DataSheet1_Coding and educational robotics with peers: The C0D1NC experience to foster inclusion.pdf

In the present paper, the experience of the C0D1NC project (Coding for inclusion) is described. In this project an innovative methodology based on peer-education is the core of the educational approach. High school students become “teachers” as they are trained to teach coding and robotics to younger students. This approach favors inclusion and digital inclusion. To affirm this, we evaluated different aspects: relations between peers, perceived self-efficacy, and attitude towards technology at the beginning of activities (pre-test) and the end (post-test). Results indicate that this approach can be effective to favor personal growth, improved relations between peers, and increased self-efficacy too.</p

Trasferimento di giochi di ruolo psico-pedagogici in contesti digitali

In materia di competenze chiave per l’educazione, la formazione e l’apprendimento permanente, l’attenzione si è spostata dalle hard skill, ovvero competenze relative a un determinato dominio di conoscenza, alle soft skill e numerose sono le ricerche empiriche che hanno accertato l’efficacia del role-playing in ambito formativo. Anche il mondo dell’e-learning si sta progressivamente avvicinando a tale ambito. Ci riferiamo in modo specifico alle simulazioni per l’apprendimento basate sulle tecniche del role-play per lo sviluppo di videogiochi che riproducono ambienti virtuali grafici per l’apprendimento delle soft skill: competenze trasversali espressione di un continuum rispetto alle sfere della vita personale, professionale e sociale (es. comunicazione, leadership, negoziazione). In un recente lavoro edito da Springer (Dell’Aquila et al., 2017) abbiamo presentato e proposto una serie di esperienze per l’utilizzo di nuove tecnologie all’interno di contesti educativi e per la formazione professionale delle soft skill, personalizzate per una vasta comunità di attori sociali, istituzionali e non, così da facilitare la trasferibilità dei comportamenti e delle competenze apprese nella realtà quotidiana. Tale esperienza è stata da un lato di impulso per la realizzazione di un MOOC che renda fruibile l’esperienza di tali applicazioni alla vasta comunità di professionisti quali pedagogisti, psicologi, formatori che possono avvalersi di attività per implementare percorsi personalizzati di apprendimento. Dall’altro ha condotto allo sviluppo di un nuovo progetto ACCORD che si pone come obiettivo la realizzazione di un serious game per la risoluzione di conflitti in ambito interculturale per gli insegnanti che consentirà verificarne tanto l’efficacia formativa quanto metodologica con una diversa competenza relazionale e in un diverso contesto di applicazione

Do Anti-SARS-CoV-2 Monoclonal Antibodies Have an Impact on Pregnancy Outcome? A Systematic Review and Meta-Analysis

Monoclonal antibodies (mAbs) have been used as a rescue strategy for pregnant women affected by COVID-19. To explore its impact on maternal-fetal health, we included all observational studies reporting maternal, fetal, delivery and neonatal outcomes in women who underwent mAbs infusion for COVID-19. Primary outcome was the percentage of preterm delivery. We used meta-analyses of proportions to combine data for maternal, fetal, delivery and neonatal outcome of women treated with mAbs for COVID-19 and reported pooled proportions and their 95% confidence intervals (CIs) for categorical variables or mean difference (MD) with their 95% confidence intervals for continuous variables. Preterm birth was observed in 22.8% of cases (95% CI 12.9–34.3). Fetal distress was reported in 4.2% (95% CI 1.6–8.2). Gestational hypertension and pre-eclampsia were observed in 3.0% (95% CI 0.8–6.8) and 3.4% (95% CI 0.8–7.5) of cases, respectively. Fetal growth restriction was observed in 3.2% of fetuses (95% CI 0.8–7.0). Secondary prophylaxis with mAbs is currently considered the best treatment option for people with mild to moderate COVID-19 disease. More attention should be paid to infants born from mothers who were treated with mAbs, for the risk of immunosuppression

Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer

Background: Although most of the analyses included transverse colon cancers (TCC) among right colon cancer (RCC), it is not completely clear if they present total similarities with RCC or if they have their specific features. Therefore, we present an observational study to evaluate clinicopathological characteristics and survival data of patients with TCC. Methods: We retrospectively reviewed 450 RCC, of whom 97 stages I&ndash;IV TCC were included in this multicenter study; clinicopathological and molecular parameters were analyzed to identify prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: Most of TCC cases were male (61%), with &le;70 years old (62%), and good performance status (ECOG PS 0, 68%). According to WHO classification, 41 (49%) and 40 (48%) tumors were classified as well to moderate and poorly/undifferentiated respectively, regardless of mucinous component (30%). About molecular data, 8 (26%), 45 (63%), and 14 (24%) were MSI-H, KRAS wild-type, and BRAF V600E mutant, respectively. With a median follow-up of 34 months, there were 29 and 50 disease recurrences and deaths respectively. Charlson comorbidity index &ge;5 was a significant prognostic factor for DFS (HR = 7.67, 95% CI 2.27&ndash;25.92). Colon obstruction/perforation (HR = 2.65, 95% CI 1.01&ndash;7.01), and BRAF mutant (HR = 3.03, 95% CI 0.97&ndash;9.50) cases showed a worst, despite not statistically significant, DFS. Whereas for OS, at the multivariate model, only tumor grade differentiation (HR = 5.26, 95% CI 1.98&ndash;14.01) and BRAF mutation status (3.71, 95% CI 1.07&ndash;12.89) were independent prognostic factors. Conclusions: Poorly/undifferentiated tumor grade and BRAF V600E mutation are independent prognostic factors for OS in TCC. Further prospective clinical trials are needed to better define TCC treatment in order to improve patient outcome

Comparative study of four reactions at onset of pre-equilibrium emission

The study of the emitted particles, comparing pre-equilibrium and thermal components, is a useful tool to examine the nuclear structure of emitters. Possible clustering effects, which may change the expected decay chain probability, could be highlighted on the competition between different reaction mechanisms. The NUCL-EX collaboration (INFN, Italy) has carried out an extensive research campaign on pre-equilibrium emission of light charged particles from hot nuclei. In this framework, the reactions 16O+30Si, 18O+28Si, 19F+27Al at 7 AMeV and 16O+30Si at 8 AMeV have been carried out using the GARFIELD+RCo array at Legnaro National Laboratories. Some anomalies in the α-particle emission channels have been evidenced in the measurement reported above, showing in an exclusive way the observed effects related to the entrance channels. The experimental results are compared to model prediction, for which the same filtering and complete event selection have been applied

Comparative study of four reactions at onset of pre-equilibrium emission

The study of the emitted particles, comparing pre-equilibrium and thermal components, is a useful tool to examine the nuclear structure of emitters. Possible clustering effects, which may change the expected decay chain probability, could be highlighted on the competition between different reaction mechanisms. The NUCL-EX collaboration (INFN, Italy) has carried out an extensive research campaign on pre-equilibrium emission of light charged particles from hot nuclei. In this framework, the reactions 16O+30Si, 18O+28Si, 19F+27Al at 7 AMeV and 16O+30Si at 8 AMeV have been carried out using the GARFIELD+RCo array at Legnaro National Laboratories. Some anomalies in the α-particle emission channels have been evidenced in the measurement reported above, showing in an exclusive way the observed effects related to the entrance channels. The experimental results are compared to model prediction, for which the same filtering and complete event selection have been applied

A multicenter study of skin toxicity management in patients with left-sided, RAS/BRAF wild-type metastatic colorectal cancer treated with first-line anti-EGFR-based doublet regimen: is there room for improvement?

Background Skin toxicity in patients affected by metastatic colorectal cancer (mCRC) treated with epidermal growth factor receptor (EGFR) inhibitors is well known. However, ad hoc ESMO guidelines have only recently been published. Aim and methods To describe the management (pre-emptive or reactive) of anti-EGFR-related cutaneous adverse events (AEs), in a real-life clinical context, in a selected population of patients with left-sided, metastatic RAS/BRAF wild-type mCRC treated with doublet chemotherapy plus anti-EGFR monoclonal antibody (i.e., panitumumab or cetuximab) as first-line regimen at 22 Institutions. The measured clinical outcomes were treatment-related adverse events, objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Results Of 515 patients included in the analysis, 173 (33.6%) received a pre-emptive and 342 (66.4%) a reactive treatment. The median follow-up period for the overall population was 30.0 months. A significantly lower incidence of any grade acneiform rash was found in the pre-emptive compared to the reactive cohort both in the overall population (78.6% vs 94.4%, p &lt; 0.001) and in patients treated with panitumumab (76.1% vs 93.7%, p &lt; 0.001) or cetuximab (83.3% vs 95.4%, p = 0.004), respectively. A lower incidence of any grade (41.6% vs 50.9%, p = 0.047) but a higher incidence of G3-G4 (9.2% vs 4.7%, p = 0.042) paronychia/nail disorders were found in the pre-emptive compared to the reactive cohort. Nevertheless, a lower rate of patients within the reactive compared to the pre-emptive cohort was referred to dermatological counseling (21.4% vs 15.3%, respectively, p = 0.001). A higher rate of anti-EGFR therapy modification was needed in the pre-emptive compared to the reactive cohort (35.9% vs 41.6%, respectively, p &lt; 0.001). The pre-emptive approach did not reduce the efficacy of antineoplastic therapy compared to the reactive in terms of ORR (69.2% vs 72.8%), median PFS (12.3 vs 13.0 months), and median OS (28.8 vs 33.5 months). Conclusion Although recommended by international guidelines, the pre-emptive approach of anti-EGFR-related skin toxicity in mCRC patients still appears less adopted in daily clinical practice, compared to the reactive one. A wider reception and application of this indication is desirable to improve patients' quality of life without compromising the continuity and efficacy of antineoplastic therapy