Real rank geometry of ternary forms

We study real ternary forms whose real rank equals the generic complex rank, and we characterize the semialgebraic set of sums of powers representations with that rank. Complete results are obtained for quadrics and cubics. For quintics, we determine the real rank boundary: It is a hypersurface of degree 168. For quartics, sextics and septics, we identify some of the components of the real rank boundary. The real varieties of sums of powers are stratified by discriminants that are derived from hyperdeterminants

Digital Power Network Parameters Measurement

Exact measurement of the parameters of a power network is now possible by digital methods. The description of the proposed and realized instrument based on the digital sampling method is given. It can measure basic parameters of the three-phase power network such as rms values of voltages and currents, powers, energies, power factors and the network frequency. Questions concerning the accuracy of measurement, error sources, and error correction are also given. A method of calibration based on the frequency output is proposed and its calculation accuracy evaluated by MATLAB

Building community - or why we need on ongoing conference platform for TA

As a background for current outlooks towards strengthening the technology assessment (TA) community, Scherz et al. give a historical overview of efforts to establish international fora for communication among professionals and researchers in TA. Against this background, the article conveys experiences from the first two bi-annual TA conferences, arranged in the context of the PACITA project. The authors describe experiences of mutual learning across national boundaries and communicate a renewed understanding of the necessity for supporting TA capacities at the national level through professional community building. Ultimately, Scherz et al. argue that a European TA platform is necessary for establishing a common language for TA and for supporting the spread of TA across borders

On the full, strongly exceptional collections on toric varieties with Picard number three

We investigate full strongly exceptional collections on smooth, com- plete toric varieties. We obtain explicit results for a large family of varieties with Picard number three, containing many of the families already known. We also describe the relations between the collections and the split of the push forward of the trivial line bundle by the toric Frobenius morphism

Determination of solidus and liquidus temperatures for S34MnV steel grade by thermal analysis and calculations

The paper is devoted to the comparison of the results in the frame of solidus and liquidus temperatures obtained by thermo analytical methods with the generally used empirically based formulas and thermo dynamical Computherm software. The series of thermal analysis measurements of high temperature phase transformations of real steel grade (S34MnV) under conditions of two analytical devices (Netzsch STA 449 F3 Jupiter; Setaram Multi High Temperature Calorimeter (MHTC)) were carried out. Two thermo analytical methods were used (DSC and Direct Thermal Analysis). The different weight of samples was used (2,6 g; 23 g). The liquidus and solidus temperatures for close to equilibrium conditions during heating (DSC: 1 °C/min; 2 °C/min) and during cooling (Direct Thermal Analysis: 1 °C/min) were determined and compared. Then, the discussion on the different values obtained by experiments and empirically based calculation is realised

Aging and the Environment: A Research Framework

The rapid growth in the number of older Americans has many implications for public health, including the need to better understand the risks posed to older adults by environmental exposures. Biologic capacity declines with normal aging; this may be exacerbated in individuals with pre-existing health conditions. This decline can result in compromised pharmacokinetic and pharmacodynamic responses to environmental exposures encountered in daily activities. In recognition of this issue, the U.S. Environmental Protection Agency (EPA) is developing a research agenda on the environment and older adults. The U.S. EPA proposes to apply an environmental public health paradigm to better understand the relationships between external pollution sources → human exposures → internal dose → early biologic effect → adverse health effects for older adults. The initial challenge will be using information about aging-related changes in exposure, pharmacokinetic, and pharmacodynamic factors to identify susceptible subgroups within the diverse population of older adults. These changes may interact with specific diseases of aging or medications used to treat these conditions. Constructs such as “frailty” may help to capture some of the diversity in the older adult population. Data are needed regarding a) behavior/activity patterns and exposure to the pollutants in the microenvironments of older adults; b) changes in absorption, distribution, metabolism, and excretion with aging; c) alterations in reserve capacity that alter the body’s ability to compensate for the effects of environmental exposures; and d) strategies for effective communication of risk and risk reduction methods to older individuals and communities. This article summarizes the U.S. EPA’s development of a framework to address and prioritize the exposure, health effects, and risk communications concerns for the U.S. EPA’s evolving research program on older adults as a susceptible subpopulation

Preclinical Testing of Erlotinib in a Transgenic Alveolar Rhabdomyosarcoma Mouse Model

Rhabdomyosarcoma is an aggressive childhood malignancy, accounting for more than 50% of all soft-tissue sarcomas in children. Even with extensive therapy, the survival rate among alveolar rhabdomyosarcoma patients with advanced disease is only 20%. The receptor tyrosine kinase Epidermal Growth Factor Receptor (EGFR) has been found to be expressed and activated in human rhabdomyosarcomas. In this study we have used a genetically engineered mouse model for alveolar rhabdomyosarcoma (ARMS) which faithfully recapitulates the human disease by activating the pathognomic Pax3:Fkhr fusion gene and inactivating p53 in the maturing myoblasts. We have demonstrated that tumors from our mouse model of alveolar rhabdomyosarcoma express EGFR at both the mRNA and protein levels. We then tested the EGFR inhibitor, Erlotinib, for its efficacy in this mouse model of alveolar rhabdomyosarcoma. Surprisingly, Erlotinib had no effect on tumor progression, yet mice treated with Erlotinib showed 10–20% loss of body weight. These results suggest that EGFR might not be an a priori monotherapy target in alveolar rhabdomyosarcoma