Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours

(1) Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression. (Pro)renin receptor (PRR) is a novel receptor of the renin–angiotensin system (RAS) that has been associated with the development and progression of some solid tumours by RAS-dependent and -independent mechanisms. (2) Methods: In this study, we analysed the immunohistochemical expression of PRR at the centre and border in a series of 83 clear-cell renal cell (CCRCCs), 19 papillary (PRCC) and 7 chromophobe (ChRCC) renal cell carcinomas, and the benign tumour renal oncocytoma (RO, n = 11). (3) Results: PRR is expressed in all the tumour subtypes, with higher mean staining intensity in ChRCCs and ROs. A high expression of PRR at the tumour centre and at the infiltrative front of CCRCC tissues is significantly associated with high grade, tumour diameter, local invasion and stage, and with high mortality risk by UCLA integrated staging system (UISS) scale. (4) Conclusions: These findings indicate that PRR is associated with the development and progression of renal tumours. Its potential as a novel biomarker for RCC diagnosis/prognosis and as a promising therapeutic target should be taken into account in the future.The work was funded by the Basque Government (ELKARTEK KK2018-00090 and KK-2020/00069)

Recensiones [Revista de Historia Económica Año XIV Invierno 1996 n. 1 pp. 241-297]

Editada en la Fundación Empresa PúblicaJordi Nadal y Jordi Catalán (eds.). La cara oculta de la industrialización española. La modernización de los sectores no líderes {siglos XIX y XX) (Por Miguel Martorell Linares).-- Blanca Sánchez Alonso. Las causas de la emigración española, 1880-1910 (Por Alan M. Taylor).-- Pedro Tedde de Lorca y Carlos Marichal (coords.). La formación de los bancos centrales en España y América Latina (Por Antonio Cubel).-- Josef M. Benaul, Jordi Calvei y Esteve Deu; Indústria i ciutat. Sabadell 1800-1980 (Por José Antonio Miranda Encarnación).-- Carlos Arenas Posadas (ed.). Industria y clases trabajadoras en la Sevilla del siglo XX (Por Ricardo M. Martín de la Guardia).-- Pegerto Saavedra. La vida cotidiana en la Galicia del Antiguo Régimen (Por Amparo Bejarano Rubio).-- Mauro Hernández Benítez. A la sombra de la Corona. Poder local y oligarquía urbana (Por Miguel Ángel Melón Jiménez).-- Carmen Sarasúa. Criados, nodrizas y amos. El servicio doméstico en la formación del mercado de trabajo madrileño, 1758-1868 (Por Esmeralda Ballesteros Doncel).-- Hilario Rodríguez de Gracia. Vivir y morir en Montilla. Actitudes económicas y sociales en el siglo XVII (Por Carlos Larrinaga Rodríguez).-- Enrioque Diez Sanz. La Tierra de Soria. Un universo campesino en la Castilla oriental del siglo xvi (Por Alfonso Rodríguez Grajera).-- Josep Bernabeu Mestre. Enfermedad y población. Introducción a los problemas y métodos de la epidemiología histórica (Por Abel F. Losada Alvarez).-- Herbert Klein. The American Finances of the Spanish Empire: Royal Income and Expenditures in México, Perú and Charcas, 1680-1809 (Por Carlos Marichal).-- Marcello Carmagnani. Estado y Mercado. La economía pública del liberalismo mexicano, 1850-1911 (Por Juan Carlos Sola Corbacho).-- Walther L. Bernecker. De agiotistas y empresarios. Entorno de la temprana industrialización mexicana (siglo XIX) (Por Juan Carlos Sola Corbacho).-- P. Scholliers y Vera Zamagni (eds.). Labour's Reward. Real Wages and Economic Change in 19th-and 29th-century Europe (Por Guillermo A. Pérez Sánchez).-- Pier Angelo Toninelli. Nascita de una nazione. Lo sviluppo económico degli Stati Uniti (1780-1914) (Por Gabriel Tortella Casares)Publicad

Soluble PD-L1 Is an Independent Prognostic Factor in Clear Cell Renal Cell Carcinoma

(1). Background: Immunohistochemical (IHC) evaluation of programmed death-1 (PD-1) and its ligand (PD-L1) is being used to evaluate advanced malignancies with potential response to immune checkpoint inhibitors. We evaluated both plasma and tissue expression of PD-1 and PD-L1 in the same cohort of patients, including non-metastatic and metastatic clear cell renal cell carcinoma (CCRCC). Concomitant plasma and tissue expression of PD-1 and PD-L1 was evaluated with emphasis on diagnostic and prognostic implications. (2) Methods: we analyzed PD-1 and PD-L1 IHC expression in tumor tissues and soluble forms (sPD-1 and sPD-L1) in plasma from 89 patients with CCRCC, of which 23 were metastatic and 16 received systemic therapy. The primary endpoint was evaluation of overall survival using Kaplan-Meier analysis and the Cox regression model. Plasma samples from healthy volunteers were also evaluated. (3) Results: Interestingly, sPD-1 and sPD-L1 levels were lower in cancer patients than in controls. sPD-1 and sPD-L1 levels and their counterpart tissue expression both at the tumor center and infiltrating front were not associated. Higher expression of both PD-1 and PD-L1 were associated with tumor grade, necrosis and tumor size. PD-1 was associated to tumor stage (pT) and PD-L1 to metastases. sPD-1 and sPD-L1 were not associated with clinico-pathological parameters, although both were higher in patients with synchronous metastases compared to metachronous ones and sPD-L1 was also higher for metastatic patients compared to non-metastatic patients. sPD-1 was also associated with the International Metastatic Renal Cell Cancer Database Consortium (IMDC) prognostic groups in metastatic CCRCC and also to the Morphology, Attenuation, Size and Structure (MASS) response criteria in metastatic patients treated with systemic therapy, mainly tyrosine-kinase inhibitors. Regarding prognosis, PD-L1 immunostaining at the tumor center with and without the tumor front was associated with worse survival, and so was sPD-L1 at a cut-off >793 ng/mL. Combination of positivity at both the tissue and plasma level increased the level of significance to predict prognosis. (4) Conclusions: Our findings corroborate the role of PD-L1 IHC to evaluate prognosis in CCRCC and present novel data on the usefulness of plasma sPD-L1 as a promising biomarker of survival in this neoplasia.The work was funded by the Basque Government (ELKARTEK KK2018-00090 and KK-2020/00069)

Recensiones [Revista de Historia Económica Año XV Primavera-Verano 1997 n. 2 pp. 415-455]

Concepción de Castro. Campomanes. Estado y reformismo ilustrado (Por Ángel García Sanz).-- Ricardo Rodríguez González. Mercaderes castellanos del Siglo de Oro (Por Bernardo Hernández).-- Carmen García García. La crisis de las Haciendas locales. De la reforma administrativa a la reforma fiscal (1743-1845) (Por Carlos de la Hoz).-- Vicente Pinilla Navarro. Entre la inercia y el cambio. El sector agrario aragonés, 1850-1935 (Por José Miguel Martínez Carrión).-- Manuel González Portilla y otros. Ferrocarriles y desarrollo. Red y mercados en el País Vasco, 1856-1914 (Por Carlos Larrinaga Rodríguez).-- Manuel González Portilla (dir.). Bilbao en la formación del País Vasco contemporáneo (Economía, población y ciudad) (Por Montserrat Gárate Ojanguren).-- Barry Eichengreen. Globalizing Capital (Por Concepción García-Iglesias Soto).-- Giorgio Morí, Luigi Rosa, Giuseppe Galasso, Valerio Castronovo y iovanni Zanetti (eds.). Storia dell'industria elettrica in Italia (Por Gregorio Núñez Romero-Balmas).-- Jeremy Bentham. Colonies, commerce and constitucional law. Rid yourselves ofultramaria and other writings on Spain andSpanish America (Por Carlos Rodríguez Braun).-- Víctor Bulmer-Thomás. The Economic History of Latín America Since Independence (Por Daniel Díaz Fuentes)Publicad

Iberoamerican Reviews

Reseñas iberoamericanasIberoamerican Review

Recensiones [Revista de Historia Económica Año XIV Otoño-Invierno 1996 n. 3 pp. 695-744]

Editada en la Fundación Empresa PúblicaJames Foreman-Peck. Historia Económica Mundial. Relaciones Económicas Internacionales desde 1850 (Por R. Sicotte).-- Pablo Martín Aceña y M. Gárate Ojanguren. Economía y empresa en el norte de España. Una aproximación histórica (Por Stefan Houpt).-- Daniel Díaz Fuentes. Crisis y cambios estructurales en América Latina, Argentina, Brasil y México durante el período de entreguerras (Por Antonio Santamaría).-- Mª Lourdes Miró Liaño. Sociedades mercantiles de Huelva. 1886-1936 (Por Carlos Larrinaga).-- W. Meter Ward. Birth Weight and Economic Growth. Women's Living Standards in the Industrializing West (Por José M. Martínez Carrión).-- Santiago Zapata Blanco. La industria de una región no industrializada: Extremadura 1750-1990 (Por Josep M. Benaul).-- Joaquín Melgarejo. La intervención del Estado en la cuenca del Segura. 1926-1986 (Por Salvador Calatayud).-- Pablo Martin Aceña y James Simpson. The Economic Development of Spain since 1870 (Por Vera Zamagni).-- Manuel Martinez Neira. Revolución y fiscalidad municipal La hacienda de la villa de Madrid en el reinado de Fernando VII (Por Hilario Rodríguez de Gracia).-- Carlos Arenas Posadas. Sevilla y el Estado. Una perspectiva local de la formación del Capitalismo en España (1892-1923) (Por Andrés Moreno Menjíbar).-- Jesús Cruz. Political Change and Cultural Persistence Among the Spanish Dominant Groups, 1750-1850 (Por Concepción de Castro).-- Peter Temin. Lecciones de la Gran Depresión (Por José Luis García Ruiz).-- Klaus Gallo. De la invasión al reconocimiento. Gran Bretaña y el Río de la Plata, 1806-1826 (Por Carlos Rodríguez Braun).-- James K. J. Thomson. Els orígens de la induslrialització a Catalunya. El cotó a Barcelona (Por Lluis Torró Gil).-- Jeremy Edwards y Klaus Fischer. Banks, finance and investment in Germany (Por M.ª Ángeles Pons Brías)Publicad

Feminist Challenges in the Social Sciences: Gender Studies in the Basque Country

This book reflects many of the profound social, political, and economic changes that have influenced the UPV/EHU since the 1980s. This process shaped a complex social and political reality in the Basque Country that is mirrored in the diversity of authors and topics in the book. These authors do, however, share a feminist outlook and these chapters provide a general, albeit partial, overview of Basque feminist scholarship. The book is indicative of a twofold series of feminist challenges: There is the challenge of describing and reflecting upon the changes that have occurred in recent decades as regards the presence of women in the job market, in politics, and in public life. These are spheres where feminist activity—institutional, academic, and professional—has flourished to a considerable extent, but where inequalities, though often highly sophisticated and therefore difficult to identify, nonetheless remain evident. And there is a challenge in another sense as well, because the material gathered here represents a vital contribution to general research in the fields of anthropology, sociology, history, law, economics, political science, and communications sciences.This book was published with generous financial support from the Basque Government.Introduction — Mila Amurrio and Mari Luz Esteban ? Part 1 The Social Standing of Men and Women: Gender Visibility and Invisibility ? 1. The Social Status of Men and Women in the Basque Country by Ainhoa Novo and Arantxa Elizondo ? 2. The Construction of Female Identity through Press Photography: El País and El Mundo by Flora Marin Murillo and Maria Ganzabal Learreta ? Part 2 The University, Knowledge, and Feminist Research ? 3. Higher Learning and Equality Politics at the University of the Basque Country by Jasone Astola and Mertxe Larrañaga ? 4. Demythicizing, Unveiling, Challenging: A Review of Twenty-five Years of Feminist Academic Production (1985-2010) by Jone M. Hernández and Elixabete Imaz ? Part 3 Rewriting Memory, Reinterpreting Culture ? 5. "Be Cautious, Not Chaste!" Gender Ideals and Sexuality by Nerea Aresti ? 6. Patriotic Mothers of Basque Nationalism: Women's Action during the Second Spanish Republic in the Basque Country by Miren Llona ? 7. Spanish Cinema through its Women Directors: 1995-2005 by Casilda de Miguel, Leire Ituarte, and Katixa Agirre ? 8. Matriarchy versus Equality: From Mari to Feminist Demands by Carmen Díez Mintegui and Margaret Bullen ? 9. Identity, Memory, and Power Games by Teresa del Valle ? Part 4 Gender Relations: Analysis and Proposals ? 10. Three Decades of Reproductive Rights: The Highs and Lows of Biomedical Innovations by Itziar Alkorta Idiakez ? 11. Love and Violence in Learning about Relationships by Mila Amurrio and Ane Larrinaga ? 12. Conciliation and Participation by Idoye Zabala Errazti, María José Martínez Herrero, and Marta Luxán Serrano ? 13. Anthropology of the Body, Corporeal Itineraries, and Gender Relations by Mari Luz Esteban ? Index ? List of Contributor