Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R2 = 0.041, Pcorr < 0.001) and cingulum (right: R2 = 0.041, left: R2 = 0.040, Pcorr < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org

Creating sanctioning norms in the lab: The influence of descriptive norms and the bad apple effect in third-party punishment

third-party punishment is a form of peer-to-peer sanctioning that is influenced by descriptive norms. The present study aims to investigate how aggregate peer punishment and the presence of a free rider who never punishes influences the formation of third-party punishment norms. Participants were exposed to social feedback indicating either low, high, or high & free rider peer punishment. Over time, participants conformed to average peer punishment leading to the emergence and persistence of different sanctioning norms in each group. The presence of one free rider significantly reduced the average punishment and increased the frequency of free riding behavior. These findings highlight the critical role of descriptive norms and suggest the presence of a ‘bad apple’ effect in third-party punishment

Scripts to Calculate Stress Resilience Scores as Regression Residuals

These scripts calculate stress resilience scores for cross-sectional data using a) SPSS Syntax OR b) an R function. Stress exposure and mental health data are required. The code is built upon the work of van Harmelen and her colleagues (2017, https://doi.org/10.1017/S0033291717000836). Please cite this OSF project and the paper when using the analysis code

Honest mistake or perhaps not:The role of descriptive and injunctive norms on the magnitude of dishonesty

Trivial acts of dishonesty are very prevalent in everyday life and have severe economic and societal consequences. The present study aims to examine the role of descriptive and injunctive norms in minor and major dishonesty under ambiguity. We devised a novel experimental design in which rule violations can be the result of honest mistakes or various dishonest processes. In this ambiguous context, we observed a high prevalence of minor rule violations at baseline. In two experiments, exposure to increased peer cheating (i.e., negative descriptive norms) promoted major rule violations, whereas the presence of explicit or subtle rule reminders (i.e., injunctive norms) marginally reduced minor rule violations but had no impact on major rule violations. We interpret these findings within the framework of social norm theory, self‐maintenance theory, and bounded ethicality. Implications regarding policies that target ordinary unethical behavior are discussed

Script-based Reappraisal Test - Introducing a new paradigm to investigate the effect of reappraisal inventiveness on reappraisal effectiveness

The ability to regulate emotions is essential for psychological well-being. Therefore, it is particularly important to investigate the specific dynamics of emotion regulation. In a new approach, we developed a novel paradigm – the Script-based Reappraisal Test (SRT) – to measure the processes involved in reappraisal, especially reappraisal inventiveness, i.e. the ability to create multiple and differing reappraisals. The aim of this study was twofold: (1) experimentally validate the SRT and (2) investigate whether reappraisal inventiveness increases reappraisal effectiveness. Healthy students (N = 143) completed the SRT. In this task, we presented everyday emotional situations in textual form and instructed participants to either decrease negative emotions by generating different reappraisals (reappraisal-trials) or react naturally (control-trials) to the situations. After each trial, participants indicated their affective state (SAM) and typed in their reappraisal thoughts. Within-subjects analyses showed significantly less negative affect and arousal in reappraisal-trials compared to control-trials, indicating a successful emotion regulation through reappraisal. Contrary to our hypothesis, reappraisal inventiveness and reappraisal effectiveness were not related. The theoretical and practical implications are discussed in the light of a person-by-situation approach

A Translational Paradigm to Study the Effects of Uncontrollable Stress in Humans

Data and analysis scripts for Meine, L.E., Schüler, K. , Richter-Levin, G., Scholz, V., Wessa, M. (2020). A translational paradigm to study the effects of uncontrollable stress in humans. Int. J. Mol. Sci, 21(17), 6010. ABSTRACT: Theories on the aetiology of depression in humans are intimately linked to animal research on stressor controllability effects. However, explicit translations of established animal designs are lacking. In two consecutive studies, we developed a translational paradigm to study stressor controllability effects in humans. In the first study, we compared three groups of participants, one exposed to escapable stress, one yoked inescapable stress group, and a control group not exposed to stress. Although group differences indicated successful stress induction, the manipulation failed to differentiate groups according to controllability. In the second study, we employed an improved paradigm and contrasted only an escapable stress group to a yoked inescapable stress group. The final design successfully induced differential effects on self-reported perceived control, exhaustion, helplessness, and behavioural indices of adaptation to stress. The latter were examined in a new escape behaviour test which was modelled after the classic shuttle box animal paradigm. Contrary to the learned helplessness literature, exposure to uncontrollable stress led to more activity and exploration; however, these behaviours were ultimately not adaptive. We discuss the results and possible applications in light of the findings on learning and agency beliefs, inter-individual differences, and interventions aimed at improving resilience to stress-induced mental dysfunction

Adverse competition-related cognitions questionnaire (ACCQ): Development and preliminary validation of a measure identifying different factors of athletes’ cognitions related to competitions

This research project presents the development and preliminary validation of a German version of the Adverse Competition-related Cognitions Questionnaire (ACCQ) and comprises four studies. In Study 1, 101 athletes and 124 coaches from different team and individual sports generated a large pool of cognitions, which was reduced to an initial item pool of 54 cognitions through a multi-step procedure with different experts. In Study 2, the underlying factor structure of the questionnaire was examined by an exploratory factor analysis (N2 = 348), which revealed six factors (athletic comparison, coach devaluation, devaluation of one's own performance, appreciation by coach and family, inner resistance against competitions, and general exhaustion) with 26 items retained. Subsequently, in Study 3, the results were re-examined with a confirmatory factor analysis (CFA, N3 = 419; CFI = 0.91, RMSEA = 0.06, SRMR = 0.06). In addition, preliminary support for the construct validity (i.e., convergent, divergent, and concurrent validity) of the ACCQ was obtained by examining associations among the ACCQ subscales and theoretical correlates such as social comparison, cognitive interference, irrational performance beliefs, and fear of negative evaluation. In Study 4, a second CFA (N4 = 153; CFI = 0.89, RMSEA = 0.06, SRMR = 0.07) was conducted to test the identified 6-factor solution in a sample of high-performance competitive athletes. With its broad range of factors, the ACCQ provides a useful and valid measure for assessing different adverse competition-related cognitions, offering a wide range of potential applications in research and sport psychology practice