Avoiding bias in comparative creole studies : Stratification by lexifier and substrate

One major research question in creole studies has been whether the social/diachronic circumstances of the creolizaton processes are unique, and if so, whether this uniqueness of the evolution of creoles also leads to unique structural changes, which are reflected in a unique structural profile. Some creolists have claimed that indeed the answer to both questions is yes, e.g. Bickerton (1981), McWhorter (2001), and more recently Peter Bakker and Ayméric Daval-Markussen. But these authors have generally overlooked that cross-creole generalizations require representative sampling, especially when working quantitatively. Sampling for genealogical and areal control has been a much discussed topic within world-wide typology, but not yet in comparative creolistics. In all available comparative creoles studies, European-based Atlantic creoles are strongly overrepresented, so that typical features of these languages are taken as "pan-creole" features, e.g. serial verbs, double-object constructions, or obligatory use of overt pronominal subjects. But many of these Atlantic creoles have the same genealogical/areal profile, i.e. European (lexifier) + Macro-Sudan (substrate). I therefore propose a new sampling method that controls for genealogical/areal relatedness of both the substrate and the lexifier, which I call "bi-clan" control (where "clan" is a cover term for linguistic families and convergence areas)

Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells

BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology. RESULTS: Bioinformatics analysis of gene expression data revealed that expression of angiogenesis-associated genes significantly differs between chemosensitive and chemoresistant neuroblastoma cells. A subsequent systematic analysis of a panel of 14 chemosensitive and chemoresistant neuroblastoma cell lines in vitro and in animal experiments indicated a consistent shift to a more pro-angiogenic phenotype in chemoresistant neuroblastoma cells. The molecular mechanims underlying increased pro-angiogenic activity of neuroblastoma cells are individual and differ between the investigated chemoresistant cell lines. Treatment of animals carrying doxorubicin-resistant neuroblastoma xenografts with doxorubicin, a cytotoxic drug known to exert anti-angiogenic activity, resulted in decreased tumour vessel formation and growth indicating chemoresistance-associated enhanced pro-angiogenic activity to be relevant for tumour progression and to represent a potential therapeutic target. CONCLUSION: A bioinformatics approach allowed to identify a relevant chemoresistance-associated shift in neuroblastoma cell biology. The chemoresistance-associated enhanced pro-angiogenic activity observed in neuroblastoma cells is relevant for tumour progression and represents a potential therapeutic target

Die COVID-19-Pandemie in Steglitz-Zehlendorf – sozialräumliche Betrachtung des Infektionsgeschehens

Die laborbestätigten SARS-CoV-2-Falldaten des Berliner Bezirks Steglitz-Zehlendorf im Zeitraum 01.03.2020 bis 30.09.2021 wurden mit dem Ziel ausgewertet, genauere Erkenntnisse über den zeitlichen Verlauf und die kleinräumige Verteilung des Infektionsgeschehens zu gewinnen. Es wurde außerdem geprüft, ob Zusammenhänge zwischen dem Infektionsgeschehen und der Verteilung soziodemografischer Merkmale über die verschiedenen Sozialräume erkennbar sind.Peer Reviewe

Dynamic Nuclear Polarization of 1H, 13C, and 59Co in a Tris(ethylenediamine)cobalt(III) Crystalline Lattice Doped with Cr(III)

The study of inorganic crystalline materials by solid-state NMR spectroscopy is often complicated by the low sensitivity of heavy nuclei. However, these materials often contain or can be prepared with paramagnetic dopants without significantly affecting the structure of the crystalline host. Dynamic nuclear polarization (DNP) is generally capable of enhancing NMR signals by transferring the magnetization of unpaired electrons to the nuclei. Therefore, the NMR sensitivity in these paramagnetically doped crystals might be increased by DNP. In this paper we demonstrate the possibility of efficient DNP transfer in polycrystalline samples of [Co(en)[subscript 3]Cl[subscript 3]][subscript 2]·NaCl·6H[subscript 2]O (en = ethylenediamine, C[subscript 2]H[subscript 8]N[subscript 2]) doped with Cr(III) in varying concentrations between 0.1 and 3 mol %. We demonstrate that [superscript 1]H, [superscript 13]C, and [superscript 59]Co can be polarized by irradiation of Cr(III) with 140 GHz microwaves at a magnetic field of 5 T. We further explain our findings on the basis of electron paramagnetic resonance spectroscopy of the Cr(III) site and analysis of its temperature-dependent zero-field splitting, as well as the dependence of the DNP enhancement factor on the external magnetic field and microwave power. This first demonstration of DNP transfer from one paramagnetic metal ion to its diamagnetic host metal ion will pave the way for future applications of DNP in paramagnetically doped materials or metalloproteins.National Institutes of Health (U.S.) (EB00280)National Institutes of Health (U.S.) (EB002026)German Science Foundation (DFG Research Fellowship CO 802/1-1)Natural Sciences and Engineering Research Council of Canada (Banting Postdoctoral Fellowship)European Molecular Biology Organization (ASTF-491/2013

Inanspruchnahme von Angebotsuntersuchungen in der arbeitsmedizinischen Vorsorge

In den vergangenen zehn Jahren wurde die arbeitsmedizinische Vorsorge zu einem individuellen Arbeitsschutzinstrument weiterentwickelt, das der Aufklärung und Beratung der Beschäftigten über die Wechselwirkungen zwischen Arbeit und Gesundheit dient und bei dem die Selbstbestimmungs- und Datenschutzrechte zu achten sind. In dem vorliegenden Forschungsprojekt hat das Institut für Arbeitsmedizin, Sozialmedizin und Versorgungsforschung der Universitätsklinik Tübingen exemplarisch untersucht, welche Faktoren für die erfolgreiche Durchführung von Angebotsuntersuchungen bedeutsam sind. Die Studie bedient sich hierfür eines multimodularen Ansatzes mit qualitativen und quantitativen Anteilen. Im Ergebnis wird sichtbar, dass die Verordnung zur arbeitsmedizinischen Vorsorge (ArbMedVV) in der Praxis angekommen ist. Zum Teil werden arbeitsmedizinische Vorsorge und Eignungsuntersuchungen jedoch nicht adäquat unterschieden. Mit der Änderung der ArbMedVV Ende Oktober 2013 konnten bereits wichtige Klarstellungen erreicht werden. Unsicherheiten bestehen auch im Zusammenhang mit den so genannten Berufsgenossenschaftlichen Grundsätzen, die teilweise irrtümlich als verbindlich verstanden werden. Hier besteht noch Änderungs- und Klarstellungsbedarf. Übergreifend zeigt die Studie, dass die Inanspruchnahme der arbeitsmedizinischen Vorsorge maßgeblich vom Kenntnisstand aller Beteiligten zur Rechtslage abhängt und das Vertrauensverhältnis zum Betriebsarzt für die Beschäftigten von besonderer Bedeutung ist. Aufklärungsarbeit spielt deshalb auch weiterhin eine wichtige Rolle

Explanation in typology: Diachronic sources, functional motivations and the nature of the evidence

This volume provides an up-to-date discussion of a foundational issue that has recently taken centre stage in linguistic typology and which is relevant to the language sciences more generally: To what extent can cross-linguistic generalizations, i.e. statistical universals of linguistic structure, be explained by the diachronic sources of these structures? Everyone agrees that typological distributions are the result of complex histories, as “languages evolve into the variation states to which synchronic universals pertain” (Hawkins 1988). However, an increasingly popular line of argumentation holds that many, perhaps most, typological regularities are long-term reflections of their diachronic sources, rather than being ‘target-driven’ by overarching functional-adaptive motivations. On this view, recurrent pathways of reanalysis and grammaticalization can lead to uniform synchronic results, obviating the need to postulate global forces like ambiguity avoidance, processing efficiency or iconicity, especially if there is no evidence for such motivations in the genesis of the respective constructions. On the other hand, the recent typological literature is equally ripe with talk of "complex adaptive systems", "attractor states" and "cross-linguistic convergence". One may wonder, therefore, how much room is left for traditional functional-adaptive forces and how exactly they influence the diachronic trajectories that shape universal distributions. The papers in the present volume are intended to provide an accessible introduction to this debate. Covering theoretical, methodological and empirical facets of the issue at hand, they represent current ways of thinking about the role of diachronic sources in explaining grammatical universals, articulated by seasoned and budding linguists alike

Explanation in typology: Diachronic sources, functional motivations and the nature of the evidence

This volume provides an up-to-date discussion of a foundational issue that has recently taken centre stage in linguistic typology and which is relevant to the language sciences more generally: To what extent can cross-linguistic generalizations, i.e. statistical universals of linguistic structure, be explained by the diachronic sources of these structures? Everyone agrees that typological distributions are the result of complex histories, as “languages evolve into the variation states to which synchronic universals pertain” (Hawkins 1988). However, an increasingly popular line of argumentation holds that many, perhaps most, typological regularities are long-term reflections of their diachronic sources, rather than being ‘target-driven’ by overarching functional-adaptive motivations. On this view, recurrent pathways of reanalysis and grammaticalization can lead to uniform synchronic results, obviating the need to postulate global forces like ambiguity avoidance, processing efficiency or iconicity, especially if there is no evidence for such motivations in the genesis of the respective constructions. On the other hand, the recent typological literature is equally ripe with talk of "complex adaptive systems", "attractor states" and "cross-linguistic convergence". One may wonder, therefore, how much room is left for traditional functional-adaptive forces and how exactly they influence the diachronic trajectories that shape universal distributions. The papers in the present volume are intended to provide an accessible introduction to this debate. Covering theoretical, methodological and empirical facets of the issue at hand, they represent current ways of thinking about the role of diachronic sources in explaining grammatical universals, articulated by seasoned and budding linguists alike

Explanation in typology: Diachronic sources, functional motivations and the nature of the evidence

This volume provides an up-to-date discussion of a foundational issue that has recently taken centre stage in linguistic typology and which is relevant to the language sciences more generally: To what extent can cross-linguistic generalizations, i.e. statistical universals of linguistic structure, be explained by the diachronic sources of these structures? Everyone agrees that typological distributions are the result of complex histories, as “languages evolve into the variation states to which synchronic universals pertain” (Hawkins 1988). However, an increasingly popular line of argumentation holds that many, perhaps most, typological regularities are long-term reflections of their diachronic sources, rather than being ‘target-driven’ by overarching functional-adaptive motivations. On this view, recurrent pathways of reanalysis and grammaticalization can lead to uniform synchronic results, obviating the need to postulate global forces like ambiguity avoidance, processing efficiency or iconicity, especially if there is no evidence for such motivations in the genesis of the respective constructions. On the other hand, the recent typological literature is equally ripe with talk of "complex adaptive systems", "attractor states" and "cross-linguistic convergence". One may wonder, therefore, how much room is left for traditional functional-adaptive forces and how exactly they influence the diachronic trajectories that shape universal distributions. The papers in the present volume are intended to provide an accessible introduction to this debate. Covering theoretical, methodological and empirical facets of the issue at hand, they represent current ways of thinking about the role of diachronic sources in explaining grammatical universals, articulated by seasoned and budding linguists alike

Explanation in typology: Diachronic sources, functional motivations and the nature of the evidence

This volume provides an up-to-date discussion of a foundational issue that has recently taken centre stage in linguistic typology and which is relevant to the language sciences more generally: To what extent can cross-linguistic generalizations, i.e. statistical universals of linguistic structure, be explained by the diachronic sources of these structures? Everyone agrees that typological distributions are the result of complex histories, as “languages evolve into the variation states to which synchronic universals pertain” (Hawkins 1988). However, an increasingly popular line of argumentation holds that many, perhaps most, typological regularities are long-term reflections of their diachronic sources, rather than being ‘target-driven’ by overarching functional-adaptive motivations. On this view, recurrent pathways of reanalysis and grammaticalization can lead to uniform synchronic results, obviating the need to postulate global forces like ambiguity avoidance, processing efficiency or iconicity, especially if there is no evidence for such motivations in the genesis of the respective constructions. On the other hand, the recent typological literature is equally ripe with talk of "complex adaptive systems", "attractor states" and "cross-linguistic convergence". One may wonder, therefore, how much room is left for traditional functional-adaptive forces and how exactly they influence the diachronic trajectories that shape universal distributions. The papers in the present volume are intended to provide an accessible introduction to this debate. Covering theoretical, methodological and empirical facets of the issue at hand, they represent current ways of thinking about the role of diachronic sources in explaining grammatical universals, articulated by seasoned and budding linguists alike