Appetizers of Maruthanilathar

Food is essential for all living things in the world. Without food there is no life in this world. Without food, the world cannot move. The excellence of the food lies in the praise of all. In the Sangha literature, the Maruthana mantras also lived with food playing an important role. So this article is on the topic of Hungry Foods of Maruda Nilamanthars

METHOD TO IMPROVE LINK BRING-UP TIME FOR HIGH-SPEED ETHERNET BACKPLANE AND COPPER CABLES

Modern Massively Scalable Datacenters (MSDCs) delivering high availability software such as Software-as-a-Service (SaaS), Infrastructure-as-a-Service, etc. have stringent metrics to which to adhere. Link availability is one such crucial factor. Techniques presented herein may facilitate decreasing link bring-up time by maintaining a cache for link training (LT) transmit (TX) Finite Impulse Response (FIR) settings. Thus, these techniques may provide for faster link bring-up, faster convergence, and faster fabric module bring-up in an End of Rack (EoR) chassis. Using techniques presented herein, faster link bring-up may become the norm rather than the exception

Honeycomb Structures for High Shear Flexure

The present invention provides an improved shear band for use in non-pneumatic tires, pneumatic tires, and other technologies. The improved shear band is uniquely constructed of honeycomb shaped units that can replace the elastomeric continuum materials such as natural or synthetic rubber or polyurethane that are typically used. In particular, honeycomb structures made of high modulus materials such as metals or polycarbonates are used that provide the desired shear strains and shear modulus when subjected to stress. When used in tire construction, improvements in rolling resistance can be obtained because of less mass being deformed and reduced hysteresis provided by these materials. The resulting mass of the shear band is greatly reduced if using low density materials. Higher density materials can be used (such as metals) without increasing mass while utilizing their characteristic low energy loss

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma

Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways. Previous studies of diffuse midline glioma with altered H3K27 (DMG-H3K27a) have shown that the RAS pathway, specifically through its downstream kinase, extracellular-signal-related kinase 5 (ERK5), is critical for tumor growth. Further downstream effectors of ERK5 and their role in DMG-H3K27a metabolic reprogramming have not been explored. We establish that ERK5 is a critical regulator of cell proliferation and glycolysis in DMG-H3K27a. We demonstrate that ERK5 mediates glycolysis through activation of transcription factor MEF2A, which subsequently modulates expression of glycolytic enzyme PFKFB3. We show that in vitro and mouse models of DMG-H3K27a are sensitive to the loss of PFKFB3. Multi-targeted drug therapy against the ERK5-PFKFB3 axis, such as with small-molecule inhibitors, may represent a promising therapeutic approach in patients with pediatric diffuse midline glioma

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of therapeutic leads are necessary. Ependymomas are chemotherapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets. Intracranial ependymomas are segregated on the basis of anatomical location (supratentorial region or posterior fossa) and further divided into distinct molecular subgroups that reflect differences in the age of onset, gender predominance and response to therapy1,2,3. The most common and aggressive subgroup, posterior fossa ependymoma group A (PF-EPN-A), occurs in young children and appears to lack recurrent somatic mutations2. Conversely, posterior fossa ependymoma group B (PF-EPN-B) tumours display frequent large-scale copy number gains and losses but have favourable clinical outcomes1,3. More than 70% of supratentorial ependymomas are defined by highly recurrent gene fusions in the NF-κB subunit gene RELA (ST-EPN-RELA), and a smaller number involve fusion of the gene encoding the transcriptional activator YAP1 (ST-EPN-YAP1)1,3,4. Subependymomas, a distinct histologic variant, can also be found within the supratetorial and posterior fossa compartments, and account for the majority of tumours in the molecular subgroups ST-EPN-SE and PF-EPN-SE. Here we describe mapping of active chromatin landscapes in 42 primary ependymomas in two non-overlapping primary ependymoma cohorts, with the goal of identifying essential super-enhancer-associated genes on which tumour cells depend. Enhancer regions revealed putative oncogenes, molecular targets and pathways; inhibition of these targets with small molecule inhibitors or short hairpin RNA diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymomas. Through profiling of transcriptional enhancers, our study provides a framework for target and drug discovery in other cancers that lack known genetic drivers and are therefore difficult to treat.This work was supported by an Alex's Lemonade Stand Young Investigator Award (S.C.M.), The CIHR Banting Fellowship (S.C.M.), The Cancer Prevention Research Institute of Texas (S.C.M., RR170023), Sibylle Assmus Award for Neurooncology (K.W.P.), the DKFZ-MOST (Ministry of Science, Technology & Space, Israel) program in cancer research (H.W.), James S. McDonnell Foundation (J.N.R.) and NIH grants: CA154130 (J.N.R.), R01 CA169117 (J.N.R.), R01 CA171652 (J.N.R.), R01 NS087913 (J.N.R.) and R01 NS089272 (J.N.R.). R.C.G. is supported by NIH grants T32GM00725 and F30CA217065. M.D.T. is supported by The Garron Family Chair in Childhood Cancer Research, and grants from the Pediatric Brain Tumour Foundation, Grand Challenge Award from CureSearch for Children’s Cancer, the National Institutes of Health (R01CA148699, R01CA159859), The Terry Fox Research Institute and Brainchild. M.D.T. is also supported by a Stand Up To Cancer St. Baldrick’s Pediatric Dream Team Translational Research Grant (SU2C-AACR-DT1113)

Taxonomy of physical prototypes: structure and validation

This thesis introduces a taxonomy of physical prototypes, and validates the proposed taxonomy by five different approaches. The proposed taxonomy is validated by, (i) checking the orthogonality of individual elements of the taxonomy, (ii) benchmarking the taxonomy with existing classifications of prototypes, (iii) demonstrating its utility by applying it to classify different prototypes, (iv) building a prototype database containing 35 different prototypes, and (v) consistency evaluation of the prototype database using a description logic based software called ProtŽgŽ. The results indicate that the proposed taxonomy is capable of distinguishing prototypes with greater accuracy when compared to existing classifications. The orthogonality of the proposed taxonomy is satisfactory, allowing for more consistent delineation between prototypes. Furthermore, the utility of the taxonomy to classify prototypes, and the building of prototype database demonstrates the flexibility of the proposed taxonomy to classify wide gamut of prototypes. Implementation of prototype database into Description Logic (DL) based ontology revealed the definitions for each prototype class is consistent. This demonstrates the ability of the proposed taxonomy to differentiate distinct prototypes. In addition to the consistency evaluation, ProtŽgŽ is used to generate the automatic class hierarchy of 35 prototypes, which classifies prototypes based on user defined classes. Finally, the DL implementation of the proposed taxonomy and the prototype database provides scope for future research to develop design tools that can aid designers in identifying prototypes necessary for a specific design scenario