The Interaction Of Multiple Convection Zones In A-type Stars

A-type stars have a complex internal structure with the possibility of multiple convection zones. If not sufficiently separated, such zones will interact through the convectively stable regions that lie between them. It is therefore of interest to ask whether the typical conditions that exist within such stars are such that these convections zones can ever be considered as disjoint. In this paper we present results from numerical simulations that help in understanding how increasing the distance between the convectively unstable regions are likely to interact through the stable region that separates them. This has profound implications for mixing and transport within these stars.Comment: 9 pages, 15 figures, Preprint accepted for publication in MNRA

N-Benzyl-1,3-dide­oxy-1,3-imino-l-xylitol

The structure determination confirms the stereochemistry of the title compound, C12H17NO3, which contains a four-membered azetidine ring system. The absolute configuration was determined by the use of d-glucose as the starting material. In the crystal, O—H⋯O and O—H⋯N hydrogen bonds link the mol­ecules into layers in the ab plane

Emission Lines in the Spectrum of the 3He Star 3 Cen A

Emission in the 4d - 4f transitions of MnII (multiplet 13, 6122-6132 Ang), in the 4f - 6g transitions of PII, and in 6149.5 Ang of HgII has been detected in the spectrum of the helium weak star 3 Centauri A (B5 III-IVp). Weaker emission from the same MnII multiplet is also seen in the hot, mild HgMn star 46 Aquila (B9 III).It is suggested that the emission is of photospheric origin and may be evidence for the stratification of manganese, phosphorus and mercury in the photosphere of 3 CenA, and of manganese in 46Aql.Comment: 16 pages, 3 figure

A Modular Approach for a Family of Ground Mobile Robots

This paper deals with Epi.q, a family of mobile robots whose main characteristic is a wheel-legged hybrid locomotion. These multi-purpose robots can be successfully exploited for security and surveillance tasks. The document presents state of the art security robotics, the Epi.q mechanical architecture, the concept behind the robot driving unit, three prototypes and the design of a new on

Infiltration of fibrous preforms by a pure metal: Part V. Influence of preform compressibility

Infiltration by a pure matrix in the presence of preform deformation and partial matrix solidification is analyzed using a bounding approach for the preform rheology where solid metal is present. It is found, using parameters for the infiltration of short alumina fiber preforms by aluminum, that the two bounds are close in comparison to other factors of uncertainty in the prediction of infiltration rate. Using this approach, preform compression is shown to exert a significant influence on the infiltration rate for the system explored; in particular, the analysis shows the existence of an optimal value of applied pressure. Simplifications in the analysis are also presented, which yield fairly accurate results while easing their computation significantly

Using Cerebrospinal Fluid Biomarker Testing to Target Treatment to Patients with Mild Cognitive Impairment: A Cost-Effectiveness Analysis

Objective Cerebrospinal fluid (CSF) biomarkers are shown to facilitate a risk identification of patients with mild cognitive impairment (MCI) into different risk levels of progression to Alzheimer’s disease (AD). Knowing a patient’s risk level provides an opportunity for earlier interventions, which could result in potential greater benefits. We assessed the cost effectiveness of the use of CSF biomarkers in MCI patients where the treatment decision was based on patients’ risk level. Methods We developed a state-transition model to project lifetime quality-adjusted life-years (QALYs) and costs for a cohort of 65-year-old MCI patients from a US societal perspective. We compared four test-and-treat strategies where the decision to treat was based on a patient’s risk level (low, intermediate, high) of progressing to AD with two strategies without testing, one where no patients were treated during the MCI phase and in the other all patients were treated. We performed deterministic and probabilistic sensitivity analyses to evaluate parameter uncertainty. Results Testing and treating low-risk MCI patients was the most cost-effective strategy with an incremental cost-effectiveness ratio (ICER) of US$37,700 per QALY. Our results were most sensitive to the level of treatment effectiveness for patients with mild AD and for MCI patients. Moreover, the ICERs for this strategy at the 2.5th and 97.5th percentiles were US$18,900 and US$50,100 per QALY, respectively. Conclusion Based on the best available evidence regarding the treatment effectiveness for MCI, this study suggests the potential value of performing CSF biomarker testing for early targeted treatments among MCI patients with a narrow range for the ICER

Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes

BACKGROUND: The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow hair pigmentation by signalling through the melanocortin 1 receptor (Mc1r) on melanocytes. Lethal yellow (A(y)) and viable yellow (A(vy)) are dominant regulatory mutations in the mouse agouti gene that cause the wild-type protein to be produced at abnormally high levels throughout the body. Mice harboring these mutations exhibit a pleiotropic syndrome characterized by yellow coat color, obesity, hyperglycemia, hyperinsulinemia, and increased susceptibility to hyperplasia and carcinogenesis in numerous tissues, including the liver. The goal of this research was to determine if ectopic expression of the agouti gene in the liver alone is sufficient to recapitulate any aspect of this syndrome. For this purpose, we generated lines of transgenic mice expressing high levels of agouti in the liver under the regulatory control of the albumin promoter. Expression levels of the agouti transgene in the liver were quantified by Northern blot analysis. Functional agouti protein in the liver of transgenic mice was assayed by its ability to inhibit binding of the α-melanocyte stimulating hormone (αMSH) to the Mc1r. Body weight, plasma insulin and blood glucose levels were analyzed in control and transgenic mice. Control and transgenic male mice were given a single intraperitoneal injection (10 mg/kg) of the hepatocellular carcinogen, diethylnitrosamine (DEN), at 15 days of age. Mice were euthanized at 36 or 40 weeks after DEN injection and the number of tumors per liver and total liver weights were recorded. RESULTS: The albumin-agouti transgene was expressed at high levels in the livers of mice and produced a functional agouti protein. Albumin-agouti transgenic mice had normal body weights and normal levels of blood glucose and plasma insulin, but responded to chemical initiation of the liver with an increased number of liver tumors compared to non-transgenic control mice. CONCLUSIONS: The data demonstrate that liver-specific expression of the agouti gene is not sufficient to induce obesity or diabetes, but, in the absence of these factors, agouti continues to promote hepatocellular carcinogenesis

Hermitian D-brane solutions

A low-energy background field solution describing D-membrane configurations is constructed which is distinguished by the appearance of a Hermitian metric on the internal space. This metric is composed of a number of independent harmonic functions on the transverse space. Thus this construction generalizes the usual harmonic superposition rule. The BPS bound of these solutions is shown to be saturated indicating that they are supersymmetric. By means of T-duality, we construct more solutions of the IIA and IIB theories.Comment: 14 pages, Latex, no figure

OPserver: interactive online-computations of opacities and radiative accelerations

Codes to compute mean opacities and radiative accelerations for arbitrary chemical mixtures using the Opacity Project recently revised data have been restructured in a client--server architecture and transcribed as a subroutine library. This implementation increases efficiency in stellar modelling where element stratification due to diffusion processes is depth dependent, and thus requires repeated fast opacity reestimates. Three user modes are provided to fit different computing environments, namely a web browser, a local workstation and a distributed grid.Comment: 5 pages, 1 figur

Three very young HgMn stars in the Orion OB1 Association

We report the detection of three mercury-manganese stars in the Orion OB1 association. HD 37886 and BD-0 984 are in the approximately 1.7 million year old Orion OB1b. HD 37492 is in the approximately 4.6 million year old Orion OB1c. Orion OB1b is now the youngest cluster with known HgMn star members. This places an observational upper limit on the time scale needed to produce the chemical peculiarities seen in mercury-manganese stars, which should help in the search for the cause or causes of the peculiar abundances in HgMn and other chemically peculiar upper main sequence stars.Comment: 8 pages including 1 figure. To appear in Astrophysical Journal Letter