Reduction in the Consumption of Electrical Energy during Computer Network

Tato diplomová práce se zabývá analýzou problémů úspor v elektrické energiích. Na základě změřených skutečností obsahuje analýzu nákladů na elektrickou energii.This Master’s thesis deals with the analysis problem during of electrical energy. On the basis of findings, the work includes analysis of the costs on electrical energy.

Polish spaces of Banach spaces. Complexity of isometry classes and generic properties

We present and thoroughly study natural Polish spaces of separable Banach spaces. These spaces are defined as spaces of norms, resp. pseudonorms on the countable infinite-dimensional rational vector space. We provide an exhaustive comparison of these spaces with the admissible topologies recently introduced by Godefroy and Saint-Raymond and show that Borel complexities differ little with respect to these two different topological approaches. We then focus mainly on the Borel complexities of isometry classes of the most classical Banach spaces. We prove that the infinite-dimensional Hilbert space is characterized as the unique separable infinite-dimensional Banach space whose isometry class is closed, and also as the unique separable infinite-dimensional Banach space whose isomorphism class is $F_\sigma$. For $p\in\left[1,2\right)\cup\left(2,\infty\right)$, we show that the isometry classes of $L_p[0,1]$ and $\ell_p$ are $G_\delta$-complete and $F_{\sigma\delta}$-complete, respectively. Then we show that the isometry class of the Gurari\u{\i} space is $G_\delta$-complete and the isometry class of $c_0$ is $F_{\sigma\delta}$-complete. The isometry class of the former space is moreover proved to be dense $G_\delta$. Additionally, we compute the complexities of many other natural classes of Banach spaces; for instance, $\mathcal{L}_{p,\lambda+}$-spaces, for $p,\lambda\geq 1$, are shown to be $G_\delta$, superreflexive spaces are shown to be $F_{\sigma\delta}$, and spaces with local $\Pi$-basis structure are shown to be $\boldsymbol{\Sigma}^0_6$. The paper is concluded with many open problems and suggestions for a future research.Comment: The second version contains the same results, but the structure of the paper and the order of the results are changed a bi

HIV-1 protease-induced apoptosis

BACKGROUND: Apoptosis is one of the presumptive causes of CD4(+) T cell depletion during HIV infection and progression to AIDS. However, the precise role of HIV-1 in this process remains unexplained. HIV-1 protease (PR) has been suggested as a possible factor, but a direct link between HIV-1 PR enzymatic activity and apoptosis has not been established. RESULTS: Here, we show that expression of active HIV-1 PR induces death in HeLa and HEK-293 cells via the mitochondrial apoptotic pathway. This conclusion is based on in vivo observations of the direct localization of HIV-1 PR in mitochondria, a key player in triggering apoptosis. Moreover, we observed an HIV-1 PR concentration-dependent decrease in mitochondrial membrane potential and the role of HIV-1 PR in activation of caspase 9, PARP cleavage and DNA fragmentation. In addition, in vitro data demonstrated that HIV-1 PR mediates cleavage of mitochondrial proteins Tom22, VDAC and ANT, leading to release of AIF and Hsp60 proteins. By using yeast two-hybrid screening, we also identified a new HIV-1 PR interaction partner, breast carcinoma-associated protein 3 (BCA3). We found that BCA3 accelerates p53 transcriptional activity on the bax promoter, thus elevating the cellular level of pro-apoptotic Bax protein. CONCLUSION: In summary, our results describe the involvement of HIV-1 PR in apoptosis, which is caused either by a direct effect of HIV-1 PR on mitochondrial membrane integrity or by its interaction with cellular protein BCA3

GrassPlot v. 2.00 – first update on the database of multi-scale plant diversity in Palaearctic grasslands

Abstract: GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). Following a previous Long Database Report (Dengler et al. 2018, Phyto- coenologia 48, 331–347), we provide here the first update on content and functionality of GrassPlot. The current version (GrassPlot v. 2.00) contains a total of 190,673 plots of different grain sizes across 28,171 independent plots, with 4,654 nested-plot series including at least four grain sizes. The database has improved its content as well as its functionality, including addition and harmonization of header data (land use, information on nestedness, structure and ecology) and preparation of species composition data. Currently, GrassPlot data are intensively used for broad-scale analyses of different aspects of alpha and beta diversity in grassland ecosystems