Aggro Duality

Aggro Duality features sculptures inspired by skateboarding and custom–automobile cultures. This body of work is inspired by the manufacturing process, physicality of materials, individual aesthetic, and attention to craft. Each sculpture in Aggro Duality is created through intensive construction techniques that aim to modify materials into a unified form; which indicate a combination, a duality of mechanical and organic coexistence. Within the skateboarding and custom/automobile cultures there is an aggressive attitude that pushes individuals above and beyond boundaries of traditional standards, meaning, and styles. These cultures intend to create products that are dramatic, personalized, and stand-out from the norm. This is known as “Aggro” and it is expressed through personalization of color, form and attention to detail

Cooptation and Coalition Mobilization

The question addressed by this research was, “When structural circumstances make revolutionary action likely, under what conditions will a cooptation strategy prevent subordinate revolts?” Experimental procedures established a group status hierarchy consisting of a leader and two subordinates. Groups earned collective outcomes, and the leader usurped an inequitable portion of these outcomes. In this context, the first experiment shows that a cooptation strategy (i.e., offer of a promotion to one of two subordinates) inhibits subordinate revolts. Two additional experiments indicate that the cooptation strategy is most effective (a) if the offer (strategy) provides the target of cooptation a source of personal gain; (b) if the offer (strategy) is a result of the leader’s own volition, rather than situational constraints; and (c) if the leader conveys a strong commitment to follow through on the promotion offer. The results are interpreted with reference to subjective-expected-utility and reciprocity theories

Virtual Cohorts and Synthetic Data in Dementia: An Illustration of Their Potential to Advance Research

When attempting to answer questions of interest, scientists often encounter hurdles that may stem from limited access to existing adequate datasets as a consequence of poor data sharing practices, constraining administrative practices. Further, when attempting to integrate data, differences in existing datasets also impose challenges that limit opportunities for data integration. As a result, the pace of scientific advancements is suboptimal. Synthetic data and virtual cohorts generated using innovative computational techniques represent an opportunity to overcome some of these limitations and consequently, to advance scientific developments. In this paper, we demonstrate the use of virtual cohorts techniques to generate a synthetic dataset that mirrors a deeply phenotyped sample of preclinical dementia research participants

Beyond Differential Privacy: Synthetic Micro-Data Generation with Deep Generative Neural Networks

Recent advances in generative modeling, based on large scale deep neural networks, provide a novel approach for sharing individual-level datasets (micro-data) without privacy concerns. Unlike differential privacy, which enforces a specific query mechanism on data to ensure privacy, generative models can accurately learn the statistical patterns of such micro-data and then be used to generate “synthetic data” that accurately reflects these statistical patterns, yet contain none of the original data itself, and thus can be safely shared for analysis and modeling without compromising privacy. The successful application of these techniques to various industries including healthcare, finance, and autonomous vehicles is promising and results in continued investment in research and development of generative models in both academia and industry

Proactive and reactive cognitive control and dorsolateral prefrontal cortex dysfunction in first episode schizophrenia.

Cognitive control deficits have been consistently documented in patients with schizophrenia. Recent work in cognitive neuroscience has hypothesized a distinction between two theoretically separable modes of cognitive control-reactive and proactive. However, it remains unclear the extent to which these processes are uniquely associated with dysfunctional neural recruitment in individuals with schizophrenia. This functional magnetic resonance imaging (fMRI) study utilized the color word Stroop task and AX Continuous Performance Task (AX-CPT) to tap reactive and proactive control processes, respectively, in a sample of 54 healthy controls and 43 patients with first episode schizophrenia. Healthy controls demonstrated robust dorsolateral prefrontal, anterior cingulate, and parietal cortex activity on both tasks. In contrast, patients with schizophrenia did not show any significant activation during proactive control, while showing activation similar to control subjects during reactive control. Critically, an interaction analysis showed that the degree to which prefrontal activity was reduced in patients versus controls depended on the type of control process engaged. Controls showed increased dorsolateral prefrontal cortex (DLPFC) and parietal activity in the proactive compared to the reactive control task, whereas patients with schizophrenia did not demonstrate this increase. Additionally, patients' DLPFC activity and performance during proactive control was associated with disorganization symptoms, while no reactive control measures showed this association. Proactive control processes and concomitant dysfunctional recruitment of DLPFC represent robust features of schizophrenia that are also directly associated with symptoms of disorganization

“Cristal Tachycardias”: Origin of Right Atrial Tachycardias From the Crista Terminalis Identified by Intracardiac Echocardiography 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.

AbstractObjectives. We sought to use intracardiac echocardiography (ICE) to identify the anatomic origin of focal right atrial tachycardias and to define their relation with the crista terminalis (CT).Background. Previous studies using ICE during mapping of atrial flutter and inappropriate sinus tachycardia have demonstrated an important relation between endocardial anatomy and electrophysiologic events. Recent studies have suggested that right atrial tachycardias may also have a characteristic anatomic distribution.Methods. Twenty-three consecutive patients with 27 right atrial tachycardias were included in the study. ICE was used to facilitate activation mapping in relation to endocardial structures. A 20-pole catheter was positioned along the CT under ICE guidance. ICE was also used to assist in guiding detailed mapping with the ablation catheter in the right atrium.Results. Of 27 focal right atrial tachycardias, 18 (67%, 95% confidence interval [CI] 46% to 83%) were on the CT (2 high medial, 8 high lateral, 6 mid and 2 low). ICE identified the location of the tip of the ablation catheter in immediate relation to the CT in all 18 cases. The 20-pole mapping catheter together with echocardiographic visualization of the CT provided a guide to the site of tachycardia origin along this structure. Radiofrequency ablation was successful in 26 (96%) of 27 (95% CI 81% to 100%) right atrial tachycardias.Conclusions. This study demonstrates that approximately two thirds of focal right atrial tachycardias occurring in the absence of structural heart disease will arise along the CT. Recognition of this common distribution may potentially facilitate mapping and ablation of these tachycardias

RF and Optical Communications: A Comparison of High Data Rate Returns From Deep Space in the 2020 Timeframe

As NASA proceeds with plans for increased science data return and higher data transfer capacity for science missions, both RF and optical communications are viable candidates for significantly higher-rate communications from deep space to Earth. With the inherent advantages, smaller apertures and larger bandwidths, of optical communications, it is reasonable to expect that at some point in time and combination of increasing distance and data rate, the rapidly emerging optical capabilities would become more advantageous than the more mature and evolving RF techniques. This paper presents a comparison of the burden to a spacecraft by both RF and optical communications systems for data rates of 10, 100, and 1000 Mbps and large distances. Advanced technology for RF and optical communication systems have been considered for projecting capabilities in the 2020 timeframe. For the comparisons drawn, the optical and RF ground terminals were selected to be similar in cost. The RF system selected is composed of forty-five 12-meter antennas, whereas the selected optical system is equivalent to a 10-meter optical telescope. Potential differences in availability are disregarded since the focus of this study is on spacecraft mass and power burden for high-rate mission data, under the assumption that essential communications will be provided by low-rate, high availability RF. For both the RF and optical systems, the required EIRP, for a given data rate and a given distance, was achieved by a design that realized the lowest possible communications subsystem mass (power + aperture) consistent with achieving the lowest technology risk. A key conclusion of this paper is that optical communications has great potential for high data rates and distances of 2.67 AU and beyond, but requires R&D and flight demonstrations to prove out technologies