86 research outputs found
Algorithm to determine the outcome of patients with acute liver failure: a data-mining analysis using decision trees
Resonant Visible Light Modulation with Graphene
Fast modulation and switching of light at visible and near-infrared (vis-NIR)
frequencies is of utmost importance for optical signal processing and sensing
technologies. No fundamental limit appears to prevent us from designing
wavelength-sized devices capable of controlling the light phase and intensity
at gigaherts (and even terahertz) speeds in those spectral ranges. However,
this problem remains largely unsolved, despite recent advances in the use of
quantum wells and phase-change materials for that purpose. Here, we explore an
alternative solution based upon the remarkable electro-optical properties of
graphene. In particular, we predict unity-order changes in the transmission and
absorption of vis-NIR light produced upon electrical doping of graphene sheets
coupled to realistically engineered optical cavities. The light intensity is
enhanced at the graphene plane, and so is its absorption, which can be switched
and modulated via Pauli blocking through varying the level of doping.
Specifically, we explore dielectric planar cavities operating under either
tunneling or Fabry-Perot resonant transmission conditions, as well as Mie modes
in silicon nanospheres and lattice resonances in metal particle arrays. Our
simulations reveal absolute variations in transmission exceeding 90% as well as
an extinction ratio >15 dB with small insertion losses using feasible material
parameters, thus supporting the application of graphene in fast electro-optics
at vis-NIR frequencies.Comment: 17 pages, 13 figures, 54 reference
An Endoscopic Case Report of Jejunal Leiomyosarcoma and Review of the Japanese Literature
Jejunoscopy for a small intestinal leiomyosarcoma was performed on a 73-year-old male. The patient was admitted because of a palpable abdominal mass. A barium meal study, abdominal ultrasonography, computed tomography and angiography suggested a leiomyogenic tumor with a central cavity arising from the jejunal loop extraluminally. Enteroscopy with a pediatric colonofiberscope (PCF) enabled us to observe a mucosal ulcer and a part of the cavity of the tumor. Histology of the resected tumor revealed it to be a leiomyosarcoma with a large central hollow connected to the mucosal ulcer. The authors discussed the endoscopic findings of 17 previously reported Japanese cases of jejunal leiomyosarcoma and the present case
Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual\u27s circadian and sleep phenotypes
Neonatal Mortality Levels for 193 Countries in 2009 with Trends since 1990: A Systematic Analysis of Progress, Projections, and Priorities
Mikkel Oestergaard and colleagues develop annual estimates for neonatal mortality rates and neonatal deaths for 193 countries for 1990 to 2009, and forecasts into the future
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Phase I study of sunitinib plus S-1 and cisplatin in Japanese patients with advanced or metastatic gastric cancer
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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