UV Properties of Galactic Globular Clusters with GALEX I. The Color-Magnitude Diagrams

We present GALEX data for 44 Galactic globular clusters obtained during 3 GALEX observing cycles between 2004 and 2008. This is the largest homogeneous data set on the UV photometric properties of Galactic globular clusters ever collected. The sample selection and photometric analysis are discussed, and color-magnitude diagrams are presented. The blue and intermediate-blue horizontal branch is the dominant feature of the UV color-magnitude diagrams of old Galactic globular clusters. Our sample is large enough to display the remarkable variety of horizontal branch shapes found in old stellar populations. Other stellar types that are obviously detected are blue stragglers and post core-He burning stars. The main features of UV color-magnitude diagrams of Galactic globular clusters are briefly discussed. We establish the locus of post-core He burning stars in the UV color-magnitude diagram and present a catalog of candidate AGB-manqu \'e, post early-AGB, and post-AGB stars within our cluster sample.Comment: Accepted for publication by The Astronomical Journal. 46 pages, including 21 Figures and 3 tables. All data will be made publicly available by the time the article is published. In the meantime, please contact the authors for data requests. Revised version fixed error with figure numbers and caption

Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox

Obesity sometimes seems protective in disease. This obesity paradox is predominantly described in reports from the Western Hemisphere during acute illnesses. Since adipose triglyceride composition corresponds to long-term dietary patterns, we performed a meta-analysis modeling the effect of obesity on severity of acute pancreatitis, in the context of dietary patterns of the countries from which the studies originated. Increased severity was noted in leaner populations with a higher proportion of unsaturated fat intake. In mice, greater hydrolysis of unsaturated visceral triglyceride caused worse organ failure during pancreatitis, even when the mice were leaner than those having saturated triglyceride. Saturation interfered with triglyceride\u27s interaction and lipolysis by pancreatic triglyceride lipase, which mediates organ failure. Unsaturation increased fatty acid monomers in vivo and aqueous media, resulting in greater lipotoxic cellular responses and organ failure. Therefore, visceral triglyceride saturation reduces the ensuing lipotoxicity despite higher adiposity, thus explaining the obesity paradox

Quantifying the CDK inhibitor VMY-1-103\u27s activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.

The development of new small molecule-based therapeutic drugs requires accurate quantification of drug bioavailability, biological activity and treatment efficacy. Rapidly measuring these endpoints is often hampered by the lack of efficient assay platforms with high sensitivity and specificity. Using an in vivo model system, we report a simple and sensitive liquid chromatography-tandem mass spectrometry assay to quantify the bioavailability of a recently developed novel cyclin-dependent kinase inhibitor VMY-1-103, a purvalanol B-based analog whose biological activity is enhanced via dansylation. We developed a rapid organic phase extraction technique and validated wide and functional VMY-1-103 distribution in various mouse tissues, consistent with its enhanced potency previously observed in a variety of human cancer cell lines. More importantly, in vivo MRI and single voxel proton MR-Spectroscopy further established that VMY-1-103 inhibited disease progression and affected key metabolites in a mouse model of hedgehog-driven medulloblastoma

Early Vegetation Development on an Exposed Reservoir: Implications for Dam Removal

The 4-year drawdown of Horsetooth Reservoir, Colorado, for dam maintenance, provides a case study analog of vegetation response on sediment that might be exposed from removal of a tall dam. Early vegetation recovery on the exposed reservoir bottom was a combination of (1) vegetation colonization on bare, moist substrates typical of riparian zones and reservoir sediment of shallow dams and (2) a shift in moisture status from mesic to the xeric conditions associated with the pre-impoundment upland position of most of the drawdown zone. Plant communities changed rapidly during the first four years of exposure, but were still substantially different from the background upland plant community. Predictions from the recruitment box model about the locations of Populus deltoides subsp. monilifera (plains cottonwood) seedlings relative to the water surface were qualitatively confirmed with respect to optimum locations. However, the extreme vertical range of water surface elevations produced cottonwood seed regeneration well outside the predicted limits of drawdown rate and height above late summer stage. The establishment and survival of cottonwood at high elevations and the differences between the upland plant community and the community that had developed after four years of exposure suggest that vegetation recovery following tall dam removal will follow a trajectory very different from a simple reversal of the response to dam construction, involving not only long time scales of establishment and growth of upland vegetation, but also possibly decades of persistence of legacy vegetation established during the reservoir to upland transition

Luminosity segregation in three clusters of galaxies (A119, 2443, 2218)

We use deep wide-field V-band imaging obtained with the Wide Field Camera at the prime focus of the Issac Newton Telescope to study the spatial and luminosity distribution of galaxies in three low redshift (0.04<z<0.2) clusters: Abell 119, Abell 2443 and Abell 2218. The absolute magnitude limits probed in these clusters are M_{V} - 5logh_{0.7} = -13.3, -15.4 and -16.7mag respectively. The galaxy population, at all luminosities, along the line-of-sight to the clusters can be described by the linear combination of a King profile and a constant surface density of field galaxies. We find that, for these three clusters, the core radius is invariant with intrinsic luminosity of the cluster population to the above limits and thus there is no evidence for luminosity segregation in these clusters. The exception is the brightest galaxies in A2218 which exhibit a more compact spatial distribution. We find the total projected luminosity distribution (within 1Mpc of the cluster centre) can be well represented by a single Schechter function with moderately flat faint-end slopes: alpha=-1.22 (A119), alpha=-1.11 (A2443) and alpha=-1.14 (A2218). We perform a geometric deprojection of the cluster galaxy population and confirm that no `statistically significant' evidence of a change in the shape of the luminosity distribution with cluster-centric radius exists. Again, the exception being A2218 which exhibits a core region with a flatter faint-end slope.Comment: 12 pages, 11 figures, accepted MNRA