Prospectus, May 13, 1974

CLASS OF \u2774 COMMENCEMENT; Openhouse Set For May 19; 648 Parkland Students Eligible To Participate; Dr. Winters To Speak At Graduation; Parkland Groups Win Awards At Jazz Fest; StuGo President Offers Welcome; Dental Students Capped At Banquet; The Short Circuit; Letters To The Editor; New Stu-Go Officer; President\u27s Report; Crosswords; Parkland College Student Life; Instructional Programs; Admission: Who may Enroll?; Tuition & Fees; Financial Aid; Counseling; Placement; Veterans; Student Life; Summer Session 1974; Academic Calendar 1974-1975; Semester System Fall 1975; In Campus Design, Parkland: Not Just Another School; No Golden Quill This Quarter; Petitioned and Qualified Candidates Spring Quarter 1973-1974; One-Punch Leads To Death Of UI Student; Movie Projector Reported Missing; A Column By and For Women; A Column By and For Men; Self-Help Clinic Set For Women; Vet\u27s Corner; Field Trip Meeting Set; Pig Guards Pot Plot From Police Raid; Blood Drive; Summer Field Course In American Southwest; P/C Student Wins Distinguished Award; Allerton Day Shows Ecological Benefits Of Park; Debate Team Finishes Best Year Ever; Monday\u27s Coach; Thank You; High-Scoring Henrichs Opts For Parkland Cage Team; Parkland Coaches Review Year; Cobras Bat Way Over .500; P/C Players Thrill Audience; Bartow On His Way; Pritchett Not To Be Outdone; On The Way Out; Classified Ads; End-Of-Year Gala Planned By Phys Ed. Dept.; Social, Religious Traditions Expressed In Roots Afrikana; Jones Cites Improvements In Prospectus; Prospectus Staff Positions Open For New School Year; Business Student Wins Award; Krannert Art Schedule; Many Financial Awards Open To Incoming Parkland Students; Parkland Vets Info Center On Wheelshttps://spark.parkland.edu/prospectus_1974/1012/thumbnail.jp

Prospectus, May 6, 1974

KAREN COLEMAN ELECTED NEW STU-GO PRES; Gallup Explains Effect Of Polls; Parkland Debate Team Ends Year At Nationals; All Races Close Despite Poor Voter Turnout; Enthusiam Abounds At IOC Spring Carnival; IE Team Winds-Up Season With Good National Showing; Parkland College Foundation Officers Selected At Meeting; Cruisin\u27 \u2774; Letter To The Editor; The Short Circuit; Let\u27s Go To The Bars; IVC New Service Officer, Menaugh; Vet\u27s Corner; Monday\u27s Coach; Cobras Win One, Lose Three In Double-Header; Parkland Athlete Randy Williams Looks Over Schools; I/M Tryouts Now For And Tennis Track, Golf; Amana Commune, A Lifestyle From A Dream; Pulitzer Prize Poet To Appear At Parkland; Library Hours During Exam Week; A Column By and For Women; National Women\u27s Music Festival; Crosswords; Student Raffle; President\u27s Report; Registration Info For Fall, 1974 Available To Students Now; Happy Birthday; Classified Ads; Parkland Players To Present Play; Recycle Paper; Wainwright Captures Audience With Real Life Situations; American Odyssey; Parkland Events; Final Exam Schedule - Spring Quarter, 1973-1974; Sangamon State Representative; Krannert Art Schedulehttps://spark.parkland.edu/prospectus_1974/1013/thumbnail.jp

Prospectus, October 12, 1973

AGNEW RESIGNS VICE-PRESIDENCY; Small Turnout For Election; Prospectus Editors Announced; Walk Attracts Over 600; All Amendments Pass; Prospectus In Perspective: Excellent Bike Path Choice, Letters From Our Readers, New Magazine Coming, At this point in time.....; The Short Circuit; Drama Department Introduces New Lounge Theatre; United Way Campaign Begins; Announces $19,290 Bog Award; Ieardi Headlines Talent Program; Road Rally Club; New Breed of Businessman: Young College Graduate; Student Appointed As Board Member; New Concept For P/C Typing Classes; New Name, Faces For Magazine; Parkland Team To Debate At Bradley Oct. 20; Parkland Instructor Hospitalized at Mercy; PCA Appoints Student Affairs Committee Members; C-U Politics To Be Discussed At Forum; Walk For Mankind; Parkland Announces Bike Rules; Student Senate Reviews Charters, Future Plans; Gayle Wright Chosen To Advise Capstone; Vet\u27s Outreach Aids Readjustment; Prospectus Gains Two Campus Cartoonists; Seminar Planned On \u27Volunteering\u27; P/C Biologists At IACCB Convention; \u27Siege\u27 Shocking, Relevant Film; Faculty Members To Hold Offices; Winter Registration Information; Parkland Student Wins Santa Fe Scholarship; Birthday Wishes; Pre-Registration Benefits All; Target Program To Sponsor Open House; Women Voters Begin Sale Of ERA Bracelet; Ferlinghetti Sues San Francisco Police; Applications Must Be Filed; A Column By And For Women: Born To Be A Woman, The Way It Used To Be, The Lib, I Am Woman; Mutt and Mortie; Fast Freddy\u27s Football Forecast; Fall Intramural; Bowling Bulletin Board; Football Results; Dennis Bailen Wins Fast Freddy; Monday\u27s Coach; Rugby Play Not Football; Harriers Slump To Third, Fourth; Hiser Receives Babe Ruth Award; Graduation; TARGET Sets Sights On Juveniles; Classified Ads; Johnson Calls For Truth, Integrity; Gammon: \u27Everyone Born With Ability\u27; Student President\u27s Report; Lives Changed By Jesus Christ; Cruisin\u27 \u2773; Candidates Learn Voting Procedure; Speleunkers Travel Virgin Paths; Krannert Art Center Schedule; Illini Student Union Movies; Lab Develops Self-Study Habits; Callboard; Race To Fund Town With Doctor; Council Member Proposes Later Bar Hourshttps://spark.parkland.edu/prospectus_1973/1004/thumbnail.jp

Prospectus, April 29, 1974

STUDENTS SEEK GOVERNMENT POSTS; 14 Candidates Run For Major Stu-Go Positions; College Construction Nearing Completion; I.O.C. Sponsors Spring Carnival; Cruisin\u27 \u2774; President\u27s Report; Raines To Speak On Education; Parkland\u27s New School Fight Song; P/C Sponsors Festival Of Foreign Films; A Film For The Times; Doobie\u27s Latest Disappointing; A Column By and For Women; Going Back To Work; Hypertension Screening Tests May 6; Candidates\u27 Platforms; Let\u27s Go To The Bars; Fire Destroys Campus Building; Monday\u27s Coach; IM Department Still Scheduling Sports Events; Give The Girls A Break; Parkland College Baseball (Tentative 1974 Scehdule); Bowling Bulletin Board; Cobra Statistics Reveal Good Odds; Classified Ads; Prepare For Graduation; Graduation Calendar Events; Cobra Tracksters Run To Second At Harper Meet; Crosswords; Parkland Events; Krannert Art Schedule; P/C Jazz Band To Perform In J/C Competition; Committee Announced Special Day; SCI Plans Symposium; Attention E. I. U. Transfer Students; Mime Group Performs Visual Composition; Blood Bank I.D. Cards; Summer Field Course In American Southwesthttps://spark.parkland.edu/prospectus_1974/1014/thumbnail.jp

Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients

Recent developments of tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles (NFTs) deposition in human brain. Among the tau PET molecular probes, 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates over amyloid plaques, limited non-specific binding in white and gray matter, and confined off-target binding. The objectives of the study are (1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD participants; (2) to evaluate the correlations between cerebrospinal fluid (CSF) biomarkers or Mini-Mental State Examination (MMSE) and 18F-AV1451 PET standardized uptake value ratio (SUVR); and (3) to evaluate the partial volume effects on 18F-AV1451 brain uptake.Methods: The study included total 115 participants (CN = 49, MCI = 58, and AD = 8) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. A reblurred Van Cittertiteration method was used for voxelwise partial volume correction (PVC) on PET images. Structural MRIs were used for PET spatial normalization and region of interest (ROI) definition in standard space. The parametric images of 18F-AV1451 SUVR relative to cerebellum were calculated. The ROI SUVR measurements from PVC and non-PVC SUVR images were compared. The correlation between ROI 18F-AV1451 SUVR and the measurements of MMSE, CSF total tau (t-tau), and phosphorylated tau (p-tau) were also assessed.Results:18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups (p < 0.01). Although there was an increasing tendency of 18F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18F-AV1451 deposition was found between CN and MCI brains with or without PVC (p > 0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. PVC improved the results of 18F-AV-1451 tau deposition and correlation studies in small brain regions.Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18F-AV1451 tau PET quantification

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo