiluminescence recording, the reached detection limits for colorimetric and chemiluminescent ELISA’s were, respectively, 0.6 ng/ml and 0.08 ng/ml. The measurement range was extended by more than 20 times for chemiluminescent ELISA. The chemiluminescent ELISA for anti-erythropoietin antibody detection showed a 1.9 to 2.6-fold increase in sensitivity for rabbit serum, and 1.8 to 8.9-fold for guinea pigs serum. Good correlation of results was found for quantitative detection of antibodies in rabbit sera using the two methods (R = 0.981). Thus, chemiluminescent ELISA allowed develop a more sensitive detection technique of IgG antibodies to human erythropoietin

Power spectrum features of the near-Earth atmospheric electric field in Kamchatka

Power spectrum of the diurnal variations of the quasi-electrostatic field Ez in the near-Earth atmosphere have been presented for the first time. The Ez power spectrum variations in the period of fine weather have been shown to exhibit two bands of the periods of natural atmospheric oscillations with T = 1-5 and 6-24 h. These oscillations are the modes of the internal gravity and tidal waves in the lower atmosphere. On the days under atmospheric precipitation, the spectral power of Ez increases by an order of magnitude. During the pre-earthquake period, when the diurnal Ez variation had an anomaly, the intensity of harmonics with T = 1.8, 2.2, and 3.8 h increased by an order of magnitude or more in comparison with the Ez spectra in fine weather. Two additional spectral bands with T = 0.6 and 1 h have appeared simultaneously