45 research outputs found

    Genetic and Biochemical Factors Related to the Risk and Disability Progression in Multiple Sclerosis

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    Sclerosis multiplex (multiple sclerosis, MS) is a chronic autoimmune inflammatory disease of the central nervous system. The immune regulatory defects lead to the process of inflammation and neurodegenerationthat results in the deterioration of neurological functions. It is still unclear as to why MS is so devastating and rapidly progressive in one patient and less so in another. It is known that the etiopathogenesis of MS is very complex, and many factors can be involved in the risk and character of the disease and its progression. In this chapter, we discuss the general molecular and cellular mechanisms of action of genetic and biochemical factors that are related to immune system regulation and thus can be connected to the individually varying risk and disability progression of MS. We found that gene variants of the gene polymorphism rs6897932 in interleukin 7 receptor α chain gene rs10735810 in vitamin D receptor gene and HLA-DR and HLA-DQ genes as well as the serum level of vitamin D are associated with MS risk or disability progression in Central European Slovak population

    Study of surface roughness of machined polymer composite material

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    The aim of this paper is to evaluate the influence of selected cutting parameters (speed of rotation and feed rate) on the surface topography of drilled WPC material. Objective of the study is to establish dependence of the surface roughness of borehole walls (parameter —average maximum height) on the speed of rotation and feed rate of a drill bit. Technological parameters of experimental drilling were feed rate of 100–300 mm·min−1 and speed of rotation of 2000–6000 rpm.Web of Scienceart. no. 30351

    CMOS-MEMS resonant pressure sensors: optimization and validation through comparative analysis

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    The final publication is available at Springer via http://dx.doi.org/10.1007/s00542-016-2878-3An optimized CMOS-MEMS resonant pressure sensor with enhanced sensitivity at atmospheric pressure has been reported in this paper. The presented work reports modeling and characterization of a resonant pressure sensor, based on the variation of the quality factor with pressure. The relevant regimes of air flow have been determined by the Knudsen number, which is the ratio of the mean free path of the gas molecule to the characteristic length of the device. The sensitivity has been monitored for the resonator design from low vacuum to atmospheric levels of air pressure. This has been accomplished by reducing the characteristic length and optimization of other parameters for the device. While the existing analytical model has been adapted to simulate the squeeze film damping effectively and it is validated at higher values of air pressure, it fails to compute the structural damping mechanisms dominant in the molecular flow regime, i.e. at lower levels of air pressure. This discrepancy has been solved by finite element modeling that has incorporated both structural and film damping effects. The sensor has been designed with an optimal geometry of 140 × 140 × 8 µm having 6 × 6 perforations along the row and column of the plate, respectively, for maximum Q, with an effective mass of 0.4 µg. An enhanced quality factor of 60 and reduced damping coefficient of 4.34 µNs/m have been obtained for the reported device at atmospheric pressure. The sensitivity of the manufactured device is approximately -0.09 at atmospheric pressure and increases to -0.3 at 40 kPa i.e. in the lower pressures of slip flow regime. The experimental measurements of the manufactured resonant pressure sensor have been compared with that of the analytical and finite element modeling to validate the optimization procedure. The device has been manufactured using standard 250 nm CMOS technology followed by an in-house BEOL metal-layer release through wet etching.Peer ReviewedPostprint (author's final draft

    The evaluation of the production of the shaped part using the workshop programming method on the two-spindle multi-axis CTX alpha 500 lathe

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    The article deals with the description of the production of a shaped part composed of an outer pyramid and cylindrical surface, of inner cylindrical surfaces of different diameters and of an inner tongue groove. It describes the proposed tools and tool holders resulting from the technological process. In order to meet the required tolerances and shape deviations for the given component, the CTX alpha 500 two-spindle multi-axis CNC lathe was chosen for its production. Its control system enables the workshop method of programming and simulation of individual operations in automatic mode or in block-by-block mode. The design of the selected CNC lathe enables the machining of rotary parts in one clamping, which is ensured by the right and left spindle with chucks. The surface quality of the pyramidal surface and the internal diameter of D18H8 was measured using a Hommel Etamic W5 roughness gauge. The measured roughness values for the hole were: D = 18H8, Rz = 3.007 mu m, Ra = 0.729 mu m and for the pyramidal surface: Rz = 1.527 mu m and Ra = 0.329 mu m.Web of Science9166766

    Analyses of the Causes of Common Rail Piezoelectric and Electromagnetic Injectors' Premature Destruction in Self-Ignition Engines

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    In self-ignition engines with Common Rail direct fuel injection, premature destruction of injectors has been observed. New elements are also touched by the problem. In order to solve it, a group of international experts in the area have gathered. Destroyed piezoelectric and electromagnetic injectors' elements of BOSCH, DELPHI, DENSO, have been examined. Mechanical damages influencing electronic diagnostic signal have been presented. Some system solutions possible to perform as far as diagnostic prevention is concerned have been described. Some useful electronic diagnostic methods of fuel system, signal analysers: RMOG and ERDIA PRO, have been presented

    Turned Surface Monitoring Using a Confocal Sensor and the Tool Wear Process Optimization

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    Laser scanning technology has been used for several years. Nevertheless, no comprehensive study has been conducted to prove that the application of confocal chromatic sensor (CCHS) laser technology is effective and suitable to verify the integrity parameters of machined surfaces in terms of cutting tool damage. In this paper, the optimization and effects of five factors (cutting speed, feed, depth of cut, attachment length of the workpiece, and tip radius) on the roundness deviation measured by CCHS and, at the same time, on the amount of wear on the back side of the cutting part of the tool were studied according to ISO 3685, which was measured with a microscope. The results obtained were evaluated using the gray relational analysis method (GRA), in conjunction with the Taguchi method, and the significance of the factors was demonstrated using the analysis of variance (ANOVA) method

    Intelligent programming of robotic flange production by means of CAM programming

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    The article deals with the description of the production programming of a robotic flange, which consists of outer conical, cylindrical surface, face area and internal threaded surfaces. For the modelling of a 3D model and the generation of production design, the Autodesk Inventor Professional 2018 software was used. To enter the semi-finished piece, select individual tools, cutting conditions, simulation and the NC program generation for RS Fanuc, the HSMPRO 2018 software extension was used. The circularity deviation was measured using the Roundtest RA 120 measuring device. The mean arithmetic values of roughness for the hole were: D = 126, Rz = 11.43 μm, Ra = 1.92 μm. The circularity deviation was 22.3 μm

    Simulation Studies of the Underground DC Traction Substation with and without Energy Storage Device

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    This paper presents the results of the underground DC traction substation simulation studies for two versions: the substation equipped with the ESD (Energy Storage Device) and without the ESD. In these studies Supercapacitors Energy Storage System of energy capacity 10 kWh and voltage 900 V is used. Simulation studies were performed in the Simscape/Simulink

    Nuclear electromagnetic pulse

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    SIGLEAvailable from British Library Document Supply Centre- DSC:q93/10293(Nuclear) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
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