A PLASIMO global model for plasma assisted CO2 conversion

Conversion of CO2 has become a major challenge of our time as it is of interest for the reduction of greenhouse gases in our atmosphere, but also to store energy thereby relieving the supply and demand discrepancy of many alternative forms of energy. Plasma assisted CO2 conversion is heavily investigated as an efficient method to achieve this goal. Numerical modeling is an important aspect of this investigation, but is difficult due to the complex chemistry. A global model has been constructed to focus on the CO2 chemistry including its vibrational kinetics. The model has been realized using the global model module of PLASIMO, a highly modular plasma modeling framework. It is based on another model\footnote{Tom\'{a}\v{s} Koz\'{a}k and Annemie Bogaerts, submitted to Plasma Sources Sci. Tech.} that was constructed using the well-established code Global\_kin. The aim of the model is therefore twofold. First, to study the chemistry and identify the most important species and reactions and perform parametric studies. The knowledge gained can be applied to other, spatially resolved models. Second, by implementing the same chemistry in the two different global model codes, a cross validation can be performed, a vital scientific process often overlooked in practice

The Identity Correspondence Problem and its Applications

In this paper we study several closely related fundamental problems for words and matrices. First, we introduce the Identity Correspondence Problem (ICP): whether a finite set of pairs of words (over a group alphabet) can generate an identity pair by a sequence of concatenations. We prove that ICP is undecidable by a reduction of Post's Correspondence Problem via several new encoding techniques. In the second part of the paper we use ICP to answer a long standing open problem concerning matrix semigroups: "Is it decidable for a finitely generated semigroup S of square integral matrices whether or not the identity matrix belongs to S?". We show that the problem is undecidable starting from dimension four even when the number of matrices in the generator is 48. From this fact, we can immediately derive that the fundamental problem of whether a finite set of matrices generates a group is also undecidable. We also answer several question for matrices over different number fields. Apart from the application to matrix problems, we believe that the Identity Correspondence Problem will also be useful in identifying new areas of undecidable problems in abstract algebra, computational questions in logic and combinatorics on words.Comment: We have made some proofs clearer and fixed an important typo from the published journal version of this article, see footnote 3 on page 1

Investigation of the Role of Mitochondrial DNA in Multiple Sclerosis Susceptibility

Several lines of evidence suggest that mitochondrial genetic factors may influence susceptibility to multiple sclerosis. To explore this hypothesis further, we re-sequenced the mitochondrial genome (mtDNA) from 159 patients with multiple sclerosis and completed a haplogroup analysis including a further 835 patients and 1,506 controls. A trend towards over-representation of super-haplogroup U was the only evidence for association with mtDNA that we identified in these samples. In a parallel analysis of nuclear encoded mitochondrial genes, we also found a trend towards association with the complex I gene, NDUFS2. These results add to the evidence suggesting that variation in mtDNA and nuclear encoded mitochondrial genes may contribute to disease susceptibility in multiple sclerosis

High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder

We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide victims. We also analysed the potential effect of STR and CNV variations, as well as the infection of the brain with neurovirulent viruses in this behavioural disorder. As a result, we have identified several candidate genes, among others three calcium channel genes that may potentially contribute to completed suicide. We also explored the potential implication of the TGF-β signalling pathway in the pathogenesis of suicidal behaviour. To our best knowledge, this is the first study that uses whole-exome sequencing for the investigation of suicide

Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications

Cancer stem cells (CSCs) are considered a subset of the bulk tumor responsible for initiating and maintaining the disease. Several surface cellular markers have been recently used to identify CSCs. Among those is CD133, which is expressed by hematopoietic progenitor cells as well as embryonic stem cells and various cancers. We have recently isolated and cultured CD133 positive [CD133(+)] cells from various cancer cell lines using a NASA developed Hydrodynamic Focusing Bioreactor (HFB) (Celdyne, Houston, TX). For comparison, another bioreactor, the rotary cell culture system (RCCS) manufactured by Synthecon (Houston, TX) was used. Both the HFB and the RCCS bioreactors simulate aspects of hypogravity. In our study, the HFB increased CD133(+) cell growth from various cell lines compared to the RCCS vessel and to normal gravity control. We observed a (+)15-fold proliferation of the CD133(+) cellular fraction with cancer cells that were cultured for 7-days at optimized conditions. The RCCS vessel instead yielded a (−)4.8-fold decrease in the CD133(+)cellular fraction respect to the HFB after 7-days of culture. Interestingly, we also found that the hypogravity environment of the HFB greatly sensitized the CD133(+) cancer cells, which are normally resistant to chemo treatment, to become susceptible to various chemotherapeutic agents, paving the way to less toxic and more effective chemotherapeutic treatment in patients. To be able to test the efficacy of cytotoxic agents in vitro prior to their use in clinical setting on cancer cells as well as on cancer stem cells may pave the way to more effective chemotherapeutic strategies in patients. This could be an important advancement in the therapeutic options of oncologic patients, allowing for more targeted and personalized chemotherapy regimens as well as for higher response rates