Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation

Amer1/WTX has previously been shown to promote β-catenin degradation. Here, the authors uncover an unexpected role of Amer1/WTX as a positive regulator of Wnt signalling. Amer/WTX acts as a scaffold protein that is recruited to the plasma membrane in response to Wnt stimulation and is needed for the phosphorylation and activation of the LRP6 receptor