DUSP22-rearranged anaplastic lymphomas are characterized by specific morphological features and a lack of cytotoxic and JAK/STAT surrogate markers

This work was supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO, RTICC ISCIII and CIBERONC) (SAF2013-47416- R, RD06/0020/0107-RD012/0036/0060 and Plan Nacional I+D+I: PI16/01294 and PIE15/0081), AECC and the Madrid Autonomous Community

Galaxy classification: deep learning on the OTELO and COSMOS databases

Context. The accurate classification of hundreds of thousands of galaxies observed in modern deep surveys is imperative if we want to understand the universe and its evolution. Aims. Here, we report the use of machine learning techniques to classify early- and late-type galaxies in the OTELO and COSMOS databases using optical and infrared photometry and available shape parameters: either the Sersic index or the concentration index. Methods. We used three classification methods for the OTELO database: 1) u-r color separation , 2) linear discriminant analysis using u-r and a shape parameter classification, and 3) a deep neural network using the r magnitude, several colors, and a shape parameter. We analyzed the performance of each method by sample bootstrapping and tested the performance of our neural network architecture using COSMOS data. Results. The accuracy achieved by the deep neural network is greater than that of the other classification methods, and it can also operate with missing data. Our neural network architecture is able to classify both OTELO and COSMOS datasets regardless of small differences in the photometric bands used in each catalog. Conclusions. In this study we show that the use of deep neural networks is a robust method to mine the cataloged dataComment: 20 pages, 10 tables, 14 figures, Astronomy and Astrophysics (in press

The state of international collaboration for health systems research: what do publications tell?

AIM: International collaboration for health system development has been identified as a critical input to meet pressing global health needs. North-South collaboration has the potential to benefit both parties, while South-South collaboration offers promise to strengthen capacity rapidly and efficiently across developing countries. There is an emerging trend to analyze the fruits of such collaboration. This paper builds on this trend by applying an innovative concept-based bibliometric method to identify the international scope of collaboration within the field of health policy and systems research. Two key questions are addressed: to what extent are papers comparing developing countries as against reporting on single country studies? To what extent are papers in either case being produced by researchers within their respective countries or through North-South or South-South collaboration? METHODS: A total of 8,751 papers published in Medline between 1999 and 2003 with data on health systems and policies in developing countries were identified and content-analyzed using an innovative concept-based search technology. A sample of 13% of papers was used to identify the corresponding institution and countries covered. The sampled data was then analyzed by income group. RESULTS: Papers with an international, cross-country focus account for only 10% of the total. Just over a third of all papers are led by upper middle income country authors, closely followed by authors from high income countries. Just under half of all papers target low income countries. Cross-country papers are led mostly by institutions in high income countries, with 74% of the total. Only seven countries concentrate 60% of the papers led by developing country institutions. Institutions in the United States and the United Kingdom concentrate between them as many as 68% of the papers led by high income countries. Only 11% of all single-country papers and 21% of multi-country studies are the product of South-South collaboration. Health Financing is the topic with the greatest international scope, with 26% of all papers in the topic. Topics such as Costing and Cost Effectiveness, Finance, Sector Analysis and Insurance, regardless of their national or international scope, are led in 38% to 54% of cases by high income authors. CONCLUSION: While there is modest health systems research capacity in many developing countries for single country studies, capacity is severely limited for multi-country studies. While North-South collaboration is important, the number of international studies is still very limited to produce the kind of knowledge required to learn from experiences across countries. The fact that lead institutions as well as study countries are concentrated in a handful of mostly middle income countries attests to great disparities in research capacity. However, disparities in research capacity and interest are also evident in the North. It is urgent to build cross-country research capacity including appropriate forms of South-South and North-South collaboration

The OTELO survey. A case study of [O III]4959,5007 emitters at <z> = 0.83

The OTELO survey is a very deep, blind exploration of a selected region of the Extended Groth Strip and is designed for finding emission-line sources (ELSs). The survey design, observations, data reduction, astrometry, and photometry, as well as the correlation with ancillary data used to obtain a final catalogue, including photo-z estimates and a preliminary selection of ELS, were described in a previous contribution. Here, we aim to determine the main properties and luminosity function (LF) of the [O III] ELS sample of OTELO as a scientific demonstration of its capabilities, advantages, and complementarity with respect to other surveys. The selection and analysis procedures of ELS candidates obtained using tunable filter (TF) pseudo-spectra are described. We performed simulations in the parameter space of the survey to obtain emission-line detection probabilities. Relevant characteristics of [O III] emitters and the LF([O III]), including the main selection biases and uncertainties, are presented. A total of 184 sources were confirmed as [O III] emitters at a mean redshift z=0.83. The minimum detectable line flux and equivalent width (EW) in this ELS sample are $\sim$5 $\times$ 10$^{-19}$ erg s$^{-1}$ cm$^{2}$ and $\sim$6 \AA, respectively. We are able to constrain the faint-end slope ($\alpha = -1.03\pm0.08$) of the observed LF([O III]) at z=0.83. This LF reaches values that are approximately ten times lower than those from other surveys. The vast majority (84\%) of the morphologically classified [O III] ELSs are disc-like sources, and 87\% of this sample is comprised of galaxies with stellar masses of M$_\star$ $<$ 10$^{10}$ M$_{\odot}$.Comment: v1: 16 pages, 6 figures. Accepted in Astronomy \& Astrophysics. v2: Author added in metadat

Candelilla wax edible coating with Flourensia cernua bioactives to prolong the quality of tomato fruits

The improvement of the postharvest quality of tomato fruits was evaluated using an edible coating functionalized with an Flourensia cernua extract evaluating the antifungal, structural, barrier, and optical properties. The formulation and evaluation of an edible coating and its application on tomato was evaluated using a response surface methodology to determine the ideal concentrations of candelilla wax, whey protein, and glycerol. Edible films showed good barrier properties, with water vapor permeability varying from 0.4350.404 g mm/m2 day kPa. The addition o F. cernua extract showed significant improvement in the transparency of films. The edible coating applied to tomato reduced weight and firmness loss. The sensory evaluation proved that the product obtained is acceptable for consumers. The edible coating added with F. cernua extract was the most effective in inhibiting the growth of pathogenic fungi and the visual appearance at the end of storage confirmed the beneficial effect of the edible coating.(undefined)info:eu-repo/semantics/publishedVersio

Sub-arcsec mid-IR observations of NGC 1614: Nuclear star formation or an intrinsically X-ray weak AGN?

We present new mid-infrared (mid-IR) N-band spectroscopy and Q-band photometry of the local luminous IR galaxy NGC 1614, one of the most extreme nearby starbursts. We analyse the mid-IR properties of the nucleus (central 150 pc) and four regions of the bright circumnuclear (diameter∼600 pc) star-forming (SF) ring of this object. The nucleus differs from the circumnuclear SF ring by having a strong 8–12 μm continuum (low 11.3 μm PAH equivalent width). These characteristics, together with the nuclear X-ray and sub-mm properties, can be explained by an X-ray weak active galactic nucleus (AGN), or by peculiar SF with a short molecular gas depletion time and producing an enhanced radiation field density. In either case, the nuclear luminosity (LIR < 6 × 1043 erg s−1) is only <5 per cent of the total bolometric luminosity of NGC 1614. So this possible AGN does not dominate the energy output in this object. We also compare three star formation rate (SFR) tracers (Pa α, 11.3 μm PAH, and 24 μm emissions) at 150 pc scales in the circumnuclear ring. In general, we find that the SFR is underestimated (overestimated) by a factor of 2–4 (2–3) using the 11.3 μm PAH (24 μm) emission with respect to the extinction corrected Pa α SFR. The former can be explained because we do not include diffuse polycyclic aromatic hydrocarbon (PAH) emission in our measurements, while the latter might indicate that the dust temperature is particularly warmer in the central regions of NGC 1614.We acknowledge support from the Spanish Plan Nacional de Astronomía y Astrofísica through grants AYA2010-21161-C02-01, and AYA2012-32295. AAH and AA acknowledges funding from the Spanish Ministry of Economy and Competitiveness under grants AYA2012-31447 and AYA2012-38491-CO2-02, which are party funded by the FEDER programme.MAPT acknowledges support from the Spanish MICINN through grant AYA2012-38491-C02-02. CRA acknowledges support from a Marie Curie Intra European Fellowship within the 7th European Community Framework Programme (PIEF-GA-2012-327934).Peer Reviewe

The OTELO survey: the star formation rate evolution of low-mass galaxies

We present the analysis of a sample of \ha\,, \hb\ and \oii\ emission line galaxies from the \otelo\ survey, with masses typically below log(M_*/M_\sun) \sim 9.4 and redshifts between $z \sim 0.4$ and 1.43. We study the star formation rate, star formation rate density, and number density and their evolution with redshift. We obtain a robust estimate of the specific star formation rate -- stellar mass relation based on the lowest mass sample published so far. We also determine a flat trend of the star formation rate density and number density with redshift. Our results suggest a scenario of no evolution of the number density of galaxies, regardless of their masses, up to redshift $z\sim1.4$. This implies a gradual change of the relative importance of the star forming processes, from high-mass galaxies to low-mass galaxies, with decreasing redshift. We also find little or no variation of the star formation rate density in the redshift range of $0.4<z<1.43$.Comment: 8 pages, 3 figures, accepted for publication in ApJ letter

Mitochondrial Aging and Metabolism: The Importance of a Good Relationship in the Central Nervous System

The mitochondrial theory of aging suggests that mitochondria have a decrease in production capacity of adenosine triphosphate (ATP). The question may seem trivial, but it becomes more complex when considering that dysfunctional mitochondria can be eliminated by lysosomal digestion and that cell with dysfunctional mitochondria can undergo the process of apoptosis. In organs with regenerative capacity, like the liver, cell proliferation can almost completely hide mitochondrial dysfunction. However, evidence indicates selective damage in mitochondria during aging, and so the mitochondrial aging theory is gaining recognition and respect. There is solid evidence that accumulated DNA damage in mitochondria is a cause directly related to metabolic disorders such as diabetes and degenerative disorders such as Alzheimer’s disease. The central nervous system is particularly susceptible to oxidative damage due to several factors, among which are its high oxygen consumption, its dependence on aerobic carbohydrate metabolism, and its complex composition of membrane lipids. Free radicals are generated at many cell sites, and the mitochondrial respiratory chain is one of the main sources. While many studies have been conducted in experimental animal models, the results are relevant because at least some of their interventions suggest a directing aim at reducing the effects of aging

CHAPTER 5: FORMATION AND EVOLUTION OF GALAXIES AND LARGE STRUCTURES

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